KEGG   PATHWAY: salp04020
Entry
salp04020                   Pathway                                
Name
Calcium signaling pathway - Salvelinus sp. IW2-2015 (Arctic char)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
salp04020  Calcium signaling pathway
salp04020

Other DBs
GO: 0019722
Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:salp]
Gene
111949967  LOW QUALITY PROTEIN: sodium/calcium exchanger 2-like [KO:K05849]
111978289  LOW QUALITY PROTEIN: sodium/calcium exchanger 1-like [KO:K05849]
112080719  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
111957046  sodium/calcium exchanger 2-like [KO:K05849]
112077255  sodium/calcium exchanger 3-like [KO:K05849]
111963706  sodium/calcium exchanger 1-like [KO:K05849]
111950062  sodium/calcium exchanger 2-like isoform X1 [KO:K05849]
112073062  sodium/calcium exchanger 1-like [KO:K05849]
112075443  sodium/calcium exchanger 3-like [KO:K05849]
112076554  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
111972314  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
112074612  plasma membrane calcium-transporting ATPase 2-like [KO:K05850] [EC:7.2.2.10]
111970339  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
111966505  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3-like [KO:K05850] [EC:7.2.2.10]
111976901  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3-like [KO:K05850] [EC:7.2.2.10]
111962161  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
111963489  plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
111950043  muscarinic acetylcholine receptor M1-like [KO:K04129]
111978588  muscarinic acetylcholine receptor M3-like [KO:K04131]
112078724  muscarinic acetylcholine receptor M3-like [KO:K04131]
111952068  muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
111968764  muscarinic acetylcholine receptor M5 [KO:K04133]
111973406  muscarinic acetylcholine receptor M5-like [KO:K04133]
111954565  muscarinic acetylcholine receptor M5-like [KO:K04133]
112080553  muscarinic acetylcholine receptor M5-like [KO:K04133]
111961690  adenosine receptor A2b-like [KO:K04266]
111963964  adenosine receptor A2b-like [KO:K04266]
111957440  adenosine receptor A2b [KO:K04266]
111960789  adenosine receptor A2b-like [KO:K04266]
111950047  adenosine receptor A2b-like [KO:K04267]
111980343  adora2b; adenosine receptor A2b [KO:K04267]
112071795  beta-2 adrenergic receptor-like isoform X1 [KO:K04142]
111981974  beta-2 adrenergic receptor [KO:K04142]
111965988  beta-2 adrenergic receptor-like [KO:K04142]
111958057  beta-1 adrenergic receptor-like isoform X1 [KO:K04143]
111980271  beta-1 adrenergic receptor [KO:K04143]
111974996  beta-1 adrenergic receptor-like isoform X1 [KO:K04143]
112073490  D(1) dopamine receptor-like [KO:K04144]
111950171  D(1)-like dopamine receptor [KO:K04144]
111980233  D(1)-like dopamine receptor [KO:K04144]
112078227  D(1) dopamine receptor-like [KO:K04144]
111967765  D(5)-like dopamine receptor [KO:K05840]
111970660  D(1B) dopamine receptor-like [KO:K05840]
111951637  D(1C) dopamine receptor-like [KO:K05840]
111978667  D(5)-like dopamine receptor [KO:K05840]
111962520  D(1B) dopamine receptor-like [KO:K05840]
111978724  D(5)-like dopamine receptor [KO:K05840]
112074681  histamine H2 receptor-like [KO:K04150]
111950891  histamine H2 receptor-like [KO:K04150]
111964757  histamine H2 receptor-like [KO:K04150]
111980025  5-hydroxytryptamine receptor 4-like [KO:K04160]
111965370  5-hydroxytryptamine receptor 4-like isoform X1 [KO:K04160]
112075813  5-hydroxytryptamine receptor 4-like [KO:K04160]
111967110  5-hydroxytryptamine receptor 4-like [KO:K04160]
111972502  5-hydroxytryptamine receptor 5A-like [KO:K04161]
111953282  5-hydroxytryptamine receptor 5A-like [KO:K04161]
111976902  5-hydroxytryptamine receptor 6-like [KO:K04162]
111966934  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
111967768  5-hydroxytryptamine receptor 7-like [KO:K04163]
111978470  5-hydroxytryptamine receptor 7-like [KO:K04163]
112069991  5-hydroxytryptamine receptor 7-like [KO:K04163]
111974355  5-hydroxytryptamine receptor 7-like [KO:K04163]
111966254  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
111976616  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
111972774  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
111953575  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
112070221  LOW QUALITY PROTEIN: adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
111978905  LOW QUALITY PROTEIN: adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
111954801  adcy2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
111955524  LOW QUALITY PROTEIN: adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
112069658  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
111972593  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
111952465  adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
111974474  LOW QUALITY PROTEIN: adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
112076728  LOW QUALITY PROTEIN: adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
111957123  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112074752  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
112071492  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
111979502  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111975986  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112077218  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112079295  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
111954270  cardiac phospholamban-like isoform X1 [KO:K05852]
111972671  cardiac phospholamban-like [KO:K05852]
111959869  sln; sarcolipin [KO:K22642]
111957697  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111961687  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111963967  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
111974497  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
112080847  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
111980465  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
111981689  atp2a1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
111971456  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
111978308  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
111982576  stromal interaction molecule 1 isoform X1 [KO:K16059]
111950701  stromal interaction molecule 1 isoform X1 [KO:K16059]
111960783  stromal interaction molecule 1 isoform X1 [KO:K16059]
111960063  stim2; stromal interaction molecule 2 isoform X1 [KO:K18196]
111980663  calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
111958192  calcium release-activated calcium channel protein 1 [KO:K16056]
111974514  calcium release-activated calcium channel protein 1 [KO:K16056]
111961480  calcium release-activated calcium channel protein 1 [KO:K16056]
111981133  protein orai-2 [KO:K16057]
111950265  orai2; protein orai-2 isoform X1 [KO:K16057]
111966893  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111976881  cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
111962116  voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111970724  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
111966955  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
111962608  LOW QUALITY PROTEIN: dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
111970366  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
111976724  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
111974985  voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
111973906  LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B-like [KO:K04849]
111961707  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
111975957  cacna1e; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
111971849  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
111979599  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
111957028  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
111972209  voltage-dependent R-type calcium channel subunit alpha-1E-like isoform X1 [KO:K04852]
111968236  cacna1g; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
111962087  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
111965726  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
111965733  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
112075067  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
112078124  CHRNA7-FAM7A fusion protein-like [KO:K04809]
111974953  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
111971808  glutamate receptor ionotropic, NMDA 1-like [KO:K05208]
111967824  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
111980118  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
112069504  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
111977535  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
112076372  serine/arginine repetitive matrix protein 2-like [KO:K05212]
111954854  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
111955475  LOW QUALITY PROTEIN: uncharacterized protein LOC111955475 [KO:K05212]
112077154  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D-like [KO:K05212]
111975916  glutamate receptor ionotropic, NMDA 3B [KO:K05214]
112068588  glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
111981022  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
112071901  P2X purinoceptor 1-like [KO:K05215]
111974915  P2X purinoceptor 2-like [KO:K05216]
111957983  P2X purinoceptor 2 isoform X1 [KO:K05216]
112080840  LOW QUALITY PROTEIN: P2X purinoceptor 3-like [KO:K05217]
111967499  P2X purinoceptor 3 isoform X1 [KO:K05217]
111965746  P2X purinoceptor 3-like isoform X1 [KO:K05217]
111958199  P2X purinoceptor 4 [KO:K05218]
112080615  P2X purinoceptor 4-like [KO:K05218]
111979975  P2X purinoceptor 5 [KO:K05219]
111958937  P2X purinoceptor 5-like isoform X1 [KO:K05219]
111950908  P2X purinoceptor 5 isoform X1 [KO:K05219]
111949945  P2X purinoceptor 5 [KO:K05219]
111958198  P2X purinoceptor 4 isoform X1 [KO:K05220]
111974561  P2X purinoceptor 4-like isoform X1 [KO:K05220]
111964257  LOW QUALITY PROTEIN: ryanodine receptor 1-like [KO:K04961]
111950321  ryanodine receptor 1-like [KO:K04961]
111951725  ryanodine receptor 2-like [KO:K04962]
111969023  LOW QUALITY PROTEIN: ryanodine receptor 3-like [KO:K04963]
112080552  ryanodine receptor 3-like [KO:K04963]
111954137  triadin-like [KO:K23449]
111972920  probable serine/threonine-protein kinase kinX [KO:K23449]
112068854  calsequestrin-1-like isoform X1 [KO:K23468]
111960032  calsequestrin-1-like isoform X1 [KO:K23468]
111956668  calsequestrin-1 [KO:K23468]
111970995  calsequestrin-2 [KO:K23445]
111979032  calsequestrin-2 [KO:K23445]
111959273  calsequestrin-2-like [KO:K23445]
111953589  aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
111972783  aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
111979344  aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
111953870  aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
112067901  triadin-like isoform X1 [KO:K00476] [EC:1.14.11.16]
111970279  cysteinyl leukotriene receptor 2 [KO:K04322]
112073953  cysteinyl leukotriene receptor 1-like [KO:K04322]
112076487  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
111964554  cysteinyl leukotriene receptor 2-like [KO:K04322]
111981924  cysteinyl leukotriene receptor 2-like [KO:K04323]
112067845  cysteinyl leukotriene receptor 2-like [KO:K04323]
112072779  cysteinyl leukotriene receptor 2-like [KO:K04323]
111951125  cysteinyl leukotriene receptor 2-like [KO:K04323]
111982232  muscarinic acetylcholine receptor M2-like [KO:K04130]
111952341  muscarinic acetylcholine receptor M2-like [KO:K04130]
111957462  alpha-1A adrenergic receptor-like [KO:K04135]
111974020  LOW QUALITY PROTEIN: alpha-1A adrenergic receptor-like [KO:K04135]
111963652  alpha-1A adrenergic receptor-like [KO:K04135]
111961090  alpha-1A adrenergic receptor-like [KO:K04135]
111965371  alpha-1A adrenergic receptor [KO:K04136]
111951002  alpha-1A adrenergic receptor-like [KO:K04136]
111979943  alpha-1A adrenergic receptor-like [KO:K04136]
111967360  alpha-1A adrenergic receptor [KO:K04136]
111964345  alpha-1D adrenergic receptor-like [KO:K04137]
111958286  alpha-1D adrenergic receptor [KO:K04137]
112073876  type-1 angiotensin II receptor-like [KO:K04166]
112074818  type-1 angiotensin II receptor-like [KO:K04166]
112068355  endothelin receptor type B-like [KO:K04198]
111957246  LOW QUALITY PROTEIN: endothelin receptor type B-like [KO:K04198]
112072588  endothelin receptor type B-like [KO:K04198]
111979541  endothelin receptor type B [KO:K04198]
111963916  proteinase-activated receptor 1 [KO:K03914]
111957859  proteinase-activated receptor 1 isoform X1 [KO:K03914]
111961750  proteinase-activated receptor 1 [KO:K03914]
111954626  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
111972819  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
111963537  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
111971717  grpr; gastrin-releasing peptide receptor [KO:K04169]
112071345  histamine H1 receptor-like [KO:K04149]
112078149  hrh1; histamine H1 receptor [KO:K04149]
111963730  5-hydroxytryptamine receptor 2C-like [KO:K04157]
111950974  5-hydroxytryptamine receptor 2C-like [KO:K04157]
111956268  5-hydroxytryptamine receptor 2C-like [KO:K04157]
112075377  5-hydroxytryptamine receptor 2A-like [KO:K04157]
111971421  5-hydroxytryptamine receptor 2A-like [KO:K04157]
111952261  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
111959800  5-hydroxytryptamine receptor 2A-like [KO:K04157]
111975551  5-hydroxytryptamine receptor 2B [KO:K04157]
111968053  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
111978016  lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
111966417  ntsr1; neurotensin receptor type 1 [KO:K04211]
111963925  isotocin receptor-like [KO:K04229]
111966390  isotocin receptor [KO:K04229]
111970313  isotocin receptor-like [KO:K04229]
111970133  isotocin receptor-like [KO:K04229]
111971674  arg8-vasotocin receptor-like [KO:K04226]
111950833  arg8-vasotocin receptor-like isoform X1 [KO:K04226]
111951288  arg8-vasotocin receptor [KO:K04226]
111962212  arg8-vasotocin receptor [KO:K04226]
111956669  leukotriene B4 receptor 1 isoform X1 [KO:K04297]
111960062  leukotriene B4 receptor 1 [KO:K04297]
111952596  LOW QUALITY PROTEIN: leukotriene B4 receptor 1-like [KO:K04297]
111979310  leukotriene B4 receptor 1 isoform X1 [KO:K04297]
111968927  platelet-activating factor receptor [KO:K04279]
112068083  platelet-activating factor receptor-like [KO:K04279]
111968389  platelet-activating factor receptor-like [KO:K04279]
111982096  prostaglandin E2 receptor EP1 subtype [KO:K04258]
112069393  prostaglandin E2 receptor EP1 subtype-like [KO:K04258]
111978673  prostaglandin E2 receptor EP1 subtype [KO:K04258]
112068821  ptger3; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP3 subtype [KO:K04260]
111952972  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
111972891  B2 bradykinin receptor-like [KO:K03916]
111963043  B1 bradykinin receptor-like [KO:K03916]
111963044  B2 bradykinin receptor [KO:K03916]
111954559  B2 bradykinin receptor-like [KO:K03916]
112081141  B2 bradykinin receptor-like [KO:K03916]
111957486  LOW QUALITY PROTEIN: substance-P receptor-like [KO:K04222]
111974779  LOW QUALITY PROTEIN: substance-P receptor-like [KO:K04222]
111961113  substance-P receptor-like [KO:K04222]
111963864  LOW QUALITY PROTEIN: substance-P receptor-like [KO:K04222]
111968132  neuromedin-K receptor [KO:K04223]
111977665  neuromedin-K receptor-like [KO:K04223]
111958480  neuromedin-K receptor [KO:K04224]
112067744  tacr3; neuromedin-K receptor [KO:K04224]
112072351  neuromedin-K receptor-like isoform X1 [KO:K04224]
111971554  neuromedin-K receptor [KO:K04224]
112070279  thromboxane A2 receptor-like [KO:K04264]
111975363  thromboxane A2 receptor-like isoform X1 [KO:K04264]
111958725  thyrotropin-releasing hormone receptor-like [KO:K04282]
112071776  thyrotropin-releasing hormone receptor-like [KO:K04282]
111965274  thyrotropin-releasing hormone receptor-like [KO:K04282]
111956171  thyrotropin-releasing hormone receptor-like [KO:K04282]
111961162  thyrotropin-releasing hormone receptor-like [KO:K04282]
111977169  thyrotropin-releasing hormone receptor-like [KO:K04282]
111952345  thyrotropin-releasing hormone receptor-like [KO:K04282]
111971121  cholecystokinin receptor-like [KO:K04194]
111953652  cholecystokinin receptor-like [KO:K04194]
112075610  cholecystokinin receptor type A-like [KO:K04194]
111960371  cholecystokinin receptor type A [KO:K04194]
111979451  C-X-C chemokine receptor type 4 [KO:K04189]
111974007  C-X-C chemokine receptor type 4-like [KO:K04189]
111974259  C-X-C chemokine receptor type 4 [KO:K04189]
112079928  C-X-C chemokine receptor type 4-like [KO:K04189]
112073225  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
111974605  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111957798  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111975941  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111961320  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
111980819  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111972124  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
111953718  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
111975535  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
111957901  guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
111973720  guanine nucleotide-binding protein subunit alpha-14-like [KO:K04636]
111971179  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04637]
111968192  egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
111970297  protransforming growth factor alpha-like [KO:K08774]
111963590  protransforming growth factor alpha-like [KO:K08774]
112074508  LOW QUALITY PROTEIN: platelet-derived growth factor subunit A-like [KO:K04359]
112075283  platelet-derived growth factor subunit A-like [KO:K04359]
111965835  platelet-derived growth factor C-like isoform X1 [KO:K05450]
111967581  platelet-derived growth factor C [KO:K05450]
111950164  putative fibroblast growth factor 1 [KO:K18496]
112070232  putative fibroblast growth factor 1 isoform X1 [KO:K18496]
111980315  putative fibroblast growth factor 1 [KO:K18496]
112069820  putative fibroblast growth factor 1 [KO:K18496]
111965796  fibroblast growth factor 2 [KO:K18497]
111967553  fgf2; fibroblast growth factor 2 [KO:K18497]
112073254  LOW QUALITY PROTEIN: fibroblast growth factor 18-like [KO:K04358]
112079581  fibroblast growth factor 6-like [KO:K04358]
111974890  fibroblast growth factor 17 [KO:K04358]
111971613  fibroblast growth factor 10-like [KO:K04358]
111975358  fibroblast growth factor 10-like [KO:K04358]
111949387  fibroblast growth factor 4B [KO:K04358]
111965803  fibroblast growth factor 18-like isoform X1 [KO:K04358]
111953093  fibroblast growth factor 6-like [KO:K04358]
111950484  fibroblast growth factor 18-like [KO:K04358]
111980242  fibroblast growth factor 10-like [KO:K04358]
111967279  fibroblast growth factor 20 [KO:K04358]
111957497  fibroblast growth factor 10-like [KO:K04358]
111951592  fibroblast growth factor 8 isoform X1 [KO:K04358]
111974798  LOW QUALITY PROTEIN: fibroblast growth factor 4B-like [KO:K04358]
111974799  fibroblast growth factor 3-like [KO:K04358]
111961394  fibroblast growth factor 10 [KO:K04358]
112070707  fibroblast growth factor 7-like [KO:K04358]
111973815  fibroblast growth factor 10-like [KO:K04358]
112079489  fibroblast growth factor 20-like [KO:K04358]
112073880  fibroblast growth factor 8b-like [KO:K04358]
111952893  fibroblast growth factor 3 [KO:K04358]
111952918  fibroblast growth factor 4B-like [KO:K04358]
111974107  fibroblast growth factor 17 [KO:K04358]
111965608  fibroblast growth factor 18 isoform X1 [KO:K04358]
112070043  fibroblast growth factor 4B-like [KO:K04358]
112070044  fibroblast growth factor 3-like [KO:K04358]
111969234  fibroblast growth factor 3-like [KO:K04358]
111977377  fibroblast growth factor 8-like isoform X1 [KO:K04358]
111974797  fgf19; fibroblast growth factor 19 [KO:K22603]
111977638  fibroblast growth factor 21-like [KO:K22429]
111951572  fibroblast growth factor 23-like [KO:K22428]
111949406  fibroblast growth factor 23-like [KO:K22428]
111949412  fibroblast growth factor 23-like [KO:K22428]
111951372  fibroblast growth factor 23-like [KO:K22428]
111962628  fibroblast growth factor 23 [KO:K22428]
111952115  fibroblast growth factor 23 isoform X1 [KO:K22428]
111954382  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
111967094  snake venom vascular endothelial growth factor toxin VR-1'-like [KO:K05448]
111965947  vascular endothelial growth factor A [KO:K05448]
111972734  vascular endothelial growth factor A-A [KO:K05448]
111959024  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
111965312  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
111971611  vascular endothelial growth factor C-like [KO:K05449]
111958513  vegfc; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
111951197  vascular endothelial growth factor C [KO:K05449]
111964401  vascular endothelial growth factor C-like [KO:K05449]
112073500  LOW QUALITY PROTEIN: neurotrophin-7-like [KO:K02582]
111970599  nerve growth factor-like [KO:K02582]
112069023  nerve growth factor-like [KO:K02582]
112075847  hepatocyte growth factor-like [KO:K05460]
111962524  hepatocyte growth factor [KO:K05460]
111969786  hepatocyte growth factor-like protein [KO:K23441]
111970086  LOW QUALITY PROTEIN: hepatocyte growth factor-like protein [KO:K23441]
111961441  glial cell line-derived neurotrophic factor-like [KO:K05452]
111974978  glial cell line-derived neurotrophic factor-like [KO:K05452]
111980375  glial cell line-derived neurotrophic factor-like [KO:K05452]
111953517  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
111972787  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
111979429  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
111956947  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
111977625  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
112071672  LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
111966704  LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
111970095  receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
111966807  receptor tyrosine-protein kinase erbB-3-like [KO:K05084] [EC:2.7.10.1]
112068952  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
111972315  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111976174  platelet-derived growth factor receptor alpha-like [KO:K04363] [EC:2.7.10.1]
111967388  platelet-derived growth factor receptor beta-like isoform X1 [KO:K05089] [EC:2.7.10.1]
111965401  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111950745  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111961779  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
111963890  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
111957683  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
111974100  fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
111981929  fibroblast growth factor receptor homolog 1 [KO:K05093] [EC:2.7.10.1]
111978528  LOW QUALITY PROTEIN: fibroblast growth factor receptor 2-like [KO:K05093] [EC:2.7.10.1]
111951954  fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
111980554  fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111950259  LOW QUALITY PROTEIN: fibroblast growth factor receptor 4-like [KO:K05095] [EC:2.7.10.1]
112068190  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
111967451  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111953844  LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1-like [KO:K05096] [EC:2.7.10.1]
111965680  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111972318  vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111965133  high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
111959090  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
111961321  BDNF/NT-3 growth factors receptor-like [KO:K04360] [EC:2.7.10.1]
111973875  BDNF/NT-3 growth factors receptor-like isoform X1 [KO:K04360] [EC:2.7.10.1]
111981917  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
111958102  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
111952403  NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
111960971  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
111952422  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111961046  LOW QUALITY PROTEIN: hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
111969766  macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
111969288  macrophage-stimulating protein receptor-like [KO:K05100] [EC:2.7.10.1]
111972219  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
111978543  proto-oncogene tyrosine-protein kinase receptor Ret-like isoform X1 [KO:K05126] [EC:2.7.10.1]
111952048  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
112073063  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05857] [EC:3.1.4.11]
111953164  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
111963729  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
112072257  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like [KO:K05857] [EC:3.1.4.11]
111970959  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
111980769  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A-like [KO:K05857] [EC:3.1.4.11]
111981409  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
111973823  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like [KO:K05857] [EC:3.1.4.11]
112069482  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
111959376  plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
112069030  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
111968629  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111963020  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
111951782  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
111954271  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
111963363  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
111954482  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111954289  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111976591  plcg1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
111975516  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
111952198  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
111977758  LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like [KO:K05860] [EC:3.1.4.11]
111967754  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like isoform X1 [KO:K05860] [EC:3.1.4.11]
111978664  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like [KO:K05860] [EC:3.1.4.11]
111952002  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
111966193  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111969857  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
111969325  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111970151  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111952558  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111960994  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
111966445  itpr3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
111976834  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
111953730  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
111958163  two pore calcium channel protein 1 [KO:K16896]
111974650  two pore calcium channel protein 1 isoform X1 [KO:K16896]
111974167  two pore calcium channel protein 2 isoform X1 [KO:K14077]
111974169  two pore calcium channel protein 2 isoform X1 [KO:K14077]
111955855  mucolipin-1-like [KO:K04992]
112069395  mucolipin-1-like [KO:K04992]
111962952  LOW QUALITY PROTEIN: mucolipin-2-like [KO:K04993]
111979435  mucolipin-3 [KO:K04994]
111975987  mucolipin-3 isoform X1 [KO:K04994]
112073208  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
111951624  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
111980109  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
111982461  sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
112069107  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
112078416  calcium uniporter protein, mitochondrial-like [KO:K20858]
111981335  voltage-dependent anion-selective channel protein 1 [KO:K05862]
112069672  voltage-dependent anion-selective channel protein 1 [KO:K05862]
112071388  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
112070114  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111978262  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111977551  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111961367  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
111973756  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
111980279  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
111958215  voltage-dependent anion-selective channel protein 2 [KO:K15041]
111967456  ADP/ATP translocase 2 [KO:K05863]
111964311  ADP/ATP translocase 2 [KO:K05863]
111965685  ADP/ATP translocase 2 [KO:K05863]
112068694  ADP/ATP translocase 2-like [KO:K05863]
111950124  ADP/ATP translocase 2-like [KO:K05863]
111971534  slc25a4; ADP/ATP translocase 1 [KO:K05863]
112073456  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
111952026  peptidyl-prolyl cis-trans isomerase A [KO:K09565] [EC:5.2.1.8]
112072576  peptidyl-prolyl cis-trans isomerase A-like isoform X1 [KO:K09565] [EC:5.2.1.8]
111966212  troponin C, slow skeletal and cardiac muscles [KO:K05865]
111977235  troponin C, slow skeletal and cardiac muscles [KO:K05865]
111976226  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
111976518  troponin C, skeletal muscle [KO:K12042]
111976520  troponin C, skeletal muscle-like [KO:K12042]
111966433  troponin C, skeletal muscle-like [KO:K12042]
111964166  calmodulin isoform X1 [KO:K02183]
111962084  calmodulin-like protein 4 isoform X1 [KO:K02183]
112076507  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
111972950  calmodulin [KO:K02183]
111951811  calm2; calmodulin-2 [KO:K02183]
111954258  calmodulin [KO:K02183]
111960601  calmodulin [KO:K02183]
111977843  calmodulin [KO:K02183]
111963424  calmodulin [KO:K02183]
111950244  calmodulin [KO:K02183]
111968561  calmodulin [KO:K02183]
111949612  calmodulin [KO:K02183]
111982583  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
111956767  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
111977401  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
111969247  phkb; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta [KO:K07190]
111974181  LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta-like [KO:K07190]
111978375  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
111976280  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111974136  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
111969255  myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
111971173  myosin light chain kinase family member 4-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111980481  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
111979255  myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
111980444  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
111974361  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
111952827  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
111970318  calcium/calmodulin-dependent protein kinase type 1-like [KO:K08794] [EC:2.7.11.17]
111976622  calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
111963142  calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
111963152  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
111963156  calcium/calmodulin-dependent protein kinase type 1-like [KO:K08794] [EC:2.7.11.17]
111968116  calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
111970651  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
111949825  calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
111966121  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type 1G-like [KO:K08794] [EC:2.7.11.17]
111951359  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
111969967  calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
111951177  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
111967811  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111960283  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
111977542  calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
111955361  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111951816  calcium/calmodulin-dependent protein kinase type II subunit gamma-like [KO:K04515] [EC:2.7.11.17]
111960905  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
111974573  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
111964725  calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
111961323  camk4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
111981716  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
111975601  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
111952601  calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
111954403  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111961376  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111980862  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111958241  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111974548  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111964297  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
111950316  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111960463  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
111960213  calcineurin subunit B type 1 [KO:K06268]
111978195  calcineurin subunit B type 1 [KO:K06268]
112078025  calcineurin subunit B type 1-like [KO:K06268]
112072130  LOW QUALITY PROTEIN: transcription factor EB-like [KO:K15590]
111970012  tfeb; transcription factor EB isoform X1 [KO:K15590]
111956111  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
111965266  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
111961710  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
111976218  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
111966754  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
111952638  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
111962688  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
112069880  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111956623  nuclear factor of activated T-cells, cytoplasmic 4-like [KO:K17334]
111979577  nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
111958203  LOW QUALITY PROTEIN: nitric oxide synthase, brain-like [KO:K13240] [EC:1.14.13.39]
111974596  LOW QUALITY PROTEIN: nitric oxide synthase, brain-like isoform X1 [KO:K13240] [EC:1.14.13.39]
111960727  nos2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
111949918  nitric oxide synthase, inducible-like isoform X1 [KO:K13241] [EC:1.14.13.39]
111970504  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
111973265  pde1c; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
112069129  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
111977688  LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
112068139  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
111960579  inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
111949586  inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
111967090  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
111981669  inositol-trisphosphate 3-kinase C-like isoform X1 [KO:K00911] [EC:2.7.1.127]
111968866  inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
111950113  inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
111954147  inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
111963127  inositol-trisphosphate 3-kinase A-like [KO:K00911] [EC:2.7.1.127]
111957424  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111982249  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
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Calcium signalling: dynamics, homeostasis and remodelling.
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Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
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Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
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Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
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FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
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Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
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Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
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Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
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  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
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Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
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Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
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STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
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Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
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Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
salp04010  MAPK signaling pathway
salp04070  Phosphatidylinositol signaling system
salp04210  Apoptosis
KO pathway
ko04020   
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