KEGG   PATHWAY: salp04261
Entry
salp04261                   Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Salvelinus sp. IW2-2015 (Arctic char)
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
salp04261  Adrenergic signaling in cardiomyocytes
salp04261

Other DBs
GO: 0001997
Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:salp]
Gene
112071795  beta-2 adrenergic receptor-like isoform X1 [KO:K04142]
111981974  beta-2 adrenergic receptor [KO:K04142]
111965988  beta-2 adrenergic receptor-like [KO:K04142]
111966254  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
111976616  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
112070221  LOW QUALITY PROTEIN: adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
111978905  LOW QUALITY PROTEIN: adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
111954801  adcy2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
111955524  LOW QUALITY PROTEIN: adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
112069658  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
111972593  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
111952465  adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
111977149  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
111959500  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111976578  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
111976437  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
111974474  LOW QUALITY PROTEIN: adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
112076728  LOW QUALITY PROTEIN: adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
111957123  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112074752  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
111964911  LOW QUALITY PROTEIN: blood vessel epicardial substance [KO:K21108]
111959541  popeye domain-containing 2-like isoform X1 [KO:K26206]
111978695  popeye domain-containing 2-like [KO:K26206]
111964896  popeye domain-containing protein 3-like [KO:K26207]
111972626  potassium channel subfamily K member 2-like [KO:K04913]
111968425  potassium channel subfamily K member 2-like [KO:K04913]
112071492  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
111979502  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111975986  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112077218  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112079295  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
111970831  sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
111979355  sodium/potassium-transporting ATPase subunit alpha-2-like [KO:K01539] [EC:7.2.2.13]
111974345  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
111955661  LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-3-like [KO:K01539] [EC:7.2.2.13]
112081173  sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
111950741  sodium/potassium-transporting ATPase subunit beta-2-like [KO:K01540]
111967619  protein ATP1B4 [KO:K01540]
111965867  protein ATP1B4-like [KO:K01540]
111978896  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
111960651  sodium/potassium-transporting ATPase subunit beta-3-like isoform X1 [KO:K01540]
111949653  sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
111957150  sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
111981831  sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
112076102  sodium/potassium-transporting ATPase subunit beta-233-like [KO:K01540]
111955156  Na(+)/H(+) exchanger beta isoform X1 [KO:K05742]
111959135  sodium/hydrogen exchanger 1 [KO:K05742]
111959156  sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
111971815  potassium voltage-gated channel subfamily KQT member 1-like [KO:K04926]
111960961  potassium voltage-gated channel subfamily KQT member 1-like [KO:K04926]
112076554  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
111972314  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
112074612  plasma membrane calcium-transporting ATPase 2-like [KO:K05850] [EC:7.2.2.10]
111970339  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
111966505  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3-like [KO:K05850] [EC:7.2.2.10]
111976901  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3-like [KO:K05850] [EC:7.2.2.10]
111962161  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
111963489  plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
111949967  LOW QUALITY PROTEIN: sodium/calcium exchanger 2-like [KO:K05849]
111978289  LOW QUALITY PROTEIN: sodium/calcium exchanger 1-like [KO:K05849]
112080719  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
111957046  sodium/calcium exchanger 2-like [KO:K05849]
112077255  sodium/calcium exchanger 3-like [KO:K05849]
111963706  sodium/calcium exchanger 1-like [KO:K05849]
111950062  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
112073062  sodium/calcium exchanger 1-like [KO:K05849]
112075443  sodium/calcium exchanger 3-like [KO:K05849]
111953617  sodium channel protein type 2 subunit alpha-like isoform X1 [KO:K04838]
112068568  LOW QUALITY PROTEIN: sodium channel protein type 3 subunit alpha-like [KO:K04838]
111954749  sodium channel subunit beta-1 [KO:K04845]
112068606  sodium channel subunit beta-1-like [KO:K04845]
112068607  sodium channel subunit beta-1-like [KO:K04845]
112068525  sodium channel subunit beta-1-like [KO:K04845]
111956218  sodium channel subunit beta-1-like [KO:K04845]
111956238  sodium channel subunit beta-1-like [KO:K04845]
111958820  sodium channel subunit beta-1-like [KO:K04845]
111980534  sodium channel subunit beta-4 [KO:K04848]
111960550  sodium channel subunit beta-4-like [KO:K04848]
111949469  sodium channel subunit beta-4 isoform X1 [KO:K04848]
111951008  sodium channel subunit beta-4-like [KO:K04848]
111966893  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111976881  cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
111962116  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111970724  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111966955  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
111962608  LOW QUALITY PROTEIN: dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
111970366  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
111976724  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
111980767  voltage-dependent L-type calcium channel subunit beta-1-like isoform X1 [KO:K04862]
111981289  voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
111953390  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
111973182  voltage-dependent L-type calcium channel subunit beta-2-like isoform X1 [KO:K04863]
111966240  cacnb3; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
111959873  voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
111977107  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
111962521  LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
111970080  cacna2d2; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
112070377  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
111970558  voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
111962190  LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
111970722  LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3-like [KO:K04860]
111971793  voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
111962195  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
111982430  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
111971237  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
111957640  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
111980129  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
111964574  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
111982287  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
111957559  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
111982331  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
111955630  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
111964830  voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
111955383  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
111955608  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
111954896  voltage-dependent calcium channel gamma-7 subunit-like [KO:K04872]
112075967  uncharacterized protein LOC112075967 [KO:K04872]
111954891  voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
111964166  calmodulin isoform X1 [KO:K02183]
111962084  calmodulin-like protein 4 isoform X1 [KO:K02183]
112076507  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
111972950  calmodulin [KO:K02183]
111951811  calm2; calmodulin-2 [KO:K02183]
111954258  calmodulin [KO:K02183]
111960601  calmodulin [KO:K02183]
111977843  calmodulin [KO:K02183]
111963424  calmodulin [KO:K02183]
111950244  calmodulin [KO:K02183]
111968561  calmodulin [KO:K02183]
111949612  calmodulin [KO:K02183]
111951177  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
111967811  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111960283  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
111977542  calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
111955361  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111951816  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
111960905  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
111974573  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
111964725  calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
111951725  ryanodine receptor 2-like [KO:K04962]
112069371  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
111981188  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111961930  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
111963815  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
111974279  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112069675  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
111965999  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111960566  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
111982763  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
112073472  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
111964087  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
111978157  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
111951856  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
111961541  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
111950041  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
111957879  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
111974262  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
112069053  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1 [KO:K04354]
112069729  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112075388  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha-like [KO:K11583]
111959909  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
111963430  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
111954381  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
111968941  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112070452  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
111972729  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
111968652  ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
111951887  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
111954655  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112072581  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like [KO:K11584]
111951769  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
111957760  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111977895  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
112068674  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111954331  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111974671  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112075309  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111980195  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
111966212  troponin C, slow skeletal and cardiac muscles [KO:K05865]
111977235  troponin C, slow skeletal and cardiac muscles [KO:K05865]
111976226  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
111962763  troponin T, cardiac muscle isoforms-like [KO:K12045]
111950401  troponin T, cardiac muscle-like isoform X1 [KO:K12045]
111969728  troponin T, cardiac muscle isoforms isoform X1 [KO:K12045]
111951525  troponin T, cardiac muscle isoform X1 [KO:K12045]
111974277  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
111952112  tropomyosin alpha-1 chain isoform X4 [KO:K10373]
112067751  tropomyosin alpha-1 chain [KO:K10373]
112080348  tropomyosin alpha-1 chain-like isoform X1 [KO:K10373]
111961950  LOW QUALITY PROTEIN: tropomyosin beta chain-like [KO:K10374]
111955886  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
111965034  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
111954950  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
111950280  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
112068990  tropomyosin alpha-1 chain-like isoform X1 [KO:K10375]
111976112  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
111952571  tropomyosin alpha-1 chain-like isoform X1 [KO:K10375]
111954389  actin, alpha cardiac muscle 1-like [KO:K12314]
111968583  actc1; actin, alpha cardiac muscle 1 [KO:K12314]
111962756  actin, alpha cardiac muscle 1-like [KO:K12314]
112070447  actin, alpha cardiac [KO:K12314]
112070495  actin, alpha cardiac [KO:K12314]
111968769  actin, alpha cardiac-like [KO:K12314]
111952750  actin, alpha cardiac muscle 1-like [KO:K12314]
111973043  actin, alpha cardiac muscle 1-like [KO:K12314]
111963243  actin, alpha cardiac-like [KO:K12314]
112072575  myosin-7-like [KO:K17751]
111979807  myosin-6 [KO:K17751]
111972756  myosin-6-like [KO:K17751]
111953950  myosin-7-like [KO:K17751]
111953951  myosin-7-like [KO:K17751]
111964589  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
111956293  myosin light chain 1, cardiac muscle-like [KO:K12749]
111978968  myosin light chain 1, cardiac muscle [KO:K12749]
111981341  myosin light chain 4 [KO:K12750]
111954270  cardiac phospholamban-like isoform X1 [KO:K05852]
111972671  cardiac phospholamban-like [KO:K05852]
111957697  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111961687  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111963967  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
111974497  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
112080847  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
111980465  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
111981689  atp2a1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
111971456  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
111978308  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
111968013  agt; angiotensinogen [KO:K09821]
112073876  type-1 angiotensin II receptor-like [KO:K04166]
112074818  type-1 angiotensin II receptor-like [KO:K04166]
111950882  type-2 angiotensin II receptor [KO:K04167]
111957462  alpha-1A adrenergic receptor-like [KO:K04135]
111974020  LOW QUALITY PROTEIN: alpha-1A adrenergic receptor-like [KO:K04135]
111963652  alpha-1A adrenergic receptor-like [KO:K04135]
111961090  alpha-1A adrenergic receptor-like [KO:K04135]
111965371  alpha-1A adrenergic receptor [KO:K04136]
111951002  alpha-1A adrenergic receptor-like [KO:K04136]
111979943  alpha-1A adrenergic receptor-like [KO:K04136]
111967360  alpha-1A adrenergic receptor [KO:K04136]
111964345  alpha-1D adrenergic receptor-like [KO:K04137]
111958286  alpha-1D adrenergic receptor [KO:K04137]
112073225  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
111974605  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111957798  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111975941  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111961320  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
111980819  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
112069030  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
111968629  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111963020  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
111951782  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
111954271  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
111963363  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
111954482  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111954289  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111957424  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111982249  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
111970503  protein phosphatase 1 regulatory subunit 1A-like isoform X1 [KO:K08050]
111982013  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111971459  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
112071015  ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
112068043  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-5-like [KO:K04445] [EC:2.7.11.1]
111976709  creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112073124  cyclic AMP-responsive element-binding protein 1-like isoform X1 [KO:K05870]
111975332  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111959522  cyclic AMP-dependent transcription factor ATF-2-like [KO:K04450]
111980403  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111981084  cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
111957533  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111965024  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
111973752  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
111951327  LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
111957824  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
111974768  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
111971200  cyclic AMP-responsive element-binding protein 3-like protein 3-B [KO:K09048]
111950274  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
111951321  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
111969220  LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
111975858  cyclic AMP-responsive element-binding protein 3-like protein 3-B [KO:K09048]
111979556  cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
111955868  creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
111954764  cyclic AMP-dependent transcription factor ATF-7-like [KO:K09047]
111955634  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
111955063  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
111973080  cAMP-responsive element modulator isoform X1 [KO:K09052]
111957053  cAMP-responsive element modulator isoform X1 [KO:K09052]
111979360  cAMP-responsive element modulator isoform X1 [KO:K09052]
111979635  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
111972792  apoptosis regulator Bcl-2-like [KO:K02161]
111953485  apoptosis regulator Bcl-2 [KO:K02161]
111966719  rap guanine nucleotide exchange factor 3-like isoform X1 [KO:K08014]
111977003  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 3-like [KO:K08014]
111959839  rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
112072432  rap guanine nucleotide exchange factor 4-like [KO:K04351]
111975159  rap guanine nucleotide exchange factor 4-like isoform X1 [KO:K04351]
111979745  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 4-like [KO:K04351]
111966845  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111966852  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
111969695  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
111970954  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
111952389  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111962512  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111951416  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111951418  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
111966361  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
111976670  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111976697  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111949493  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111949504  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
112068603  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
111962476  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
111967055  guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
111970075  guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
111952770  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111966508  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111982469  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111969763  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111970119  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111976813  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
111966435  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
111950351  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
111951534  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
112069568  phosphoinositide 3-kinase regulatory subunit 6-like isoform X1 [KO:K21290]
111980341  LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
111965635  phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
111981919  phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
111964855  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
111982456  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
111982464  phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
111982815  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111958430  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111982431  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111968784  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111972741  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111968260  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111954329  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111963228  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111964418  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112068897  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111950092  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:20923637
  Authors
Soltis AR, Saucerman JJ
  Title
Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
  Journal
Biophys J 99:2038-47 (2010)
DOI:10.1016/j.bpj.2010.08.016
Reference
PMID:12439640
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
PMID:11604549
  Authors
Xiao RP
  Title
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
  Journal
Sci STKE 2001:re15 (2001)
DOI:10.1126/stke.2001.104.re15
Reference
PMID:10571541
  Authors
Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
  Title
Recent advances in cardiac beta(2)-adrenergic signal transduction.
  Journal
Circ Res 85:1092-100 (1999)
DOI:10.1161/01.RES.85.11.1092
Reference
PMID:15979723
  Authors
Zheng M, Zhu W, Han Q, Xiao RP
  Title
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
  Journal
Pharmacol Ther 108:257-68 (2005)
DOI:10.1016/j.pharmthera.2005.04.006
Reference
PMID:17826821
  Authors
Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
  Title
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
  Journal
Prog Biophys Mol Biol 96:171-86 (2008)
DOI:10.1016/j.pbiomolbio.2007.07.005
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:20658186
  Authors
Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
  Title
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
  Journal
Heart Fail Rev 15:495-512 (2010)
DOI:10.1007/s10741-010-9183-5
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:15765137
  Authors
Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
  Journal
J Clin Invest 115:556-64 (2005)
DOI:10.1172/JCI24159
Reference
PMID:15232578
  Authors
Wehrens XH, Marks AR
  Title
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
  Journal
Nat Rev Drug Discov 3:565-73 (2004)
DOI:10.1038/nrd1440
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:18407781
  Authors
Barry SP, Davidson SM, Townsend PA
  Title
Molecular regulation of cardiac hypertrophy.
  Journal
Int J Biochem Cell Biol 40:2023-39 (2008)
DOI:10.1016/j.biocel.2008.02.020
Related
pathway
salp04020  Calcium signaling pathway
salp04260  Cardiac muscle contraction
KO pathway
ko04261   
LinkDB

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