KEGG   PATHWAY: uah04217
Entry
uah04217                    Pathway                                
Name
Necroptosis - Ursus arctos horribilis (North American brown bear)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
uah04217  Necroptosis
uah04217

Organism
Ursus arctos horribilis (North American brown bear) [GN:uah]
Gene
113243711  TNF; tumor necrosis factor [KO:K03156]
113257988  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
113252355  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
113248591  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
113248645  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
113262665  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
113264397  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
113260143  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
113260144  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
113270927  XIAP; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
113258444  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
113245982  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
113247618  SHARPIN; sharpin isoform X1 [KO:K20894]
113258704  SPATA2; spermatogenesis-associated protein 2 [KO:K17595]
113252125  SPATA2L; spermatogenesis-associated protein 2-like protein [KO:K17595]
113252226  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
113243978  FADD; FAS-associated death domain protein [KO:K02373]
113250592  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
113246058  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
113265816  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
113263946  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
113257849  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
113255589  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
113259192  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
113262270  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
113240791  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
113241271  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
113255470  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
113255803  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
113261734  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
113259206  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
113245581  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
113259253  GLUD1; glutamate dehydrogenase 1, mitochondrial isoform X1 [KO:K00261] [EC:1.4.1.3]
113262718  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
113244160  PYGM; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
113248361  PYGB; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
113266218  PYGL; glycogen phosphorylase, liver form isoform X1 [KO:K00688] [EC:2.4.1.1]
113263180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113261548  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113243106  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113246990  FTH1; ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
113268344  LOW QUALITY PROTEIN: ferritin, mitochondrial-like [KO:K13625]
113243324  FTL; ferritin light chain [KO:K13625]
113262763  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
113241915  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
113241916  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
113241996  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
113271093  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
113244126  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
113262899  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
113245851  SMPD1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
113266837  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
113257740  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
113247462  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
113267721  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
113242506  IL1B; interleukin-1 beta [KO:K04519]
113248035  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
113248787  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
113258502  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
113246033  CHMP4A; LOW QUALITY PROTEIN: charged multivesicular body protein 4a [KO:K12194]
113252998  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
113244530  CHMP6; charged multivesicular body protein 6 [KO:K12195]
113253497  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
113252426  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
113245926  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
113252129  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
113260526  CHMP5; charged multivesicular body protein 5 [KO:K12198]
113269987  CHMP7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
113269614  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
113268160  IL1A; interleukin-1 alpha [KO:K04383]
113260625  IL33; interleukin-33 isoform X1 [KO:K12967]
113251226  HMGB1; high mobility group protein B1 [KO:K10802]
113255024  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
113262825  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
113258968  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
113260290  interferon alpha-1/2-like [KO:K05414]
113260291  interferon alpha-1/2-like [KO:K05414]
113260293  interferon alpha-1/2-like [KO:K05414]
113260294  interferon alpha-2-like [KO:K05414]
113260295  IFNB1; interferon beta [KO:K05415]
113256304  IFNG; interferon gamma [KO:K04687]
113264796  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
113259485  IFNGR1; interferon gamma receptor 1 [KO:K05132]
113264675  IFNGR2; interferon gamma receptor 2 [KO:K05133]
113254577  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
113270160  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
113256691  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
113242985  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
113250654  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
113256419  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
113265422  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
113250651  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
113265423  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
113265424  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
113256394  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
113245987  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
113241346  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
113266343  TLR4; toll-like receptor 4 [KO:K10160]
113261605  TIR domain-containing adapter molecule 2-like [KO:K05409]
113242838  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
113262283  TLR3; toll-like receptor 3 [KO:K05401]
113258759  ZBP1; Z-DNA-binding protein 1 isoform X1 [KO:K12965]
113246735  USP21; ubiquitin carboxyl-terminal hydrolase 21 isoform X1 [KO:K21634] [EC:3.4.19.12]
113261555  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
113261246  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
113267248  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
113259486  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
113262926  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
113258065  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
113243322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
113270952  AIFM1; apoptosis-inducing factor 1, mitochondrial [KO:K04727] [EC:1.-.-.-]
113249966  histone H2A-Bbd type 1-like [KO:K11251]
113264221  histone H2A type 1-A [KO:K11251]
113264249  histone H2A type 1-like [KO:K11251]
113261754  core histone macro-H2A.1 isoform X1 [KO:K11251]
113241852  histone H2A-like [KO:K11251]
113263111  histone H2A.Z [KO:K11251]
113257773  histone H2A.V isoform X1 [KO:K11251]
113257855  histone H2A.J [KO:K11251]
113259135  core histone macro-H2A.2 [KO:K11251]
113247479  histone H2A type 3 [KO:K11251]
113249354  histone H2A type 1 isoform X1 [KO:K11251]
113264274  histone H2A type 1-C [KO:K11251]
113264275  histone H2A type 1-E [KO:K11251]
113264276  histone H2A type 1-E [KO:K11251]
113264277  histone H2A type 1 [KO:K11251]
113264278  histone H2A type 1 [KO:K11251]
113264279  histone H2A type 1-B/E [KO:K11251]
113264280  histone H2A type 1-D-like [KO:K11251]
113264281  histone H2A type 1-H [KO:K11251]
113264317  histone H2A type 1-H-like [KO:K11251]
113259972  histone H2AX [KO:K11251]
113250285  histone H2A type 1-E-like [KO:K11251]
113250287  histone H2A type 1-E-like [KO:K11251]
113246100  histone H2A type 2-A [KO:K11251]
113248330  histone H2A-Bbd type 2/3-like [KO:K11251]
113257787  PPIA; peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
113253490  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
uah00250  Alanine, aspartate and glutamate metabolism
uah04210  Apoptosis
uah04668  TNF signaling pathway
uah04922  Glucagon signaling pathway
KO pathway
ko04217   
LinkDB

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