KEGG   PATHWAY: aoce04060
Entry
aoce04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Amphiprion ocellaris (clown anemonefish)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
aoce04060  Cytokine-cytokine receptor interaction
aoce04060

Organism
Amphiprion ocellaris (clown anemonefish) [GN:aoce]
Gene
111570623  C-C motif chemokine 25-like [KO:K13072]
111575495  C-C motif chemokine 20-like [KO:K13072]
111565603  C-C motif chemokine 19-like [KO:K05512]
111565606  C-C motif chemokine 21-like [KO:K05512]
111562942  C-C motif chemokine 4-like [KO:K12964]
111570217  C-C motif chemokine 20-like [KO:K05513]
111565510  C-C motif chemokine 20-like [KO:K14625]
111570223  C-C motif chemokine 20-like [KO:K14625]
111567661  C-C motif chemokine 20-like [KO:K14625]
111567845  interleukin-8-like [KO:K10030]
111567847  interleukin-8-like [KO:K10030]
111580213  interleukin-8-like [KO:K10030]
111587724  platelet factor 4-like [KO:K10030]
111577429  C-X-C motif chemokine 10-like [KO:K05416]
111563068  C-X-C motif chemokine 13-like isoform X1 [KO:K10032]
111563069  C-X-C motif chemokine 13-like [KO:K10032]
111569928  stromal cell-derived factor 1-like [KO:K10031]
111577430  stromal cell-derived factor 1-like [KO:K10031]
111580483  cxcl14; C-X-C motif chemokine 14 [KO:K10033]
111568839  interleukin-15-like [KO:K05433]
111571580  epo; erythropoietin isoform X1 [KO:K05437]
111568175  somatotropin [KO:K05438]
111569181  somatolactin-like [KO:K05438]
111564969  prolactin-like [KO:K05439]
111573136  prolactin-like [KO:K05439]
111583853  prolactin-like [KO:K05439]
111578815  thpo; thrombopoietin isoform X1 [KO:K06854]
111578156  leptin-B-like [KO:K05424]
111573783  interleukin-6-like [KO:K05405]
111585490  uncharacterized protein LOC111585490 [KO:K05417]
111572772  interleukin-12 subunit alpha-like [KO:K05406]
111567434  interleukin-12 subunit beta-like [KO:K05425]
111588038  il12b; interleukin-12 subunit beta isoform X1 [KO:K05425]
111566717  interleukin-12 subunit beta-like [KO:K05425]
111579852  uncharacterized protein LOC111579852 [KO:K22629]
111582903  ebi3; interleukin-27 subunit beta [KO:K24476]
111566563  il10; interleukin-10 [KO:K05443]
111566560  interleukin-20-like [KO:K22667]
111583810  uncharacterized protein LOC111583810 [KO:K05445]
111570784  interferon a3-like [KO:K05414]
111570786  interferon a3-like [KO:K05414]
111566734  interferon a3-like [KO:K05442]
111583887  interleukin-1 beta-like isoform X1 [KO:K04519]
111580399  interleukin-1 beta-like [KO:K04519]
111585325  interleukin-17F-like [KO:K05494]
111574796  interleukin-17F-like [KO:K05494]
111578889  interleukin-17F-like [KO:K05494]
111568207  il17c; interleukin-17C [KO:K05491]
111584736  il17d; interleukin-17D [KO:K05492]
111564510  il16; pro-interleukin-16 [KO:K22628]
111562990  uncharacterized protein LOC111562990 [KO:K22628]
111576593  il34; interleukin-34 isoform X1 [KO:K22633]
111579085  tumor necrosis factor-like [KO:K03156]
111575173  tumor necrosis factor-like [KO:K03156]
111569930  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
111573689  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111566322  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111577528  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111563445  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
111570135  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
111567569  eda; ectodysplasin-A isoform X1 [KO:K05480]
111573866  nerve growth factor-like [KO:K02582]
111579897  nerve growth factor-like [KO:K02582]
111573218  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
111566609  tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
111567576  tumor necrosis factor ligand superfamily member 13B-like [KO:K05476]
111581736  transforming growth factor beta-1-like [KO:K13375]
111569136  tgfb2; transforming growth factor beta-2 [KO:K13376]
111576372  transforming growth factor beta-2-like [KO:K13376]
111568923  transforming growth factor beta-3-like [KO:K13377]
111572013  transforming growth factor beta-3-like [KO:K13377]
111578302  tgfb3; transforming growth factor beta-3 [KO:K13377]
111566854  gdf15; growth/differentiation factor 15 [KO:K05504]
111563169  growth/differentiation factor 2-like [KO:K05503]
111588233  bone morphogenetic protein 10-like [KO:K22670]
111567979  bone morphogenetic protein 10-like [KO:K22670]
111565644  inhibin alpha chain-like [KO:K05500]
111565793  bmp3; bone morphogenetic protein 3 [KO:K05496]
111563164  gdf10; growth/differentiation factor 10 [KO:K22674]
111577446  growth/differentiation factor 10-like [KO:K22674]
111579728  growth/differentiation factor 11-like isoform X1 [KO:K22679]
111563281  mstn; growth/differentiation factor 8 [KO:K05497]
111574834  growth/differentiation factor 8-like [KO:K05497]
111562489  inhba; inhibin beta A chain [KO:K04667]
111581434  inhibin beta A chain-like [KO:K04667]
111574682  inhbb; inhibin beta B chain [KO:K22687]
111588356  inhibin beta B chain-like [KO:K22687]
111579121  inhibin beta B chain-like [KO:K22687]
111565777  gdf3; growth/differentiation factor 3 [KO:K22672]
111575900  nodal homolog [KO:K04666]
111565733  nodal homolog 2-A-like [KO:K04666]
111568088  nodal; nodal homolog [KO:K04666]
111567549  growth/differentiation factor 9-like [KO:K22673]
111566581  amh; muellerian-inhibiting factor isoform X1 [KO:K04665]
111572058  bone morphogenetic protein 2-like [KO:K21283]
111570811  bone morphogenetic protein 4-like [KO:K21283]
111569676  bmp2; bone morphogenetic protein 2 [KO:K21283]
111575499  bone morphogenetic protein 2-like [KO:K21283]
111573266  bmp4; bone morphogenetic protein 4 [KO:K04662]
111564479  gdf5; growth/differentiation factor 5 [KO:K04664]
111566805  growth/differentiation factor 6-A-like [KO:K20012]
111569256  gdf6; growth/differentiation factor 6 [KO:K20012]
111562715  bmp15; bone morphogenetic protein 15 isoform X1 [KO:K05498]
111562674  bmp5; bone morphogenetic protein 5 [KO:K04663]
111589138  bmp6; bone morphogenetic protein 6 [KO:K16620]
111570498  bone morphogenetic protein 7-like [KO:K16621]
111588709  bone morphogenetic protein 7-like [KO:K16621]
111563196  bone morphogenetic protein 8A-like [KO:K16622]
111564492  bone morphogenetic protein 5-like [KO:K16622]
111563837  C-C chemokine receptor type 9-like [KO:K04184]
111568782  C-C chemokine receptor type 9-like [KO:K04184]
111565543  atypical chemokine receptor 4-like [KO:K04186]
111581397  atypical chemokine receptor 4-like [KO:K04186]
111587561  C-C chemokine receptor type 7-like isoform X1 [KO:K04182]
111569988  ccr7; C-C chemokine receptor type 7 [KO:K04182]
111571142  C-C chemokine receptor type 7-like [KO:K04179]
111577427  C-C chemokine receptor type 3-like [KO:K04179]
111573427  C-C chemokine receptor type 4-like [KO:K04179]
111573431  C-C chemokine receptor type 4-like [KO:K04179]
111573428  C-C chemokine receptor type 5-like [KO:K04180]
111565406  C-C chemokine receptor type 3-like [KO:K04178]
111577407  C-C chemokine receptor type 6-like [KO:K04181]
111570999  ccr6; C-C chemokine receptor type 6 [KO:K04181]
111581085  C-X-C chemokine receptor type 1-like [KO:K05050]
111580286  C-X-C chemokine receptor type 1-like [KO:K05050]
111578399  C-X-C chemokine receptor type 1-like [KO:K05050]
111562955  cxcr3; C-X-C chemokine receptor type 3 isoform X1 [KO:K04188]
111562956  C-X-C chemokine receptor type 3-2-like [KO:K04188]
111562957  C-X-C chemokine receptor type 3-like [KO:K04188]
111585550  C-X-C chemokine receptor type 3-2-like [KO:K04188]
111585551  C-X-C chemokine receptor type 3-like [KO:K04188]
111577346  cxcr5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
111571831  C-X-C chemokine receptor type 4-like [KO:K04189]
111571313  C-X-C chemokine receptor type 4-like [KO:K04189]
111578933  ackr3; atypical chemokine receptor 3 [KO:K04304]
111570411  chemokine XC receptor 1-like [KO:K04193]
111570412  chemokine XC receptor 1-like [KO:K04193]
111570413  chemokine XC receptor 1-like [KO:K04193]
111570416  chemokine XC receptor 1-like [KO:K04193]
111570417  chemokine XC receptor 1-like [KO:K04193]
111584307  xcr1; chemokine XC receptor 1 [KO:K04193]
111579883  csf2rb; cytokine receptor common subunit beta [KO:K05069]
111579444  interleukin-2 receptor subunit beta-like [KO:K05069]
111573091  cytokine receptor common subunit gamma-like [KO:K05070]
111587969  uncharacterized protein LOC111587969 [KO:K05071]
111579124  il15ra; interleukin-15 receptor subunit alpha [KO:K05074]
111579090  interleukin-21 receptor-like [KO:K05075]
111584916  uncharacterized protein LOC111584916 [KO:K05075]
111581338  uncharacterized protein LOC111581338 [KO:K04738]
111562567  uncharacterized protein LOC111562567 isoform X1 [KO:K05076]
111562560  uncharacterized protein LOC111562560 [KO:K05076]
111574273  interleukin-13 receptor subunit alpha-2-like [KO:K05077]
111586038  erythropoietin receptor-like [KO:K05079]
111575664  growth hormone receptor-like isoform X1 [KO:K05080]
111572695  growth hormone receptor-like [KO:K05080]
111573340  growth hormone receptor-like isoform X1 [KO:K05080]
111587892  prolactin receptor-like [KO:K05081]
111578447  mpl; thrombopoietin receptor [KO:K05082]
111572351  csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
111582044  lepr; leptin receptor [KO:K05062]
111562998  interleukin-6 receptor subunit alpha-like [KO:K05055]
111573454  interleukin-31 receptor subunit alpha-like [KO:K05060]
111579143  il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
111587984  interleukin-6 receptor subunit beta-like [KO:K05060]
111581613  ciliary neurotrophic factor receptor subunit alpha-like [KO:K05056]
111576546  interleukin-6 receptor subunit beta-like [KO:K05063]
111563495  interleukin-12 receptor subunit beta-2-like [KO:K05064]
111563607  interleukin-12 receptor subunit beta-2-like [KO:K05064]
111564681  interleukin-12 receptor subunit beta-2-like [KO:K05064]
111583152  interleukin-6 receptor subunit beta-like [KO:K22630]
111589049  ciliary neurotrophic factor receptor subunit alpha-like [KO:K05059]
111565256  leukemia inhibitory factor receptor-like [KO:K05058]
111564697  leukemia inhibitory factor receptor-like [KO:K05058]
111588499  interferon alpha/beta receptor 1b-like [KO:K05135]
111588632  interleukin-10 receptor subunit beta-like [KO:K05135]
111578307  uncharacterized protein LOC111578307 [KO:K05136]
111586558  interleukin-20 receptor subunit beta-like [KO:K05137]
111588622  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
111588460  interferon alpha/beta receptor 2-like [KO:K05131]
111583941  uncharacterized protein LOC111583941 [KO:K05132]
111567671  uncharacterized protein LOC111567671 [KO:K05132]
111563964  interleukin-1 receptor type 1-like [KO:K04386]
111586849  interleukin-1 receptor accessory protein-like isoform X1 [KO:K04723]
111564373  interleukin-1 receptor type 2-like [KO:K04387]
111566421  uncharacterized protein LOC111566421 [KO:K04387]
111564859  interleukin-18 receptor 1-like [KO:K05173]
111564828  interleukin-18 receptor accessory protein-like [KO:K05174]
111571686  interleukin-1 receptor-like 1 [KO:K05171]
111583635  interleukin-17 receptor A-like [KO:K05164]
111567057  interleukin-17 receptor A-like [KO:K05164]
111587117  interleukin-17 receptor C-like [KO:K05166]
111588722  interleukin-17 receptor C-like isoform X1 [KO:K05166]
111588736  uncharacterized protein LOC111588736 isoform X1 [KO:K05168]
111569482  T-cell surface glycoprotein CD4-like [KO:K06454]
111575718  macrophage colony-stimulating factor 1 receptor 2-like [KO:K05090] [EC:2.7.10.1]
111569513  csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
111586342  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
111588021  tumor necrosis factor receptor superfamily member 1B-like isoform X1 [KO:K05141]
111586784  tumor necrosis factor receptor superfamily member 5-like [KO:K03159]
111586298  tumor necrosis factor receptor superfamily member 5-like [KO:K05152]
111565161  tumor necrosis factor receptor superfamily member 5-like [KO:K05152]
111571914  tumor necrosis factor receptor superfamily member 6B-like [KO:K05143]
111578979  tumor necrosis factor receptor superfamily member 6B-like [KO:K05143]
111588573  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
111566190  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
111583694  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
111574127  tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
111580593  edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
111588910  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
111579039  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
111572032  death domain-containing membrane protein NRADD-like [KO:K02583]
111578984  tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
111565920  tumor necrosis factor receptor superfamily member 11A-like [KO:K05147]
111564296  cd27; CD27 antigen [KO:K05144]
111584762  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
111566221  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160]
111588354  tumor necrosis factor receptor superfamily member 9-like [KO:K05146]
111584764  tumor necrosis factor receptor superfamily member 4-like [KO:K05142]
111571624  tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
111588943  tnfrsf19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
111580974  relt; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
111563098  nascent polypeptide-associated complex subunit alpha, muscle-specific form-like [KO:K26541]
111571089  RELT-like protein 1 [KO:K26541]
111569578  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
111573752  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111569697  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111568072  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111564865  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
111577405  activin receptor type-1-like [KO:K13594] [EC:2.7.11.30]
111563996  activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
111581847  activin receptor type-2A-like [KO:K04670] [EC:2.7.11.30]
111567532  bone morphogenetic protein receptor type-2-like [KO:K04671] [EC:2.7.11.30]
111565854  bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
111576974  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
111587864  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
111566612  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
111577291  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
111573304  acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
111577012  activin receptor type-1-like isoform X1 [KO:K04675] [EC:2.7.11.30]
111580336  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
111585792  bmpr1a; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
111576466  bmpr1b; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
111574921  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   
LinkDB

DBGET integrated database retrieval system