KEGG   PATHWAY: schu04068
Entry
schu04068                   Pathway                                
Name
FoxO signaling pathway - Siniperca chuatsi (mandarin fish)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
schu04068  FoxO signaling pathway
schu04068

Other DBs
GO: 0009267
Organism
Siniperca chuatsi (mandarin fish) [GN:schu]
Gene
122879501  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
122880230  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
122880976  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
122863261  transforming growth factor beta-3 proprotein-like [KO:K13377]
122861438  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
122866616  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
122864473  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
122885136  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
122881213  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
122876696  mothers against decapentaplegic homolog 4 [KO:K04501]
122863799  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
122865489  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
122862259  smad3a; mothers against decapentaplegic homolog 3a isoform X1 [KO:K23605]
122875137  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
122886527  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
122877156  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122866157  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
122876033  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
122865732  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
122886406  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
122872181  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
122885372  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
122867091  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
122887133  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
122869035  nlk1; nemo-like kinase, type 1 isoform X1 [KO:K04468] [EC:2.7.11.24]
122878823  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
122865389  skp2; S-phase kinase-associated protein 2 [KO:K03875]
122871542  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
122880152  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
122868808  LOW QUALITY PROTEIN: CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
122869593  ep300b; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
122873931  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
122867407  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
122884868  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
122870058  solute carrier family 2, facilitated glucose transporter member 4-like isoform X1 [KO:K07191]
122883942  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122865666  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122880393  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122867451  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122870071  serine/threonine-protein kinase 4-like [KO:K04411]
122883752  igf3; insulin-like growth factor 3 [KO:K05459]
122871522  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
122874941  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
122875174  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
122888298  ins; insulin [KO:K04526]
122880879  insb; preproinsulin b [KO:K04526]
122887603  insra; insulin receptor a isoform X1 [KO:K04527] [EC:2.7.10.1]
122878004  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
122888843  si:ch211-284e13.4; insulin receptor substrate 1-B isoform X1 [KO:K16172]
122870633  si:ch73-335l21.1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
122869974  insulin receptor substrate 2-B isoform X1 [KO:K07187]
122872245  insulin receptor substrate 2-like isoform X1 [KO:K07187]
122885444  irs2b; insulin receptor substrate 2 isoform X1 [KO:K07187]
122870088  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
122883224  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122878181  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
122878474  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122886592  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122887535  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
122876770  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
122877580  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
122878127  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
122865334  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122887224  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122868056  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
122884588  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
122868207  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
122875692  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
122884033  ptena; phosphatase and tensin homolog A [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122867304  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122888423  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
122878451  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122884935  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122873144  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122861346  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122881638  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
122863241  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
122865010  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
122882717  sgk2a; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
122866243  sgk3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
122888851  forkhead box protein O1-A-like isoform X1 [KO:K07201]
122878567  foxo1a; forkhead box protein O1-A [KO:K07201]
122862797  foxo3b; forkhead box protein O3B [KO:K09408]
122863992  foxo6b; forkhead box protein O6b [KO:K09408]
122880085  foxo4; forkhead box protein O6 [KO:K12358]
122881138  forkhead box protein O4-like [KO:K17847]
122861998  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
122863172  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
122876421  homer1b; homer protein homolog 1b isoform X1 [KO:K15010]
122878104  homer3b; homer protein homolog 3b isoform X1 [KO:K15010]
122865755  homer protein homolog 1-like [KO:K15010]
122879601  homer2; homer protein homolog 2 isoform X1 [KO:K15010]
122887226  homer protein homolog 3 isoform X1 [KO:K15010]
122888233  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
122882562  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
122868613  casein kinase I [KO:K08960] [EC:2.7.11.1]
122867676  csnk1e; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
122864664  interleukin-6-like [KO:K05405]
122867749  il10; interleukin-10 [KO:K05443]
122869591  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
122880618  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
122866464  LOW QUALITY PROTEIN: melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
122886268  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122869414  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
122862135  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122872843  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
122875107  GTPase HRas [KO:K02833]
122874834  kras; GTPase KRas isoform X1 [KO:K07827]
122871272  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122883572  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122876305  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
122875138  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122877476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122886281  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
122876093  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122868217  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
122882679  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
122883274  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122883528  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
122871338  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122871339  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
122874303  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
122863907  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
122869586  prmt1; protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
122884272  forkhead box protein G1-like [KO:K09385]
122878621  foxg1c; forkhead box protein G1c [KO:K09385]
122861866  foxg1a; forkhead box protein G1 [KO:K09385]
122865794  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
122881991  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like [KO:K21770]
122878453  cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
122879039  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like [KO:K21770]
122870508  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
122876462  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
122875207  G1/S-specific cyclin-D1-like [KO:K04503]
122868879  ccndx; cyclin Dx [KO:K10151]
122871393  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
122874759  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
122875838  cyclin-G2-like [KO:K10146]
122865210  ccng2; cyclin-G2 [KO:K10146]
122872953  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
122873541  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
122871065  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
122861465  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
122875381  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
122874402  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
122873527  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
122876249  plk2b; serine/threonine-protein kinase PLK2b [KO:K08861] [EC:2.7.11.21]
122886601  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
122862294  plk4; serine/threonine-protein kinase PLK4 [KO:K08863] [EC:2.7.11.21]
122861943  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
122876144  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
122877489  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
122877856  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
122865550  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
122865551  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
122887265  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
122878277  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122879886  cd40lg; CD40 ligand [KO:K04389]
122884174  bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
122861996  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
122866216  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
122877131  bcl6aa; BCL6A transcription repressor a isoform X1 [KO:K15618]
122887305  bcl6ab; BCL6A transcription repressor b [KO:K15618]
122884135  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15464]
122865747  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
122882105  atg12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
122882104  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
122870653  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
122873347  gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
122874991  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
122875219  cat; catalase [KO:K03781] [EC:1.11.1.6]
122862609  sod2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
122878436  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
122863401  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
122866816  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
122885851  glucose-6-phosphatase 2-like [KO:K01084] [EC:3.1.3.9]
122867147  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
122867323  g6pc1a.2; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
122867324  g6pc1a.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
122865361  il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
122887593  klf2b; Krueppel-like factor 2b isoform X1 [KO:K17845]
122877917  Krueppel-like factor 2 [KO:K17845]
122877741  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
122877812  s1pr4; sphingosine 1-phosphate receptor 4 isoform X1 [KO:K04293]
122875347  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
122875332  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
122862955  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
122880982  fbxo32; F-box only protein 32 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
schu00010  Glycolysis / Gluconeogenesis
schu00020  Citrate cycle (TCA cycle)
schu00190  Oxidative phosphorylation
schu04010  MAPK signaling pathway
schu04110  Cell cycle
schu04120  Ubiquitin mediated proteolysis
schu04140  Autophagy - animal
schu04210  Apoptosis
schu04350  TGF-beta signaling pathway
schu04910  Insulin signaling pathway
KO pathway
ko04068   
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