KEGG   PATHWAY: mnb04810
Entry
mnb04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Merops nubicus (carmine bee-eater)
Class
Cellular Processes; Cell motility
Pathway map
mnb04810  Regulation of actin cytoskeleton
mnb04810

Other DBs
GO: 0030036
Organism
Merops nubicus (carmine bee-eater) [GN:mnb]
Gene
103776957  lysophosphatidic acid receptor 1-like [KO:K04289]
103774121  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103775164  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103777545  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103772864  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103777712  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
103768922  F2R; proteinase-activated receptor 1 [KO:K03914]
103768524  INS; insulin [KO:K04526]
103772713  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
103777588  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
103772985  FGF6; fibroblast growth factor 6 [KO:K04358]
103780839  fibroblast growth factor 4-like [KO:K04358]
103780961  fibroblast growth factor 5-like [KO:K04358]
103768821  fibroblast growth factor 10-like [KO:K04358]
103769942  FGF8; fibroblast growth factor 8 [KO:K04358]
103775970  FGF16; fibroblast growth factor 16 [KO:K04358]
103777528  FGF7; fibroblast growth factor 7 [KO:K04358]
103777931  FGF3; fibroblast growth factor 3 [KO:K04358]
103771889  fibroblast growth factor 20-like [KO:K04358]
103772703  FGF18; fibroblast growth factor 18 [KO:K04358]
103779056  FGF9; fibroblast growth factor 9 [KO:K04358]
103774185  FGF19; fibroblast growth factor 19 [KO:K22603]
103776266  fibroblast growth factor 23-like [KO:K22428]
103772210  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
103782038  PDGFC; platelet-derived growth factor C [KO:K05450]
103777188  PDGFD; platelet-derived growth factor D [KO:K05450]
103773796  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103775054  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103771881  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103774564  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103778913  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103776410  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103768526  fibronectin [KO:K05717]
103772610  integrin alpha-1-like [KO:K06480]
103781532  ITGA2; integrin alpha-2 [KO:K06481]
103772971  ITGA4; integrin alpha-4 [KO:K06483]
103778005  ITGA6; integrin alpha-6 [KO:K06485]
103772159  ITGA9; integrin alpha-9 [KO:K06585]
103773656  ITGA11; integrin alpha-11 [KO:K06587]
103778532  LOW QUALITY PROTEIN: integrin alpha-V-like [KO:K06487]
103774002  ITGAE; integrin alpha-E [KO:K06524]
103776233  ITGB1; integrin beta-1 [KO:K05719]
103780280  ITGB2; integrin beta-2 [KO:K06464]
103778519  ITGB3; integrin beta-3 [KO:K06493]
103771618  ITGB4; integrin beta-4 [KO:K06525]
103780440  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103773254  ITGB8; integrin beta-8 [KO:K06591]
103770977  KNG1; kininogen-1 [KO:K03898]
103769704  BDKRB1; B1 bradykinin receptor [KO:K03915]
103769705  BDKRB2; B2 bradykinin receptor [KO:K03916]
103773997  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103775291  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
103782075  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
103776822  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103779942  C5; complement C5 [KO:K03994]
103781325  C6; complement component C6 [KO:K03995]
103775359  C7; complement component C7 [KO:K03996]
103776999  C8A; complement component C8 alpha chain [KO:K03997]
103776522  C8B; complement component C8 beta chain [KO:K03998]
103772307  C9; complement component C9 [KO:K04000]
103776247  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
103781356  GNA13; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
103775085  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
103782464  focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
103775687  CRKL; crk-like protein [KO:K04438]
103777038  CRK; adapter molecule crk [KO:K04438]
103775284  neuronal proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103779189  SOS1; son of sevenless homolog 1 [KO:K03099]
103777136  SOS2; son of sevenless homolog 2 [KO:K03099]
103769106  LOW QUALITY PROTEIN: GTPase HRas-like [KO:K02833]
103776418  GTPase HRas [KO:K02833]
103782490  KRAS; GTPase KRas isoform X1 [KO:K07827]
103781606  NRAS; GTPase NRas [KO:K07828]
103776961  RRAS2; ras-related protein R-Ras2 [KO:K07830]
103768398  MRAS; ras-related protein M-Ras [KO:K07831]
103778906  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
103780557  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103781787  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103778679  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103768794  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103776111  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103771343  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
103769301  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103770485  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103777033  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103778610  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103769043  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103773038  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103769215  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103769347  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103781211  RGCC; regulator of cell cycle RGCC [KO:K26108]
103771597  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
103775302  ARHGAP35; LOW QUALITY PROTEIN: rho GTPase-activating protein 35 [KO:K05732]
103773600  rho-related GTP-binding protein RhoC-like [KO:K04513]
103776231  RHOA; transforming protein RhoA [KO:K04513]
103773950  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103778948  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103771344  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
103778941  CDC42; cell division control protein 42 homolog [KO:K04393]
103776282  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
103768183  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103774240  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
103771949  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
103776356  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
103771507  rho guanine nucleotide exchange factor 7 [KO:K13710]
103781637  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103773779  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
103770588  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103771017  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103771834  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103778907  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103771501  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103773231  myosin regulatory light polypeptide 9-like [KO:K12755]
103770484  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
103777014  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
103775618  MYH10; myosin-10 isoform X1 [KO:K10352]
103776275  LOW QUALITY PROTEIN: myosin-11-like [KO:K10352]
103772684  MYH9; myosin-9 isoform X1 [KO:K10352]
103781761  protein diaphanous homolog 2-like [KO:K05740]
103781391  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103776087  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
103776654  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
103772705  phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
103781857  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
103778248  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
103771581  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
103769404  LIMK2; LOW QUALITY PROTEIN: LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
103769523  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
103776029  ENAH; protein enabled homolog [KO:K05746]
103781177  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
103775237  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
103775933  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
103776602  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
103779786  NCKAP1; nck-associated protein 1 [KO:K05750]
103777140  abl interactor 2 [KO:K05751]
103769327  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
103768209  ACTR2; actin-related protein 2 [KO:K17260]
103773256  actin-related protein 3 [KO:K18584]
103774331  ACTR3B; actin-related protein 3B [KO:K18584]
103769988  actin-related protein 2/3 complex subunit 1A [KO:K05757]
103776071  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103780838  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103775103  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103780525  actin, cytoplasmic type 5-like [KO:K05692]
103775609  actin, cytoplasmic 1 isoform X1 [KO:K05692]
103773787  PFN3; profilin-3 [KO:K05759]
103770577  PFN2; profilin-2 [KO:K05759]
103776694  PXN; paxillin [KO:K05760]
103768748  EZR; ezrin [KO:K08007]
103770960  RDX; radixin isoform X1 [KO:K05762]
103773089  MSN; moesin isoform X1 [KO:K05763]
103780369  TMSB4X; thymosin beta-4 [KO:K05764]
103778986  CFL2; cofilin-2 [KO:K05765]
103769425  protein phosphatase Slingshot homolog 1-like [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103776690  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103782604  VCL; vinculin [KO:K05700]
103781392  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
103780138  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
103769595  SCIN; LOW QUALITY PROTEIN: adseverin [KO:K05768]
103777962  GSN; gelsolin [KO:K05768]
103780497  alpha-actinin-1 [KO:K05699]
103772641  APC; adenomatous polyposis coli protein [KO:K02085]
103768112  spermatogenesis-associated protein 13-like isoform X1 [KO:K05769]
103769322  uncharacterized protein LOC103769322 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mnb04010  MAPK signaling pathway
mnb04510  Focal adhesion
mnb04520  Adherens junction
KO pathway
ko04810   
LinkDB

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