KEGG   PATHWAY: hhip04068
Entry
hhip04068                   Pathway                                
Name
FoxO signaling pathway - Hippoglossus hippoglossus (Atlantic halibut)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
hhip04068  FoxO signaling pathway
hhip04068

Other DBs
GO: 0009267
Organism
Hippoglossus hippoglossus (Atlantic halibut) [GN:hhip]
Gene
117772384  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
117769623  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
117777108  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
117756644  tgfb3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
117758516  transforming growth factor beta-3 proprotein-like [KO:K13377]
117753981  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
117754491  tgfbr2l; LOW QUALITY PROTEIN: TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
117770903  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117777178  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
117767308  mothers against decapentaplegic homolog 4-like [KO:K04501]
117776628  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
117771112  si:dkey-222b8.1; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
117771484  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
117756333  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
117763466  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
117778177  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
117760639  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
117771521  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
117778453  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
117767355  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
117771209  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a isoform X1 [KO:K07199]
117778456  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
117753907  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
117761288  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
117777476  prkag3a; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
117766000  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
117773159  LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
117771425  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
117757032  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
117769700  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
117766207  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
117753189  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
117766859  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
117761398  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
117775685  sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
117765682  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
117752058  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
117772227  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117769257  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
117775780  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117752542  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117762186  serine/threonine-protein kinase 4-like isoform X1 [KO:K04411]
117757155  igf1; insulin-like growth factor I [KO:K05459]
117765172  insulin-like growth factor I [KO:K05459]
117754056  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117763797  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117774639  ins; insulin [KO:K04526]
117769264  insb; preproinsulin b [KO:K04526]
117778848  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
117760725  insrb; LOW QUALITY PROTEIN: insulin receptor b [KO:K04527] [EC:2.7.10.1]
117774495  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
117752039  si:ch73-335l21.1; LOW QUALITY PROTEIN: insulin receptor substrate 1-B [KO:K16172]
117774049  insulin receptor substrate 2-like isoform X1 [KO:K07187]
117755348  irs2b; insulin receptor substrate 2 [KO:K07187]
117751826  insulin receptor substrate 2-B [KO:K07187]
117772752  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117779227  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117760503  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
117764692  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117778034  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117760130  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117760625  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117768381  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
117771255  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
117777997  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117778159  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117753368  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117753178  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117775975  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117767714  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
117775205  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117752448  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117772327  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117774515  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
117755641  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117775231  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117764087  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117776559  sgk2b; serine/threonine-protein kinase Sgk2b isoform X1 [KO:K13302] [EC:2.7.11.1]
117770584  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
117757978  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
117764836  sgk2a; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
117753714  sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
117772879  foxo1a; forkhead box protein O1-A [KO:K07201]
117774873  forkhead box protein O1-A-like [KO:K07201]
117756109  foxo3a; forkhead box protein O3a [KO:K09408]
117770704  foxo6b; forkhead box protein O6b [KO:K09408]
117758842  foxo3b; forkhead box protein O3B [KO:K09408]
117768923  foxo4; forkhead box protein O4 [KO:K12358]
117777183  forkhead box protein O6-like [KO:K17847]
117756137  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
117758227  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
117778414  homer protein homolog 3-like isoform X1 [KO:K15010]
117759861  homer protein homolog 3-like isoform X1 [KO:K15010]
117767255  homer1b; homer protein homolog 1b isoform X1 [KO:K15010]
117754391  homer2; homer protein homolog 2 isoform X1 [KO:K15010]
117771771  homer protein homolog 1-like [KO:K15010]
117761424  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
117764378  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
117766259  casein kinase I [KO:K08960] [EC:2.7.11.1]
117753225  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
117770770  interleukin-6-like [KO:K05405]
117762109  il10; interleukin-10 isoform X1 [KO:K05443]
117766856  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
117769534  egf; pro-epidermal growth factor [KO:K04357]
117753648  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
117777712  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
117766449  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
117756659  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
117763559  son of sevenless homolog 1-like isoform X1 [KO:K03099]
117763573  GTPase HRas [KO:K02833]
117766775  zgc:55558; GTPase HRas [KO:K07827]
117762987  kras; GTPase KRas isoform X1 [KO:K07827]
117757425  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117765330  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117767832  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
117763104  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117759678  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117766747  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117767997  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117761402  mapk14b; mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
117757226  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117757227  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
117763532  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
117764155  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117764159  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
117764912  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
117761594  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
117767014  prmt1; protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
117773486  foxg1c; forkhead box protein G1c [KO:K09385]
117756469  foxg1a; forkhead box protein G1 [KO:K09385]
117776047  foxg1b; forkhead box protein G1b [KO:K09385]
117771671  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
117772338  ccnp; cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
117752035  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
117759437  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
117762757  G1/S-specific cyclin-D1-like isoform X1 [KO:K04503]
117766356  ccndx; cyclin Dx [KO:K10151]
117757192  G1/S-specific cyclin-D2-like [KO:K10151]
117763749  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
117768094  cyclin-G2-like isoform X1 [KO:K10146]
117771364  ccng2; cyclin-G2 [KO:K10146]
117765838  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
117766770  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
117761857  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
117757274  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
117762828  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
117756987  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
117762639  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
117770384  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
117767980  plk2b; serine/threonine-protein kinase PLK2b isoform X1 [KO:K08861] [EC:2.7.11.21]
117778212  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
117755877  plk4; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
117772062  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117772065  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
117778664  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
117760569  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
117760651  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117768221  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
117755691  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
117760140  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117769667  cd40lg; CD40 ligand isoform X1 [KO:K04389]
117776052  bcl-2-like protein 11 [KO:K16341]
117753842  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
117756449  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
117760298  bcl6aa; BCL6A transcription repressor a isoform X1 [KO:K15618]
117778043  bcl6ab; BCL6A transcription repressor b isoform X1 [KO:K15618]
117772147  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
117775381  bnip4; BCL2 interacting protein 4 [KO:K15464]
117777116  atg12; ubiquitin-like protein ATG12 [KO:K08336]
117776843  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
117763863  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
117752082  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
117752555  gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
117767808  si:ch73-6k14.2; uncharacterized protein si:ch73-6k14.2 [KO:K27679]
117763812  cat; catalase [KO:K03781] [EC:1.11.1.6]
117758117  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
117772580  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
117753963  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
117761378  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
117752846  g6pca.2; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
117752848  g6pca.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
117753080  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
117754755  glucose-6-phosphatase 2-like isoform X1 [KO:K01084] [EC:3.1.3.9]
117771349  il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
117760770  Krueppel-like factor 2 [KO:K17845]
117778071  klf2b; Krueppel-like factor 2b [KO:K17845]
117759844  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
117760607  s1pr4; sphingosine 1-phosphate receptor 4 [KO:K04293]
117763719  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
117763073  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
117776179  fbxo32; F-box only protein 32 [KO:K10305]
117758661  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
hhip00010  Glycolysis / Gluconeogenesis
hhip00020  Citrate cycle (TCA cycle)
hhip00190  Oxidative phosphorylation
hhip04010  MAPK signaling pathway
hhip04110  Cell cycle
hhip04120  Ubiquitin mediated proteolysis
hhip04140  Autophagy - animal
hhip04210  Apoptosis
hhip04350  TGF-beta signaling pathway
hhip04910  Insulin signaling pathway
KO pathway
ko04068   
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