KEGG   PATHWAY: sasa04371
Entry
sasa04371                   Pathway                                
Name
Apelin signaling pathway - Salmo salar (Atlantic salmon)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
sasa04371  Apelin signaling pathway
sasa04371

Other DBs
GO: 0060183
Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106599721  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106569164  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106584068  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106560395  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
106570343  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
106588693  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
106584132  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106605024  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106607897  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
106608969  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
106582348  adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
106586396  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
106566714  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106572701  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106571946  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106567013  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106562384  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
106587576  adenylate cyclase type 2-like [KO:K08047] [EC:4.6.1.1]
106611404  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
106568630  adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
106590289  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106590466  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106601887  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106601890  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106606489  adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
106564461  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106564466  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
106575294  adcy10; adenylate cyclase 10, soluble [KO:K11265] [EC:4.6.1.1]
106592286  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106564260  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
106569146  KAPCB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106613442  prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106599750  KAPCB; cAMP-dependent protein kinase catalytic subunit beta-like [KO:K04345] [EC:2.7.11.11]
106606839  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
106577399  hormone-sensitive lipase-like [KO:K07188] [EC:3.1.1.79]
106605704  hormone-sensitive lipase-like [KO:K07188] [EC:3.1.1.79]
106570130  hormone-sensitive lipase-like [KO:K07188] [EC:3.1.1.79]
100380378  lips; Hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
106611529  apln; apelin [KO:K05225]
106564789  APJB; apelin receptor B-like [KO:K04174]
106563182  APJB; apelin receptor B-like [KO:K04174]
106579928  apelin receptor A-like [KO:K04174]
100195339  apja; Apelin receptor A [KO:K04174]
106586995  apelin receptor B-like [KO:K04174]
106609493  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
106565669  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
106566064  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
106573324  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
106572859  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
106576428  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
100380647  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
106566384  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
100217348  gnai2; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [KO:K04630]
100196762  gnai3; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 [KO:K04630]
106583193  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
106582753  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
106566880  GBB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
106571997  GBB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
106565997  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
106582769  GBB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like [KO:K04536]
100380691  gbb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
106567879  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2-like [KO:K04537]
106583400  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like [KO:K07825]
106605091  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like [KO:K07825]
106570161  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like [KO:K07825]
106588420  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3-like [KO:K07825]
106613499  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
106574143  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
106562494  guanine nucleotide-binding protein subunit beta-5-like [KO:K04539]
106561786  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
106587671  guanine nucleotide-binding protein subunit beta-5-like [KO:K04539]
106584742  guanine nucleotide-binding protein subunit beta-5-like [KO:K04539]
106603227  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2-like [KO:K07826]
100286576  gbg2; Guanine nucleotide-binding protein GI/GS/GO subunit gamma-2 [KO:K07826]
106603148  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3-like [KO:K04540]
106563484  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
106578768  gng4; G protein subunit gamma 4 [KO:K04541]
106592341  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
106600423  GBG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
106601714  GBG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
106606784  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
106569310  GBG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
106564270  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
106596157  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
106592977  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
106575248  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04543]
106574481  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
106563550  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8-like [KO:K04544]
100195688  gbg8; Guanine nucleotide-binding protein GI/GS/GO subunit gamma-8 [KO:K04544]
106568570  gng10; G protein subunit gamma 10 [KO:K04545]
106598933  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106606473  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106606536  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106560325  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
100195016  gbg12; Guanine nucleotide-binding protein GI/GS/GO subunit gamma-12 [KO:K04347]
106584173  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
106568432  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
106591949  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
106593686  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
106586030  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
106586032  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
106570493  guanine nucleotide-binding protein G(T) subunit gamma-T1-like [KO:K04548]
106588941  gng11; G protein subunit gamma 11 [KO:K04548]
106600976  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2-like [KO:K04549]
106607532  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2-like [KO:K04549]
100195975  gbgt2; Guanine nucleotide-binding protein GI/GS/GO subunit gamma-T2 [KO:K04549]
106562028  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
106568348  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
106580086  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
106585689  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
106599624  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
106608040  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
106608062  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
106608066  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
106610872  plcb2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
106610916  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
106571556  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
106571557  plcb4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
106578106  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like [KO:K05858] [EC:3.1.4.11]
106583165  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
106565476  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
106582863  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
106565749  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
100196824  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
106573309  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
106572092  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
106566485  inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
106603084  ryr1; ryanodine receptor 1 [KO:K04961]
106577062  ryanodine receptor 2-like [KO:K04962]
106587081  ryanodine receptor 3-like [KO:K04963]
106610839  ryanodine receptor 3-like [KO:K04963]
106571102  RYR3; ryanodine receptor 3-like [KO:K04963]
106608253  ryanodine receptor 3-like [KO:K04963]
106601272  CALM; calmodulin [KO:K02183]
106605143  CALM; calmodulin [KO:K02183]
106603160  calmodulin [KO:K02183]
106608223  CALM; calmodulin [KO:K02183]
106611171  calm1; calmodulin 1 [KO:K02183]
100195847  call4; Calmodulin-like protein 4 [KO:K02183]
106566003  calml6; calmodulin like 6 [KO:K02183]
106612378  CALM; calmodulin [KO:K02183]
106563500  CALM; calmodulin [KO:K02183]
106562770  calmodulin-like protein 4 [KO:K02183]
106560757  calml4; calmodulin like 4 [KO:K02183]
100194628  calm2; calmodulin 2 [KO:K02183]
100194629  CALM; calmodulin 2 (phosphorylase kinase, delta)-3 [KO:K02183]
106597685  calmodulin-like protein 4 [KO:K02183]
106597678  calmodulin-like protein 4 [KO:K02183]
100136388  nos1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
106585241  nitric oxide synthase, brain-like [KO:K13240] [EC:1.14.13.39]
100136358  nos2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
106589721  prkce; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
106589411  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
106611052  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
106591157  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
106582892  sodium/hydrogen exchanger 1-like [KO:K05742]
106605147  sodium/hydrogen exchanger 1-like [KO:K05742]
106570377  Na(+)/H(+) exchanger beta [KO:K05742]
106600501  sodium/calcium exchanger 3-like [KO:K05849]
106600873  sodium/calcium exchanger 3-like [KO:K05849]
106608331  sodium/calcium exchanger 1-like [KO:K05849]
106585125  sodium/calcium exchanger 1-like [KO:K05849]
106603153  sodium/calcium exchanger 1-like [KO:K05849]
106603691  sodium/calcium exchanger 2-like [KO:K05849]
106563494  sodium/calcium exchanger 1-like [KO:K05849]
106564793  sodium/calcium exchanger 1-like [KO:K05849]
106580848  sodium/calcium exchanger 2-like [KO:K05849]
106578109  sodium/calcium exchanger 1-like [KO:K05849]
106593974  sodium/calcium exchanger 3-like [KO:K05849]
106577160  sodium/calcium exchanger 1-like [KO:K05849]
106591009  sodium/calcium exchanger 3-like [KO:K05849]
106612604  sodium/calcium exchanger 2-like [KO:K05849]
106581830  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
106579130  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
106566930  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
106586160  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
106587297  myosin light chain kinase 3-like [KO:K00907] [EC:2.7.11.18]
106584199  myosin light chain kinase family member 4-like [KO:K00907] [EC:2.7.11.18]
106601032  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
106599743  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
106607302  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
106560377  myosin light chain kinase family member 4-like [KO:K00907] [EC:2.7.11.18]
106569150  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
106562001  myosin light chain kinase 3-like [KO:K00907] [EC:2.7.11.18]
106583376  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
100196342  mlrv; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
106585309  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
100136504  MLEC; slow myosin light chain 1 [KO:K12749]
100194663  myosin light chain 1-3 [KO:K12749]
106600870  myosin light chain 4-like [KO:K12750]
100196435  myl4; Myosin light polypeptide 4 [KO:K12750]
106573361  GTPase HRas-like [KO:K02833]
100196603  rash; GTPase HRas [KO:K02833]
106601908  GTPase HRas-like [KO:K07827]
106606379  GTPase HRas-like [KO:K07827]
106561428  GTPase KRas [KO:K07827]
100380437  rask; GTPase KRas [KO:K07827]
106600695  rras; related RAS viral (r-ras) oncogene homolog [KO:K07830]
106562341  ras-related protein R-Ras2-like [KO:K07830]
106587534  ras-related protein R-Ras2 [KO:K07830]
106583918  ras-related protein R-Ras-like [KO:K07830]
106574266  ras-related protein M-Ras [KO:K07831]
106575193  ras-related protein M-Ras-like [KO:K07831]
106582394  ras-related protein M-Ras-like [KO:K07831]
106586304  ras-related protein M-Ras-like [KO:K07831]
106571905  RAF1b; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106566757  RAF1a; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
100136351  raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
106584829  map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106600441  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
106613775  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106569535  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
100194780  mp2k2; Dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106570952  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106600714  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106592057  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
100380511  mk03; Mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106602694  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
106603521  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106609967  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
106613000  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106581130  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106567964  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106602804  RS6; 40S ribosomal protein S6 [KO:K02991]
106609995  RS6; 40S ribosomal protein S6-like [KO:K02991]
106576084  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
106572104  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
106609208  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
106587067  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
106601378  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
106607060  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
106564679  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
106564678  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
106601370  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
106587077  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
106601375  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
106607012  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
106582637  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106585772  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106602915  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106607890  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106610858  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106564869  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106613111  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106581334  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106571474  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100194605  akt2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
106589689  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100380849  mtor; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
106603906  early growth response protein 1-like [KO:K09203]
106604926  early growth response protein 1-like [KO:K09203]
106611930  early growth response protein 1-like [KO:K09203]
106564817  protein jagged-1b-like [KO:K06052]
106586244  protein jagged-1b-like [KO:K06052]
106589996  protein jagged-1b-like [KO:K06052]
106578773  jag1; jagged 1 [KO:K06052]
106612485  protein jagged-1b-like [KO:K06052]
106601274  neurogenic locus notch homolog protein 1-like [KO:K20995]
106561617  G1/S-specific cyclin-D1-like [KO:K04503]
106562055  G1/S-specific cyclin-D1-like [KO:K04503]
106587137  G1/S-specific cyclin-D1 [KO:K04503]
100306852  ccnd1; cyclin D1 [KO:K04503]
106562335  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like [KO:K13296] [EC:3.1.4.17]
106587530  pde3b; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
106608867  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
106577844  phosphatidylinositol 3-kinase catalytic subunit type 3-like [KO:K00914] [EC:2.7.1.137]
106574714  phosphoinositide 3-kinase regulatory subunit 4-like [KO:K08333] [EC:2.7.11.1]
106585470  phosphoinositide 3-kinase regulatory subunit 4-like [KO:K08333] [EC:2.7.11.1]
100194789  becn1; beclin 1 [KO:K08334]
106604385  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
106573632  MLP3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
106564988  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
100286633  mlp3c; Microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
100194503  map1lc3a; microtubule-associated protein 1 light chain 3 alpha [KO:K10435]
100846961  map1lc3b; microtubule associated protein 1 light chain 3 beta [KO:K10435]
106568674  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
106562970  prkaa1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
106584208  prkaa2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
106560227  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
106565185  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
106600564  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
106569689  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
100196330  aakb1; 5-AMP-activated protein kinase subunit beta-1 [KO:K07199]
106599250  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
106575098  5'-AMP-activated protein kinase subunit gamma-3-like [KO:K07200]
106569190  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
106574322  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
106565531  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
106579597  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
106592041  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
106590432  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
100196740  prkag1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
106573782  plin1; perilipin 1 [KO:K08768]
106608616  peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like [KO:K07202]
106577610  peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like [KO:K07202]
106609786  nrf1; nuclear respiratory factor 1 [KO:K11831]
106577401  transcription factor A, mitochondrial-like [KO:K11830]
106591283  TFAM; transcription factor A, mitochondrial-like [KO:K11830]
106594258  TFAM; transcription factor A, mitochondrial-like [KO:K11830]
106573812  klf2; Kruppel like factor 2 [KO:K17845]
106569606  Krueppel-like factor 2 [KO:K17845]
100286404  klf2; Krueppel-like factor 2 [KO:K17845]
106613686  KLF2; Krueppel-like factor 2 [KO:K17845]
106577300  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
106588251  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
106601398  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
106606991  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
106605728  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
106605743  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
106564913  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
106606258  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
106594878  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
106589443  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
106562078  camk4; calcium/calmodulin dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
106568343  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
106613573  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
106574056  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
106601252  histone deacetylase 5-like [KO:K11406] [EC:3.5.1.98]
106607176  histone deacetylase 5-like [KO:K11406] [EC:3.5.1.98]
106575618  histone deacetylase 4-like [KO:K11406] [EC:3.5.1.98]
106575641  histone deacetylase 4-like [KO:K11406] [EC:3.5.1.98]
106586120  histone deacetylase 4-like [KO:K11406] [EC:3.5.1.98]
106581867  hdac4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
106560805  mef2a; myocyte enhancer factor 2A [KO:K09260]
106573766  myocyte-specific enhancer factor 2A-like [KO:K09260]
106573587  mef2b; myocyte enhancer factor 2B [KO:K09261]
106613729  myocyte-specific enhancer factor 2B-like [KO:K09261]
106568324  myocyte-specific enhancer factor 2C-like [KO:K04454]
106563077  myocyte-specific enhancer factor 2C-like [KO:K04454]
100500787  myocyte-specific enhancer factor 2C [KO:K04454]
106580134  myocyte-specific enhancer factor 2C-like [KO:K04454]
106580711  mef2d; myocyte enhancer factor 2D [KO:K09262]
106605316  myocyte-specific enhancer factor 2D homolog [KO:K09262]
106569867  myocyte-specific enhancer factor 2D homolog [KO:K09262]
106588308  myocyte-specific enhancer factor 2D homolog [KO:K09262]
106599285  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106579675  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106569209  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106590284  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106580048  mothers against decapentaplegic homolog 2-like [KO:K04500]
106585370  mothers against decapentaplegic homolog 2 [KO:K04500]
106563948  mothers against decapentaplegic homolog 4-like [KO:K04501]
106580167  mothers against decapentaplegic homolog 4-like [KO:K04501]
106605446  SMAD4; mothers against decapentaplegic homolog 4-like [KO:K04501]
106568180  mothers against decapentaplegic homolog 4-like [KO:K04501]
106569881  mothers against decapentaplegic homolog 4-like [KO:K04501]
106585826  smad4; SMAD family member 4 [KO:K04501]
100195274  smad4; MAD homolog 4 (Drosophila) [KO:K04501]
106588319  mothers against decapentaplegic homolog 4-like [KO:K04501]
106578961  actin, aortic smooth muscle [KO:K12313]
106589387  actin, aortic smooth muscle [KO:K12313]
106573965  cadherin-4-like [KO:K05689]
106573979  B-cadherin-like [KO:K05689]
106562057  B-cadherin-like [KO:K05689]
106587268  CADH1; B-cadherin-like [KO:K05689]
106571301  connective tissue growth factor-like [KO:K06827]
106570673  connective tissue growth factor-like [KO:K06827]
100194970  ctgf; connective tissue growth factor [KO:K06827]
106597308  connective tissue growth factor-like [KO:K06827]
106589042  connective tissue growth factor-like [KO:K06827]
106579762  type-1 angiotensin II receptor-like [KO:K04166]
106590686  type-1 angiotensin II receptor-like [KO:K04166]
106608947  plasminogen activator inhibitor 1-like [KO:K03982]
106577897  plasminogen activator inhibitor 1-like [KO:K03982]
106580425  tissue-type plasminogen activator-like [KO:K01343] [EC:3.4.21.68]
106585058  tissue-type plasminogen activator-like [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
Related
pathway
sasa04010  MAPK signaling pathway
sasa04020  Calcium signaling pathway
sasa04140  Autophagy - animal
sasa04150  mTOR signaling pathway
sasa04270  Vascular smooth muscle contraction
sasa04530  Tight junction
KO pathway
ko04371   
LinkDB

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