Entry
Name
MAPK signaling pathway - Opisthocomus hoazin (hoatzin)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Disease
H02157 Short-rib thoracic dysplasia
Other DBs
Organism
Opisthocomus hoazin (hoatzin) [GN:
oha ]
Gene
104327051 RASA2; LOW QUALITY PROTEIN: ras GTPase-activating protein 2 [KO:K08053 ]
104327182 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
104327457 B9D1; LOW QUALITY PROTEIN: B9 domain-containing protein 1 [KO:K04855 ]
104328154 MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434 ]
104328278 CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391 ]
104328536 NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
104328697 TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
104328961 ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
104329443 MAP4K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407 ] [EC:2.7.11.1 ]
104329819 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
104329864 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
104329866 CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856 ]
104330270 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850 ]
104330272 CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861 ]
104330400 MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454 ]
104330463 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
104331208 GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346 ]
104331389 GADD45G; LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
104331710 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
104331757 CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865 ]
104332497 CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863 ]
104332595 MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430 ] [EC:2.7.12.2 ]
104332852 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
104332926 CACNG5; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-5 subunit [KO:K04870 ]
104332927 CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
104332943 CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
104332991 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
104333159 RAP1A; LOW QUALITY PROTEIN: ras-related protein Rap-1A [KO:K04353 ]
104333188 CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860 ]
104333228 IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209 ] [EC:2.7.11.10 ]
104333657 MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436 ]
104333720 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
104333734 CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852 ]
104334768 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
104335194 CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854 ]
104335526 RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326 ]
104335646 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849 ]
104335786 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
104336793 NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
104337212 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
104337640 CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858 ]
104337830 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
104338025 CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867 ]
104338432 CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
Title
MAP kinases.
Journal
Reference
Authors
Tanoue T, Nishida E.
Title
Docking interactions in the mitogen-activated protein kinase cascades.
Journal
Reference
Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
Title
MAPK pathways in radiation responses.
Journal
Reference
Authors
Huang EJ, Reichardt LF.
Title
Trk receptors: roles in neuronal signal transduction.
Journal
Reference
Authors
Harper SJ, LoGrasso P.
Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
Journal
Reference
Authors
Takeda K, Ichijo H
Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Journal
Reference
Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
Title
Transcriptional regulation by the MAP kinase signaling cascades.
Journal
Reference
Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
Journal
Reference
Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
Journal
Reference
Authors
Lemmon MA, Schlessinger J
Title
Cell signaling by receptor tyrosine kinases.
Journal
Reference
Authors
Skaper SD
Title
The neurotrophin family of neurotrophic factors: an overview.
Journal
Reference
Authors
Chu WM
Title
Tumor necrosis factor.
Journal
Reference
Authors
Newton K, Dixit VM
Title
Signaling in innate immunity and inflammation.
Journal
Reference
Authors
Gaestel M, Kotlyarov A, Kracht M
Title
Targeting innate immunity protein kinase signalling in inflammation.
Journal
Reference
Authors
Ajibade AA, Wang HY, Wang RF
Title
Cell type-specific function of TAK1 in innate immune signaling.
Journal
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Related pathway
oha04070 Phosphatidylinositol signaling system
KO pathway