KEGG   PATHWAY: oha04010
Entry
oha04010                    Pathway                                
Name
MAPK signaling pathway - Opisthocomus hoazin (hoatzin)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
oha04010  MAPK signaling pathway
oha04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Opisthocomus hoazin (hoatzin) [GN:oha]
Gene
104326261  SOS1; son of sevenless homolog 1 [KO:K03099]
104326264  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
104326288  STMN1; stathmin [KO:K04381]
104326324  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104326744  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
104326757  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
104326768  RAP1B; ras-related protein Rap-1b [KO:K07836]
104326853  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104326885  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104326892  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104326895  CSF1R; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104326896  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104326982  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
104327051  RASA2; LOW QUALITY PROTEIN: ras GTPase-activating protein 2 [KO:K08053]
104327076  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104327179  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104327182  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104327240  EGF; pro-epidermal growth factor [KO:K04357]
104327342  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
104327457  B9D1; LOW QUALITY PROTEIN: B9 domain-containing protein 1 [KO:K04855]
104327497  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104327669  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104327785  SOS2; son of sevenless homolog 2 [KO:K03099]
104327864  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
104327896  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
104328000  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
104328027  JUN; transcription factor AP-1 [KO:K04448]
104328049  NLK; LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
104328057  NF1; neurofibromin [KO:K08052]
104328115  [KO:K16342] [EC:3.1.1.4]
104328116  [KO:K16342] [EC:3.1.1.4]
104328117  [KO:K16342] [EC:3.1.1.4]
104328118  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104328137  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104328154  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
104328175  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
104328178  [KO:K16342] [EC:3.1.1.4]
104328179  [KO:K16342] [EC:3.1.1.4]
104328181  [KO:K16342] [EC:3.1.1.4]
104328218  CRKL; crk-like protein [KO:K04438]
104328278  CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
104328536  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104328697  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104328821  STK4; serine/threonine-protein kinase 4 [KO:K04411]
104328901  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104328943  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
104328961  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104328966  [KO:K04424] [EC:2.7.11.25]
104329097  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104329111  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104329190  [KO:K17534] [EC:2.7.11.25]
104329276  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
104329294  VEGFA; vascular endothelial growth factor A [KO:K05448]
104329443  MAP4K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
104329456  [KO:K04386]
104329581  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
104329660  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104329819  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104329862  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104329864  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104329866  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
104330023  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104330049  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104330076  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
104330111  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
104330120  INS; insulin [KO:K04526]
104330137  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104330162  IGF2; insulin-like growth factor II [KO:K13769]
104330166  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104330270  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104330272  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
104330387  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104330400  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
104330403  RASA1; ras GTPase-activating protein 1 [KO:K04352]
104330463  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104330707  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
104330758  FGF3; fibroblast growth factor 3 [KO:K04358]
104330759  FGF19; fibroblast growth factor 19 [KO:K22603]
104330857  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104330862  [KO:K25414]
104330959  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104330967  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
104330969  KITLG; kit ligand [KO:K05461]
104331165  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
104331208  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104331389  GADD45G; LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104331428  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
104331464  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
104331483  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
104331598  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104331648  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104331666  PDGFC; platelet-derived growth factor C [KO:K05450]
104331685  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104331707  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104331710  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104331757  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
104331780  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104331794  BDNF; brain-derived neurotrophic factor [KO:K04355]
104331868  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104331900  AREG; amphiregulin [KO:K09782]
104331901  EREG; proepiregulin [KO:K09784]
104331975  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
104332133  STK3; serine/threonine-protein kinase 3 [KO:K04412]
104332214  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104332338  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104332368  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104332497  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
104332595  MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104332631  TGFBR2; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104332713  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104332732  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
104332779  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
104332852  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104332926  CACNG5; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
104332927  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
104332942  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104332943  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
104332991  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104333008  FGF6; fibroblast growth factor 6 [KO:K04358]
104333009  FGF23; fibroblast growth factor 23 [KO:K22428]
104333013  NTF3; neurotrophin-3 [KO:K04356]
104333036  PDGFD; platelet-derived growth factor D [KO:K05450]
104333148  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104333159  RAP1A; LOW QUALITY PROTEIN: ras-related protein Rap-1A [KO:K04353]
104333188  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
104333228  IKBKB; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104333473  VEGFC; vascular endothelial growth factor C [KO:K05449]
104333487  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104333528  NGF; beta-nerve growth factor [KO:K02582]
104333531  NRAS; GTPase NRas [KO:K07828]
104333590  SRF; serum response factor [KO:K04378]
104333597  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104333636  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104333657  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
104333720  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104333734  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
104334089  PGF; placenta growth factor [KO:K16859]
104334109  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
104334135  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
104334192  TGFB3; transforming growth factor beta-3 [KO:K13377]
104334257  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
104334394  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
104334600  FGF7; fibroblast growth factor 7 [KO:K04358]
104334710  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
104334768  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104334853  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104334893  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104334921  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
104334922  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104334932  FGF20; fibroblast growth factor 20 [KO:K04358]
104334967  FIGF; vascular endothelial growth factor D [KO:K05449]
104334983  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
104335067  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
104335080  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
104335194  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
104335221  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104335225  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
104335264  KRAS; GTPase KRas isoform X1 [KO:K07827]
104335294  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104335306  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
104335340  HRAS; GTPase HRas [KO:K02833]
104335526  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
104335646  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
104335669  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104335786  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104335878  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
104335932  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104335960  [KO:K03158]
104335991  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
104336126  EFNA5; ephrin-A5 [KO:K05462]
104336128  [KO:K19662] [EC:2.7.11.13]
104336129  [KO:K04868]
104336307  [KO:K04441] [EC:2.7.11.24]
104336312  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104336332  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104336356  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104336402  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104336557  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104336637  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104336793  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104337164  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104337212  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104337214  [KO:K04421] [EC:2.7.11.25]
104337216  [KO:K04348] [EC:3.1.3.16]
104337229  MRAS; ras-related protein M-Ras [KO:K07831]
104337298  FGF9; fibroblast growth factor 9 [KO:K04358]
104337385  ARRB1; beta-arrestin-1 [KO:K04439]
104337513  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104337524  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104337571  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104337639  HGF; hepatocyte growth factor [KO:K05460]
104337640  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
104337680  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
104337698  FGF10; fibroblast growth factor 10 [KO:K04358]
104337710  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104337811  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104337830  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104337970  ANGPT1; angiopoietin-1 [KO:K05465]
104338025  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
104338111  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104338114  [KO:K04519]
104338189  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104338219  [KO:K04388] [EC:2.7.11.30]
104338273  IGF1; insulin-like growth factor I [KO:K05459]
104338321  FGF18; fibroblast growth factor 18 [KO:K04358]
104338432  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104338506  [KO:K05096] [EC:2.7.10.1]
104338674  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
104338682  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
104338719  MAPT; microtubule-associated protein tau [KO:K04380]
104338831  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104338927  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
104339011  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104339110  FGF16; fibroblast growth factor 16 [KO:K04358]
104339193  [KO:K05085] [EC:2.7.10.1]
104339270  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104339317  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104339480  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
104339510  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
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ko04010   

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