KEGG   PATHWAY: mcal03040
Entry
mcal03040                   Pathway                                
Name
Spliceosome - Mus caroli (Ryukyu mouse)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
mcal03040  Spliceosome
mcal03040

Other DBs
GO: 0005681
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
115032189  U1 spliceosomal RNA [KO:K14276]
115029837  U1 spliceosomal RNA [KO:K14276]
115029826  U1 spliceosomal RNA [KO:K14276]
115031996  U1 spliceosomal RNA [KO:K14276]
115032626  U1 spliceosomal RNA [KO:K14276]
115030823  U1 spliceosomal RNA [KO:K14276]
115030496  U1 spliceosomal RNA [KO:K14276]
115029769  U1 spliceosomal RNA [KO:K14276]
115029968  U1 spliceosomal RNA [KO:K14276]
115030323  U1 spliceosomal RNA [KO:K14276]
115030931  U1 spliceosomal RNA [KO:K14276]
115032393  U1 spliceosomal RNA [KO:K14276]
115030203  U1 spliceosomal RNA [KO:K14276]
115030809  U1 spliceosomal RNA [KO:K14276]
115030662  U1 spliceosomal RNA [KO:K14276]
115030003  U1 spliceosomal RNA [KO:K14276]
115031392  U1 spliceosomal RNA [KO:K14276]
115031425  U1 spliceosomal RNA [KO:K14276]
115031403  U1 spliceosomal RNA [KO:K14276]
115030528  U1 spliceosomal RNA [KO:K14276]
115032728  U2 spliceosomal RNA [KO:K14277]
115032744  U2 spliceosomal RNA [KO:K14277]
115032490  U2 spliceosomal RNA [KO:K14277]
115032726  U2 spliceosomal RNA [KO:K14277]
115032729  U2 spliceosomal RNA [KO:K14277]
115032743  U2 spliceosomal RNA [KO:K14277]
115030306  U2 spliceosomal RNA [KO:K14277]
115029805  U4 spliceosomal RNA [KO:K14278]
115031255  U4 spliceosomal RNA [KO:K14278]
115031256  U4 spliceosomal RNA [KO:K14278]
115030562  U4 spliceosomal RNA [KO:K14278]
115032091  U4 spliceosomal RNA [KO:K14278]
115031861  U4 spliceosomal RNA [KO:K14278]
115032554  U5 spliceosomal RNA [KO:K14279]
115032553  U5 spliceosomal RNA [KO:K14279]
115030354  U5 spliceosomal RNA [KO:K14279]
115031064  U5 spliceosomal RNA [KO:K14279]
115032095  U5 spliceosomal RNA [KO:K14279]
115032094  U5 spliceosomal RNA [KO:K14279]
115031066  U5 spliceosomal RNA [KO:K14279]
115030657  U6 spliceosomal RNA [KO:K14280]
115031863  U6 spliceosomal RNA [KO:K14280]
115032110  U6 spliceosomal RNA [KO:K14280]
115032559  U6 spliceosomal RNA [KO:K14280]
115030568  U6 spliceosomal RNA [KO:K14280]
115032279  U6 spliceosomal RNA [KO:K14280]
115031266  U6 spliceosomal RNA [KO:K14280]
115031265  U6 spliceosomal RNA [KO:K14280]
115029682  U6 spliceosomal RNA [KO:K14280]
115029520  U6 spliceosomal RNA [KO:K14280]
115029360  U6 spliceosomal RNA [KO:K14280]
115030121  U6 spliceosomal RNA [KO:K14280]
115031865  U6 spliceosomal RNA [KO:K14280]
115030244  U6 spliceosomal RNA [KO:K14280]
115030246  U6 spliceosomal RNA [KO:K14280]
115029176  U6 spliceosomal RNA [KO:K14280]
115029683  U6 spliceosomal RNA [KO:K14280]
115029177  U6 spliceosomal RNA [KO:K14280]
115030827  U6 spliceosomal RNA [KO:K14280]
115029364  U6 spliceosomal RNA [KO:K14280]
115030567  U6 spliceosomal RNA [KO:K14280]
115031467  U6 spliceosomal RNA [KO:K14280]
115029684  U6 spliceosomal RNA [KO:K14280]
115032899  U6 spliceosomal RNA [KO:K14280]
115032285  U6 spliceosomal RNA [KO:K14280]
115029368  U6 spliceosomal RNA [KO:K14280]
115031268  U6 spliceosomal RNA [KO:K14280]
115029936  U6 spliceosomal RNA [KO:K14280]
115032585  U6 spliceosomal RNA [KO:K14280]
115029375  U6 spliceosomal RNA [KO:K14280]
115031461  U6 spliceosomal RNA [KO:K14280]
115032281  U6 spliceosomal RNA [KO:K14280]
115030247  U6 spliceosomal RNA [KO:K14280]
115030410  U6 spliceosomal RNA [KO:K14280]
115030250  U6 spliceosomal RNA [KO:K14280]
115029679  U6 spliceosomal RNA [KO:K14280]
115031263  U6 spliceosomal RNA [KO:K14280]
115029371  U6 spliceosomal RNA [KO:K14280]
115030829  U6 spliceosomal RNA [KO:K14280]
115030115  U6 spliceosomal RNA [KO:K14280]
115029823  U6 spliceosomal RNA [KO:K14280]
115030579  U6 spliceosomal RNA [KO:K14280]
115032111  U6 spliceosomal RNA [KO:K14280]
115030245  U6 spliceosomal RNA [KO:K14280]
115029817  U6 spliceosomal RNA [KO:K14280]
115031692  U6 spliceosomal RNA [KO:K14280]
115032579  U6 spliceosomal RNA [KO:K14280]
110307943  Ddx46; probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
110284033  Ddx39b; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
110312219  Dhx16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
110299784  Dhx38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
110303037  Cdc40; pre-mRNA-processing factor 17 [KO:K12816]
110290023  Prpf18; pre-mRNA-splicing factor 18 isoform X2 [KO:K12817]
110304219  Dhx8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
110304410  Slu7; pre-mRNA-splicing factor SLU7 [KO:K12819]
110294312  Dhx15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
110311547  Snrpb; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
110284860  Snrpd1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
110295505  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
110298683  Snrpd2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
110302957  Snrpd3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
110298925  Snrpe; small nuclear ribonucleoprotein E [KO:K11097]
110307479  small nuclear ribonucleoprotein F-like [KO:K11098]
110308952  small nuclear ribonucleoprotein F-like [KO:K11098]
110303562  Snrpf; small nuclear ribonucleoprotein F [KO:K11098]
110296808  Snrpg; small nuclear ribonucleoprotein G [KO:K11099]
110298227  Snrnp70; U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
110298795  Snrpa; U1 small nuclear ribonucleoprotein A [KO:K11091]
110283856  Snrpc; U1 small nuclear ribonucleoprotein C [KO:K11095]
110309173  Prpf40a; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
110310030  Prpf40b; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
110306490  Rbm25; RNA-binding protein 25 isoform X1 [KO:K12822]
110304573  Ddx5; LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
110304788  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
110284708  Tcerg1; transcription elongation regulator 1 isoform X1 [KO:K12824]
110298234  Fus; RNA-binding protein FUS isoform X1 [KO:K13098]
110298104  Snrpa1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
110286827  Snrpb2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
110304786  Sf3a1; splicing factor 3A subunit 1 [KO:K12825]
110291437  splicing factor 3A subunit 2 [KO:K12826]
110303668  Sf3a2; splicing factor 3A subunit 2 [KO:K12826]
110292116  Sf3a3; splicing factor 3A subunit 3 [KO:K12827]
110295228  Sf3b1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
110285513  Sf3b2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
110300119  Sf3b3; splicing factor 3B subunit 3 [KO:K12830]
110290785  Sf3b4; splicing factor 3B subunit 4 [KO:K12831]
110303670  Sf3b5; splicing factor 3B subunit 5 [KO:K12832]
110307142  Sf3b6; splicing factor 3B subunit 6 [KO:K12833]
110310593  Phf5a; PHD finger-like domain-containing protein 5A [KO:K12834]
110305766  Ddx42; ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
110312692  U2af1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
110297714  U2af1l4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
110297610  U2af2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
110310243  Puf60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
110285507  Smndc1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
110285784  Rbm17; splicing factor 45 [KO:K12840]
110299656  Cherp; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
110302413  U2surp; U2 snRNP-associated SURP motif-containing protein [KO:K12842]
110301873  Rp9; retinitis pigmentosa 9 protein [KO:K19604]
110312699  Lsm2; U6 snRNA-associated Sm-like protein LSm2 isoform X1 [KO:K12621]
110295715  Lsm3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
110300133  Lsm4; U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
110296825  Lsm5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
110300290  Lsm6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
110303621  Lsm7; U6 snRNA-associated Sm-like protein LSm7 isoform X2 [KO:K12626]
110296848  Lsm8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
110312627  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
110290716  Prpf3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
110292329  Prpf4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
110292470  Ppih; peptidyl-prolyl cis-trans isomerase H isoform X3 [KO:K09567] [EC:5.2.1.8]
110297743  Prpf31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
110310556  Snu13; NHP2-like protein 1 [KO:K12845]
110288039  Snrnp27; LOW QUALITY PROTEIN: U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
110296017  Usp39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
110285415  Sart1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
110284731  Zmat2; zinc finger matrin-type protein 2 [KO:K12848]
110293222  Prpf38a; pre-mRNA-splicing factor 38A [KO:K12849]
110291170  Prpf38b; pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
110304296  Eftud2; 116 kDa U5 small nuclear ribonucleoprotein component isoform X1 [KO:K12852]
110290448  Snrnp200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
110307828  Prpf6; pre-mRNA-processing factor 6 [KO:K12855]
110305788  Prpf8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
110292255  Snrnp40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
110310725  Ddx23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
110284876  Txnl4a; thioredoxin-like protein 4A isoform X1 [KO:K12859]
110293241  thioredoxin-like protein 4A [KO:K12859]
110285364  Prpf19; pre-mRNA-processing factor 19 isoform X1 [KO:K10599] [EC:2.3.2.27]
110283906  Cdc5l; cell division cycle 5-like protein [KO:K12860]
110291016  Bcas2; pre-mRNA-splicing factor SPF27 [KO:K12861]
110290824  Plrg1; pleiotropic regulator 1 [KO:K12862]
110301648  Cwc15; spliceosome-associated protein CWC15 homolog [KO:K12863]
110288260  Ctnnbl1; beta-catenin-like protein 1 [KO:K12864]
110312581  heat shock 70 kDa protein 1A-like [KO:K03283]
110312589  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
110312667  heat shock 70 kDa protein 1A [KO:K03283]
110301384  heat shock cognate 71 kDa protein [KO:K03283]
110286902  Pqbp1; LOW QUALITY PROTEIN: polyglutamine-binding protein 1 [KO:K12865]
110296259  Wbp11; WW domain-binding protein 11 [KO:K12866]
110284569  SNW domain-containing protein 1-like [KO:K06063]
110306970  Snw1; SNW domain-containing protein 1 [KO:K06063]
110300067  Xab2; pre-mRNA-splicing factor SYF1 [KO:K12867]
110292866  Syf2; pre-mRNA-splicing factor SYF2 [KO:K12868]
110309327  Crnkl1; crooked neck-like protein 1 [KO:K12869]
110295606  crooked neck-like protein 1 [KO:K12869]
110295541  pre-mRNA-splicing factor ISY1 homolog isoform X1 [KO:K12870]
110283748  Ppil1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
110292197  Ppie; peptidyl-prolyl cis-trans isomerase E [KO:K09564] [EC:5.2.1.8]
110301818  Ccdc12; coiled-coil domain-containing protein 12 [KO:K12871]
110284661  Rbm22; pre-mRNA-splicing factor RBM22 [KO:K12872]
110294249  Bud31; protein BUD31 homolog [KO:K12873]
110309430  Aqr; RNA helicase aquarius [KO:K12874]
110309502  Acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
110305855  Eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
110295828  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
110291320  Rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
110296686  Magohb; protein mago nashi homolog 2 isoform X1 [KO:K12877]
110293082  Magoh; protein mago nashi homolog [KO:K12877]
110284475  Thoc1; THO complex subunit 1 [KO:K12878]
110287124  Thoc2; THO complex subunit 2 isoform X2 [KO:K12879]
110308383  Thoc3; THO complex subunit 3 [KO:K12880]
110288243  aly/REF export factor 2-like [KO:K12881]
110288362  THO complex subunit 4-like [KO:K12881]
110299590  aly/REF export factor 2 [KO:K12881]
110305355  Alyref; THO complex subunit 4 [KO:K12881]
110289025  aly/REF export factor 2-like [KO:K12881]
110292304  Ncbp1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
110311812  Ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
110294700  nuclear cap-binding protein subunit 2-like isoform X1 [KO:K12883]
110310344  Hnrnpa1; heterogeneous nuclear ribonucleoprotein A1 isoform X2 [KO:K12741]
110312439  Hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
110287357  heterogeneous nuclear ribonucleoprotein A3-like isoform X1 [KO:K12741]
110290303  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
110308891  Hnrnpc; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
110286484  Rbmx; RNA-binding motif protein, X chromosome isoform X1 [KO:K12885]
110307768  Hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
110312361  Hnrnpm; heterogeneous nuclear ribonucleoprotein M isoform X3 [KO:K12887]
110297467  Hnrnpu; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
110296125  Pcbp1; poly(rC)-binding protein 1 [KO:K12889]
110306118  Srsf1; serine/arginine-rich splicing factor 1 [KO:K12890]
110304711  Srsf2; serine/arginine-rich splicing factor 2 [KO:K12891]
110312663  Srsf3; serine/arginine-rich splicing factor 3 [KO:K12892]
110307359  Srsf5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
110285043  Srsf6; serine/arginine-rich splicing factor 6 [KO:K12893]
110292983  Srsf4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
110283779  Srsf7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
110294276  Srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
110294822  LOW QUALITY PROTEIN: transformer-2 protein homolog alpha-like [KO:K12897]
110311639  Tra2b; transformer-2 protein homolog beta isoform X1 [KO:K12897]
110295599  Tra2a; transformer-2 protein homolog alpha [KO:K12897]
110292674  Srsf10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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