KEGG   PATHWAY: pvp00230
Entry
pvp00230                    Pathway                                
Name
Purine metabolism - Pteropus vampyrus (large flying fox)
Class
Metabolism; Nucleotide metabolism
Pathway map
pvp00230  Purine metabolism
pvp00230

Module
pvp_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pvp00230]
pvp_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:pvp00230]
pvp_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pvp00230]
pvp_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pvp00230]
pvp_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pvp00230]
pvp_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pvp00230]
pvp_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pvp00230]
Other DBs
GO: 0006163 0042278
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105289576  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
105291270  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
105291704  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
105298357  PGM1; LOW QUALITY PROTEIN: phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
105295806  PGM2; LOW QUALITY PROTEIN: phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
105294041  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
105293883  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
105296111  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
105293762  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
105295844  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
105291250  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
111741353  uncharacterized protein LOC111741353 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
105293760  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
105298063  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
105291087  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
105299914  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
105289824  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
105291337  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
105294543  cytosolic purine 5'-nucleotidase isoform X2 [KO:K01081] [EC:3.1.3.5]
105309667  cytosolic purine 5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
105309742  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
105295305  NT5E; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
105308946  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
105298470  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
105308114  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
105290179  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
105302373  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
105299833  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
105302355  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
105295427  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
105303254  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
105303313  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
105295241  AK9; LOW QUALITY PROTEIN: adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
105290332  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
105298553  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
105301362  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
105304713  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
105304071  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X9 [KO:K01511] [EC:3.6.1.6]
105299241  ectonucleoside triphosphate diphosphohydrolase 5 isoform X5 [KO:K01511] [EC:3.6.1.6]
105303482  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
105298428  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
105299158  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
105306425  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1 [KO:K01518] [EC:3.6.1.17]
105304924  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
105293941  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
105309390  GMPR2; GMP reductase 2 isoform X2 [KO:K00364] [EC:1.7.1.7]
105299485  GDA; guanine deaminase isoform X2 [KO:K01487] [EC:3.5.4.3]
105299953  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
105303696  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
105300863  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
105295442  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
105291185  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
105290749  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
105292330  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
105302878  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
105303825  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
105308299  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
105299581  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105289813  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105309400  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105288850  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105297518  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105292087  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105301250  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105303095  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105288555  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
105301508  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
105292195  GUCY1A1; guanylate cyclase soluble subunit alpha-3 isoform X1 [KO:K12318] [EC:4.6.1.2]
105297478  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
105292196  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
105298913  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
105302778  GUCY2C; heat-stable enterotoxin receptor isoform X1 [KO:K12320] [EC:4.6.1.2]
105297649  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
105291238  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
105301583  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
105291506  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
105306167  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105306470  NPR2; atrial natriuretic peptide receptor 2 isoform X4 [KO:K12324] [EC:4.6.1.2]
105289761  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
105293685  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
105302622  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
105303688  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
105306548  cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
105301483  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
105299165  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
105299479  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
105309867  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
105293068  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
105308012  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
105301151  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
105300637  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
105309573  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
105302218  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
105289998  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
105303886  ADSSL1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
105298713  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
105296563  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
105298084  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
105303553  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
105288966  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
105298263  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
105297246  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
105289045  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
105290597  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
105298362  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
105298675  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
105298798  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
111747536  LOW QUALITY PROTEIN: adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
105294833  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
105300508  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
105303178  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
105298606  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
105305260  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
105291130  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
105291176  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
105296601  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
105305599  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
105298365  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
105299350  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
105289524  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
105295066  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
105302190  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
105302891  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
105290979  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
105288508  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
105293009  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
105293113  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X3 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
105289066  uricase [KO:K00365] [EC:1.7.3.3]
105304849  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
105292133  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
105301652  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pvp00030  Pentose phosphate pathway
pvp00220  Arginine biosynthesis
pvp00250  Alanine, aspartate and glutamate metabolism
pvp00260  Glycine, serine and threonine metabolism
pvp00340  Histidine metabolism
pvp00630  Glyoxylate and dicarboxylate metabolism
pvp00730  Thiamine metabolism
pvp00740  Riboflavin metabolism
pvp00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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