Entry
Name
Spliceosome - Callithrix jacchus (white-tufted-ear marmoset)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:
cjc ]
Gene
100389259 DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813 ] [EC:5.6.2.6 ]
100401360 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086 ]
108588051 small nuclear ribonucleoprotein-associated protein B-like [KO:K11086 ]
100392779 SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X2 [KO:K11093 ]
100397850 SNRPC; U1 small nuclear ribonucleoprotein C isoform X2 [KO:K11095 ]
100412480 PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X6 [KO:K12821 ]
100396321 PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X3 [KO:K12821 ]
100406533 TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824 ]
100397457 LOW QUALITY PROTEIN: splicing factor 3B subunit 4-like [KO:K12831 ]
100388995 PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834 ]
100415206 U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836 ]
100407900 U2AF1L4; LOW QUALITY PROTEIN: splicing factor U2AF 26 kDa subunit [KO:K12836 ]
100400743 U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837 ]
100394446 PUF60; poly(U)-binding-splicing factor PUF60 isoform X2 [KO:K12838 ]
100410864 SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839 ]
100388903 CHERP; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841 ]
100411013 U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842 ]
100407527 LSM2; U6 snRNA-associated Sm-like protein LSm2 isoform X1 [KO:K12621 ]
100408877 LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623 ]
100409872 LSM5; U6 snRNA-associated Sm-like protein LSm5 isoform X1 [KO:K12624 ]
100401332 LSM6; U6 snRNA-associated Sm-like protein LSm6 isoform X2 [KO:K12625 ]
100403275 PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843 ]
100391764 PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X2 [KO:K12662 ]
100407606 SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
100391028 SART1; U4/U6.U5 tri-snRNP-associated protein 1 isoform X1 [KO:K11984 ]
100397037 PRPF38B; LOW QUALITY PROTEIN: pre-mRNA-splicing factor 38B [KO:K12850 ]
100391578 EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component isoform X1 [KO:K12852 ]
100392445 SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein isoform X2 [KO:K12857 ]
100410880 CCDC12; coiled-coil domain-containing protein 12 isoform X1 [KO:K12871 ]
100395500 ACIN1; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875 ]
100398174 NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882 ]
100404338 NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883 ]
118150460 NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883 ]
100411573 heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
100407564 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
100385123 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741 ]
108591245 heterogeneous nuclear ribonucleoprotein A1 isoform X2 [KO:K12741 ]
118143590 heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741 ]
118148454 heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741 ]
100404309 HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884 ]
100385445 RBMX; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885 ]
100390554 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
100385202 HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X6 [KO:K12887 ]
100394575 HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888 ]
100392422 SRSF1; serine/arginine-rich splicing factor 1 isoform X2 [KO:K12890 ]
100411323 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
100385878 SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896 ]
100389324 SRSF9; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 9 [KO:K21123 ]
100395598 TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
100387136 SRSF10; serine/arginine-rich splicing factor 10 isoform X3 [KO:K12900 ]
100410694 LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 10-like [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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