KEGG   PATHWAY: pmei05168
Entry
pmei05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Poecilia mexicana (shortfin molly)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
pmei05168  Herpes simplex virus 1 infection
pmei05168

Disease
H00365  Herpes simplex virus infection
Organism
Poecilia mexicana (shortfin molly) [GN:pmei]
Gene
106903295  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
106903618  [KO:K06752]
106903619  [KO:K06752]
106904240  c5; complement C5 isoform X1 [KO:K03994]
106904317  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
106904394  [KO:K04734]
106904534  [KO:K12794]
106904584  [KO:K05131]
106904588  [KO:K05131]
106904726  [KO:K07208]
106904784  [KO:K21123]
106904966  itga5; integrin alpha-5 [KO:K06484]
106905173  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
106905590  hcfc1; host cell factor 1 [KO:K14966]
106905594  bcl2l1; bcl-2-like protein 1 [KO:K04570]
106905741  irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
106906082  [KO:K02187] [EC:3.4.22.56]
106906108  [KO:K05411]
106906312  rhebl1; GTPase RhebL1 [KO:K07208]
106906339  [KO:K07206]
106906548  [KO:K00922] [EC:2.7.1.153]
106906595  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
106906819  alyref; THO complex subunit 4 [KO:K12881]
106906888  syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
106906948  [KO:K05425]
106907132  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106907216  cd74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
106907379  [KO:K04390]
106907457  [KO:K06269] [EC:3.1.3.16]
106907458  [KO:K04735]
106907592  itgb3; integrin beta-3 [KO:K06493]
106907627  [KO:K08738]
106907676  [KO:K11220]
106907688  [KO:K04519]
106907697  [KO:K05411]
106907785  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
106907915  [KO:K02649]
106908122  [KO:K02649]
106908352  [KO:K05654] [EC:7.4.2.14]
106908377  [KO:K12893]
106908735  [KO:K03156]
106908749  [KO:K06752]
106908750  [KO:K06752]
106908755  [KO:K08055]
106908907  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
106908943  hcfc2; host cell factor 2 [KO:K27390]
106908953  srsf1; serine/arginine-rich splicing factor 1 [KO:K12890]
106909014  [KO:K05406]
106909108  [KO:K06081]
106909533  [KO:K06751]
106909628  [KO:K11221]
106909697  ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
106909765  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
106909806  [KO:K04733] [EC:2.7.11.1]
106909973  stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
106910062  tmem173; stimulator of interferon genes protein [KO:K12654]
106910161  [KO:K08738]
106910271  [KO:K02649]
106910306  [KO:K05152]
106910517  [KO:K02159]
106910681  [KO:K07206]
106910902  [KO:K14966]
106911031  [KO:K02308]
106911032  [KO:K08058]
106911450  [KO:K06751]
106911451  [KO:K06751]
106911452  [KO:K06751]
106911808  [KO:K17834] [EC:2.7.7.86]
106911935  [KO:K03990]
106911951  srsf7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
106912044  [KO:K06751]
106912079  [KO:K06751]
106912590  fadd; FAS-associated death domain protein isoform X1 [KO:K02373]
106912684  [KO:K06751]
106913258  [KO:K06751]
106913259  [KO:K06751]
106913360  [KO:K05152]
106913936  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106913976  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
106914778  [KO:K08057]
106914909  [KO:K12892]
106915153  [KO:K04467] [EC:2.7.11.10]
106915255  pvrl1; nectin-1 isoform X1 [KO:K06081]
106915593  jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
106915669  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
106915984  [KO:K05654] [EC:7.4.2.14]
106915993  [KO:K04467] [EC:2.7.11.10]
106916137  [KO:K08056] [EC:5.3.4.1]
106916375  [KO:K04389]
106916462  [KO:K05842]
106916463  [KO:K05842]
106916906  bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
106917048  [KO:K03173] [EC:2.3.2.27]
106917051  [KO:K02649]
106917087  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
106917126  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106917165  [KO:K05425]
106917394  [KO:K15409] [EC:2.7.11.1]
106917430  traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
106917577  tsc2; tuberin isoform X1 [KO:K07207]
106917864  [KO:K06531]
106917869  pou2f2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
106919021  [KO:K02649]
106919132  tp53; cellular tumor antigen p53 [KO:K04451]
106919213  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
106919345  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
106919504  [KO:K06751]
106919799  bcl2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
106920012  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
106920022  eif2b4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
106920078  socs3; suppressor of cytokine signaling 3 [KO:K04696]
106920168  srsf6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
106920377  [KO:K10159]
106920386  [KO:K05468]
106920607  [KO:K00922] [EC:2.7.1.153]
106920845  [KO:K04389]
106921037  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
106921186  [KO:K12890]
106921188  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
106921217  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
106921305  [KO:K06081]
106921375  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106921379  tapbpl; tapasin-related protein [KO:K28445]
106921383  [KO:K05414]
106921384  [KO:K05414]
106921385  [KO:K05414]
106921387  [KO:K05414]
106921388  [KO:K05414]
106921645  [KO:K04427] [EC:2.7.11.25]
106921698  [KO:K03158]
106921755  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106921808  [KO:K12881]
106922023  [KO:K03990]
106922024  [KO:K05477]
106922060  [KO:K03990]
106922061  [KO:K03990]
106922062  [KO:K03990]
106922651  [KO:K07205]
106922882  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
106922947  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
106923428  [KO:K17834] [EC:2.7.7.86]
106923569  [KO:K08738]
106923581  [KO:K08738]
106923598  cfp; properdin [KO:K15412]
106923896  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
106924075  [KO:K04398] [EC:3.4.22.61]
106924079  [KO:K04398] [EC:3.4.22.61]
106924266  [KO:K06752]
106924267  [KO:K06752]
106924268  tlr2; toll-like receptor 2 isoform X1 [KO:K10159]
106924395  [KO:K11221]
106924493  [KO:K05152]
106924494  [KO:K05152]
106924700  [KO:K06269] [EC:3.1.3.16]
106924736  srsf5; serine/arginine-rich splicing factor 5 [KO:K12893]
106925041  [KO:K06484]
106925142  [KO:K02159]
106925143  [KO:K02159]
106925185  pou2f1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
106925204  [KO:K05414]
106925262  eif2b1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
106925686  [KO:K05406]
106925693  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
106926303  [KO:K09364]
106926427  [KO:K04398] [EC:3.4.22.61]
106926612  [KO:K05425]
106926837  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
106926962  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
106927015  [KO:K05477]
106927467  [KO:K04696]
106927474  srsf2; serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
106927524  [KO:K04456] [EC:2.7.11.1]
106927666  [KO:K05704] [EC:2.7.10.2]
106927715  [KO:K06493]
106927941  pdia3; LOW QUALITY PROTEIN: protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
106928115  [KO:K06752]
106928117  [KO:K06752]
106928187  [KO:K12892]
106928488  [KO:K03990]
106928883  [KO:K02649]
106928990  [KO:K00922] [EC:2.7.1.153]
106929012  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
106929179  [KO:K06752]
106929180  [KO:K06752]
106929181  [KO:K06752]
106929183  [KO:K06752]
106929365  rheb; GTP-binding protein Rheb [KO:K07208]
106929406  [KO:K12893]
106929594  [KO:K05132]
106929973  [KO:K06751]
106929982  [KO:K06751]
106930107  nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
106930126  [KO:K05132]
106930372  [KO:K12896]
106930400  [KO:K07205]
106930528  [KO:K03173] [EC:2.3.2.27]
106930552  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106931037  [KO:K02187] [EC:3.4.22.56]
106931366  [KO:K15409] [EC:2.7.11.1]
106931439  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
106931920  [KO:K06269] [EC:3.1.3.16]
106931933  [KO:K08055]
106931968  tlr3; toll-like receptor 3 [KO:K05401]
106932106  [KO:K04456] [EC:2.7.11.1]
106932226  [KO:K08057]
106932448  [KO:K06269] [EC:3.1.3.16]
106932483  [KO:K05477]
106932994  [KO:K07293] [EC:3.1.3.48]
106933422  pou2f3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
106933429  [KO:K16195] [EC:2.7.11.1]
106933496  [KO:K06752]
106933497  [KO:K06752]
106933555  traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
106933633  [KO:K04456] [EC:2.7.11.1]
106933640  [KO:K04570]
106933748  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
106933859  [KO:K04447] [EC:2.7.10.2]
106933879  irf9; interferon regulatory factor 9 [KO:K04693]
106933981  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
106934087  [KO:K04398] [EC:3.4.22.61]
106934105  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
106934274  [KO:K06751]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
pmei03040  Spliceosome
pmei03050  Proteasome
pmei04115  p53 signaling pathway
pmei04210  Apoptosis
pmei04620  Toll-like receptor signaling pathway
pmei04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   

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