KEGG   PATHWAY: elk05415
Entry
elk05415                    Pathway                                
Name
Diabetic cardiomyopathy - Enhydra lutris kenyoni (northern sea otter)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
elk05415  Diabetic cardiomyopathy
elk05415

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111143335  solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
111161132  solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191]
111158888  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
111148069  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X1 [KO:K00820] [EC:2.6.1.16]
111140840  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
111145432  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111153485  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111156985  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
111140065  troponin I, cardiac muscle isoform X1 [KO:K12044]
111144745  LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
111147537  cardiac phospholamban [KO:K05852]
111158763  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
111162286  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
111159008  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3-like [KO:K05853] [EC:7.2.2.10]
111156353  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111157856  transcription factor Sp1 isoform X1 [KO:K04684]
111160516  angiotensinogen [KO:K09821]
111151146  renin [KO:K01380] [EC:3.4.23.15]
111139042  chymase-like [KO:K01329] [EC:3.4.21.39]
111139669  mast cell protease 1-like [KO:K01329] [EC:3.4.21.39]
111162208  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111152179  advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
111150330  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
111145864  neutrophil cytosol factor 1 [KO:K08011]
111152928  cytochrome b-245 light chain [KO:K08009]
111150725  neutrophil cytosol factor 2 isoform X1 [KO:K08010]
111157529  neutrophil cytosol factor 4 [KO:K08012]
111145636  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
111157484  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111150851  type-1 angiotensin II receptor [KO:K04166]
111153611  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111149956  transcription factor p65 [KO:K04735]
111152267  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
111157625  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111157628  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111152183  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111144860  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111158897  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111154016  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111157340  72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
111141396  matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
111151317  collagen alpha-1(I) chain isoform X1 [KO:K06236]
111147195  collagen alpha-2(I) chain [KO:K06236]
111148079  collagen alpha-1(III) chain [KO:K19720]
111161420  transforming growth factor beta-1 isoform X1 [KO:K13375]
111151068  transforming growth factor beta-2 isoform X1 [KO:K13376]
111148592  transforming growth factor beta-3 [KO:K13377]
111155278  platelet glycoprotein 4 [KO:K06259]
111157485  peroxisome proliferator-activated receptor alpha [KO:K07294]
111157490  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
111151349  pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
111147260  pyruvate dehydrogenase kinase, isozyme 4 isoform X1 [KO:K00898] [EC:2.7.11.2]
111150441  pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
111158087  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111144045  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
111145946  serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
111156372  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
111144767  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111149674  serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
111139288  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111149567  cathepsin D [KO:K01379] [EC:3.4.23.5]
111154565  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
111142846  carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
111150279  insulin [KO:K04526]
111161798  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
111143995  insulin receptor substrate 1 [KO:K16172]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111144778  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111154883  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111149921  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111161347  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
111160708  glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
111146968  TBC1 domain family member 4 isoform X1 [KO:K17902]
111158690  mitochondrial pyruvate carrier 1 [KO:K22138]
111150325  mitochondrial pyruvate carrier 1-like protein [KO:K22138]
111143047  mitochondrial pyruvate carrier-like protein [KO:K22138]
111155618  mitochondrial pyruvate carrier-like protein [KO:K22138]
111150805  mitochondrial pyruvate carrier 2 [KO:K22139]
111150409  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
111157464  pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
111144180  pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform X1 [KO:K00162] [EC:1.2.4.1]
111149612  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
111142406  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
111155738  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
111157253  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
111140937  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
111139570  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
111152555  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
111147374  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
111160211  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
111154239  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
111151938  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
111155596  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
111157547  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1 [KO:K03950]
111161756  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
111145557  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
111159811  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
111161328  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
111162309  acyl carrier protein, mitochondrial [KO:K03955]
111161769  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
111142148  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
111143867  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
111148723  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
111151936  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
111141342  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
111148802  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform X1 [KO:K03960]
111147306  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
111146284  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
111162542  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
111145242  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
111146716  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
111156034  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
111150594  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
111141377  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
111138869  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
111149396  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
111141116  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
111142993  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
111153450  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
111161695  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
111149681  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
111149131  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
111154340  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
111153400  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
111154638  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
111138865  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
111153893  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
111139384  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
111146626  cytochrome c1, heme protein, mitochondrial [KO:K00413]
111143869  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
111162256  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
111142816  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
111146514  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
111141027  cytochrome b-c1 complex subunit 8 isoform X1 [KO:K00418]
111160042  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
111161710  cytochrome b-c1 complex subunit 10 [KO:K00420]
111153043  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
111141707  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
111153215  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
111155858  cytochrome c oxidase subunit 5B, mitochondrial isoform X1 [KO:K02265]
111162190  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
111156401  cytochrome c oxidase subunit 6A1, mitochondrial isoform X1 [KO:K02266]
111161463  cytochrome c oxidase subunit 6B1 isoform X1 [KO:K02267]
111155471  cytochrome c oxidase subunit 6B1-like [KO:K02267]
111139590  cytochrome c oxidase subunit 6B2 [KO:K02267]
111147664  cytochrome c oxidase subunit 6C [KO:K02268]
111146812  cytochrome c oxidase subunit 6C [KO:K02268]
111161502  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
111147649  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
111158437  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
111146524  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
111156868  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
111160926  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
111149314  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
111149315  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
111148335  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
111152225  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
111160948  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
111149630  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
111152453  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
111142536  ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
111160107  ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
111158608  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
111161765  ATP synthase subunit delta, mitochondrial [KO:K02134]
111152423  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
111141583  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
111143342  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
111150035  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
111157857  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
111151344  ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
111160337  ATP synthase subunit d, mitochondrial [KO:K02138]
111155772  ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
111147126  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
111151840  ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
111141207  voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
111145442  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111144425  voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
111157245  ADP/ATP translocase 2 [KO:K05863]
111144412  ADP/ATP translocase 1 [KO:K05863]
111157056  ADP/ATP translocase 4 [KO:K05863]
111157123  ADP/ATP translocase 3 [KO:K05863]
111145350  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
111139613  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
111154402  nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
111140561  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111140562  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111153258  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111160720  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111153592  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111151005  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111159713  glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
111161852  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
111150644  poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
111139199  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111144593  glutathione reductase, mitochondrial isoform X1 [KO:K00383] [EC:1.8.1.7]
111146071  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
111158999  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
111142395  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
111153179  mothers against decapentaplegic homolog 3 [KO:K23605]
111141432  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111162302  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111141620  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111150005  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
111158152  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
111158167  LOW QUALITY PROTEIN: angiotensin-converting enzyme [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
Zamora M, Villena JA
  Title
Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E2833 (2019)
DOI:10.3390/ijms20112833
Reference
PMID:29605388
  Authors
Palomer X, Pizarro-Delgado J, Vazquez-Carrera M
  Title
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
  Journal
Trends Pharmacol Sci 39:452-467 (2018)
DOI:10.1016/j.tips.2018.02.010
Reference
PMID:28439258
  Authors
Mishra PK, Ying W, Nandi SS, Bandyopadhyay GK, Patel KK, Mahata SK
  Title
Diabetic Cardiomyopathy: An Immunometabolic Perspective.
  Journal
Front Endocrinol (Lausanne) 8:72 (2017)
DOI:10.3389/fendo.2017.00072
Reference
PMID:28177068
  Authors
Chong CR, Clarke K, Levelt E
  Title
Metabolic Remodeling in Diabetic Cardiomyopathy.
  Journal
Cardiovasc Res 113:422-430 (2017)
DOI:10.1093/cvr/cvx018
Reference
PMID:11742414
  Authors
Brownlee M
  Title
Biochemistry and molecular cell biology of diabetic complications.
  Journal
Nature 414:813-20 (2001)
DOI:10.1038/414813a
Reference
PMID:32821697
  Authors
Gollmer J, Zirlik A, Bugger H
  Title
Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
  Journal
J Lipid Atheroscler 8:26-47 (2019)
DOI:10.12997/jla.2019.8.1.26
Reference
PMID:17592090
  Authors
Boudina S, Abel ED
  Title
Diabetic cardiomyopathy revisited.
  Journal
Circulation 115:3213-23 (2007)
DOI:10.1161/CIRCULATIONAHA.106.679597
Reference
PMID:29109032
  Authors
Varma U, Koutsifeli P, Benson VL, Mellor KM, Delbridge LMD
  Title
Molecular mechanisms of cardiac pathology in diabetes - Experimental insights.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1949-1959 (2018)
DOI:10.1016/j.bbadis.2017.10.035
Reference
PMID:23147391
  Authors
Mandavia CH, Aroor AR, Demarco VG, Sowers JR
  Title
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
  Journal
Life Sci 92:601-8 (2013)
DOI:10.1016/j.lfs.2012.10.028
Reference
PMID:21626163
  Authors
Falcao-Pires I, Leite-Moreira AF
  Title
Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.
  Journal
Heart Fail Rev 17:325-44 (2012)
DOI:10.1007/s10741-011-9257-z
Reference
PMID:27148064
  Authors
Westermeier F, Riquelme JA, Pavez M, Garrido V, Diaz A, Verdejo HE, Castro PF, Garcia L, Lavandero S
  Title
New Molecular Insights of Insulin in Diabetic Cardiomyopathy.
  Journal
Front Physiol 7:125 (2016)
DOI:10.3389/fphys.2016.00125
Reference
PMID:33276047
  Authors
Randhawa VK, Dhanvantari S, Connelly K
  Title
How Diabetes and Heart Failure Modulate Each Other and Condition Management.
  Journal
Can J Cardiol S0828-282X(20)31115-6 (2020)
DOI:10.1016/j.cjca.2020.11.014
Reference
PMID:31641426
  Authors
Athithan L, Gulsin GS, McCann GP, Levelt E
  Title
Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date.
  Journal
World J Diabetes 10:490-510 (2019)
DOI:10.4239/wjd.v10.i10.490
Reference
PMID:21111987
  Authors
Murarka S, Movahed MR
  Title
Diabetic cardiomyopathy.
  Journal
J Card Fail 16:971-9 (2010)
DOI:10.1016/j.cardfail.2010.07.249
Reference
PMID:25085967
  Authors
Thomas CM, Yong QC, Rosa RM, Seqqat R, Gopal S, Casarini DE, Jones WK, Gupta S, Baker KM, Kumar R
  Title
Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
  Journal
Am J Physiol Heart Circ Physiol 307:H1036-45 (2014)
DOI:10.1152/ajpheart.00340.2014
Reference
PMID:28236380
  Authors
Brahma MK, Pepin ME, Wende AR
  Title
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
  Journal
Diabetes Metab J 41:1-9 (2017)
DOI:10.4093/dmj.2017.41.1.1
Reference
PMID:18829990
  Authors
Singh VP, Le B, Khode R, Baker KM, Kumar R
  Title
Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis.
  Journal
Diabetes 57:3297-306 (2008)
DOI:10.2337/db08-0805
Reference
PMID:18296558
  Authors
Singh VP, Baker KM, Kumar R
  Title
Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.
  Journal
Am J Physiol Heart Circ Physiol 294:H1675-84 (2008)
DOI:10.1152/ajpheart.91493.2007
Reference
PMID:26678809
  Authors
Jia G, DeMarco VG, Sowers JR
  Title
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
  Journal
Nat Rev Endocrinol 12:144-53 (2016)
DOI:10.1038/nrendo.2015.216
Reference
PMID:18309108
  Authors
Kim JA, Wei Y, Sowers JR
  Title
Role of mitochondrial dysfunction in insulin resistance.
  Journal
Circ Res 102:401-14 (2008)
DOI:10.1161/CIRCRESAHA.107.165472
Reference
PMID:30170598
  Authors
Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuniga FA
  Title
Association between insulin resistance and the development of cardiovascular disease.
  Journal
Cardiovasc Diabetol 17:122 (2018)
DOI:10.1186/s12933-018-0762-4
Reference
PMID:31269778
  Authors
Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
  Title
Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
  Journal
Int J Mol Sci 20:E3264 (2019)
DOI:10.3390/ijms20133264
Reference
PMID:24307101
  Authors
Joshi M, Kotha SR, Malireddy S, Selvaraju V, Satoskar AR, Palesty A, McFadden DW, Parinandi NL, Maulik N
  Title
Conundrum of pathogenesis of diabetic cardiomyopathy: role of vascular endothelial dysfunction, reactive oxygen species, and mitochondria.
  Journal
Mol Cell Biochem 386:233-49 (2014)
DOI:10.1007/s11010-013-1861-x
Reference
PMID:29867137
  Authors
Knapp M, Tu X, Wu R
  Title
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
  Journal
Acta Pharmacol Sin 40:1-8 (2019)
DOI:10.1038/s41401-018-0042-6
Reference
PMID:16487830
  Authors
Asbun J, Villarreal FJ
  Title
The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.
  Journal
J Am Coll Cardiol 47:693-700 (2006)
DOI:10.1016/j.jacc.2005.09.050
Reference
PMID:32024054
  Authors
Levick SP, Widiapradja A
  Title
The Diabetic Cardiac Fibroblast: Mechanisms Underlying Phenotype and Function.
  Journal
Int J Mol Sci 21:E970 (2020)
DOI:10.3390/ijms21030970
Related
pathway
elk00010  Glycolysis / Gluconeogenesis
elk00020  Citrate cycle (TCA cycle)
elk00190  Oxidative phosphorylation
elk00520  Amino sugar and nucleotide sugar metabolism
elk03320  PPAR signaling pathway
elk04071  Sphingolipid signaling pathway
elk04150  mTOR signaling pathway
elk04210  Apoptosis
elk04260  Cardiac muscle contraction
elk04350  TGF-beta signaling pathway
elk04614  Renin-angiotensin system
elk04910  Insulin signaling pathway
elk04930  Type II diabetes mellitus
elk04931  Insulin resistance
elk04933  AGE-RAGE signaling pathway in diabetic complications
elk04940  Type I diabetes mellitus
KO pathway
ko05415   
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