KEGG   PATHWAY: plop04144
Entry
plop04144                   Pathway                                
Name
Endocytosis - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
plop04144  Endocytosis
plop04144

Other DBs
GO: 0006897
Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125363162  Arf6; ADP-ribosylation factor 6 [KO:K07941]
125340951  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
125348631  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
125359078  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
125349483  Pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
125351980  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
125365880  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
125360255  Dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
125349549  Dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
125348724  Dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
125341484  Clta; clathrin light chain A [KO:K04644]
125342183  Cltb; clathrin light chain B [KO:K04645]
125366135  Cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
125362746  Ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
125338588  Ap2a1; AP-2 complex subunit alpha-1 [KO:K11824]
125366451  Ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
125352055  Ap2m1; AP-2 complex subunit mu [KO:K11826]
125359760  AP-2 complex subunit mu-like [KO:K11826]
125338766  Ap2s1; AP-2 complex subunit sigma [KO:K11827]
125368256  Ehd2; EH domain-containing protein 2 [KO:K12469]
125345915  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
125353128  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
125340212  Zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
125355159  Zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
125338693  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
125364233  Smad2; mothers against decapentaplegic homolog 2 [KO:K04500]
125341157  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
125351806  Tfrc; transferrin receptor protein 1 isoform X1 [KO:K06503]
125346757  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125364960  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125345313  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125345984  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125364429  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
125341968  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
125368530  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125349649  Cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
125351651  Cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
125338956  Cblc; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
125343537  Sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
125368058  Sh3gl3; endophilin-A3 [KO:K11247]
125348607  Sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
125358422  Sh3gl2; endophilin-A1 isoform X1 [KO:K11247]
125355365  Sh3glb1; endophilin-B1 isoform X1 [KO:K11248]
125350125  Sh3glb2; endophilin-B2 isoform X1 [KO:K21269]
125346692  Amph; amphiphysin [KO:K12562]
125350816  Bin1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
125339042  Epn1; epsin-1 isoform X1 [KO:K12471]
125365840  Epn3; epsin-3 [KO:K12471]
125366138  Epn2; epsin-2 isoform X1 [KO:K12471]
125355147  Eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
125348971  Eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
125348348  Spart; spartin [KO:K19366]
125340517  Nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
125364280  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
125361439  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
125361532  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125362916  Rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
125353391  Itch; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
125367010  Smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
125365259  Smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
125360678  Wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
125343816  LOW QUALITY PROTEIN: NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
125348726  Ldlr; low-density lipoprotein receptor [KO:K12473]
125354741  Ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
125367808  Dab2; disabled homolog 2 isoform X1 [KO:K12475]
125342292  C-C chemokine receptor type 5-like [KO:K04180]
125350836  Cxcr1; C-X-C chemokine receptor type 1 [KO:K04175]
125349904  Cxcr2; C-X-C chemokine receptor type 2 [KO:K05050]
125350729  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
125349736  Grk1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
125361351  Grk2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
125349001  Grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
125341987  Grk6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
125364441  Grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
125345996  Grk5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
125362293  Arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
125365304  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
125347084  Wasl; neural Wiskott-Aldrich syndrome protein [KO:K23612]
125356265  Actr2; actin-related protein 2 [KO:K17260]
125347342  Actr3b; actin-related protein 3B isoform X1 [KO:K18584]
125350761  Actr3; actin-related protein 3 [KO:K18584]
125367028  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
125367331  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
125352250  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
125350315  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
125349137  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
125358803  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
125348907  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
125359279  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
125346768  Wipf3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
125350540  Wipf1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
125365491  Wipf2; WAS/WASL-interacting protein family member 2 [KO:K19475]
125349671  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
125352770  heat shock 70 kDa protein 1B-like [KO:K03283]
125352771  heat shock 70 kDa protein 1B-like [KO:K03283]
125352772  heat shock 70 kDa protein 1-like [KO:K03283]
125355264  Dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
125359158  Washc4; WASH complex subunit 4 isoform X1 [KO:K18465]
125360435  Washc5; WASH complex subunit 5 isoform X1 [KO:K18464]
125346586  Washc2a; LOW QUALITY PROTEIN: WASH complex subunit 2A [KO:K18462]
125359471  Washc3; WASH complex subunit 3 isoform X1 [KO:K18463]
125347057  Capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
125355393  Capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
125342912  Capza3; F-actin-capping protein subunit alpha-3 [KO:K10364]
125343232  F-actin-capping protein subunit alpha-1-like [KO:K10364]
125354656  Capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
125349135  Vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
125346403  Vps26a; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
125349469  Vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
125358507  Vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
125357076  Snx3; sorting nexin-3 [KO:K17918]
125364674  sorting nexin-12-like [KO:K17918]
125343650  Snx12; sorting nexin-12 [KO:K17918]
125341123  Usp8; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
125356349  STAM-binding protein [KO:K11866] [EC:3.4.19.12]
125358878  Rab7a; ras-related protein Rab-7a [KO:K07897]
125366215  Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
125366815  Stam; signal transducing adapter molecule 1 [KO:K04705]
125350664  Stam2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
125362674  Tsg101; tumor susceptibility gene 101 protein [KO:K12183]
125348898  Mvb12a; multivesicular body subunit 12A isoform X1 [KO:K12186]
125349149  Mvb12b; multivesicular body subunit 12B [KO:K12186]
125360850  Vps28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
125339603  Vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
125361619  Vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
125368271  Vps37d; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
125349181  Vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
125365363  Snf8; vacuolar-sorting protein SNF8 [KO:K12188]
125348323  Vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
125366399  Vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
125365490  Chmp6; charged multivesicular body protein 6 [KO:K12195]
125353386  Chmp4b; charged multivesicular body protein 4b [KO:K12194]
125363507  Chmp4a; charged multivesicular body protein 4a [KO:K12194]
125360566  Chmp4c; charged multivesicular body protein 4c [KO:K24782]
125356204  Chmp3; charged multivesicular body protein 3 [KO:K12193]
125368032  Chmp2a; charged multivesicular body protein 2a [KO:K12191]
125351585  Chmp2b; charged multivesicular body protein 2b [KO:K12192]
125339654  Chmp7; LOW QUALITY PROTEIN: charged multivesicular body protein 7 [KO:K15053]
125360813  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
125363768  Vps4b; vacuolar protein sorting-associated protein 4B [KO:K12196]
125358246  Vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
125357349  Vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
125343049  charged multivesicular body protein 1b-2-like [KO:K12197]
125364004  Chmp1b; charged multivesicular body protein 1b [KO:K12197]
125358066  Chmp1a; charged multivesicular body protein 1a isoform X1 [KO:K12197]
125363626  Chmp5; charged multivesicular body protein 5 [KO:K12198]
125358220  Ist1; IST1 homolog isoform X1 [KO:K19476]
125353158  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
125340760  Spg21; maspardin [KO:K19367]
125357465  Igf2r; LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor [KO:K06564]
125340929  Snx1; sorting nexin-1 [KO:K17917]
125352076  Snx2; sorting nexin-2 isoform X1 [KO:K17917]
125353225  Snx5; sorting nexin-5 [KO:K17920]
125362977  Snx6; sorting nexin-6 isoform X1 [KO:K17920]
125353459  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
125362333  Hras; GTPase HRas isoform X1 [KO:K02833]
125367340  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
125353753  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
125343243  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
125367464  transforming protein RhoA-like [KO:K04513]
125347858  transforming protein RhoA-like [KO:K04513]
125342586  Rhoa; transforming protein RhoA [KO:K04513]
125352790  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
125352791  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
125352794  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
125352795  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
125352797  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
125361192  folate receptor alpha-like [KO:K13649]
125361194  folate receptor beta-like isoform X1 [KO:K13649]
125347053  Cav1; caveolin-1 isoform X1 [KO:K06278]
125347054  Cav2; caveolin-2 [KO:K12958]
125358120  Cav3; caveolin-3 [KO:K12959]
125356587  Ehd3; EH domain-containing protein 3 [KO:K12476]
125340634  Ehd4; EH domain-containing protein 4 [KO:K12477]
125360324  Eea1; early endosome antigen 1 isoform X1 [KO:K12478]
125358649  Rab5a; ras-related protein Rab-5A [KO:K07887]
125363327  Rab5b; ras-related protein Rab-5B [KO:K07888]
125365387  Rab5c; ras-related protein Rab-5C [KO:K07889]
125365938  Rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
125358832  Rbsn; rabenosyn-5 isoform X1 [KO:K12481]
125366851  Rab4a; ras-related protein Rab-4A isoform X1 [KO:K07879]
125346387  Rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
125341930  Rufy1; RUN and FYVE domain-containing protein 1 isoform X1 [KO:K12482]
125362357  Ehd1; EH domain-containing protein 1 [KO:K12483]
125359004  Vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
125351797  Snx4; sorting nexin-4 [KO:K17919]
125353917  Rab22a; ras-related protein Rab-22A [KO:K07891]
125355660  ras-related protein Rab-31-like [KO:K07891]
125363822  Rab31; ras-related protein Rab-31 [KO:K07891]
125356664  Rab10; ras-related protein Rab-10 [KO:K07903]
125348964  Rab8a; ras-related protein Rab-8A [KO:K07901]
125349063  Rab35; ras-related protein Rab-35 isoform X1 [KO:K07876]
125340572  Rab11a; ras-related protein Rab-11A [KO:K07904]
125348674  Rab11b; ras-related protein Rab-11B [KO:K07905]
125339486  Rab11fip1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
125356333  Rab11fip5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
125346007  Rab11fip2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
125346189  Zfyve27; protrudin isoform X1 [KO:K19368]
125362201  Kif5a; kinesin heavy chain [KO:K10396]
125350691  Kif5c; kinesin heavy chain [KO:K10396]
125366707  Kif5b; kinesin-1 heavy chain [KO:K10396]
125341033  Rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
125365152  Rab11fip4; LOW QUALITY PROTEIN: rab11 family-interacting protein 4 [KO:K12485]
125367288  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
125353886  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
125363895  Pard6g; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
125358289  Pard6a; partitioning defective 6 homolog alpha [KO:K06093]
125354478  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
125351989  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
125354689  Cdc42; cell division control protein 42 homolog [KO:K04393]
125345861  cell division control protein 42 homolog [KO:K04393]
125354981  Smap2; stromal membrane-associated protein 2 [KO:K12486]
125357164  Smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
125365277  Git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
125349037  Git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
125360461  Asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
125354708  Asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
125356749  Asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
125354455  Acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
125351847  Acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
125366459  Acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12489]
125361259  Arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
125364432  Arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
125339770  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
125347319  Agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
125350157  Agap1; LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 [KO:K12491]
125362090  Agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
125353965  Arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
125362350  Arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
125357394  Arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
125339626  Psd3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
125339983  Psd2; PH and SEC7 domain-containing protein 2 [KO:K12494]
125356091  Psd4; PH and SEC7 domain-containing protein 4 [KO:K12494]
125346118  Psd; PH and SEC7 domain-containing protein 1 [KO:K12494]
125342889  Iqsec3; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
125344088  Iqsec2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
125358854  Iqsec1; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 1 [KO:K12495]
125353721  Cyth4; cytohesin-4 [KO:K18441]
125365406  Cyth1; LOW QUALITY PROTEIN: cytohesin-1 [KO:K18441]
125338481  Cyth2; cytohesin-2 [KO:K18441]
125366743  Cyth3; cytohesin-3 [KO:K18441]
125360670  Arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
125353870  Arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
125346123  Gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
125359998  Arf1; ADP-ribosylation factor 1 [KO:K07937]
125366524  ADP-ribosylation factor 2 [KO:K07937]
125365284  Arf3; ADP-ribosylation factor 3 [KO:K07938]
125341909  ADP-ribosylation factor 4-like [KO:K07939]
125358677  Arf4; ADP-ribosylation factor 4 [KO:K07939]
125347100  Arf5; ADP-ribosylation factor 5 [KO:K07940]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
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pathway
plop04060  Cytokine-cytokine receptor interaction
plop04070  Phosphatidylinositol signaling system
plop04130  SNARE interactions in vesicular transport
plop04142  Lysosome
plop04350  TGF-beta signaling pathway
KO pathway
ko04144   
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