KEGG   PATHWAY: mcf04510
Entry
mcf04510                    Pathway                                
Name
Focal adhesion - Macaca fascicularis (crab-eating macaque)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mcf04510  Focal adhesion
mcf04510

Other DBs
GO: 0005925
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
101864805  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X6 [KO:K06270]
101865065  CRK; adapter molecule crk isoform X1 [KO:K04438]
101865181  VAV3; guanine nucleotide exchange factor VAV3 isoform X6 [KO:K05730]
101865339  PARVB; beta-parvin isoform X1 [KO:K06275]
101865406  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101865630  RHOA; transforming protein RhoA [KO:K04513]
101865646  CAV1; caveolin-1 isoform X2 [KO:K06278]
101865773  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101865999  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101866132  PAK1; serine/threonine-protein kinase PAK 1 isoform X5 [KO:K04409] [EC:2.7.11.1]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101866329  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101866379  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101866436  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
101867036  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101867161  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
101867220  COMP; cartilage oligomeric matrix protein [KO:K04659]
101867234  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101925057  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101925271  ITGA6; integrin alpha-6 isoform X3 [KO:K06485]
101925550  PTK2; focal adhesion kinase 1 isoform X14 [KO:K05725] [EC:2.7.10.2]
101925607  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X8 [KO:K00889] [EC:2.7.1.68]
101925802  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101925934  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101925936  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101926125  MYL12B; myosin regulatory light chain 12B [KO:K12757]
101926308  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101926587  DIAPH1; protein diaphanous homolog 1 isoform X2 [KO:K05740]
101926721  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
102114845  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
102114959  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102114969  ITGA5; integrin alpha-5 [KO:K06484]
102115437  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102115442  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102115695  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
102115749  MYL11; myosin regulatory light chain 11 [KO:K12758]
102116045  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
102116149  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
102116225  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102116249  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
102116296  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
102116676  LAMC2; laminin subunit gamma-2 [KO:K06246]
102116742  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102116992  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102117741  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
102117791  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102117936  PARVG; gamma-parvin isoform X2 [KO:K06275]
102118153  [KO:K05692]
102118276  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102118376  TLN2; talin-2 isoform X1 [KO:K06271]
102118497  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102118598  COL4A4; collagen alpha-4(IV) chain isoform X7 [KO:K06237]
102118744  HRAS; GTPase HRas [KO:K02833]
102119232  FN1; fibronectin isoform X1 [KO:K05717]
102119413  ITGA2B; integrin alpha-IIb isoform X4 [KO:K06476]
102119572  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
102119955  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
102120028  THBS3; thrombospondin-3 isoform X6 [KO:K04659]
102120608  COL6A3; collagen alpha-3(VI) chain isoform X3 [KO:K06238]
102120728  COL9A1; collagen alpha-1(IX) chain isoform X4 [KO:K08131]
102120952  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
102121021  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X4 [KO:K12329]
102121272  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102121587  VCL; vinculin isoform X1 [KO:K05700]
102121921  BAD; bcl2-associated agonist of cell death [KO:K02158]
102122005  CAV2; caveolin-2 isoform X1 [KO:K12958]
102122026  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
102122146  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
102122296  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102122606  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
102122623  CRKL; crk-like protein [KO:K04438]
102122692  [KO:K03853] [EC:3.4.22.53]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102122818  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
102122927  PARVA; alpha-parvin [KO:K06275]
102123168  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102123329  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102123415  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102123512  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102123592  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
102123619  ITGB5; integrin beta-5 [KO:K06588]
102124156  ZYX; zyxin [KO:K06273]
102124550  MYL12A; myosin regulatory light chain 12A isoform X1 [KO:K12757]
102124633  ITGA11; integrin alpha-11 [KO:K06587]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102125183  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102125325  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
102125329  ACTN4; alpha-actinin-4 isoform X3 [KO:K05699]
102125340  EMP2; epithelial membrane protein 2 [KO:K26256]
102125342  THBS2; thrombospondin-2 [KO:K04659]
102125366  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
102125369  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
102125644  TNN; tenascin-N isoform X1 [KO:K06252]
102125726  [KO:K04393]
102126017  ILK; scaffold protein ILK isoform X1 [KO:K06272] [EC:2.7.11.1]
102126233  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
102126339  MAPK8; mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
102126372  EMP1; epithelial membrane protein 1 [KO:K26255]
102126399  [KO:K04725] [EC:2.3.2.27]
102126446  JUN; transcription factor Jun [KO:K04448]
102126620  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102126627  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
102126878  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
102127232  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102127262  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102127552  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
102127655  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102128018  IGF1; insulin-like growth factor 1 isoform X3 [KO:K05459]
102128433  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
102128759  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102128796  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
102129227  THBS4; thrombospondin-4 [KO:K04659]
102129690  RELN; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
102130142  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102130150  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
102130245  THBS1; thrombospondin-1 [KO:K16857]
102130383  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
102130586  COL1A2; collagen alpha-2(I) chain [KO:K06236]
102130741  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
102130928  VTN; vitronectin isoform X1 [KO:K06251]
102131093  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
102131342  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102131393  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102131497  TNXB; tenascin-X isoform X13 [KO:K06252]
102131974  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
102132043  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102132595  ITGB4; integrin beta-4 isoform X10 [KO:K06525]
102132631  VWF; von Willebrand factor isoform X1 [KO:K03900]
102132640  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
102132675  ITGA1; integrin alpha-1 [KO:K06480]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102133022  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
102133054  ROCK2; rho-associated protein kinase 2 isoform X3 [KO:K17388] [EC:2.7.11.39]
102133064  TNR; tenascin-R isoform X1 [KO:K06252]
102133242  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102133300  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
102133302  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
102133753  CAV3; caveolin-3 [KO:K12959]
102133756  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102133907  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102134285  FLNB; filamin-B isoform X4 [KO:K27392]
102134620  PGF; placenta growth factor isoform X6 [KO:K16859]
102134921  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
102135079  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102135194  MYL10; myosin regulatory light chain 10 isoform X2 [KO:K12756]
102135245  CHAD; chondroadherin [KO:K06248]
102135329  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102135628  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
102135642  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102135688  IBSP; integrin-binding sialoprotein [KO:K06253]
102135875  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102136180  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
102136227  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102137056  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102137082  ITGB7; integrin beta-7 isoform X3 [KO:K06590]
102137208  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102137531  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
102137533  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X5 [KO:K06277]
102137568  [KO:K06238]
102137780  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102137879  SPP1; osteopontin [KO:K06250]
102137961  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
102138168  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X5 [KO:K16060]
102138212  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102138249  PXN; paxillin isoform X3 [KO:K05760]
102138313  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102138392  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102138402  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102138509  FLNA; filamin-A isoform X1 [KO:K04437]
102138724  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102138792  TLN1; talin-1 isoform X1 [KO:K06271]
102138836  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102138933  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102139853  ACTB; actin, cytoplasmic 1 [KO:K05692]
102140059  COL6A6; collagen alpha-6(VI) chain isoform X2 [KO:K06238]
102140241  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
102140731  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
102140851  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102141221  TNC; tenascin isoform X1 [KO:K06252]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102142777  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
102143042  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102143597  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102144586  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
102144610  ITGB1; integrin beta-1 isoform X3 [KO:K05719]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102145766  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102145776  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102145994  [KO:K05692]
102146003  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
102146168  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102146608  ERBB2; receptor tyrosine-protein kinase ErbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
102146984  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102147025  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102147194  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
107126428  VEGFD; vascular endothelial growth factor D [KO:K05449]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mcf04010  MAPK signaling pathway
mcf04060  Cytokine-cytokine receptor interaction
mcf04070  Phosphatidylinositol signaling system
mcf04110  Cell cycle
mcf04151  PI3K-Akt signaling pathway
mcf04310  Wnt signaling pathway
mcf04512  ECM-receptor interaction
mcf04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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