KEGG   PATHWAY: bgar04148
Entry
bgar04148                   Pathway                                
Name
Efferocytosis - Bufo gargarizans (Asiatic toad)
Class
Cellular Processes; Transport and catabolism
Pathway map
bgar04148  Efferocytosis
bgar04148

Organism
Bufo gargarizans (Asiatic toad) [GN:bgar]
Gene
122934399  caspase-3-like [KO:K02187] [EC:3.4.22.56]
122940788  caspase-3-like [KO:K02187] [EC:3.4.22.56]
122929475  caspase-7-like [KO:K04397] [EC:3.4.22.60]
122940313  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
122930493  caspase-1-B-like isoform X1 [KO:K01370] [EC:3.4.22.36]
122931250  PANX1; pannexin-1 [KO:K03443]
122923232  P2Y purinoceptor 2-like [KO:K04269]
122923234  P2Y purinoceptor 2-like [KO:K04269]
122923643  P2RY6; P2Y purinoceptor 6 [KO:K04272]
122933995  P2RY12; P2Y purinoceptor 12 [KO:K04298]
122942216  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
122926659  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
122943557  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
122943158  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
122943763  LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA1-like [KO:K05641]
122922035  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
122922298  probable G-protein coupled receptor 132 [KO:K08426]
122934891  disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
122933687  disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
122919690  disintegrin and metalloproteinase domain-containing protein 10-like isoform X1 [KO:K06704] [EC:3.4.24.81]
122927656  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
122940814  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
122937923  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
122945175  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
122920397  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
122923932  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
122921677  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
122923213  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
122927271  EPOR; erythropoietin receptor [KO:K05079]
122921834  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
122930454  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122924457  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122940776  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
122943713  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
122944170  peroxisome proliferator-activated receptor gamma-like [KO:K08530]
122919476  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
122927541  MFGE8; lactadherin isoform X1 [KO:K17253]
122932740  GAS6; growth arrest-specific protein 6 isoform X1 [KO:K05464]
122934691  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
122925806  CD36; platelet glycoprotein 4 [KO:K06259]
122922235  THBS1; thrombospondin-1 [KO:K16857]
122929542  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122929119  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
122943666  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
122922171  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
122924954  prostaglandin E2 receptor EP2 subtype-like [KO:K04259]
122925190  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
122935196  DNA (cytosine-5)-methyltransferase 3A-like [KO:K17398] [EC:2.1.1.37]
122933821  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
122944434  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
122946366  transforming growth factor beta-1 proprotein-like isoform X1 [KO:K13375]
122946419  transforming growth factor beta-1 proprotein-like isoform X1 [KO:K13375]
122944457  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
122924546  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
122931168  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
122928362  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
122943504  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
122939966  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122927375  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
122934162  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
122927918  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
122927919  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122943203  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
122933278  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122933460  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
122940049  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
122928477  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122928609  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122945370  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122927750  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
122927978  ANO6; anoctamin-6 isoform X1 [KO:K19500]
122925996  ANO4; anoctamin-4 [KO:K19499]
122921141  ANO5; anoctamin-5 isoform X1 [KO:K19480]
122927041  ANO7; LOW QUALITY PROTEIN: anoctamin-7 [KO:K19501]
122920549  ANO9; anoctamin-9 isoform X1 [KO:K19503]
122920299  BSG; basigin [KO:K06535]
122933117  XKR8; XK-related protein 8 [KO:K26813]
122939042  XKR9; XK-related protein 9 isoform X1 [KO:K26814]
122942322  XKR7; XK-related protein 7 [KO:K26811]
122939077  XK-related protein 4-like [KO:K26811]
122934728  XKR6; XK-related protein 6 isoform X1 [KO:K26811]
122930162  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
122941426  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
122946840  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
122933686  ATP11B; phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
122930412  ATP11A; phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
122933701  TMEM30A; cell cycle control protein 50A [KO:K26935]
122932561  cell cycle control protein 50B-like [KO:K26935]
122933050  cell cycle control protein 50C-like [KO:K26935]
122930853  PROS1; vitamin K-dependent protein S isoform X1 [KO:K03908]
122933063  vitamin K-dependent protein S-like isoform X1 [KO:K03908]
122946190  ITGAV; integrin alpha-V [KO:K06487]
122940129  ITGB3; integrin beta-3 [KO:K06493]
122942561  ITGB5; integrin beta-5 [KO:K06588]
122946194  tyrosine-protein kinase receptor UFO-like [KO:K05115] [EC:2.7.10.1]
122926902  tyrosine-protein kinase receptor UFO-like [KO:K05115] [EC:2.7.10.1]
122921653  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
122938621  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
122928325  T-cell immunoglobulin and mucin domain-containing protein 4-like [KO:K20413]
122943055  STAB1; stabilin-1 [KO:K19020]
122928099  STAB2; stabilin-2 [KO:K19013]
122937761  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122920389  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
122934259  CRKL; crk-like protein [KO:K04438]
122922790  CRK; adapter molecule crk isoform X1 [KO:K04438]
122938214  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
122939903  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
122944424  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122944817  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122944818  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122942311  disintegrin and metalloproteinase domain-containing protein 9-like isoform X1 [KO:K06834] [EC:3.4.24.-]
122925669  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
122927318  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
122944131  calreticulin-like [KO:K08057]
122927281  CALR; calreticulin [KO:K08057]
122927026  C1QA; complement C1q subcomponent subunit A [KO:K03986]
122927029  C1QB; complement C1q subcomponent subunit B [KO:K03987]
122927027  C1QC; complement C1q subcomponent subunit C [KO:K03988]
122930508  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
122935265  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
122929545  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
122932520  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
122944407  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
122944466  RAB17; ras-related protein Rab-17 isoform X1 [KO:K07909]
122938335  RAB5A; ras-related protein Rab-5A [KO:K07887]
122930417  RAB5B; ras-related protein Rab-5B [KO:K07888]
122945611  ras-related protein Rab-5B-like [KO:K07888]
122940669  RAB5C; ras-related protein Rab-5C [KO:K07889]
122932361  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
122923145  vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
122944991  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
122934937  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
122944401  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
122921987  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
122924531  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
122921243  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
122938470  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
122943453  RAB7A; ras-related protein Rab-7a [KO:K07897]
122933452  RAB7B; ras-related protein Rab-7b [KO:K07898]
122934627  lysosomal amino acid transporter 1 homolog [KO:K23678]
122924090  lysosomal amino acid transporter 1 homolog [KO:K23678]
122927057  lysosomal amino acid transporter 1 homolog [KO:K23678]
122921929  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
122933763  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
122934503  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
122935611  ornithine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
122932165  AZIN2; antizyme inhibitor 2 [KO:K01581] [EC:4.1.1.17]
122929725  cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
122925766  cholesterol 25-hydroxylase-like protein 1, member 1 [KO:K10223] [EC:1.14.99.38]
122940819  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
122928616  oxysterols receptor LXR-beta-like [KO:K08535]
122928620  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
122920010  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
122927755  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
122931431  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
122942172  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
122943293  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
122932426  IL10; interleukin-10 [KO:K05443]
122942165  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
122940650  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
122940948  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
122941188  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
122926331  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
122930258  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
122934078  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
122940685  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
122927773  uncharacterized protein LOC122927773 isoform X1 [KO:K06551]
122927775  uncharacterized protein LOC122927775 isoform X1 [KO:K06551]
122941187  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
122928690  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
122924570  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
bgar00010  Glycolysis / Gluconeogenesis
bgar04140  Autophagy - animal
bgar04145  Phagosome
KO pathway
ko04148   
LinkDB

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