KEGG   PATHWAY: pcoq05012
Entry
pcoq05012                   Pathway                                
Name
Parkinson disease - Propithecus coquereli (Coquerel's sifaka)
Description
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pcoq05012  Parkinson disease
pcoq05012

Disease
H00057  Parkinson disease
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804942  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105804976  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
105805217  TXN2; thioredoxin, mitochondrial [KO:K03671]
105805232  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105805267  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105805355  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
105805497  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
105805667  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
105805895  CALM2; calmodulin [KO:K02183]
105805900  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105806237  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105806239  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
105806404  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
105806434  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105806582  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
105806589  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
105806701  [KO:K02271]
105806914  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
105807023  [KO:K02266]
105807119  CALM1; calmodulin [KO:K02183]
105807267  [KO:K02264]
105807308  [KO:K02136]
105807375  [KO:K08738]
105807458  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105807577  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105807599  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105807721  TXN; thioredoxin [KO:K03671]
105807821  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105807952  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105808093  SLC39A10; zinc transporter ZIP10 [KO:K14716]
105808189  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
105808354  [KO:K02265]
105808520  ATP5C1; ATP synthase subunit gamma, mitochondrial [KO:K02136]
105808623  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
105808667  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105808688  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105808722  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
105808789  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
105808883  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105808983  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105809033  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
105809065  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
105809316  BAX; apoptosis regulator BAX [KO:K02159]
105809322  [KO:K02267]
105809466  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105809556  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105809719  [KO:K03946]
105809747  [KO:K02268]
105809797  [KO:K00417]
105809975  [KO:K04553] [EC:2.3.2.23]
105810108  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105810111  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105810190  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
105810198  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
105810204  [KO:K00419]
105810299  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105810555  [KO:K08738]
105810742  [KO:K02272]
105810895  [KO:K00415]
105810924  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105811066  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
105811067  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
105811072  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105811110  [KO:K02270]
105811230  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105811286  [KO:K00420]
105811289  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
105811799  [KO:K02270]
105811880  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
105811892  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105811945  SLC39A3; zinc transporter ZIP3 [KO:K14709]
105812168  [KO:K02263]
105812318  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105812371  PARK2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
105812491  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
105812493  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105812509  [KO:K08738]
105812563  [KO:K00411] [EC:7.1.1.8]
105812612  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
105812661  SNCA; alpha-synuclein isoform X1 [KO:K04528]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812706  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
105812967  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
105813050  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105813404  [KO:K00413]
105813410  SLC39A4; zinc transporter ZIP4 [KO:K14710]
105813564  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105813610  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105813709  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
105813715  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105813718  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
105814072  [KO:K00416]
105814216  RYR3; ryanodine receptor 3 [KO:K04963]
105814369  SLC39A2; zinc transporter ZIP2 [KO:K14709]
105814447  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
105814632  [KO:K02128]
105814660  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105814705  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105814707  [KO:K05611] [EC:3.4.19.12]
105814728  [KO:K04570]
105814731  [KO:K02730] [EC:3.4.25.1]
105814769  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
105814872  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
105815021  [KO:K21398]
105815072  [KO:K02266]
105815191  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
105815218  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
105815299  GPR37; prosaposin receptor GPR37 [KO:K04243]
105815301  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105815384  TUBA1A; tubulin alpha-1A chain isoform X1 [KO:K07374]
105815399  [KO:K07374]
105815409  [KO:K07374]
105815498  [KO:K07374]
105815572  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105815577  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
105815609  [KO:K08738]
105815718  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105815768  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
105815811  TUBA8; tubulin alpha-8 chain [KO:K07374]
105815885  [KO:K07374]
105815896  [KO:K03237]
105815999  [KO:K04440] [EC:2.7.11.24]
105816029  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105816045  [KO:K00418]
105816062  [KO:K07375]
105816214  [KO:K02270]
105816235  [KO:K02267]
105816363  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105816408  KIF5A; kinesin heavy chain isoform 5A isoform X1 [KO:K10396]
105816458  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
105816522  TH; tyrosine 3-monooxygenase isoform X1 [KO:K00501] [EC:1.14.16.2]
105816542  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
105816545  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105816581  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105816719  PSMD1; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
105816800  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
105816836  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105816974  UBE2G1; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
105816985  SLC39A5; zinc transporter ZIP5 [KO:K14711]
105817091  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
105817103  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
105817257  [KO:K03030]
105817283  TUBB; tubulin beta chain [KO:K07375]
105817554  [KO:K02136]
105817634  CALM3; calmodulin [KO:K02183]
105817696  KLC3; kinesin light chain 3 [KO:K10407]
105817748  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
105817755  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105817968  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105817990  [KO:K02270]
105818097  [KO:K02927]
105818146  [KO:K02927]
105818168  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105818236  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
105818541  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
105818550  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
105818686  TUBB4B; tubulin beta-4B chain [KO:K07375]
105818745  KIF5B; kinesin-1 heavy chain [KO:K10396]
105818751  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105818861  SEPT5; septin-5 [KO:K04557]
105818927  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105819043  [KO:K02273]
105819080  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
105819128  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
105819192  SLC39A8; zinc transporter ZIP8 [KO:K14714]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
105819421  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105819542  PSMD14; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
105819624  [KO:K07374]
105819681  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
105819858  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105819886  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
105820072  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
105820083  [KO:K04632]
105820084  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
105820356  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105820430  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
105820583  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
105820609  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
105820631  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
105820645  [KO:K07375]
105820827  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
105820831  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
105820913  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105820930  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
105821123  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
105821488  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
105821498  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
105821522  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
105821672  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
105821681  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105821682  DAXX; death domain-associated protein 6 [KO:K02308]
105821892  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
105821907  SLC39A1; zinc transporter ZIP1 [KO:K14709]
105821915  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105822085  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105822197  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
105822219  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
105822308  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
105822336  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105822459  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
105822845  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
105822913  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
105823056  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105823339  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105823587  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105823648  SLC39A12; zinc transporter ZIP12 [KO:K14718]
105823743  ADORA2A; adenosine receptor A2a [KO:K04266]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105823905  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105823955  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
105823972  [KO:K02263]
105824035  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105824114  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105824126  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105824308  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105824355  [KO:K00414]
105824734  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105824794  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
105824808  SLC39A11; zinc transporter ZIP11 [KO:K14717]
105824812  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105824849  DRD1; D(1A) dopamine receptor [KO:K04144]
105824864  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105824910  PARK7; protein deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
105824956  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
105825008  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105825063  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105825242  SLC18A1; chromaffin granule amine transporter [KO:K08155]
105825263  SLC39A14; zinc transporter ZIP14 isoform X1 [KO:K14720]
105825287  [KO:K05687] [EC:3.5.1.124]
105825452  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
105825486  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
105825488  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105825513  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
105825547  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105825561  UBC; polyubiquitin-C [KO:K02927]
105825671  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
105825819  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
105825847  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
105825876  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
105826075  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105826090  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105826189  [KO:K02271]
105826272  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105826315  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
105826451  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105826829  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105826892  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105826912  CALML3; calmodulin-like protein 3 [KO:K02183]
105826917  CALML5; calmodulin-like protein 5 [KO:K02183]
105827162  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105827242  [KO:K07375]
105827373  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
105827391  KLC2; kinesin light chain 2 [KO:K10407]
105827413  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105827532  [KO:K00237]
105827580  [KO:K02263]
6458115  COX2; cytochrome c oxidase subunit II [KO:K02261]
6458116  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
6458117  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
6458118  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
6458119  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
6458120  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
6458121  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
6458122  CYTB; cytochrome b [KO:K00412]
6458123  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
6458124  COX3; cytochrome c oxidase subunit III [KO:K02262]
6458125  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
6458126  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
6458127  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
Compound
C00002  ATP
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00020  AMP
C00027  Hydrogen peroxide
C00034  Manganese
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00212  Adenosine
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
C04043  3,4-Dihydroxyphenylacetaldehyde
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C14701  Paraquat
C15231  Maneb
C16844  Hydroxyl radical
C17755  Dopamine quinone
C22381  Reactive oxygen species
Reference
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Abou-Sleiman PM, Muqit MM, Wood NW
  Title
Expanding insights of mitochondrial dysfunction in Parkinson's disease.
  Journal
Nat Rev Neurosci 7:207-19 (2006)
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Reference
PMID:12938733
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Lim KL, Lim TM
  Title
Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes.
  Journal
IUBMB Life 55:315-22 (2003)
DOI:10.1080/1521654031000153030
Reference
PMID:26501339
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Bobela W, Aebischer P, Schneider BL
  Title
Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.
  Journal
Biomolecules 5:2675-700 (2015)
DOI:10.3390/biom5042675
Reference
PMID:15767499
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Molecular pathogenesis of Parkinson disease.
  Journal
Arch Neurol 62:353-7 (2005)
DOI:10.1001/archneur.62.3.353
Reference
PMID:16972273
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Olanow CW, McNaught KS
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Mov Disord 21:1806-23 (2006)
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Reference
PMID:18047737
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Lim KL, Tan JM
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Role of the ubiquitin proteasome system in Parkinson's disease.
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BMC Biochem 8 Suppl 1:S13 (2007)
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Reference
PMID:29090092
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Maiti P, Manna J, Dunbar GL
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Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments.
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Transl Neurodegener 6:28 (2017)
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Reference
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Neuropharmacology 45:1-13 (2003)
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Reference
PMID:20495568
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Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G
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Missing pieces in the Parkinson's disease puzzle.
  Journal
Nat Med 16:653-61 (2010)
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Reference
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Cali T, Ottolini D, Brini M
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Calcium signaling in Parkinson's disease.
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Cell Tissue Res 357:439-54 (2014)
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Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:28468938
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Zaichick SV, McGrath KM, Caraveo G
  Title
The role of Ca(2+) signaling in Parkinson's disease.
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Dis Model Mech 10:519-535 (2017)
DOI:10.1242/dmm.028738
Reference
PMID:28838811
  Authors
Ludtmann MHR, Abramov AY
  Title
Mitochondrial calcium imbalance in Parkinson's disease.
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Neurosci Lett 663:86-90 (2018)
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Reference
PMID:19663908
  Authors
Sandebring A, Dehvari N, Perez-Manso M, Thomas KJ, Karpilovski E, Cookson MR, Cowburn RF, Cedazo-Minguez A
  Title
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
  Journal
FEBS J 276:5041-52 (2009)
DOI:10.1111/j.1742-4658.2009.07201.x
Reference
PMID:23352769
  Authors
Mercado G, Valdes P, Hetz C
  Title
An ERcentric view of Parkinson's disease.
  Journal
Trends Mol Med 19:165-75 (2013)
DOI:10.1016/j.molmed.2012.12.005
Reference
PMID:27103567
  Authors
Mercado G, Castillo V, Soto P, Sidhu A
  Title
ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway.
  Journal
Brain Res 1648:626-632 (2016)
DOI:10.1016/j.brainres.2016.04.042
Reference
PMID:26297973
  Authors
Tsujii S, Ishisaka M, Hara H
  Title
Modulation of endoplasmic reticulum stress in Parkinson's disease.
  Journal
Eur J Pharmacol 765:154-6 (2015)
DOI:10.1016/j.ejphar.2015.08.033
Reference
PMID:31100053
  Authors
Shah A, Chao J, Legido-Quigley C, Chang RC
  Title
Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.
  Journal
Nutr Neurosci 1-16 (2019)
DOI:10.1080/1028415X.2019.1613764
Reference
PMID:24548101
  Authors
Segura-Aguilar J, Paris I, Munoz P, Ferrari E, Zecca L, Zucca FA
  Title
Protective and toxic roles of dopamine in Parkinson's disease.
  Journal
J Neurochem 129:898-915 (2014)
DOI:10.1111/jnc.12686
Reference
PMID:31587020
  Authors
Jesko H, Lenkiewicz AM, Wilkaniec A, Adamczyk A
  Title
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
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Acta Neurobiol Exp (Wars) 79:276-289 (2019)
Reference
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Perez RG, Hastings TG
  Title
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
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J Neurochem 89:1318-24 (2004)
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  Authors
Segura-Aguilar J
  Title
A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
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Neural Regen Res 10:1225-7 (2015)
DOI:10.4103/1673-5374.162750
Reference
PMID:27546335
  Authors
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  Title
Mitochondrial dysfunction in Parkinson's disease.
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J Neurochem 139 Suppl 1:216-231 (2016)
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Reference
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  Title
Emerging (and converging) pathways in Parkinson's disease: keeping mitochondrial wellness.
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Biochem Biophys Res Commun 483:1020-1030 (2017)
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Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.
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Oxid Med Cell Longev 2016:3472032 (2016)
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Reference
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Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease.
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Gaki GS, Papavassiliou AG
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Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease.
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Neuromolecular Med 16:217-30 (2014)
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PMID:25761946
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The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
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Neuroscientist 22:266-77 (2016)
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Reference
PMID:22926193
  Authors
de Vries RL, Przedborski S
  Title
Mitophagy and Parkinson's disease: be eaten to stay healthy.
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Mol Cell Neurosci 55:37-43 (2013)
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Reference
PMID:20736035
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Deas E, Wood NW, Plun-Favreau H
  Title
Mitophagy and Parkinson's disease: the PINK1-parkin link.
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Biochim Biophys Acta 1813:623-33 (2011)
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Reference
PMID:25611507
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Pickrell AM, Youle RJ
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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
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Neuron 85:257-73 (2015)
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Reference
PMID:27911343
  Authors
Truban D, Hou X, Caulfield TR, Fiesel FC, Springer W
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PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
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J Parkinsons Dis 7:13-29 (2017)
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Reference
PMID:28823929
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Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M
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Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
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Neurobiol Dis 108:65-72 (2017)
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Reference
PMID:29147906
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Oh SE, Mouradian MM
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Regulation of Signal Transduction by DJ-1.
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Adv Exp Med Biol 1037:97-131 (2017)
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Reference
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Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY
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Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
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J Bioenerg Biomembr 51:175-188 (2019)
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Reference
PMID:30370500
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Melo TQ, Copray SJCVM, Ferrari MFR
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Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.
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Neurochem Res 43:2212-2223 (2018)
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Reference
PMID:30937538
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Zhai S, Shen W, Graves SM, Surmeier DJ
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Dopaminergic modulation of striatal function and Parkinson's disease.
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J Neural Transm (Vienna) 126:411-422 (2019)
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Reference
PMID:29720658
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Parker JG, Marshall JD, Ahanonu B, Wu YW, Kim TH, Grewe BF, Zhang Y, Li JZ, Ding JB, Ehlers MD, Schnitzer MJ
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Diametric neural ensemble dynamics in parkinsonian and dyskinetic states.
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Nature 557:177-182 (2018)
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Related
pathway
pcoq00190  Oxidative phosphorylation
pcoq00350  Tyrosine metabolism
pcoq03050  Proteasome
pcoq04020  Calcium signaling pathway
pcoq04120  Ubiquitin mediated proteolysis
pcoq04137  Mitophagy - animal
pcoq04141  Protein processing in endoplasmic reticulum
pcoq04210  Apoptosis
pcoq04728  Dopaminergic synapse
KO pathway
ko05012   

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