Entry
Name
Cytokine-cytokine receptor interaction - Maylandia zebra (zebra mbuna)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
mze04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Maylandia zebra (zebra mbuna) [GN:
mze ]
Gene
101465243 clcf1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
105940863 tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
101478620 tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
101482899 tnfsf11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
101477782 tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
101484632 tumor necrosis factor ligand superfamily member 13B isoform X2 [KO:K05476 ]
101483561 tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
112434243 LOW QUALITY PROTEIN: growth/differentiation factor 9-like [KO:K22673 ]
101478654 LOW QUALITY PROTEIN: C-C chemokine receptor type 6-like [KO:K04181 ]
111501317 LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2-like [KO:K05050 ]
112432347 LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2-like [KO:K05050 ]
112433194 LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2-like [KO:K05050 ]
105941328 il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
101482752 il13ra2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077 ]
101478204 csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
101476931 il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
101484719 ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05056 ]
101483993 cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
101476032 tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K03158 ]
101479156 tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
101482032 tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
101483435 tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K05152 ]
101484190 tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
112430341 tumor necrosis factor receptor superfamily member 5-like [KO:K05152 ]
101463837 tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
112434364 tumor necrosis factor receptor superfamily member 5-like [KO:K05152 ]
101486517 tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K05152 ]
112429656 tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K05152 ]
112436375 tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K05152 ]
112436376 tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K05152 ]
112431782 tumor necrosis factor receptor superfamily member 6B-like [KO:K05143 ]
105941237 LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
101466428 tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
101465040 tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
101486402 tnfrsf21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157 ]
101484704 edar; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
101472190 tumor necrosis factor receptor superfamily member 16 isoform X2 [KO:K02583 ]
101479942 tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
101466954 tnfrsf11a; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
105941171 tnfrsf12a; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
101487191 tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160 ]
101467071 tumor necrosis factor receptor superfamily member 4-like [KO:K05142 ]
101476257 tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150 ]
112435249 tumor necrosis factor receptor superfamily member 13B-like isoform X1 [KO:K05150 ]
101479020 tnfrsf19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
101467437 relt; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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