KEGG   PATHWAY: oha04621
Entry
oha04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Opisthocomus hoazin (hoatzin)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
oha04621  NOD-like receptor signaling pathway
oha04621

Organism
Opisthocomus hoazin (hoatzin) [GN:oha]
Gene
104326589  IL6; interleukin-6 [KO:K05405]
104326696  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
104326710  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
104326741  [KO:K05414]
104326820  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
104326885  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104326951  [KO:K04570]
104327114  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
104327217  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
104327231  [KO:K10435]
104327337  CASR; extracellular calcium-sensing receptor [KO:K04612]
104327482  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104327576  TRPM2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
104327671  PANX1; pannexin-1 [KO:K03443]
104327831  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
104327883  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
104328027  JUN; transcription factor AP-1 [KO:K04448]
104328277  TMEM173; stimulator of interferon genes protein [KO:K12654]
104328344  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
104328366  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
104328379  [KO:K20899]
104328384  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
104328394  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
104328694  DHX33; putative ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
104328697  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104328746  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
104328930  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
104329011  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
104329304  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
104329706  NEK7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
104329794  MCU; LOW QUALITY PROTEIN: calcium uniporter protein, mitochondrial [KO:K20858]
104329864  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104330023  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104330049  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104330076  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
104330230  TLR4; LOW QUALITY PROTEIN: toll-like receptor 4 [KO:K10160]
104330387  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104330719  PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
104330725  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
104330757  FADD; FAS-associated death domain protein [KO:K02373]
104330856  TXNIP; thioredoxin-interacting protein [KO:K20910]
104330867  ERBB2IP; LOW QUALITY PROTEIN: protein LAP2 [KO:K12796]
104331082  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
104331287  ANTXR1; anthrax toxin receptor 1 [KO:K20909]
104331519  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
104331522  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
104331641  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
104331648  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104331780  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104331888  [KO:K10030]
104331889  [KO:K10030]
104331897  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
104332630  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
104332643  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
104332780  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
104333030  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
104333221  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
104333228  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104333297  [KO:K20865]
104333487  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104333489  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
104333706  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
104334215  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
104334420  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
104334562  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
104334640  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
104334663  CCL5; C-C motif chemokine 5 [KO:K12499]
104334740  ANTXRL; LOW QUALITY PROTEIN: anthrax toxin receptor-like [KO:K20909]
104334769  [KO:K01370] [EC:3.4.22.36]
104334853  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104335244  [KO:K08846] [EC:2.7.11.1]
104335261  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
104335475  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
104335704  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
104335758  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
104335769  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
104336048  DNM1L; dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
104336307  [KO:K04441] [EC:2.7.11.24]
104336312  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104336337  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
104336412  NLRX1; NLR family member X1 [KO:K12653]
104336468  CTSB; LOW QUALITY PROTEIN: cathepsin B [KO:K01363] [EC:3.4.22.1]
104336587  [KO:K05414]
104336596  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
104336617  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
104336940  TP53BP1; tumor suppressor p53-binding protein 1 [KO:K20915]
104336985  SUGT1; suppressor of G2 allele of SKP1 homolog [KO:K12795]
104337212  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104337513  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104337551  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
104337811  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104337854  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
104337935  NAIP; baculoviral IAP repeat-containing protein 1 [KO:K12807]
104338045  TXN2; thioredoxin, mitochondrial [KO:K03671]
104338114  [KO:K04519]
104338140  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104338189  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104338350  [KO:K21100]
104338370  [KO:K03671]
104338381  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
104338436  RHOA; transforming protein RhoA [KO:K04513]
104338587  IL18; interleukin-18 isoform X1 [KO:K05482]
104338645  [KO:K21421] [EC:1.-.-.-]
104338648  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
104338782  GPRC6A; G-protein coupled receptor family C group 6 member A [KO:K04622]
104338844  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
104339073  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
104339263  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
104339354  P2RX7; P2X purinoceptor 7 [KO:K05220]
104339612  TRPV2; transient receptor potential cation channel subfamily V member 2 [KO:K04971]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
oha04010  MAPK signaling pathway
oha04140  Autophagy - animal
oha04620  Toll-like receptor signaling pathway
KO pathway
ko04621   

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