KEGG   PATHWAY: pvp04148
Entry
pvp04148                    Pathway                                
Name
Efferocytosis - Pteropus vampyrus (large flying fox)
Class
Cellular Processes; Transport and catabolism
Pathway map
pvp04148  Efferocytosis
pvp04148

Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105291475  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
105297444  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
105301894  PANX1; pannexin-1 [KO:K03443]
105303649  P2RY2; P2Y purinoceptor 2 isoform X1 [KO:K04269]
105303648  P2RY6; P2Y purinoceptor 6 [KO:K04272]
105301532  P2RY12; P2Y purinoceptor 12 [KO:K04298]
105293381  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
105301772  SPHK2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
105297525  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
105288318  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
105295342  ABCA1; ATP-binding cassette sub-family A member 1 isoform X3 [KO:K05641]
105303879  GPR132; probable G-protein coupled receptor 132 isoform X1 [KO:K08426]
105295437  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
105294280  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
105292028  CX3CL1; fractalkine isoform X1 [KO:K05508]
105310437  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
105296040  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105303020  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105305747  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105309403  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
105308691  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
105303857  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
105299734  EPO; erythropoietin [KO:K05437]
105305625  EPOR; erythropoietin receptor [KO:K05079]
105303192  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105311247  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
105299024  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
105302941  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
105305194  MFGE8; lactadherin isoform X3 [KO:K17253]
105305101  GAS6; growth arrest-specific protein 6 [KO:K05464]
105303988  MERTK; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
105295518  CD36; platelet glycoprotein 4 [KO:K06259]
105288620  THBS1; thrombospondin-1 [KO:K16857]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105295029  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105309351  PTGER2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
105299098  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
105289809  DNMT3A; DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
105298404  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105307945  TGFB1; transforming growth factor beta-1 [KO:K13375]
105289209  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105304583  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
105291989  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
105288866  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
105308762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
105299441  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
105302767  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105308283  mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
105301035  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105301036  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105308925  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
105288958  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
105291746  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
105308545  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105306817  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105294546  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105299853  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105295122  DUSP7; LOW QUALITY PROTEIN: dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105302795  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105297568  ANO6; anoctamin-6 isoform X1 [KO:K19500]
105293748  ANO3; LOW QUALITY PROTEIN: anoctamin-3 [KO:K19498]
105288274  ANO4; anoctamin-4 [KO:K19499]
105293751  ANO5; anoctamin-5 [KO:K19480]
105305951  ANO9; anoctamin-9 [KO:K19503]
105302252  BSG; basigin [KO:K06535]
105290523  XKR8; XK-related protein 8 [KO:K26813]
105296690  XKR9; XK-related protein 9 isoform X2 [KO:K26814]
105305508  XKR7; XK-related protein 7 [KO:K26811]
105291430  XKR4; XK-related protein 4 [KO:K26811]
105291566  XKR6; XK-related protein 6 isoform X2 [KO:K26811]
105293910  ATP8A1; phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
105302441  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
105303801  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
105307343  ATP11B; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
105305093  ATP11A; probable phospholipid-transporting ATPase IH [KO:K26934] [EC:7.6.2.1]
105307891  TMEM30A; cell cycle control protein 50A [KO:K26935]
105289640  PROS1; vitamin K-dependent protein S [KO:K03908]
105289673  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
105303446  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105297528  ITGB5; integrin beta-5 [KO:K06588]
105307955  AXL; tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
105288662  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
105289919  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 [KO:K26936]
105289918  HAVCR1; hepatitis A virus cellular receptor 1 [KO:K20413]
105289917  HAVCR2; hepatitis A virus cellular receptor 2 isoform X1 [KO:K20414]
105305278  AGER; advanced glycosylation end product-specific receptor isoform X9 [KO:K19722]
105304358  STAB1; stabilin-1 [KO:K19020]
105288281  STAB2; LOW QUALITY PROTEIN: stabilin-2 [KO:K19013]
105307748  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105305354  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
105289311  CRKL; crk-like protein [KO:K04438]
105291866  CRK; adapter molecule crk isoform X1 [KO:K04438]
105293695  ELMO1; engulfment and cell motility protein 1 [KO:K12366]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105300410  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 isoform X1 [KO:K06834] [EC:3.4.24.-]
105307175  CALR; calreticulin [KO:K08057]
105290437  complement C1q subcomponent subunit A-like [KO:K03986]
105290662  complement C1q subcomponent subunit A-like [KO:K03986]
105290439  C1QB; complement C1q subcomponent subunit B [KO:K03987]
105290438  C1QC; complement C1q subcomponent subunit C [KO:K03988]
105302691  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
105290888  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
105309887  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
105291860  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
105289585  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
105289298  RAB5A; ras-related protein Rab-5A [KO:K07887]
105302599  RAB5B; ras-related protein Rab-5B [KO:K07888]
105306300  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
105298752  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
105307832  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
105308858  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
105298321  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
105288647  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
105289189  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
105292667  RAB14; ras-related protein Rab-14 [KO:K07881]
105288671  VPS39; vam6/Vps39-like protein [KO:K20183]
105303203  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
105309691  RAB7A; ras-related protein Rab-7a [KO:K07897]
105300653  RAB7B; ras-related protein Rab-7b [KO:K07898]
105290647  PQLC2; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
105291132  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
105308144  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
105295444  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
105293103  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
105290031  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
105301715  NR1H2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
105308785  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
105308270  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
105301787  carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
105301194  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
105301705  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
105306027  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
105308926  IL10; interleukin-10 [KO:K05443]
105293102  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
105305748  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
105301024  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
105304017  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
105296750  SLC16A1; monocarboxylate transporter 1 isoform X1 [KO:K08179]
105289483  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105308766  CD47; leukocyte surface antigen CD47 isoform X2 [KO:K06266]
105297715  PECAM1; platelet endothelial cell adhesion molecule [KO:K06471]
105308585  SIGLEC10; sialic acid-binding Ig-like lectin 10 [KO:K06749]
105298197  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
105308534  signal-regulatory protein beta-1-like [KO:K06551]
105295941  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
105289236  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
105309828  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
pvp00010  Glycolysis / Gluconeogenesis
pvp04140  Autophagy - animal
pvp04145  Phagosome
KO pathway
ko04148   
LinkDB

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