KEGG   PATHWAY: omy04910
Entry
omy04910                    Pathway                                
Name
Insulin signaling pathway - Oncorhynchus mykiss (rainbow trout)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
omy04910  Insulin signaling pathway
omy04910

Organism
Oncorhynchus mykiss (rainbow trout) [GN:omy]
Gene
118946006  insulin-like [KO:K04526]
100136702  preproinsulin 1 precursor [KO:K04526]
100136703  preproinsulin 2 precursor [KO:K04526]
100135870  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
100135871  insulin receptor [KO:K04527] [EC:2.7.10.1]
100136604  insulin receptor [KO:K04527] [EC:2.7.10.1]
100272218  insulin receptor [KO:K04527] [EC:2.7.10.1]
110490060  irs1; insulin receptor substrate 1-B isoform X2 [KO:K16172]
110537392  insulin receptor substrate 1-B [KO:K16172]
110531720  si:ch73-335l21.1; insulin receptor substrate 1-B isoform X3 [KO:K16172]
110500592  insulin receptor substrate 1-B [KO:K16172]
110533721  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
110501605  insulin receptor substrate 2 isoform X2 [KO:K07187]
110495980  insulin receptor substrate 2 [KO:K07187]
110528824  irs2a; insulin receptor substrate 2 [KO:K07187]
110510164  insulin receptor substrate 2-A-like [KO:K07187]
110531423  insulin receptor substrate 2-B [KO:K07187]
110500338  insulin receptor substrate 2-B [KO:K07187]
110520474  insulin receptor substrate 2 [KO:K07187]
110508523  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110521824  pik3r3b; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110508907  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110509692  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110523476  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110530129  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110524144  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110530540  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110524761  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110493506  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110526129  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
110508222  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110503149  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110530052  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110524465  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110532334  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110507192  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118942980  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110491592  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
110498855  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110486327  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a isoform X1 [KO:K06276] [EC:2.7.11.1]
110534202  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110522300  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110503159  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110510210  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
110529687  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110497971  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110505486  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110486000  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110499295  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110493716  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110507997  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
110501619  gsk3ba; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
110527544  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110495932  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110504531  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110490187  gys2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
110487423  glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
110487454  glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
110522515  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110535906  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
110529802  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110491770  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
110531833  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110538620  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
110525529  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
110486660  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
110500690  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110521347  uncharacterized protein LOC110521347 [KO:K07189]
110502551  protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
110528688  protein phosphatase 1 regulatory subunit 3D [KO:K07189]
110523662  si:dkey-242g16.2; protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
110523785  protein phosphatase 1 regulatory subunit 3B isoform X1 [KO:K07189]
110529985  LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
110537139  protein phosphatase 1 regulatory subunit 3B isoform X2 [KO:K07189]
110491403  protein phosphatase 1 regulatory subunit 3C-B isoform X1 [KO:K07189]
110499001  protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
110492867  ppp1r3ab; uncharacterized protein ppp1r3ab isoform X1 [KO:K07189]
110532308  ppp1r3da; protein phosphatase 1, regulatory subunit 3Da [KO:K07189]
110506617  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
110532475  uncharacterized protein LOC110532475 isoform X1 [KO:K07189]
110500239  uncharacterized protein LOC110500239 [KO:K07189]
110526959  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
118938812  uncharacterized protein LOC118938812 isoform X1 [KO:K07189]
110491588  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
110507716  phkg1a; phosphorylase kinase, gamma 1a (muscle) [KO:K00871] [EC:2.7.11.19]
110496992  phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
110514320  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
110506355  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
110526270  phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
110532906  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
118944415  calmodulin-like protein 4 [KO:K02183]
110502333  calmodulin-1 [KO:K02183]
110522561  calmodulin-1 isoform X1 [KO:K02183]
110509958  calmodulin-1 isoform X1 [KO:K02183]
110503503  calmodulin-1 [KO:K02183]
110529767  calmodulin-1 [KO:K02183]
110497737  calmodulin-1 [KO:K02183]
110491789  calml4b; calmodulin-like protein 4 isoform X1 [KO:K02183]
110505729  calm1a; calmodulin-1a [KO:K02183]
110507424  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
110526758  calmodulin-like protein 4 isoform X1 [KO:K02183]
110527080  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
110533970  calmodulin-1 isoform X1 [KO:K02183]
110527550  pygb; glycogen phosphorylase, brain form isoform X1 [KO:K00688] [EC:2.4.1.1]
110510122  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
110498264  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
110531846  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
110505964  glycogen phosphorylase, liver form isoform X1 [KO:K00688] [EC:2.4.1.1]
110500703  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
110534123  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
110506676  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
110526545  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
110508616  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110521954  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
100136597  testis catalytic subunit of cyclic adenosine 3', 5'-monophosphate dependent protein kinase [KO:K04345] [EC:2.7.11.11]
110538670  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110486718  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110493397  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
118936519  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
110494975  prkar2ab; protein kinase, cAMP-dependent, regulatory, type II, alpha, B [KO:K04739]
110528410  cAMP-dependent protein kinase type II-alpha regulatory subunit [KO:K04739]
110503022  cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
110490268  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
110485311  cAMP-dependent protein kinase type I-alpha regulatory subunit-like [KO:K04739]
110492322  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X1 [KO:K04739]
110525287  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
110499215  prkar1ab; cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
110518411  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1 [KO:K04739]
110532076  prkar2aa; protein kinase, cAMP-dependent, regulatory, type II, alpha A isoform X1 [KO:K04739]
110487025  cAMP-dependent protein kinase type I-beta regulatory subunit-like [KO:K04739]
110500209  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
118938336  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit [KO:K04739]
110500475  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
110510088  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
110537667  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
100505413  lipe1; hormone-sensitive lipase subtype 1 [KO:K07188] [EC:3.1.1.79]
100505414  lipea; lipase, hormone-sensitive a [KO:K07188] [EC:3.1.1.79]
110491852  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
110531259  protein kinase C zeta type-like isoform X1 [KO:K18952] [EC:2.7.11.13]
110508318  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
110531020  protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
110531822  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
110500678  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
110488361  flotillin-1 [KO:K07192]
110496217  flotillin-1 [KO:K07192]
110503894  flotillin-2 [KO:K07192]
110512480  flotillin-1 isoform X1 [KO:K07192]
110537504  flotillin-2a isoform X1 [KO:K07192]
100653448  flotillin-2a isoform X1 [KO:K07192]
110485712  flotillin-1 [KO:K07192]
110507733  flot2b; flotillin-2b [KO:K07192]
110537537  SH2B adapter protein 2 isoform X1 [KO:K07193]
110517470  SH2B adapter protein 2-like isoform X1 [KO:K07193]
110508074  SH2B adapter protein 2 isoform X1 [KO:K07193]
110502275  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
110526377  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
110503541  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
110537552  E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
110507383  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
110533571  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
110490114  cblb; E3 ubiquitin-protein ligase CBL-B isoform X2 [KO:K22517] [EC:2.3.2.27]
110509747  crk-like protein [KO:K04438]
110503643  adapter molecule crk [KO:K04438]
110523531  crk-like protein isoform X1 [KO:K04438]
110537676  adapter molecule crk [KO:K04438]
110507520  adapter molecule crk [KO:K04438]
110533469  adapter molecule crk [KO:K04438]
110509502  rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
110535740  rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
110523299  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
110525335  rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
110502329  rho-related GTP-binding protein RhoQ [KO:K07194]
110527002  rho-related GTP-binding protein RhoQ [KO:K07194]
110502799  exoc7; exocyst complex component 7 isoform X5 [KO:K07195]
110538416  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
110486377  trip10a; cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
110518978  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
118936551  cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
110538040  srebf1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
110486859  sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
110537238  acaca; acetyl-CoA carboxylase 1 isoform X4 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
110533878  acetyl-CoA carboxylase isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
110535755  acetyl-CoA carboxylase isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
110525352  acetyl-CoA carboxylase isoform X3 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
110502946  fatty acid synthase [KO:K00665] [EC:2.3.1.85]
110499230  fatty acid synthase [KO:K00665] [EC:2.3.1.85]
110502729  hk1; hexokinase-1 [KO:K00844] [EC:2.7.1.1]
110502730  hkdc1; hexokinase HKDC1 isoform X1 [KO:K00844] [EC:2.7.1.1]
110536248  hexokinase-2 [KO:K00844] [EC:2.7.1.1]
100136279  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
110537523  hexokinase-2 [KO:K00844] [EC:2.7.1.1]
110485868  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
110499407  hexokinase-1 isoform X1 [KO:K00844] [EC:2.7.1.1]
110525863  hk2; hexokinase-2 [KO:K00844] [EC:2.7.1.1]
100135866  gk; glucokinase [KO:K12407] [EC:2.7.1.2]
110536311  hexokinase-4 isoform X1 [KO:K12407] [EC:2.7.1.2]
110523382  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100653467  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
100653468  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110524515  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110523663  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a isoform X1 [KO:K07199]
100305241  aakb1; 5-AMP-activated protein kinase subunit beta-1 [KO:K07199]
100653486  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
110530723  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
110501965  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
110528118  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
110535288  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
110495960  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
110489719  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
100136666  5'-AMP-activated protein kinase gamma-1 subunit [KO:K07200]
110530403  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
100653470  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
110508110  foxo1a; forkhead box protein O1-A [KO:K07201]
110534227  forkhead box protein O1-A [KO:K07201]
110490984  forkhead box protein O1-A [KO:K07201]
100462762  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
110500614  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
100135885  glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
110491474  glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
110499065  glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
110486384  glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
110499253  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
110520084  glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
100136618  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
110536494  fbp1a; fructose-1,6-bisphosphatase 1a isoform X1 [KO:K03841] [EC:3.1.3.11]
110537035  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
110525137  fbp2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
100135908  phosphoenolpyruvate carboxykinase [KO:K01596] [EC:4.1.1.32]
110489769  phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
110493880  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
100136723  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
110485936  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
110493661  regulatory-associated protein of mTOR isoform X1 [KO:K07204]
110534357  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
110503989  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
110497524  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
110537477  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110533646  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110507821  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110534271  40S ribosomal protein S6 [KO:K02991]
100135859  40S ribosomal protein S6 [KO:K02991]
110536086  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
100305244  4ebp2; Eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
110508356  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
110488918  eif4ea; eukaryotic translation initiation factor 4E-1A isoform X2 [KO:K03259]
110502643  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
110510089  eif4e1b; eukaryotic translation initiation factor 4E-1B [KO:K03259]
100301791  if4ea; Eukaryotic translation initiation factor 4E-1A [KO:K03259]
110530850  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
110505666  eif4eb; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
110518555  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
110509856  hamartin isoform X1 [KO:K07206]
110522917  tsc1b; TSC complex subunit 1b [KO:K07206]
110526086  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
110495049  tsc2; tuberin isoform X1 [KO:K07207]
118951919  tuberin-like isoform X1 [KO:K07207]
118959021  tuberin-like [KO:K07207]
110510382  tuberin isoform X1 [KO:K07207]
118944870  GTP-binding protein Rheb-like [KO:K07208]
110528119  GTP-binding protein Rheb [KO:K07208]
110535269  GTP-binding protein Rheb isoform X1 [KO:K07208]
110489739  GTP-binding protein Rheb isoform X1 [KO:K07208]
110517235  GTP-binding protein Rheb [KO:K07208]
110494318  GTP-binding protein Rheb [KO:K07208]
110509964  bcl2-associated agonist of cell death [KO:K02158]
110532989  badb; BCL2 associated agonist of cell death b [KO:K02158]
110533975  uncharacterized protein LOC110533975 isoform X1 [KO:K02158]
110536161  SHC-transforming protein 1 isoform X1 [KO:K06279]
110520788  SHC-transforming protein 1 isoform X1 [KO:K06279]
110521457  SHC-transforming protein 2-like isoform X1 [KO:K17447]
110524319  shc2; SHC-transforming protein 2 isoform X2 [KO:K17447]
110536941  shc3; SHC-transforming protein 3 [KO:K17448]
110485811  grb2a; growth factor receptor-bound protein 2 [KO:K04364]
110538508  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110486545  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110493557  growth factor receptor-bound protein 2 [KO:K04364]
110498275  son of sevenless homolog 2 isoform X1 [KO:K03099]
110498405  sos2; son of sevenless homolog 2 [KO:K03099]
110486079  son of sevenless homolog 1 isoform X1 [KO:K03099]
110493792  son of sevenless homolog 1 isoform X1 [KO:K03099]
110522187  GTPase HRas [KO:K02833]
110496976  GTPase HRas [KO:K02833]
100136753  p-ras; G-protein [KO:K07827]
100170208  kras; GTPase KRas isoform X1 [KO:K07827]
110497629  GTPase KRas isoform X1 [KO:K07827]
110487030  GTPase HRas [KO:K07827]
110536286  serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
110525904  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
118938871  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
110500907  serine/threonine-protein kinase B-raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
110492413  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
110531995  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
110522687  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
110508416  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100136127  tmek; MAPK /ERK kinase [KO:K04369] [EC:2.7.12.2]
110524297  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110530696  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
110521892  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110535142  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110525139  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110539092  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110521512  MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
110524378  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
110530894  MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
110537830  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
110492576  elk1; ETS domain-containing protein Elk-3 isoform X1 [KO:K04375]
118948711  suppressor of cytokine signaling 1-like [KO:K04694]
100272210  socs1; suppressor of cytokine signaling 1 [KO:K04694]
100272211  suppressor of cytokine signaling 2 [KO:K04695]
110492178  suppressor of cytokine signaling 2 [KO:K04695]
110532426  suppressor of cytokine signaling 2 [KO:K04695]
110500152  socs2; suppressor of cytokine signaling 2 isoform X2 [KO:K04695]
110502743  suppressor of cytokine signaling 3 [KO:K04696]
100272212  socs3; suppressor of cytokine signaling 3 [KO:K04696]
110499415  LOW QUALITY PROTEIN: suppressor of cytokine signaling 3 [KO:K04696]
118937780  suppressor of cytokine signaling 3-like [KO:K04696]
110504313  suppressor of cytokine signaling 4-like [KO:K04697]
110498687  suppressor of cytokine signaling 4-like [KO:K04697]
110492134  tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
110532529  tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
110521733  receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
110524627  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
110492646  receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
110488604  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110502239  mitogen-activated protein kinase 8 isoform X2 [KO:K04440] [EC:2.7.11.24]
110510208  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110536777  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110523975  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110491440  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
110499038  mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
110525944  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110536185  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110503189  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
110504957  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B [KO:K15909] [EC:3.1.3.86]
110507218  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
110487728  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B [KO:K15909] [EC:3.1.3.86]
110502317  inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
110526894  inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
omy00010  Glycolysis / Gluconeogenesis
omy00061  Fatty acid biosynthesis
omy00500  Starch and sucrose metabolism
omy04010  MAPK signaling pathway
omy04070  Phosphatidylinositol signaling system
omy04210  Apoptosis
KO pathway
ko04910   
LinkDB

DBGET integrated database retrieval system