KEGG   PATHWAY: mgp04060
Entry
mgp04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Meleagris gallopavo (turkey)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mgp04060  Cytokine-cytokine receptor interaction
mgp04060

Organism
Meleagris gallopavo (turkey) [GN:mgp]
Gene
100034741  IL1RN; interleukin 1 receptor antagonist [KO:K04519]
100034742  IL8; interleukin 8 precursor [KO:K10030]
100125334  LEPR; leptin receptor precursor [KO:K05062]
100126248  PRLR; prolactin receptor precursor [KO:K05081]
100126554  CD4; CD4 molecule precursor [KO:K06454]
100303659  MSTN; growth/differentiation factor 8 [KO:K05497]
100303661  INHA; inhibin alpha chain precursor [KO:K05500]
100303662  INHBA; inhibin beta A chain [KO:K04667]
100303681  [KO:K05438]
100303688  [KO:K05429]
100303691  IL18; interleukin-18 isoform X1 [KO:K05482]
100303694  PRL; prolactin precursor [KO:K05439]
100303696  IL12B; interleukin-12 subunit beta [KO:K05425]
100303698  IL10; interleukin-10 precursor [KO:K05443]
100538700  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
100538936  RELL1; RELT-like protein 1 [KO:K26541]
100539019  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
100539066  BMP7; bone morphogenetic protein 7 [KO:K16621]
100539302  [KO:K02583]
100539434  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
100539587  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100539605  [KO:K04722]
100539893  [KO:K05439]
100540018  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100540119  BMP3; bone morphogenetic protein 3 [KO:K05496]
100540172  [KO:K04180]
100540193  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B isoform X1 [KO:K05143]
100540245  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
100540289  [KO:K05064]
100540328  XCR1; chemokine XC receptor 1 [KO:K04193]
100540336  CCL20; C-C motif chemokine 20 [KO:K14625]
100540398  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
100540439  [KO:K05050]
100540488  EDA; ectodysplasin-A [KO:K05480]
100540563  CCR7; C-C chemokine receptor type 7 [KO:K04182]
100540581  BMP6; bone morphogenetic protein 6 [KO:K16620]
100540676  [KO:K04386]
100540830  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
100541131  [KO:K05507]
100541154  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100541265  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
100541677  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
100541684  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
100541995  [KO:K22689]
100542079  MPL; thrombopoietin receptor [KO:K05082]
100542145  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
100542150  INHBC; LOW QUALITY PROTEIN: inhibin beta C chain [KO:K22688]
100542296  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
100542401  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
100542423  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B isoform X1 [KO:K05148]
100542453  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
100542511  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100542669  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100542672  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
100542828  [KO:K05172]
100542954  IL12A; interleukin-12 subunit alpha [KO:K05406]
100542982  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
100543203  IL15; interleukin-15 [KO:K05433]
100543219  IL17RE; interleukin-17 receptor E [KO:K05168]
100543302  BMPR1B; bone morphogenetic protein receptor type-1B isoform X2 [KO:K13578] [EC:2.7.11.30]
100543502  IFNG; interferon gamma [KO:K04687]
100543654  IL22; interleukin-22 [KO:K05445]
100543801  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
100543883  IL16; pro-interleukin-16 isoform X2 [KO:K22628]
100543917  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
100543941  THPO; thrombopoietin isoform X1 [KO:K06854]
100544064  [KO:K03158]
100544085  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
100544097  RELL2; RELT-like protein 2 [KO:K26541]
100544182  BMP4; bone morphogenetic protein 4 [KO:K04662]
100544289  [KO:K04183]
100544445  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
100544554  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
100544567  IL17C; interleukin-17C [KO:K05491]
100544878  IL17B; interleukin-17B isoform X2 [KO:K05490]
100544883  [KO:K12964]
100544932  [KO:K05141]
100544957  BMP15; bone morphogenetic protein 15 [KO:K05498]
100545035  [KO:K12964]
100545119  [KO:K05077]
100545137  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
100545173  ACVR2A; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
100545187  [KO:K12499]
100545239  [KO:K05058]
100545370  CCR4; C-C chemokine receptor type 4 [KO:K04179]
100545473  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
100545600  [KO:K05408]
100545706  CSF3; granulocyte colony-stimulating factor [KO:K05423]
100545739  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
100545927  CCR6; C-C chemokine receptor type 6 [KO:K04181]
100545967  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100546187  [KO:K10030]
100546208  IL34; interleukin-34 [KO:K22633]
100546235  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
100546352  ACKR3; atypical chemokine receptor 3 [KO:K04304]
100546430  [KO:K04666]
100546525  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
100546529  [KO:K04665]
100546560  ACVR1; LOW QUALITY PROTEIN: activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
100546658  CD40LG; CD40 ligand [KO:K03161]
100546746  [KO:K05489]
100546861  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100546929  [KO:K05080]
100547247  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
100547361  [KO:K05494]
100547386  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
100547615  IL17RA; interleukin-17 receptor A [KO:K05164]
100547769  [KO:K05068]
100547985  CNTF; ciliary neurotrophic factor [KO:K05420]
100547990  GDF2; growth/differentiation factor 2 [KO:K05503]
100548010  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
100548143  GDF10; growth/differentiation factor 10 [KO:K22674]
100548155  GDF9; growth/differentiation factor 9 [KO:K22673]
100548397  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
100548428  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
100548599  IL6; interleukin-6 [KO:K05405]
100548721  [KO:K05514]
100548813  CX3CL1; fractalkine isoform X1 [KO:K05508]
100548990  [KO:K13594] [EC:2.7.11.30]
100549067  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
100549089  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
100549559  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
100549677  CXCL12; stromal cell-derived factor 1 [KO:K10031]
100549829  [KO:K04388] [EC:2.7.11.30]
100549842  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
100549907  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
100549917  BMP2; bone morphogenetic protein 2 [KO:K21283]
100550061  CCL19; C-C motif chemokine 19 isoform X2 [KO:K05512]
100550136  [KO:K22669]
100550139  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
100550140  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
100550143  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
100550309  GDF5; LOW QUALITY PROTEIN: growth/differentiation factor 5 [KO:K04664]
100550313  [KO:K05060]
100550628  TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160]
100550637  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100550694  IL21; interleukin-21 [KO:K05434]
100550777  BMP8A; bone morphogenetic protein 8A [KO:K16622]
100550834  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
100550945  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
100551045  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
100551080  BMP10; bone morphogenetic protein 10 [KO:K22670]
100551086  GDF11; growth/differentiation factor 11 [KO:K22679]
100551227  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
100551315  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100551416  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
104909443  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
104909985  IL26; interleukin-26 [KO:K05446]
104910029  GDF7; growth/differentiation factor 7 [KO:K20013]
104910273  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
104910575  [KO:K10032]
104911125  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
104911311  [KO:K04738]
104911312  [KO:K04738]
104911544  ACKR4; atypical chemokine receptor 4 [KO:K04186]
104911548  [KO:K04183]
104911551  CCR9; C-C chemokine receptor type 9 [KO:K04184]
104911792  INHBB; inhibin beta B chain [KO:K22687]
104911967  [KO:K21283]
104912104  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
104912206  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
104912333  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
104912413  [KO:K05065]
104912975  [KO:K21083]
104913203  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
104913392  [KO:K05073]
104913573  LIF; leukemia inhibitory factor [KO:K05419]
104914080  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
104914113  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
104914137  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
104914330  IFNLR1; interferon lambda receptor 1 [KO:K05140]
104914490  [KO:K22667]
104914615  CCR10; C-C chemokine receptor type 10 [KO:K04185]
104914668  AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665]
104914723  GDF15; growth/differentiation factor 15 [KO:K05504]
104914777  CNTFR; LOW QUALITY PROTEIN: ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
104914778  [KO:K16062]
104914848  [KO:K05057]
104914894  [KO:K22630]
104914896  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
104915046  [KO:K05414]
104915407  [KO:K05063]
104915450  [KO:K05420]
104915962  IL17RC; interleukin-17 receptor C [KO:K05166]
104916097  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
104916148  [KO:K05066]
104916176  IL23A; interleukin-23 subunit alpha [KO:K05426]
104916413  [KO:K05066]
104916799  [KO:K04738]
104916891  [KO:K05483]
104916911  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
104917170  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
104917524  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
109363864  [KO:K05415]
109364721  [KO:K13377]
109367188  [KO:K10032]
109367190  [KO:K10032]
116217774  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
664712  TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b precursor [KO:K04722]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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