KEGG   PATHWAY: cge04360
Entry
cge04360                    Pathway                                
Name
Axon guidance - Cricetulus griseus (Chinese hamster)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
cge04360  Axon guidance
cge04360

Other DBs
GO: 0007411
Organism
Cricetulus griseus (Chinese hamster) [GN:cge]
Gene
100773944  Ntng1; netrin-G1 isoform X2 [KO:K07522]
100764012  Ntng2; netrin-G2 isoform X4 [KO:K16359]
100765202  leucine-rich repeat-containing protein 4C [KO:K07523]
103159912  Lrrc4; leucine-rich repeat-containing protein 4 isoform X2 [KO:K16351]
100750350  Ntn1; netrin-1 isoform X2 [KO:K06843]
100771322  Ntn3; netrin-3 [KO:K06844]
100754393  Ntn4; netrin-4 isoform X3 [KO:K06845]
100758377  Dcc; netrin receptor DCC isoform X2 [KO:K06765]
100769697  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100752475  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100689206  Trpc1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
100689209  Trpc3; short transient receptor potential channel 3 isoform X5 [KO:K04966]
100770387  Trpc4; short transient receptor potential channel 4 isoform X2 [KO:K04967]
100754603  Trpc5; short transient receptor potential channel 5 [KO:K04968]
100757179  Trpc6; short transient receptor potential channel 6 isoform X1 [KO:K04969]
100751412  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X6 [KO:K04348] [EC:3.1.3.16]
100752571  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100764987  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100754314  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
100773706  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100762227  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100760989  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
100768420  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
100759464  Ptk2; focal adhesion kinase 1 isoform X5 [KO:K05725] [EC:2.7.10.2]
100772355  Fyn; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
100757188  Src; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
100756792  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
113837706  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100767225  ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
100757479  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
100765433  Cdc42; cell division control protein 42 homolog [KO:K04393]
100759449  Ablim3; actin-binding LIM protein 3 isoform X2 [KO:K07520]
100767228  Ablim1; actin-binding LIM protein 1 isoform X13 [KO:K07520]
100774533  Ablim2; actin-binding LIM protein 2 isoform X1 [KO:K07520]
100769675  Nck1; cytoplasmic protein NCK1 [KO:K07365]
100767503  Pak1; serine/threonine-protein kinase PAK 1 isoform X4 [KO:K04409] [EC:2.7.11.1]
100751503  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100774215  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
100760399  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
100770198  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100758984  serine/threonine-protein kinase PAK 6 isoform X2 [KO:K05735] [EC:2.7.11.1]
100762797  Rhoa; transforming protein RhoA [KO:K04513]
100757042  transforming protein RhoA isoform X1 [KO:K04513]
100770074  Rock1; rho-associated protein kinase 1 isoform X3 [KO:K04514] [EC:2.7.11.1]
100767265  Rock2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
100760860  Unc5b; netrin receptor UNC5B isoform X1 [KO:K07521]
100762594  Unc5d; netrin receptor UNC5D isoform X2 [KO:K07521]
100762557  Unc5c; netrin receptor UNC5C isoform X3 [KO:K07521]
100766199  Unc5a; netrin receptor UNC5A isoform X4 [KO:K07521]
100771077  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
100758121  Rgma; repulsive guidance molecule A isoform X2 [KO:K23096]
100759045  Neo1; neogenin isoform X2 [KO:K06766]
100753477  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
100773835  myosin regulatory light chain 12B [KO:K12757]
100773545  myosin regulatory light polypeptide 9 [KO:K12757]
100765006  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X3 [KO:K07532]
100767403  Lrig2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X3 [KO:K24609]
100773125  Efna3; ephrin-A3 isoform X2 [KO:K05462]
100756587  Efna5; ephrin-A5 isoform X2 [KO:K05462]
100758074  Efna1; ephrin-A1 [KO:K05462]
100755670  Efna2; ephrin-A2 isoform X2 [KO:K05462]
113833115  Efna4; ephrin-A4 isoform X2 [KO:K05462]
103158763  ephrin-B2 isoform X2 [KO:K05463]
100755216  Efnb1; ephrin-B1 isoform X2 [KO:K05463]
100753573  Efnb2; ephrin-B2 isoform X2 [KO:K05463]
100756800  Efnb3; ephrin-B3 isoform X2 [KO:K05463]
113839076  ephrin-B2-like isoform X1 [KO:K05463]
113838057  ephrin-B2-like isoform X2 [KO:K05463]
113838063  ephrin-B2-like isoform X1 [KO:K05463]
103162695  LOW QUALITY PROTEIN: ephrin-B2 isoform X2 [KO:K05463]
113838916  ephrin-B2-like [KO:K05463]
113831860  ephrin-B2 [KO:K05463]
113838971  ephrin-B2-like [KO:K05463]
113839047  ephrin-B2-like isoform X1 [KO:K05463]
113837977  LOW QUALITY PROTEIN: ephrin-B2-like [KO:K05463]
100752024  Epha1; ephrin type-A receptor 1 isoform X2 [KO:K05102] [EC:2.7.10.1]
100752851  Epha2; ephrin type-A receptor 2 isoform X2 [KO:K05103] [EC:2.7.10.1]
100768107  Epha3; ephrin type-A receptor 3 [KO:K05104] [EC:2.7.10.1]
100754542  Epha4; ephrin type-A receptor 4 isoform X2 [KO:K05105] [EC:2.7.10.1]
100770099  Epha5; ephrin type-A receptor 5 isoform X3 [KO:K05106] [EC:2.7.10.1]
113830699  ephrin type-A receptor 6 isoform X2 [KO:K05107] [EC:2.7.10.1]
100750730  Epha7; ephrin type-A receptor 7 isoform X3 [KO:K05108] [EC:2.7.10.1]
100769287  Epha8; ephrin type-A receptor 8 isoform X2 [KO:K05109] [EC:2.7.10.1]
100769764  Ephb1; ephrin type-B receptor 1 [KO:K05110] [EC:2.7.10.1]
100766993  Ephb2; ephrin type-B receptor 2 [KO:K05111] [EC:2.7.10.1]
100774807  Ephb3; ephrin type-B receptor 3 isoform X1 [KO:K05112] [EC:2.7.10.1]
100769535  Ephb4; ephrin type-B receptor 4 isoform X2 [KO:K05113] [EC:2.7.10.1]
100762813  Ephb6; ephrin type-B receptor 6 isoform X2 [KO:K05114] [EC:2.7.10.1]
100768098  Abl1; tyrosine-protein kinase ABL1 isoform X2 [KO:K06619] [EC:2.7.10.2]
100752970  Enah; LOW QUALITY PROTEIN: protein enabled homolog isoform X2 [KO:K05746]
100762440  Rasa1; ras GTPase-activating protein 1 isoform X2 [KO:K04352]
100773544  Ngef; ephexin-1 isoform X2 [KO:K07525]
100773737  Hras; GTPase HRas isoform X2 [KO:K02833]
100763178  Kras; GTPase KRas isoform X4 [KO:K07827]
113839127  GTPase KRas-like [KO:K07827]
113837935  GTPase KRas-like isoform X2 [KO:K07827]
113837956  GTPase KRas-like [KO:K07827]
113838653  GTPase KRas-like isoform X2 [KO:K07827]
113838692  GTPase KRas-like [KO:K07827]
113838722  GTPase KRas-like isoform X1 [KO:K07827]
113838818  GTPase KRas-like [KO:K07827]
113837633  GTPase KRas-like isoform X1 [KO:K07827]
113838146  GTPase KRas-like isoform X1 [KO:K07827]
113838876  GTPase KRas-like [KO:K07827]
113838228  GTPase KRas-like isoform X1 [KO:K07827]
113839011  GTPase KRas-like [KO:K07827]
100771078  GTPase KRas-like isoform X2 [KO:K07827]
113837960  GTPase KRas-like [KO:K07827]
113838098  GTPase KRas-like [KO:K07827]
113838326  GTPase KRas-like [KO:K07827]
113838417  GTPase KRas-like isoform X1 [KO:K07827]
113838488  GTPase KRas-like [KO:K07827]
113838583  GTPase KRas-like isoform X1 [KO:K07827]
113838676  GTPase KRas-like [KO:K07827]
113838679  GTPase KRas-like isoform X1 [KO:K07827]
113838746  GTPase KRas-like [KO:K07827]
113838796  GTPase KRas-like isoform X1 [KO:K07827]
113838871  GTPase KRas-like [KO:K07827]
113838872  GTPase KRas-like [KO:K07827]
113838892  GTPase KRas-like [KO:K07827]
113838898  GTPase KRas-like [KO:K07827]
113838914  GTPase KRas-like [KO:K07827]
113838921  GTPase KRas-like [KO:K07827]
113838942  GTPase KRas-like isoform X1 [KO:K07827]
113838943  GTPase KRas-like isoform X1 [KO:K07827]
113839007  GTPase HRas-like isoform X1 [KO:K07827]
118239746  GTPase KRas-like isoform X1 [KO:K07827]
118239767  GTPase KRas-like isoform X1 [KO:K07827]
118239768  GTPase KRas-like [KO:K07827]
118239770  GTPase KRas-like [KO:K07827]
118239801  GTPase KRas-like [KO:K07827]
118239825  GTPase KRas-like isoform X1 [KO:K07827]
100757614  Nras; GTPase NRas [KO:K07828]
100759514  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
100753149  Mapk3; mitogen-activated protein kinase 3 isoform X2 [KO:K04371] [EC:2.7.11.24]
100762895  Nck2; cytoplasmic protein NCK2 [KO:K19862]
100750980  Rgs3; regulator of G-protein signaling 3 isoform X6 [KO:K07524]
100759082  Cxcl12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
100767733  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
100689068  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100689072  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
100689070  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100756902  Slit1; slit homolog 1 protein [KO:K06838]
100752994  slit homolog 2 protein isoform X4 [KO:K06839]
100766846  Slit3; slit homolog 3 protein isoform X2 [KO:K06850]
100771010  Robo1; roundabout homolog 1 isoform X1 [KO:K06753]
100750990  Robo2; roundabout homolog 2 isoform X1 [KO:K06754]
100767075  Robo3; roundabout homolog 3 isoform X2 [KO:K06755]
100755954  Srgap1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X3 [KO:K07526]
100758268  Srgap2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526]
100758603  Srgap3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X6 [KO:K07526]
100764502  Sema3g; semaphorin-3G [KO:K06840]
100765927  Sema3c; semaphorin-3C isoform X2 [KO:K06840]
100757993  Sema3e; semaphorin-3E [KO:K06840]
100757705  Sema3a; semaphorin-3A [KO:K06840]
100754027  Sema3d; semaphorin-3D [KO:K06840]
100754215  Sema3b; semaphorin-3B [KO:K06840]
100755077  Sema3f; semaphorin-3F isoform X1 [KO:K06840]
100753940  Plxna4; plexin-A4 isoform X3 [KO:K06820]
100761215  Plxna3; plexin-A3 isoform X1 [KO:K06820]
100760933  Plxna1; plexin-A1 [KO:K06820]
100763940  Plxna2; plexin-A2 isoform X1 [KO:K06820]
100763324  Nrp1; neuropilin-1 isoform X1 [KO:K06724]
100769119  L1cam; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
100770918  Limk1; LIM domain kinase 1 isoform X2 [KO:K05743] [EC:2.7.11.1]
100760910  Limk2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
100757641  Cfl2; cofilin-2 isoform X2 [KO:K05765]
100760435  Cfl1; cofilin-1 [KO:K05765]
100760521  Rhod; rho-related GTP-binding protein RhoD [KO:K07530]
100767501  Rnd1; rho-related GTP-binding protein Rho6 isoform X2 [KO:K07531]
100763153  Fes; tyrosine-protein kinase Fes/Fps isoform X1 [KO:K07527] [EC:2.7.10.2]
100761240  Dpysl5; dihydropyrimidinase-related protein 5 [KO:K07529]
100759148  Dpysl2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528]
100762907  Cdk5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
100760865  Gsk3b; glycogen synthase kinase-3 beta isoform X7 [KO:K03083] [EC:2.7.11.26]
100772904  Sema4b; semaphorin-4B [KO:K06521]
100759257  Sema4f; semaphorin-4F isoform X2 [KO:K06521]
100759517  Sema4d; semaphorin-4D [KO:K06521]
100756606  Sema4g; semaphorin-4G isoform X2 [KO:K06521]
100768897  Sema4c; semaphorin-4C isoform X1 [KO:K06521]
100757026  Sema4a; semaphorin-4A [KO:K06521]
100756526  Sema5a; semaphorin-5A isoform X2 [KO:K06841]
100766544  Sema5b; semaphorin-5B isoform X2 [KO:K06841]
100753000  Sema6c; LOW QUALITY PROTEIN: semaphorin-6C isoform X3 [KO:K06842]
100758662  Sema6d; semaphorin-6D isoform X1 [KO:K06842]
100769983  Sema6a; semaphorin-6A isoform X2 [KO:K06842]
100769093  Sema6b; semaphorin-6B isoform X2 [KO:K06842]
100772866  LOW QUALITY PROTEIN: plexin-B2-like [KO:K06821]
100754620  Plxnb2; plexin-B2 isoform X3 [KO:K06821]
100762729  Plxnb1; plexin-B1 isoform X1 [KO:K06821]
100752040  Plxnb3; LOW QUALITY PROTEIN: plexin-B3 isoform X2 [KO:K06821]
100751933  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100769018  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
100766263  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
100756433  Sema7a; semaphorin-7A isoform X2 [KO:K06529]
100766140  Plxnc1; plexin-C1 isoform X2 [KO:K06572]
100763033  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
100773402  Shh; sonic hedgehog protein isoform X2 [KO:K11988]
100763926  Ptch1; protein patched homolog 1 isoform X3 [KO:K06225]
100762005  Smo; smoothened homolog isoform X2 [KO:K06226]
100766006  Prkca; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
100689388  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
100766664  Boc; brother of CDO isoform X1 [KO:K20020]
100753089  Wnt5a; protein Wnt-5a [KO:K00444]
100753017  Wnt5b; protein Wnt-5b isoform X2 [KO:K00444]
100751712  Fzd3; frizzled-3 isoform X1 [KO:K02329]
100757154  LOW QUALITY PROTEIN: tyrosine-protein kinase RYK-like isoform X2 [KO:K05128] [EC:2.7.10.1]
100771288  Ryk; tyrosine-protein kinase RYK isoform X5 [KO:K05128] [EC:2.7.10.1]
100769205  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
100763272  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
100752268  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
100765253  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X3 [KO:K04515] [EC:2.7.11.17]
100769003  Wnt4; protein Wnt-4 isoform X3 [KO:K00408]
100689251  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100769225  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100689252  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100771181  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
100750761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100774067  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100772477  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
100765823  Pard3; partitioning defective 3 homolog isoform X20 [KO:K04237]
100756860  protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
100763804  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
100761364  Pard6b; partitioning defective 6 homolog beta isoform X2 [KO:K06093]
100772936  Ssh1; protein phosphatase Slingshot homolog 1 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100755577  Ssh2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100761968  Ssh3; protein phosphatase Slingshot homolog 3 isoform X4 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100759897  Bmp7; bone morphogenetic protein 7 [KO:K16621]
113836599  growth/differentiation factor 7-like isoform X1 [KO:K20013]
100764519  Bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
100774629  bone morphogenetic protein receptor type-1B isoform X4 [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
cge04010  MAPK signaling pathway
cge04060  Cytokine-cytokine receptor interaction
cge04310  Wnt signaling pathway
cge04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
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