KEGG   PATHWAY: aamp04218
Entry
aamp04218                   Pathway                                
Name
Cellular senescence - Arvicola amphibius (Eurasian water vole)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
aamp04218  Cellular senescence
aamp04218

Other DBs
GO: 0090398
Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119821456  Tgfb1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
119827432  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
119819138  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119826264  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
119810460  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119814613  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
119809845  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
119817430  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
119803317  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119807882  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119827335  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119808297  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
119823258  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119800094  Rb1; retinoblastoma-associated protein [KO:K06618]
119814594  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
119802072  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
119815142  E2f1; transcription factor E2F1 [KO:K17454]
119816691  E2f2; transcription factor E2F2 [KO:K09389]
119817711  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
119801903  E2f4; transcription factor E2F4 [KO:K04682]
119826327  E2f5; transcription factor E2F5 [KO:K04682]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119826452  Foxo1; forkhead box protein O1 [KO:K07201]
119820620  Foxo3; forkhead box protein O3 [KO:K09408]
119823049  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119803337  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119820977  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
119804174  G1/S-specific cyclin-E2-like [KO:K06626]
119826163  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
119822313  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
119822317  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119822318  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
119822319  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
119822320  patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
119822321  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
119822487  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
119822489  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119822615  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751]
119822485  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119822617  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751]
119823810  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119823811  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119823305  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119823809  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119823812  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119802651  Rras; ras-related protein R-Ras [KO:K07829]
119800706  Rras2; ras-related protein R-Ras2 [KO:K07830]
119810543  Mras; ras-related protein M-Ras [KO:K07831]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119818627  Tsc1; hamartin isoform X1 [KO:K07206]
119811857  Tsc2; tuberin isoform X1 [KO:K07207]
119807890  Rheb; GTP-binding protein Rheb [KO:K07208]
119816408  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119806133  Pten; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119822232  Sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
119823710  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
119826737  Ccna2; cyclin-A2 [KO:K06627]
119826760  Ccna1; cyclin-A1 [KO:K06627]
119815530  Mybl2; myb-related protein B isoform X1 [KO:K21769]
119827558  Lin9; protein lin-9 homolog isoform X1 [KO:K21773]
119821168  Lin37; protein lin-37 homolog [KO:K21774]
119818770  Lin52; protein lin-52 homolog isoform X1 [KO:K21775]
119821115  Lin54; protein lin-54 homolog isoform X1 [KO:K21776]
119816889  Rbbp4; histone-binding protein RBBP4 [KO:K10752]
119819492  LOW QUALITY PROTEIN: histone-binding protein RBBP4-like [KO:K10752]
119807870  Foxm1; forkhead box protein M1 isoform X1 [KO:K09406]
119822940  Myc; myc proto-oncogene protein [KO:K04377]
119817628  tumor suppressor ARF-like isoform X1 [KO:K06621]
119803501  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
119818608  cellular tumor antigen p53-like [KO:K04451]
119813419  Tp53; cellular tumor antigen p53 [KO:K04451]
119827913  Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
119811932  Fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
119826523  Btrc; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
119800714  Hipk1; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
119814399  Hipk3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
119821155  Hipk4; homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
119806228  Hipk2; LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 2 [KO:K08826] [EC:2.7.11.1]
119801984  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
119804974  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
119825387  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
119807529  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119809022  Ets1; protein C-ets-1 isoform X1 [KO:K02678]
119813155  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
119812035  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
119822988  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119823276  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119823839  Mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
119823840  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119822349  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
119816942  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
119807493  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
119823380  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
119810462  Ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
119805267  G2/mitotic-specific cyclin-B1-like [KO:K05868]
119809842  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
119804979  Ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
119810328  Mre11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
119812363  Rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
119826828  Nbn; nibrin isoform X1 [KO:K10867]
119809052  Atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
119825027  Chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
119801976  Rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
119825213  Rad9b; cell cycle checkpoint control protein RAD9B [KO:K10995]
119809636  Rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
119824650  Hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
119809137  Atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
119809693  Chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
119810533  Cdc25a; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
119812500  Sqstm1; sequestosome-1 isoform X1 [KO:K14381]
119800020  Gata4; transcription factor GATA-4 isoform X1 [KO:K09183]
119820757  Traf3ip2; LOW QUALITY PROTEIN: E3 ubiquitin ligase TRAF3IP2 [KO:K21124]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119813991  Il1a; interleukin-1 alpha [KO:K04383]
119808459  Il6; interleukin-6 [KO:K05405]
119803267  Igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
119825044  Serpine1; plasminogen activator inhibitor 1 [KO:K03982]
119813700  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
119827858  Mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
119825282  LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
119825571  LOW QUALITY PROTEIN: mRNA decay activator protein ZFP36L1-like [KO:K18753]
119819506  Zfp36l1; mRNA decay activator protein ZFP36L1 [KO:K18753]
119806843  Zfp36l2; mRNA decay activator protein ZFP36L2 [KO:K18753]
119828004  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
119825176  Trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
119815471  Trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
119827467  Capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
119799550  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
119821021  Calm3; calmodulin-3 [KO:K02183]
119808332  Calm2; calmodulin-2 [KO:K02183]
119808754  Calml4; calmodulin-like protein 4 [KO:K02183]
119809106  calmodulin-1 [KO:K02183]
119815477  calmodulin-1 [KO:K02183]
119817551  Calml3; calmodulin-like protein 3 [KO:K02183]
119817552  calmodulin-4-like [KO:K02183]
119818370  Calm1; calmodulin-1 [KO:K02183]
119800939  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
119800012  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119800123  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119823004  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
119826596  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
119814795  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
119815528  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
119801672  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
119800411  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
119806390  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
119806213  Itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
119823109  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119807859  ADP/ATP translocase 2-like [KO:K05863]
119800309  ADP/ATP translocase 2-like [KO:K05863]
119815168  ADP/ATP translocase 2-like [KO:K05863]
119817121  LOW QUALITY PROTEIN: ADP/ATP translocase 1-like [KO:K05863]
119804458  ADP/ATP translocase 2-like [KO:K05863]
119804649  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
119812148  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
119812681  ADP/ATP translocase 2-like [KO:K05863]
119819282  ADP/ATP translocase 2-like [KO:K05863]
119826727  Slc25a31; LOW QUALITY PROTEIN: ADP/ATP translocase 4 [KO:K05863]
119826784  Ppid; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
119812709  Vdac1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
119800149  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119812859  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
119823855  Mcu; calcium uniporter protein, mitochondrial [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
aamp04020  Calcium signaling pathway
aamp04068  FoxO signaling pathway
aamp04110  Cell cycle
aamp04115  p53 signaling pathway
aamp04150  mTOR signaling pathway
KO pathway
ko04218   
LinkDB

DBGET integrated database retrieval system