KEGG   PATHWAY: mcf05146
Entry
mcf05146                    Pathway                                
Name
Amoebiasis - Macaca fascicularis (crab-eating macaque)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
mcf05146  Amoebiasis
mcf05146

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102119749  IL1B; interleukin-1 beta [KO:K04519]
102146317  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102143926  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
102138273  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
101867324  RELA; transcription factor p65 isoform X1 [KO:K04735]
101865323  HSPB1; heat shock protein beta-1 [KO:K04455]
102120778  MUC2; mucin-2 [KO:K10955]
102128759  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102130586  COL1A2; collagen alpha-2(I) chain isoform X2 [KO:K06236]
102127262  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102125366  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
102118598  COL4A4; collagen alpha-4(IV) chain isoform X3 [KO:K06237]
102122146  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
102131342  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102122606  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
102119232  FN1; fibronectin isoform X1 [KO:K05717]
102145776  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102146003  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
102128796  LAMA5; laminin subunit alpha-5 isoform X3 [KO:K06240]
102120952  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
102132640  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102126233  LAMB1; laminin subunit beta-1 [KO:K05636]
102135628  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
102116149  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
102126627  LAMB4; laminin subunit beta-4 [KO:K06245]
102116045  LAMC1; laminin subunit gamma-1 [KO:K05635]
102116676  LAMC2; laminin subunit gamma-2 [KO:K06246]
102147194  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
107128638  immunoglobulin heavy variable 3-21 [KO:K06856]
102122532  immunoglobulin heavy variable 4-59 [KO:K06856]
107130290  immunoglobulin heavy variable 3-48 [KO:K06856]
123574606  LOW QUALITY PROTEIN: immunoglobulin heavy variable 3-23 [KO:K06856]
135971582  uncharacterized protein LOC135971582 [KO:K06856]
102130397  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
102123885  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
101866007  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
102133761  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
101925220  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102140615  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102136896  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102123165  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102135875  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102116992  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101865773  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102145630  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X15 [KO:K04632]
107126444  neuroendocrine secretory protein 55 [KO:K04632]
102137826  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X2 [KO:K04633]
102147015  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
102117414  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
102142443  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101926461  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
102144117  RAB5A; ras-related protein Rab-5A [KO:K07887]
101865961  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
102116190  RAB5C; ras-related protein Rab-5C [KO:K07889]
102143515  RAB7A; ras-related protein Rab-7a [KO:K07897]
102137760  RAB7B; ras-related protein Rab-7b isoform X3 [KO:K07898]
102146068  TLR2; toll-like receptor 2 [KO:K10159]
102136906  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
102129342  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
102138971  IL6; interleukin-6 precursor [KO:K05405]
102117979  growth-regulated alpha protein [KO:K05505]
102123272  C-X-C motif chemokine 2 [KO:K05505]
102126138  CXCL1; growth-regulated alpha protein [KO:K05505]
102123657  growth-regulated alpha protein [KO:K05505]
102118747  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
102127272  CXCL8; interleukin-8 [KO:K10030]
102139631  TNF; tumor necrosis factor [KO:K03156]
102115316  IL12A; interleukin-12 subunit alpha [KO:K05406]
102124858  IL12B; interleukin-12 subunit beta [KO:K05425]
102139678  T-cell surface glycoprotein CD1e, membrane-associated isoform X2 [KO:K06448]
102141080  CD1B; T-cell surface glycoprotein CD1b isoform X2 [KO:K06448]
102142140  CD1D; antigen-presenting glycoprotein CD1d isoform X3 [KO:K06448]
102127773  CD1A; T-cell surface glycoprotein CD1a isoform X1 [KO:K06448]
102126397  CD1C; T-cell surface glycoprotein CD1c isoform X1 [KO:K06448]
123566808  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
102128291  IFNG; interferon gamma [KO:K04687]
102125232  COL3A1; collagen alpha-1(III) chain [KO:K19720]
101925550  PTK2; focal adhesion kinase 1 isoform X3 [KO:K05725] [EC:2.7.10.2]
102121587  VCL; vinculin isoform X1 [KO:K05700]
102125329  ACTN4; alpha-actinin-4 isoform X5 [KO:K05699]
102127552  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
102131487  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
101866868  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
102121432  LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
135967611  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
101925124  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
101866035  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101867473  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
101866493  SERPINB6; serpin B6 isoform X2 [KO:K13963]
102120506  SERPINB9; serpin B9 [KO:K13963]
102135021  SERPINB4; serpin B4 [KO:K13963]
102135631  serpin B3 [KO:K13963]
102131346  SERPINB10; serpin B10 [KO:K13963]
102134660  SERPINB13; serpin B13 isoform X1 [KO:K13963]
102132993  serpin B6-like isoform X2 [KO:K13963]
102128983  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
102133450  IL10; interleukin-10 [KO:K05443]
102129546  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101925182  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102119907  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102133722  C8A; complement component C8 alpha chain [KO:K03997]
102133338  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
102126692  C8G; complement component C8 gamma chain [KO:K03999]
102137382  C9; complement component C9 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
mcf00330  Arginine and proline metabolism
mcf00590  Arachidonic acid metabolism
mcf04144  Endocytosis
mcf04210  Apoptosis
mcf04510  Focal adhesion
mcf04610  Complement and coagulation cascades
mcf04612  Antigen processing and presentation
mcf04620  Toll-like receptor signaling pathway
mcf04672  Intestinal immune network for IgA production
mcf04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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