KEGG   PATHWAY: pleu05146
Entry
pleu05146                   Pathway                                
Name
Amoebiasis - Peromyscus leucopus (white-footed mouse)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
pleu05146  Amoebiasis
pleu05146

Disease
H00360  Amoebiasis
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680674  Plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
114680960  Rab7a; ras-related protein Rab-7a [KO:K07897]
114681495  [KO:K13279] [EC:1.11.1.24]
114681738  Rab5b; ras-related protein Rab-5B [KO:K07888]
114682025  [KO:K04632]
114682029  [KO:K04632]
114682099  Rela; transcription factor p65 [KO:K04735]
114682360  Gnal; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
114682623  [KO:K13279] [EC:1.11.1.24]
114682792  Rab5c; ras-related protein Rab-5C [KO:K07889]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684152  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114684682  Actn4; alpha-actinin-4 isoform X3 [KO:K05699]
114685302  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
114685827  Cd1d; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
114687523  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114688160  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
114688171  Gna15; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
114688889  [KO:K06236]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689756  Il6; interleukin-6 [KO:K05405]
114689882  Il12b; interleukin-12 subunit beta [KO:K05425]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114690812  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
114690861  Il1r2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
114691518  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
114691738  Il12a; interleukin-12 subunit alpha [KO:K05406]
114692203  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114692793  C8g; complement component C8 gamma chain isoform X1 [KO:K03999]
114692897  Col1a1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
114693330  Ifng; interferon gamma [KO:K04687]
114693444  Col1a2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693605  Fn1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693896  Muc2; mucin-2 [KO:K10955]
114693962  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
114695066  [KO:K13279] [EC:1.11.1.24]
114695104  Col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
114695105  Col4a1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114696435  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
114696436  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
114696529  Itgb2; integrin beta-2 [KO:K06464]
114696878  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
114696911  [KO:K04634]
114696913  Gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
114697344  C9; complement component C9 [KO:K04000]
114697772  Arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
114697781  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
114697904  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114698039  Il10; interleukin-10 [KO:K05443]
114698061  Rab7b; ras-related protein Rab-7b isoform X2 [KO:K07898]
114698155  Lama3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
114698210  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
114698264  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114698332  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
114698334  Col4a6; collagen alpha-6(IV) chain [KO:K06237]
114698613  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
114698623  Arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
114700210  Vcl; vinculin isoform X1 [KO:K05700]
114700344  [KO:K06464]
114700391  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
114701221  [KO:K13963]
114701227  [KO:K13963]
114701244  [KO:K13963]
114701274  [KO:K13963]
114701719  [KO:K05505]
114701735  [KO:K05505]
114701736  [KO:K05505]
114701909  [KO:K13963]
114702198  [KO:K13963]
114702393  Lamb3; laminin subunit beta-3 [KO:K06244]
114702823  [KO:K13963]
114702824  Serpinb13; serpin B13 [KO:K13963]
114703666  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
114703672  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114703788  Lamc3; laminin subunit gamma-3 [KO:K06247]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114704074  Lama1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
114704204  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
114704404  [KO:K06461]
114704659  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114705140  Cd14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
114705208  Lamb2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
114705256  Col3a1; collagen alpha-1(III) chain [KO:K19720]
114705782  Tlr4; toll-like receptor 4 isoform X2 [KO:K10160]
114705806  C8b; complement component C8 beta chain [KO:K03998]
114705811  C8a; LOW QUALITY PROTEIN: complement component C8 alpha chain [KO:K03997]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114705921  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707088  Prdx1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
114707466  Rab5a; ras-related protein Rab-5A [KO:K07887]
114708363  Serpinb10; serpin B10 isoform X1 [KO:K13963]
114708454  Lamb1; laminin subunit beta-1 [KO:K05636]
114708764  [KO:K01319] [EC:3.4.21.20]
114709520  Il1b; interleukin-1 beta [KO:K04519]
114709687  [KO:K13279] [EC:1.11.1.24]
114710188  Tlr2; toll-like receptor 2 [KO:K10159]
114710308  Hspb1; heat shock protein beta-1 [KO:K04455]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
pleu00330  Arginine and proline metabolism
pleu00590  Arachidonic acid metabolism
pleu04144  Endocytosis
pleu04210  Apoptosis
pleu04510  Focal adhesion
pleu04610  Complement and coagulation cascades
pleu04612  Antigen processing and presentation
pleu04620  Toll-like receptor signaling pathway
pleu04672  Intestinal immune network for IgA production
pleu04810  Regulation of actin cytoskeleton
KO pathway
ko05146   

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