KEGG   PATHWAY: pcla03040
Entry
pcla03040                   Pathway                                
Name
Spliceosome - Procambarus clarkii (red swamp crayfish)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
pcla03040  Spliceosome
pcla03040

Other DBs
GO: 0005681
Organism
Procambarus clarkii (red swamp crayfish) [GN:pcla]
Gene
123762474  U1 spliceosomal RNA [KO:K14276]
123772052  U1 spliceosomal RNA [KO:K14276]
123757371  U2 spliceosomal RNA [KO:K14277]
123753177  U2 spliceosomal RNA [KO:K14277]
123748727  U4 spliceosomal RNA [KO:K14278]
123748662  U4 spliceosomal RNA [KO:K14278]
123748725  U4 spliceosomal RNA [KO:K14278]
123763443  U4 spliceosomal RNA [KO:K14278]
123750852  U5 spliceosomal RNA [KO:K14279]
123761888  U6 spliceosomal RNA [KO:K14280]
123745896  U6 spliceosomal RNA [KO:K14280]
123775298  probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
123759021  spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
123758365  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16-like [KO:K12813] [EC:5.6.2.6]
123747328  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16-like [KO:K12815] [EC:5.6.2.6]
123757813  pre-mRNA-processing factor 17-like [KO:K12816]
123774742  pre-mRNA-splicing factor 18-like [KO:K12817]
123762732  ATP-dependent RNA helicase DEAH12, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
123762733  ATP-dependent RNA helicase DEAH11, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
123766459  ATP-dependent RNA helicase DHX8-like [KO:K12818] [EC:5.6.2.6]
123773659  pre-mRNA-splicing factor SLU7-like [KO:K12819]
123773763  pre-mRNA-splicing factor SLU7-like [KO:K12819]
123745321  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 isoform X1 [KO:K12820] [EC:5.6.2.6]
123764225  small nuclear ribonucleoprotein-associated protein B-like [KO:K11086]
123746704  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
123757195  probable small nuclear ribonucleoprotein Sm D2 isoform X1 [KO:K11096]
123766414  probable small nuclear ribonucleoprotein E [KO:K11097]
123756453  small nuclear ribonucleoprotein F-like [KO:K11098]
123761704  small nuclear ribonucleoprotein G-like [KO:K11099]
123747326  U1 small nuclear ribonucleoprotein 70 kDa-like isoform X1 [KO:K11093]
123765370  U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
123766992  cell surface glycoprotein 1-like [KO:K11093]
123753998  U1 small nuclear ribonucleoprotein A-like [KO:K11091]
123758349  U1 small nuclear ribonucleoprotein C-like isoform X1 [KO:K11095]
123750239  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
123752898  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
123760891  pre-mRNA-processing factor 40 homolog B-like isoform X1 [KO:K12821]
123769484  RNA-binding protein 25-like isoform X1 [KO:K12822]
123766409  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
123766410  probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
123766411  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
123764339  transcription elongation regulator 1-like isoform X1 [KO:K12824]
123747376  RNA-binding protein cabeza-like isoform X1 [KO:K13098]
123770282  U2 small nuclear ribonucleoprotein A'-like [KO:K11092]
123764343  splicing factor 3A subunit 1-like [KO:K12825]
123757632  splicing factor 3A subunit 2-like [KO:K12826]
123758693  splicing factor 3A subunit 3-like [KO:K12827]
123775127  splicing factor 3B subunit 1-like isoform X1 [KO:K12828]
123767651  splicing factor 3B subunit 2-like [KO:K12829]
123764551  splicing factor 3B subunit 3-like [KO:K12830]
123763157  splicing factor 3B subunit 4-like [KO:K12831]
123745029  splicing factor 3B subunit 5-like [KO:K12832]
123762139  splicing factor 3B subunit 6-like [KO:K12833]
123758690  PHD finger-like domain-containing protein 5A [KO:K12834]
123756752  ATP-dependent RNA helicase DDX42-like isoform X1 [KO:K12835] [EC:5.6.2.7]
123770287  splicing factor U2AF 26 kDa subunit-like [KO:K12836]
123747254  splicing factor U2af 38 kDa subunit-like [KO:K12836]
123747380  splicing factor U2af 38 kDa subunit-like [KO:K12836]
123769053  splicing factor U2AF 50 kDa subunit-like [KO:K12837]
123754220  splicing factor U2AF 50 kDa subunit-like [KO:K12837]
123754478  splicing factor U2AF 50 kDa subunit-like isoform X1 [KO:K12837]
123774314  poly(U)-binding-splicing factor PUF60-like isoform X1 [KO:K12838]
123744852  survival of motor neuron-related-splicing factor 30-like isoform X1 [KO:K12839]
123772908  splicing factor 45-like isoform X1 [KO:K12840]
123745063  calcium homeostasis endoplasmic reticulum protein-like isoform X1 [KO:K12841]
123763931  U2 snRNP-associated SURP motif-containing protein-like [KO:K12842]
123775339  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
123773143  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
123762061  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
123762090  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
123749675  U6 snRNA-associated Sm-like protein LSm6 isoform X1 [KO:K12625]
123765833  U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
123759044  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
123769833  U4/U6 small nuclear ribonucleoprotein Prp3-like [KO:K12843]
123761305  U4/U6 small nuclear ribonucleoprotein Prp4-like [KO:K12662]
123773488  peptidyl-prolyl cis-trans isomerase H-like isoform X1 [KO:K09567] [EC:5.2.1.8]
123756733  LOW QUALITY PROTEIN: U4/U6 small nuclear ribonucleoprotein Prp31-like [KO:K12844]
123764312  H/ACA ribonucleoprotein complex subunit 2-like [KO:K12845]
123764313  NHP2-like protein 1 [KO:K12845]
123760141  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
123758778  U4/U6.U5 tri-snRNP-associated protein 1-like [KO:K11984]
123768927  zinc finger matrin-type protein 2-like [KO:K12848]
123761354  pre-mRNA-splicing factor 38-like [KO:K12849]
123772932  pre-mRNA-splicing factor 38A-like [KO:K12849]
123747917  pre-mRNA-splicing factor 38A-like [KO:K12849]
123747919  pre-mRNA-splicing factor 38A-like [KO:K12849]
123747921  pre-mRNA-splicing factor 38A-like [KO:K12849]
123747922  pre-mRNA-splicing factor 38A-like [KO:K12849]
123747923  pre-mRNA-splicing factor 38A-like [KO:K12849]
123747924  pre-mRNA-splicing factor 38A-like [KO:K12849]
123747925  pre-mRNA-splicing factor 38A-like [KO:K12849]
123748485  pre-mRNA-splicing factor 38-like [KO:K12849]
123748541  pre-mRNA-splicing factor 38A-like [KO:K12849]
123748542  pre-mRNA-splicing factor 38A-like [KO:K12849]
123748631  pre-mRNA-splicing factor 38A-like [KO:K12849]
123748632  pre-mRNA-splicing factor 38A-like [KO:K12849]
123748728  pre-mRNA-splicing factor 38-like [KO:K12849]
123748729  pre-mRNA-splicing factor 38-like [KO:K12849]
123749377  pre-mRNA-splicing factor 38-like [KO:K12849]
123750585  pre-mRNA-splicing factor 38A-like [KO:K12849]
123750586  pre-mRNA-splicing factor 38A-like [KO:K12849]
123751017  pre-mRNA-splicing factor 38A-like [KO:K12849]
123751018  pre-mRNA-splicing factor 38-like [KO:K12849]
123751019  pre-mRNA-splicing factor 38A-like [KO:K12849]
123751183  pre-mRNA-splicing factor 38A-like [KO:K12849]
123751184  pre-mRNA-splicing factor 38A-like [KO:K12849]
123751185  pre-mRNA-splicing factor 38A-like [KO:K12849]
123751801  pre-mRNA-splicing factor 38-like [KO:K12849]
123752134  pre-mRNA-splicing factor 38A-like [KO:K12849]
123753001  pre-mRNA-splicing factor 38-like [KO:K12849]
123753002  pre-mRNA-splicing factor 38-like [KO:K12849]
123753003  pre-mRNA-splicing factor 38-like [KO:K12849]
123753005  pre-mRNA-splicing factor 38-like [KO:K12849]
123753006  pre-mRNA-splicing factor 38A-like [KO:K12849]
123753007  pre-mRNA-splicing factor 38-like [KO:K12849]
123753008  pre-mRNA-splicing factor 38A-like [KO:K12849]
123753009  pre-mRNA-splicing factor 38A-like [KO:K12849]
123753010  pre-mRNA-splicing factor 38A-like [KO:K12849]
123753011  pre-mRNA-splicing factor 38A-like [KO:K12849]
123753014  pre-mRNA-splicing factor 38A-like [KO:K12849]
123753016  pre-mRNA-splicing factor 38A-like [KO:K12849]
123766271  pre-mRNA-splicing factor 38A-like [KO:K12849]
123766325  pre-mRNA-splicing factor 38-like [KO:K12849]
123771931  pre-mRNA-splicing factor 38B-like isoform X1 [KO:K12850]
123758645  116 kDa U5 small nuclear ribonucleoprotein component-like [KO:K12852]
123762672  U5 small nuclear ribonucleoprotein 200 kDa helicase-like [KO:K12854] [EC:5.6.2.6]
123771484  pre-mRNA-processing factor 6-like [KO:K12855]
123760319  pre-mRNA-processing-splicing factor 8 [KO:K12856]
123759693  U5 small nuclear ribonucleoprotein 40 kDa protein-like [KO:K12857]
123771714  probable ATP-dependent RNA helicase DDX23 isoform X1 [KO:K12858] [EC:5.6.2.7]
123762445  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
123772147  thioredoxin-like protein 4A isoform X1 [KO:K12859]
123747294  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
123758427  cell division cycle 5-like protein [KO:K12860]
123755785  pre-mRNA-splicing factor SPF27-like isoform X1 [KO:K12861]
123747024  pleiotropic regulator 1-like [KO:K12862]
123745623  protein CWC15 homolog [KO:K12863]
123745624  spliceosome-associated protein CWC15 homolog [KO:K12863]
123756788  beta-catenin-like protein 1 [KO:K12864]
123759425  heat shock 70 kDa protein 1-like [KO:K03283]
123759427  heat shock 70 kDa protein 1-like [KO:K03283]
123760349  heat shock 70 kDa protein cognate 4-like [KO:K03283]
123762431  heat shock cognate 71 kDa protein-like [KO:K03283]
123763586  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
123774880  heat shock 70 kDa protein-like [KO:K03283]
123774884  heat shock 70 kDa protein-like [KO:K03283]
123774888  heat shock 70 kDa protein-like [KO:K03283]
123775010  heat shock cognate 70 kDa protein [KO:K03283]
123775012  heat shock cognate 71 kDa protein-like [KO:K03283]
123775013  heat shock cognate 70 kDa protein-like [KO:K03283]
123747427  polyglutamine-binding protein 1-like isoform X1 [KO:K12865]
123768227  WW domain-binding protein 11-like [KO:K12866]
123746612  puff-specific protein Bx42-like [KO:K06063]
123774810  pre-mRNA-splicing factor syf1 homolog [KO:K12867]
123774556  pre-mRNA-splicing factor syf2-like isoform X1 [KO:K12868]
123773450  crooked neck-like protein 1 [KO:K12869]
123751703  protein crooked neck-like [KO:K12869]
123763294  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
123771135  peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
123763181  peptidyl-prolyl cis-trans isomerase E-like isoform X1 [KO:K09564] [EC:5.2.1.8]
123763218  coiled-coil domain-containing protein 12-like [KO:K12871]
123763589  pre-mRNA-splicing factor RBM22-like isoform X1 [KO:K12872]
123760661  protein BUD31 homolog [KO:K12873]
123772218  RNA helicase aquarius-like [KO:K12874]
123772875  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
123768296  RNA-binding protein 8A-like isoform X1 [KO:K12876]
123772878  protein mago nashi homolog [KO:K12877]
123767328  THO complex subunit 1-like isoform X1 [KO:K12878]
123755915  THO complex subunit 2-like isoform X1 [KO:K12879]
123758667  THO complex subunit 3-like [KO:K12880]
123757642  THO complex subunit 4D-like [KO:K12881]
123752487  THO complex subunit 4-like [KO:K12881]
123755619  aly/REF export factor 2-like [KO:K12881]
123766807  THO complex subunit 4-like isoform X1 [KO:K12881]
123744858  nuclear cap-binding protein subunit 1-like [KO:K12882]
123758346  nuclear cap-binding protein subunit 2-like isoform X1 [KO:K12883]
123758381  heterogeneous nuclear ribonucleoprotein 87F-like isoform X1 [KO:K12741]
123762998  heterogeneous nuclear ribonucleoprotein K-like isoform X1 [KO:K12886]
123770663  serine/arginine-rich splicing factor 1B-like isoform X1 [KO:K12890]
123746008  uncharacterized protein LOC123746008 [KO:K12891]
123764627  serine/arginine-rich splicing factor 2-like isoform X1 [KO:K12891]
123761006  serine-arginine protein 55-like isoform X1 [KO:K12893]
123748291  serine/arginine-rich splicing factor 4-like [KO:K12893]
123751617  serine/arginine-rich splicing factor 4-like [KO:K12893]
123755409  serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893]
123766696  serine/arginine-rich splicing factor 5-like [KO:K12893]
123763152  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
123774628  RNA-binding protein 1-like isoform X1 [KO:K12896]
123766937  arginine/serine-rich coiled-coil protein 2-like isoform X1 [KO:K12896]
123773585  serine/arginine-rich splicing factor 3-like [KO:K12896]
123768947  transformer-2 protein homolog alpha-like isoform X1 [KO:K12897]
123775147  transformer-2 protein homolog alpha-like isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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