KEGG   PATHWAY: ipu04540
Entry
ipu04540                    Pathway                                
Name
Gap junction - Ictalurus punctatus (channel catfish)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ipu04540  Gap junction
ipu04540

Other DBs
GO: 0005921
Organism
Ictalurus punctatus (channel catfish) [GN:ipu]
Gene
108269439  gja1a; gap junction alpha-1 protein [KO:K07372]
108257942  gja1b; gap junction alpha-1 protein [KO:K07372]
108269851  gjd2b; gap junction protein delta 2b [KO:K07373]
108259863  gjd1a; gap junction protein delta 1a [KO:K07373]
108270620  gjd6; gap junction protein delta 6 [KO:K07373]
108280251  gap junction delta-2 protein [KO:K07373]
108277333  lysophosphatidic acid receptor 1 [KO:K04289]
108279833  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
108265813  gnai3; guanine nucleotide-binding protein G(i) subunit alpha isoform X2 [KO:K04630]
100526828  gnaia; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a [KO:K04630]
108254730  gnai2a; guanine nucleotide-binding protein G(i) subunit alpha-2a isoform X1 [KO:K04630]
108271854  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b isoform X1 [KO:K04630]
108259440  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108260470  pdgfbb; uncharacterized protein pdgfbb isoform X1 [KO:K04359]
108259423  si:ch211-79m20.1; myb-like protein Q isoform X3 [KO:K17386]
108277755  platelet-derived growth factor D [KO:K05450]
108269254  platelet-derived growth factor C isoform X1 [KO:K05450]
108268549  pro-epidermal growth factor isoform X1 [KO:K04357]
108258040  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108274697  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108280575  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
108256494  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
100528114  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
108270875  son of sevenless homolog 1 isoform X1 [KO:K03099]
108263000  LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
128631210  LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
100528230  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
108259582  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
108258948  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
108274959  kras; GTPase KRas isoform X2 [KO:K07827]
100305071  GTPase NRas [KO:K07828]
108276324  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X5 [KO:K04366] [EC:2.7.11.1]
108255012  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124627985  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100528123  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
108271291  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
108255782  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108256206  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108255075  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
108276199  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
108272715  mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
108259579  dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
108273635  mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
108255233  tubulin alpha-1A chain [KO:K07374]
108258562  tuba8l2; tubulin, alpha 8 like 2 [KO:K07374]
108256914  tubulin alpha-8 chain isoform X1 [KO:K07374]
108266769  tuba8l3; tubulin, alpha 8 like 3 [KO:K07374]
108275941  tuba1c; tubulin alpha-1C chain [KO:K07374]
108275942  tubulin alpha-1A chain-like [KO:K07374]
108275946  tubulin alpha-1A chain [KO:K07374]
108255063  tubulin alpha-1B chain [KO:K07374]
108268328  tubulin alpha-1A chain isoform X1 [KO:K07374]
108278211  tubulin alpha-1A chain [KO:K07374]
108273468  tubulin alpha-1A chain-like [KO:K07374]
108265838  tuba5; tubulin alpha 5 isoform X2 [KO:K07374]
124628126  tubulin alpha-1A chain [KO:K07374]
128628657  tubulin alpha-1C chain [KO:K07374]
128628737  tubulin alpha-8 chain-like [KO:K07374]
108266283  tubb5; tubulin beta-5 chain [KO:K07375]
108258863  tubulin beta-4B chain [KO:K07375]
108264056  mc1r; melanocyte-stimulating hormone receptor [KO:K07375]
108268242  tubb2; tubulin beta-2A chain [KO:K07375]
108272015  tubb6; tubulin, beta 6 class V [KO:K07375]
108258713  zgc:65894; tubulin beta-4B chain [KO:K07375]
108269625  tubulin beta-4B chain [KO:K07375]
108255360  tubulin beta-4B chain-like [KO:K07375]
108277165  tubulin beta chain [KO:K07375]
108278890  tubulin beta chain isoform X1 [KO:K07375]
108268620  tubulin beta chain isoform X1 [KO:K07375]
108260450  zgc:55461; beta-tubulin family protein [KO:K07375]
108269062  tubb4b; tubulin beta-4b chain [KO:K07375]
108261046  tubulin beta chain [KO:K07375]
108255957  tubulin beta-4B chain-like [KO:K07375]
108265894  tubb2b; tubulin beta-2b chain [KO:K07375]
108257393  tubb4bl; tubulin beta-4B chain [KO:K07375]
108272651  tubulin beta-1 chain isoform X1 [KO:K07375]
108262309  tubulin beta-4B chain-like [KO:K07375]
108274016  csnk1db; casein kinase I [KO:K08959] [EC:2.7.11.1]
108259482  csnk1da; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
100528197  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
108259232  tjp1a; tight junction protein ZO-1 isoform X1 [KO:K05701]
108274984  tjp1b; tight junction protein ZO-1 isoform X1 [KO:K05701]
108273437  beta-1 adrenergic receptor isoform X1 [KO:K04141]
108274482  drd1a; D(1) dopamine receptor [KO:K04144]
108278548  drd1b; dopamine receptor D1b [KO:K04144]
108272652  guanine nucleotide-binding protein G(s) subunit alpha isoform X3 [KO:K04632]
108265241  guanine nucleotide-binding protein G(s) subunit alpha isoform X3 [KO:K04632]
108278353  drd2a; dopamine receptor D2a [KO:K04145]
108259734  drd2b; dopamine receptor D2b [KO:K04145]
108268534  parietopsin [KO:K04145]
108278036  drd2l; dopamine receptor D2 like [KO:K04145]
108257925  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
108267157  adcy1b; adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
108272199  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
108272792  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
108275460  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
108271861  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108260803  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
108266230  adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
108276068  adcy6b; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
108259218  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
108257757  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
108280230  adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
108259388  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
108258341  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
108267323  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
108270713  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
100528913  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a [KO:K04345] [EC:2.7.11.11]
108271065  5-hydroxytryptamine receptor 2B [KO:K04157]
108267122  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
108278586  5-hydroxytryptamine receptor 2C [KO:K04157]
108272355  htr2ab; 5-hydroxytryptamine receptor 2A [KO:K04157]
108270069  grm1b; metabotropic glutamate receptor 1b [KO:K04603]
108279026  grm1a; metabotropic glutamate receptor 1 [KO:K04603]
108277301  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
108277953  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
108280682  gna11b; guanine nucleotide-binding protein subunit alpha-11b [KO:K04635]
108271202  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
108260018  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
108260019  guanine nucleotide-binding protein subunit alpha-11 [KO:K04634]
108269611  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
108258041  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108258091  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
108267602  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
108270307  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
108270308  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108254919  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108271603  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108264307  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
108265736  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
108259727  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
108273127  prkcaa; protein kinase C, alpha, a isoform X2 [KO:K02677] [EC:2.7.11.13]
108258960  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
108260780  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108266582  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
108278235  guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
108260481  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
108280635  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
108259334  gucy1b2; guanylate cyclase soluble subunit beta-2 isoform X1 [KO:K12319] [EC:4.6.1.2]
108260472  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
108274270  prkg1b; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
108263833  prkg1a; cGMP-dependent protein kinase 1a isoform X1 [KO:K07376] [EC:2.7.11.12]
108263686  cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
108255985  cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
108261320  prkg3; cGMP-dependent protein kinase 1 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
ipu04010  MAPK signaling pathway
ipu04020  Calcium signaling pathway
ipu04060  Cytokine-cytokine receptor interaction
ipu04070  Phosphatidylinositol signaling system
ipu04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
LinkDB

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