KEGG   PATHWAY: hgl04144
Entry
hgl04144                    Pathway                                
Name
Endocytosis - Heterocephalus glaber (naked mole-rat)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
hgl04144  Endocytosis
hgl04144

Other DBs
GO: 0006897
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101703058  Arf6; ADP ribosylation factor 6 [KO:K07941]
101701143  ADP-ribosylation factor 6-like [KO:K07941]
101726083  Pip5k1b; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
101703623  Pip5k1a; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
101700633  Pip5k1c; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
101716607  Pip5kl1; phosphatidylinositol-4-phosphate 5-kinase like 1 [KO:K13712] [EC:2.7.1.68]
101700438  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
101713528  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101699561  Dnm1; dynamin 1 [KO:K01528] [EC:3.6.5.5]
101700676  Dnm3; dynamin 3 [KO:K01528] [EC:3.6.5.5]
101696596  Dnm2; dynamin 2 [KO:K23484] [EC:3.6.5.5]
101707717  Clta; clathrin light chain A [KO:K04644]
101713269  Cltb; clathrin light chain B [KO:K04645]
101708690  Cltcl1; clathrin heavy chain like 1 [KO:K04646]
101720552  Cltc; clathrin heavy chain [KO:K04646]
101719967  Ap2a2; adaptor related protein complex 2 alpha 2 subunit [KO:K11824]
101715441  Ap2a1; adaptor related protein complex 2 alpha 1 subunit [KO:K11824]
101709272  Ap2b1; adaptor related protein complex 2 beta 1 subunit [KO:K11825]
101716647  Ap2m1; adaptor related protein complex 2 mu 1 subunit [KO:K11826]
101719710  Ap2s1; adaptor related protein complex 2 sigma 1 subunit [KO:K11827]
101707337  Ehd2; EH domain containing 2 [KO:K12469]
101718090  Tgfbr1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
101704397  Tgfbr2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
101697568  Zfyve16; zinc finger FYVE-type containing 16 [KO:K04679]
101711904  Zfyve9; zinc finger FYVE-type containing 9 [KO:K04679]
101707749  Pml; promyelocytic leukemia [KO:K10054] [EC:2.3.2.-]
101714203  Smad2; SMAD family member 2 [KO:K04500]
101713378  Smad3; SMAD family member 3 [KO:K23605]
100913079  Tfrc; transferrin receptor [KO:K06503]
101723771  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101697360  Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101709077  Fgfr2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
101711651  Fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
101700214  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101710224  Igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101710004  Cbl; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
101719173  Cblb; Cbl proto-oncogene B [KO:K22517] [EC:2.3.2.27]
101713714  Cblc; Cbl proto-oncogene C [KO:K22518] [EC:2.3.2.27]
101717745  Sh3kbp1; SH3 domain containing kinase binding protein 1 [KO:K12470]
101718387  Sh3gl2; SH3 domain containing GRB2 like 2, endophilin A1 [KO:K11247]
101708553  Sh3gl3; SH3 domain containing GRB2 like 3, endophilin A3 [KO:K11247]
101700266  Sh3gl1; SH3 domain containing GRB2 like 1, endophilin A2 [KO:K11247]
101708379  Sh3glb1; SH3 domain containing GRB2 like endophilin B1 [KO:K11248]
101710203  Sh3glb2; SH3 domain containing GRB2 like endophilin B2 [KO:K21269]
101723039  Bin1; bridging integrator 1 [KO:K12562]
101708603  Amph; amphiphysin [KO:K12562]
101707527  Epn3; epsin 3 [KO:K12471]
101723807  Epn1; epsin 1 [KO:K12471]
101724424  Epn2; epsin 2 [KO:K12471]
101702336  Eps15l1; epidermal growth factor receptor pathway substrate 15 like 1 [KO:K12472]
101718798  Eps15; epidermal growth factor receptor pathway substrate 15 [KO:K12472]
101721028  Spg20; spastic paraplegia 20 (Troyer syndrome) [KO:K19366]
101712885  Nedd4; neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [KO:K10591] [EC:2.3.2.26]
101715398  Nedd4l; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
101724821  Mdm2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
101697126  Traf6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
101713294  Rnf41; ring finger protein 41 [KO:K11981] [EC:2.3.2.27]
101711522  Itch; itchy E3 ubiquitin protein ligase [KO:K05632] [EC:2.3.2.26]
101723417  Smurf1; SMAD specific E3 ubiquitin protein ligase 1 [KO:K04678] [EC:2.3.2.26]
101697984  Smurf2; SMAD specific E3 ubiquitin protein ligase 2 [KO:K04678] [EC:2.3.2.26]
101725489  Wwp1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:2.3.2.26]
101703463  Ldlr; low density lipoprotein receptor [KO:K12473]
101699111  Ldlrap1; low density lipoprotein receptor adaptor protein 1 [KO:K12474]
101725399  Dab2; DAB2, clathrin adaptor protein [KO:K12475]
101723738  Ccr5; C-C motif chemokine receptor 5 [KO:K04180]
101712235  Cxcr1; C-X-C motif chemokine receptor 1 [KO:K04175]
101712581  Cxcr2; C-X-C motif chemokine receptor 2 [KO:K05050]
101699254  Cxcr4; C-X-C motif chemokine receptor 4 [KO:K04189]
101726058  Grk7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
101697548  Grk1; G protein-coupled receptor kinase 1 [KO:K00909] [EC:2.7.11.14]
101708742  Grk3; G protein-coupled receptor kinase 3 [KO:K00910] [EC:2.7.11.15]
101708906  Grk2; G protein-coupled receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
101720846  G protein-coupled receptor kinase 6-like [KO:K08291] [EC:2.7.11.16]
101718249  Grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
101718850  Grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
101720649  Grk4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
101703451  Arrb1; arrestin beta 1 [KO:K04439]
101709908  Arrb2; arrestin beta 2 [KO:K04439]
101700594  Wasl; Wiskott-Aldrich syndrome like [KO:K23612]
101711414  Actr2; ARP2 actin related protein 2 homolog [KO:K17260]
101696570  Actr3b; ARP3 actin related protein 3 homolog B [KO:K18584]
101718942  Actr3; ARP3 actin related protein 3 homolog [KO:K18584]
101724607  Arpc1a; actin related protein 2/3 complex subunit 1A [KO:K05757]
101725609  Arpc1b; actin related protein 2/3 complex subunit 1B [KO:K05757]
101711880  Arpc2; actin related protein 2/3 complex subunit 2 [KO:K05758]
101719916  Arpc3; actin related protein 2/3 complex subunit 3 [KO:K05756]
101716608  Arpc5l; actin related protein 2/3 complex subunit 5 like [KO:K05754]
101715533  Arpc5; actin related protein 2/3 complex subunit 5 [KO:K05754]
101714430  Wipf1; WAS/WASL interacting protein family member 1 [KO:K19475]
101725343  Wipf2; WAS/WASL interacting protein family member 2 [KO:K19475]
101725099  Wipf3; WAS/WASL interacting protein family member 3 [KO:K19475]
101699805  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
101700637  heat shock 70 kDa protein 1B [KO:K03283]
101701238  Hspa6; heat shock protein family A (Hsp70) member 6 [KO:K03283]
101708313  Hspa8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
101707904  Dnajc6; DnaJ heat shock protein family (Hsp40) member C6 [KO:K09526]
101701347  Washc4; WASH complex subunit 4 [KO:K18465]
101708947  Washc5; WASH complex subunit 5 [KO:K18464]
101704488  WASH complex subunit FAM21A-like [KO:K18462]
101720271  WAS protein family homolog 1 [KO:K18461]
101709358  Washc3; WASH complex subunit 3 [KO:K18463]
101708755  Capza3; capping actin protein of muscle Z-line alpha subunit 3 [KO:K10364]
101704722  F-actin-capping protein subunit alpha-2 [KO:K10364]
101702218  Capza1; capping actin protein of muscle Z-line alpha subunit 1 [KO:K10364]
101725379  Capza2; capping actin protein of muscle Z-line alpha subunit 2 [KO:K10364]
101707098  F-actin-capping protein subunit alpha-2-like [KO:K10364]
101706752  Capzb; capping actin protein of muscle Z-line beta subunit [KO:K10365]
101717156  Vps29; VPS29, retromer complex component [KO:K18467]
101707332  Vps26a; VPS26, retromer complex component A [KO:K18466]
101708860  Vps26b; VPS26, retromer complex component B [KO:K18466]
101724037  vacuolar protein sorting-associated protein 26A [KO:K18466]
101697141  Vps35; VPS35, retromer complex component [KO:K18468]
101700325  Snx3; sorting nexin 3 [KO:K17918]
101712753  Snx12; sorting nexin 12 [KO:K17918]
101710362  Usp8; ubiquitin specific peptidase 8 [KO:K11839] [EC:3.4.19.12]
101711505  Stambp; STAM binding protein [KO:K11866] [EC:3.4.19.12]
101703643  ras-related protein Rab-7a [KO:K07897]
101706323  Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
101717932  Stam; signal transducing adaptor molecule [KO:K04705]
101722782  Stam2; signal transducing adaptor molecule 2 [KO:K04705]
101723984  signal transducing adapter molecule 2-like [KO:K04705]
101716856  Tsg101; tumor susceptibility 101 [KO:K12183]
101715946  Mvb12a; multivesicular body subunit 12A [KO:K12186]
101707948  Mvb12b; multivesicular body subunit 12B [KO:K12186]
101718157  Vps28; VPS28, ESCRT-I subunit [KO:K12184]
101706319  Vps37d; VPS37D, ESCRT-I subunit [KO:K12185]
101715183  Vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
101715774  vacuolar protein sorting-associated protein 37B [KO:K12185]
101721739  Vps37c; VPS37C, ESCRT-I subunit [KO:K12185]
101700435  Vps37a; VPS37A, ESCRT-I subunit [KO:K12185]
101716552  Snf8; SNF8, ESCRT-II complex subunit [KO:K12188]
101709114  Vps36; vacuolar protein sorting 36 homolog [KO:K12190]
101713179  Vps25; vacuolar protein sorting 25 homolog [KO:K12189]
101725742  Chmp6; charged multivesicular body protein 6 [KO:K12195]
101698067  charged multivesicular body protein 4a [KO:K12194]
101700145  Chmp4a; charged multivesicular body protein 4A [KO:K12194]
101716032  Chmp4b; charged multivesicular body protein 4B [KO:K12194]
101704056  Chmp4c; charged multivesicular body protein 4C [KO:K24782]
101721449  Chmp3; charged multivesicular body protein 3 [KO:K12193]
101722413  Chmp2a; charged multivesicular body protein 2A [KO:K12191]
101717020  Chmp2b; charged multivesicular body protein 2B [KO:K12192]
101698850  Chmp7; charged multivesicular body protein 7 [KO:K15053]
101716007  Vps4a; vacuolar protein sorting 4 homolog A [KO:K12196]
101702359  Vps4b; vacuolar protein sorting 4 homolog B [KO:K12196]
101696966  Vta1; vesicle trafficking 1 [KO:K12199]
101702278  Chmp1a; charged multivesicular body protein 1A [KO:K12197]
101718227  Chmp1b; charged multivesicular body protein 1B [KO:K12197]
101699687  charged multivesicular body protein 1b-2 [KO:K12197]
101723765  Chmp5; charged multivesicular body protein 5 [KO:K12198]
101703210  Ist1; IST1 homolog [KO:K19476]
101711093  Pdcd6ip; programmed cell death 6 interacting protein [KO:K12200]
101696663  Spg21; spastic paraplegia 21 (autosomal recessive, Mast syndrome) [KO:K19367]
101707470  Igf2r; insulin like growth factor 2 receptor [KO:K06564]
101706895  Snx1; sorting nexin 1 [KO:K17917]
101721735  Snx2; sorting nexin 2 [KO:K17917]
101714241  Snx5; sorting nexin 5 [KO:K17920]
101716031  Snx6; sorting nexin 6 [KO:K17920]
101703827  Src; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
101716053  Hras; HRas proto-oncogene, GTPase [KO:K02833]
101696651  Il2ra; interleukin 2 receptor subunit alpha [KO:K05068]
101726369  Il2rb; interleukin 2 receptor subunit beta [KO:K05069]
101715243  Il2rg; interleukin 2 receptor subunit gamma [KO:K05070]
101710109  Rhoa; ras homolog family member A [KO:K04513]
101721592  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
101699175  Folr1; folate receptor alpha [KO:K13649]
101721569  Folr2; folate receptor gamma [KO:K13649]
101726366  Cav1; caveolin 1 [KO:K06278]
101696479  Cav2; caveolin 2 [KO:K12958]
101716522  Cav3; caveolin 3 [KO:K12959]
101707648  Ehd3; EH domain containing 3 [KO:K12476]
101705478  Ehd4; EH domain containing 4 [KO:K12477]
101720751  Eea1; early endosome antigen 1 [KO:K12478]
101710661  Rab5a; RAB5A, member RAS oncogene family [KO:K07887]
101724150  Rab5b; RAB5B, member RAS oncogene family [KO:K07888]
101696324  Rab5c; RAB5C, member RAS oncogene family [KO:K07889]
101696551  Rabep1; rabaptin, RAB GTPase binding effector protein 1 [KO:K12480]
101698864  Rbsn; rabenosyn, RAB effector [KO:K12481]
101722103  Rab4a; RAB4A, member RAS oncogene family [KO:K07879]
101719069  Rufy1; RUN and FYVE domain containing 1 [KO:K12482]
101700756  Rufy2; RUN and FYVE domain containing 2 [KO:K12482]
101708441  Ehd1; EH domain containing 1 [KO:K12483]
101714653  Vps45; vacuolar protein sorting 45 homolog [KO:K12479]
101704723  Snx4; sorting nexin 4 [KO:K17919]
101711368  Rab22a; RAB22A, member RAS oncogene family [KO:K07891]
101713603  Rab31; RAB31, member RAS oncogene family [KO:K07891]
101723412  Rab10; RAB10, member RAS oncogene family [KO:K07903]
101709178  Rab8a; RAB8A, member RAS oncogene family [KO:K07901]
101704071  Rab35; RAB35, member RAS oncogene family [KO:K07876]
101718831  Rab11a; RAB11A, member RAS oncogene family [KO:K07904]
101719702  Rab11b; RAB11B, member RAS oncogene family [KO:K07905]
101724135  Rab11fip2; RAB11 family interacting protein 2 [KO:K12484]
101709618  Rab11fip5; RAB11 family interacting protein 5 [KO:K12484]
101712078  Rab11fip1; RAB11 family interacting protein 1 [KO:K12484]
101703527  Zfyve27; zinc finger FYVE-type containing 27 [KO:K19368]
101711539  Kif5c; kinesin family member 5C [KO:K10396]
101718070  Kif5b; kinesin family member 5B [KO:K10396]
101711370  Kif5a; kinesin family member 5A [KO:K10396]
101723986  Rab11fip3; RAB11 family interacting protein 3 [KO:K12485]
101696997  Rab11fip4; RAB11 family interacting protein 4 [KO:K12485]
101709720  partitioning defective 3 homolog [KO:K04237]
101705735  Pard3; par-3 family cell polarity regulator [KO:K04237]
101707435  Pard6a; par-6 family cell polarity regulator alpha [KO:K06093]
101724837  Pard6b; par-6 family cell polarity regulator beta [KO:K06093]
101723191  Pard6g; par-6 family cell polarity regulator gamma [KO:K06093]
101699303  Prkcz; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
101697279  Prkci; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
106010032  protein kinase C iota type-like [KO:K06069] [EC:2.7.11.13]
106010799  protein kinase C iota type-like [KO:K06069] [EC:2.7.11.13]
101701374  Cdc42; cell division cycle 42 [KO:K04393]
101711269  cell division control protein 42 homolog [KO:K04393]
101720894  Smap2; small ArfGAP2 [KO:K12486]
101708052  Smap1; small ArfGAP 1 [KO:K12486]
101699975  Git1; GIT ArfGAP 1 [KO:K05737]
101702496  Git2; GIT ArfGAP 2 [KO:K12487]
101698673  Asap1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [KO:K12488]
101710691  Asap3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [KO:K12488]
101721882  Asap2; ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [KO:K12488]
101723627  Acap2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [KO:K12489]
101718492  Acap1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 [KO:K12489]
101718770  Acap3; ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [KO:K12489]
101724042  Arap1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 [KO:K18439]
101709490  Arap2; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [KO:K18440]
101709044  Arap3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [KO:K12490]
101706435  Agap3; ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [KO:K12491]
101714494  Agap1; ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [KO:K12491]
101702971  Agap2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [KO:K17848]
101712809  Arfgap1; ADP ribosylation factor GTPase activating protein 1 [KO:K12492]
101717408  Arfgap3; ADP ribosylation factor GTPase activating protein 3 [KO:K12493]
101717089  Arfgap2; ADP ribosylation factor GTPase activating protein 2 [KO:K12493]
101726346  Psd2; pleckstrin and Sec7 domain containing 2 [KO:K12494]
101706961  Psd4; pleckstrin and Sec7 domain containing 4 [KO:K12494]
101698221  Psd3; pleckstrin and Sec7 domain containing 3 [KO:K12494]
101717970  Psd; pleckstrin and Sec7 domain containing [KO:K12494]
101725331  Iqsec3; IQ motif and Sec7 domain 3 [KO:K12495]
101711435  Iqsec2; IQ motif and Sec7 domain 2 [KO:K12495]
101697190  Iqsec1; IQ motif and Sec7 domain 1 [KO:K12495]
101705470  Cyth1; cytohesin 1 [KO:K18441]
101709092  Cyth3; cytohesin 3 [KO:K18441]
101724172  Cyth4; cytohesin 4 [KO:K18441]
101725136  Cyth2; cytohesin 2 [KO:K18441]
101698432  Arfgef1; ADP ribosylation factor guanine nucleotide exchange factor 1 [KO:K18442]
101706311  Arfgef2; ADP ribosylation factor guanine nucleotide exchange factor 2 [KO:K18442]
101712137  Gbf1; golgi brefeldin A resistant guanine nucleotide exchange factor 1 [KO:K18443]
101716414  Arf1; ADP ribosylation factor 1 [KO:K07937]
101723462  ADP-ribosylation factor 2 [KO:K07937]
101722972  Arf3; ADP ribosylation factor 3 [KO:K07938]
101711014  ADP-ribosylation factor 4 [KO:K07939]
101711270  ADP-ribosylation factor 4 [KO:K07939]
101725842  Arf5; ADP ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
hgl04060  Cytokine-cytokine receptor interaction
hgl04070  Phosphatidylinositol signaling system
hgl04130  SNARE interactions in vesicular transport
hgl04142  Lysosome
hgl04350  TGF-beta signaling pathway
KO pathway
ko04144   
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