KEGG   PATHWAY: mthb04932
Entry
mthb04932                   Pathway                                
Name
Non-alcoholic fatty liver disease - Macaca thibetana thibetana (Pere David's macaque)
Description
Non-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepatitis (NASH). NASH may further lead to cirrhosis and hepatocellular carcinoma (HCC). This map shows a stage-dependent progression of NAFLD. In the first stage of NAFLD, excess lipid accumulation has been demonstrated. The main cause is the induction of insulin resistance, which leads to a defect in insulin suppression of free fatty acids (FAAs) disposal. In addition, two transcription factors, SREBP-1c and PPAR-alpha, activate key enzymes of lipogenesis and increase the synthesis of FAAs in liver. In the second stage, as a consequence of the progression to NASH, the production of reactive oxygen species (ROS) is enhanced due to oxidation stress through mitochondrial beta-oxidation of fatty acids and endoplamic reticulum (ER) stress, leading to lipid peroxidation. The lipid peroxidation can further cause the production of cytokines (Fas ligand, TNF-alpha, IL-8 and TGF), promoting cell death, inflammation and fibrosis. The activation of JNK, which is induced by ER stress, TNF-alpha and FAAs, is also associated with NAFLD progression. Increased JNK promotes cytokine production and initiation of HCC.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
mthb04932  Non-alcoholic fatty liver disease
mthb04932

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126950025  interleukin-6 isoform X1 [KO:K05405]
126934004  interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
126939248  suppressor of cytokine signaling 3 [KO:K04696]
126953141  tumor necrosis factor isoform X1 [KO:K03156]
126930443  tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126935873  insulin isoform X1 [KO:K04526]
126942469  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
126932885  insulin receptor substrate 1 [KO:K16172]
126940155  insulin receptor substrate 2 [KO:K07187]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126941765  glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
126949239  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126936383  oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
126936987  retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
126938791  sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
126930605  MLX-interacting protein isoform X1 [KO:K09113]
126938527  max-like protein X isoform X1 [KO:K09113]
126950339  carbohydrate-responsive element-binding protein isoform X1 [KO:K09113]
126933640  pyruvate kinase PKLR isoform X1 [KO:K12406] [EC:2.7.1.40]
126949785  LOW QUALITY PROTEIN: leptin [KO:K05424]
126936950  leptin receptor isoform X1 [KO:K05062]
126946388  adiponectin isoform X1 [KO:K07296]
126930243  adiponectin receptor protein 2 isoform X1 [KO:K07297]
126939158  adiponectin receptor protein 1 [KO:K07297]
126956450  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
126932625  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
126930676  5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
126932421  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
126930179  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
126932994  5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
126951597  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
126952773  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
126952775  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126929437  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126929447  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126963592  peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
126949058  peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
126956242  cell division control protein 42 homolog isoform X1 [KO:K04393]
126953277  cell division control protein 42 homolog [KO:K04393]
126954326  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126950508  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126935336  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
126954697  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126963142  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126956917  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126964180  E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
126939534  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
126936973  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
126952847  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
126959543  protein c-Fos [KO:K04379]
126962798  transcription factor Jun [KO:K04448]
126933365  interleukin-1 alpha isoform X1 [KO:K04383]
126933366  interleukin-1 beta [KO:K04519]
126960750  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
126963975  LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
126941775  CCAAT/enhancer-binding protein alpha [KO:K09055]
126963293  LOW QUALITY PROTEIN: cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
126963295  cytochrome P450 2E1-like isoform X1 [KO:K07415] [EC:1.14.14.-]
126941397  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126954919  interleukin-8 [KO:K10030]
126941768  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
126933911  eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
126958657  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
126963745  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
126930406  DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
126933423  bcl-2-like protein 11 isoform X1 [KO:K16341]
126943600  apoptosis regulator BAX isoform X1 [KO:K02159]
126963192  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
126932110  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
126929772  BH3-interacting domain death agonist [KO:K04726]
126949081  cytochrome c-like [KO:K08738]
126961774  cytochrome c-like [KO:K08738]
126936610  cytochrome c-like [KO:K08738]
126937973  cytochrome c-like [KO:K08738]
126944405  cytochrome c-like [KO:K08738]
126932751  cytochrome c-like [KO:K08738]
126951393  cytochrome c [KO:K08738]
126947125  cytochrome c-like [KO:K08738]
126941401  cytochrome c-like [KO:K08738]
126952962  cytochrome c-like [KO:K08738]
126942126  cytochrome c-like [KO:K08738]
126954341  caspase-3 [KO:K02187] [EC:3.4.22.56]
126962014  caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
126935373  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
126930135  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
126941129  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
126950655  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
126932207  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
126946139  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
126941467  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
126957346  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
126950258  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
126942379  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
126942872  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126943346  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
126944267  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126956821  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126930414  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
126962403  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126956036  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126949986  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
126963966  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126945886  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126958389  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126960684  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126949375  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
126938104  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
126949807  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
126960621  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126953759  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126963639  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1 [KO:K03950]
126942854  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
126937961  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
126931739  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
126932556  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
126937587  acyl carrier protein, mitochondrial-like [KO:K03955]
126944402  acyl carrier protein, mitochondrial [KO:K03955]
126951198  acyl carrier protein, mitochondrial-like [KO:K03955]
126942837  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
126932729  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
126930310  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
126942362  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
126959705  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
126948765  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
126949662  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
126932125  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
126934097  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126958757  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126934260  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126949249  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
126939064  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126935141  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126948391  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
126937431  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
126942449  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
126963088  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
126944751  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
126939420  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126950876  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126934694  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126961397  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
126944752  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
126930302  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
126945660  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
126932178  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
126935729  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
126935957  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like [KO:K03935] [EC:7.1.1.2]
126936392  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
126945830  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like [KO:K03936] [EC:7.1.1.2]
126956863  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
126938277  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126963401  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126960994  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
126961122  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126957428  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
126942790  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
126935402  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
126954622  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
126935701  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
126956207  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
126957442  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
126955714  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
126961462  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126936808  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
126962850  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
126956192  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
126950253  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126961220  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126935807  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
126930673  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
126943623  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
126960981  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
126948676  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
126944495  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
126954785  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
126961549  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
126937178  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
126934429  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
126960839  cytochrome b-c1 complex subunit 7 [KO:K00417]
126954793  cytochrome b-c1 complex subunit 8-like [KO:K00418]
126956035  cytochrome b-c1 complex subunit 8 [KO:K00418]
126963991  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
126942883  cytochrome b-c1 complex subunit 10 [KO:K00420]
126944333  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
126964308  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
126934981  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
126959142  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
126960028  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
126936073  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
126956094  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
126934339  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
126944266  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
126946802  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
126943264  cytochrome c oxidase subunit 6B2 [KO:K02267]
126939820  cytochrome c oxidase subunit 6B1-like [KO:K02267]
126941943  cytochrome c oxidase subunit 6B1 [KO:K02267]
126954498  cytochrome c oxidase subunit 6C [KO:K02268]
126961151  cytochrome c oxidase subunit 6C [KO:K02268]
126946168  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
126934205  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
126946829  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
126951565  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
126952142  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
126942121  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
126955253  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
126946324  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
126942189  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
126930116  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126943807  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126956722  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126938620  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126957169  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126957397  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126958011  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126933618  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126946671  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126958869  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126952688  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126960733  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126959711  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
126935615  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
Compound
C00031  D-Glucose
C00162  Fatty acid
Reference
PMID:23545492
  Authors
Naik A, Kosir R, Rozman D
  Title
Genomic aspects of NAFLD pathogenesis.
  Journal
Genomics 102:84-95 (2013)
DOI:10.1016/j.ygeno.2013.03.007
Reference
PMID:19352614
  Authors
Malaguarnera M, Di Rosa M, Nicoletti F, Malaguarnera L
  Title
Molecular mechanisms involved in NAFLD progression.
  Journal
J Mol Med (Berl) 87:679-95 (2009)
DOI:10.1007/s00109-009-0464-1
Reference
PMID:22705006
  Authors
Seki E, Brenner DA, Karin M
  Title
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.
  Journal
Gastroenterology 143:307-20 (2012)
DOI:10.1053/j.gastro.2012.06.004
Reference
PMID:21038418
  Authors
Tilg H, Moschen AR
  Title
Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis.
  Journal
Hepatology 52:1836-46 (2010)
DOI:10.1002/hep.24001
Reference
PMID:16364488
  Authors
Larter CZ, Farrell GC
  Title
Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
  Journal
J Hepatol 44:253-61 (2006)
DOI:10.1016/j.jhep.2005.11.030
Reference
PMID:22570745
  Authors
Farrell GC, van Rooyen D, Gan L, Chitturi S
  Title
NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications.
  Journal
Gut Liver 6:149-71 (2012)
DOI:10.5009/gnl.2012.6.2.149
Reference
PMID:20619513
  Authors
Shapiro H, Tehilla M, Attal-Singer J, Bruck R, Luzzatti R, Singer P
  Title
The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease.
  Journal
Clin Nutr 30:6-19 (2011)
DOI:10.1016/j.clnu.2010.06.001
Reference
PMID:20303879
  Authors
Hotamisligil GS
  Title
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.
  Journal
Cell 140:900-17 (2010)
DOI:10.1016/j.cell.2010.02.034
Reference
PMID:17498512
  Authors
Parekh S, Anania FA
  Title
Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease.
  Journal
Gastroenterology 132:2191-207 (2007)
DOI:10.1053/j.gastro.2007.03.055
Reference
PMID:16374858
  Authors
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Hepatology 43:163-72 (2006)
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Leung TM, Nieto N
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CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease.
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Mitochondrion 6:1-28 (2006)
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J Hepatol 54:795-809 (2011)
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Mantena SK, King AL, Andringa KK, Eccleston HB, Bailey SM
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Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases.
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Free Radic Biol Med 44:1259-72 (2008)
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Mitochondrial involvement in non-alcoholic steatohepatitis.
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Mol Aspects Med 29:22-35 (2008)
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Hepatology 58:1497-507 (2013)
DOI:10.1002/hep.26226
Related
pathway
mthb00061  Fatty acid biosynthesis
mthb00190  Oxidative phosphorylation
mthb03320  PPAR signaling pathway
mthb04141  Protein processing in endoplasmic reticulum
mthb04151  PI3K-Akt signaling pathway
mthb04210  Apoptosis
mthb04668  TNF signaling pathway
mthb04920  Adipocytokine signaling pathway
mthb04930  Type II diabetes mellitus
KO pathway
ko04932   
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