KEGG   PATHWAY: rbb05020
Entry
rbb05020                    Pathway                                
Name
Prion disease - Rhinopithecus bieti (black snub-nosed monkey)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
rbb05020  Prion disease
rbb05020

Disease
H00061  Prion disease
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
10549368  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
10549369  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
10549370  COX2; cytochrome c oxidase subunit II [KO:K02261]
10549371  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
10549372  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
10549373  COX3; cytochrome c oxidase subunit III [KO:K02262]
10549374  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
10549375  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
10549376  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
10549377  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
10549378  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
10549379  CYTB; cytochrome b [KO:K00412]
10549380  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
108512004  [KO:K05863]
108512012  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
108512073  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
108512141  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
108512335  [KO:K02267]
108512485  [KO:K03938]
108512689  [KO:K02187] [EC:3.4.22.56]
108512695  LAMC1; laminin subunit gamma-1 [KO:K05635]
108512725  NCF2; neutrophil cytosol factor 2 [KO:K08010]
108512764  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
108513174  [KO:K04741] [EC:3.4.22.-]
108513215  [KO:K02270]
108513536  SHFM1; 26S proteasome complex subunit DSS1 isoform X1 [KO:K10881]
108513654  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
108513794  [KO:K02132]
108513938  [KO:K02270]
108513939  NCF1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
108514155  [KO:K00415]
108514381  [KO:K03938]
108514539  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
108514651  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
108514742  [KO:K00420]
108514761  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
108514796  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
108515198  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108515204  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
108515311  [KO:K03949]
108515327  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
108515543  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
108515615  [KO:K05863]
108515623  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
108515681  [KO:K02737] [EC:3.4.25.1]
108515730  [KO:K03938]
108515747  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
108515883  [KO:K04392]
108515926  KIF5B; LOW QUALITY PROTEIN: kinesin-1 heavy chain [KO:K10396]
108515968  C9; complement component C9 [KO:K04000]
108516042  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
108516239  [KO:K03960]
108516255  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
108516314  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
108516511  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
108516634  [KO:K02272]
108516683  NDUFS4; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
108516875  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108516879  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
108517325  [KO:K00236]
108517346  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
108517508  [KO:K04440] [EC:2.7.11.24]
108517591  [KO:K00419]
108517636  [KO:K02272]
108517714  PSMD14; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
108517733  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
108518004  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
108518216  [KO:K02738] [EC:3.4.25.1]
108518287  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
108518420  [KO:K07374]
108518478  NCF4; neutrophil cytosol factor 4 [KO:K08012]
108518649  KLC2; kinesin light chain 2 [KO:K10407]
108518677  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
108518679  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
108518758  [KO:K05863]
108518794  RYR3; ryanodine receptor 3 [KO:K04963]
108518799  [KO:K02272]
108518846  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
108518882  EIF2AK3; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
108518996  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
108519025  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
108519118  [KO:K02273]
108519146  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
108519245  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
108519410  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
108519614  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
108519637  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
108519685  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
108519700  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
108519708  KIF5A; kinesin heavy chain [KO:K10396]
108519781  [KO:K03964]
108519898  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
108519915  [KO:K02271]
108520227  [KO:K03283]
108520228  [KO:K03283]
108520243  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
108520255  TNF; tumor necrosis factor isoform X1 [KO:K03156]
108520444  [KO:K08009]
108520463  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108520537  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
108520633  [KO:K07375]
108520942  SLC25A6; ADP/ATP translocase 3 isoform X1 [KO:K05863]
108521006  [KO:K02263]
108521141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108521164  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
108521165  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
108521361  [KO:K04853]
108521802  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
108521876  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
108522161  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
108522194  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
108522550  TUBB; tubulin beta chain [KO:K07375]
108522695  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
108522730  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
108522756  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
108522897  [KO:K21421] [EC:1.-.-.-]
108523036  NDUFB11; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
108523108  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
108523175  [KO:K02272]
108523391  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
108523439  [KO:K08738]
108523600  PSMB5; LOW QUALITY PROTEIN: proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
108523624  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108523739  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
108523982  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108524009  [KO:K08738]
108524146  [KO:K02263]
108524230  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
108524269  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
108524673  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
108524752  [KO:K07375]
108524844  PSMB6; LOW QUALITY PROTEIN: proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
108524923  [KO:K08738]
108525031  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
108525115  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
108525188  [KO:K02273]
108525461  [KO:K07374]
108525726  [KO:K07374]
108525816  [KO:K02272]
108526074  [KO:K03963]
108526140  [KO:K02268]
108526312  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X1 [KO:K03956]
108526355  [KO:K03945]
108527019  [KO:K00414]
108527083  [KO:K02272]
108527161  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
108527163  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
108527683  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108527757  [KO:K02266]
108527793  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
108528082  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
108528326  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108528327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108528700  CAV1; caveolin-1 isoform X1 [KO:K06278]
108528701  CAV2; caveolin-2 isoform X1 [KO:K12958]
108528737  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108528791  [KO:K03283]
108529080  TUBB3; LOW QUALITY PROTEIN: tubulin beta-3 chain [KO:K07375]
108529326  IL6; interleukin-6 isoform X1 [KO:K05405]
108529459  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
108529477  [KO:K02265]
108529513  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
108529563  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
108529577  [KO:K00418]
108529661  [KO:K02266]
108529724  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
108529787  [KO:K05863]
108529800  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
108529896  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
108529918  ATP5C1; LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial [KO:K02136]
108530029  [KO:K02271]
108530087  [KO:K08738]
108530245  [KO:K00420]
108530254  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
108530260  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
108530264  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
108530279  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108530376  [KO:K00236]
108530603  [KO:K00411] [EC:7.1.1.8]
108530604  [KO:K00411] [EC:7.1.1.8]
108530843  [KO:K03948]
108530950  CAV3; caveolin-3 [KO:K12959]
108530974  [KO:K03949]
108530984  [KO:K02272]
108531101  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
108531248  [KO:K02272]
108531361  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
108531375  PSMB7; proteasome subunit beta type-7 isoform X1 [KO:K02739] [EC:3.4.25.1]
108531483  [KO:K02264]
108531525  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
108531589  NCAM2; LOW QUALITY PROTEIN: neural cell adhesion molecule 2 [KO:K06491]
108531701  [KO:K00417]
108531931  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
108531954  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
108532059  [KO:K07375]
108532175  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
108532675  [KO:K03954]
108532882  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
108532893  [KO:K00411] [EC:7.1.1.8]
108532915  [KO:K08738]
108532932  C8B; complement component C8 beta chain [KO:K03998]
108532933  C8A; complement component C8 alpha chain [KO:K03997]
108532960  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108533229  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
108533239  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
108533297  [KO:K08738]
108533419  PRNP; major prion protein [KO:K05634]
108533475  KLC4; kinesin light chain 4 [KO:K10407]
108533712  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
108533896  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
108533955  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
108534025  KIF5C; kinesin heavy chain [KO:K10396]
108534276  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108534515  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
108534562  TUBB4A; tubulin beta-4A chain [KO:K07375]
108534879  [KO:K03959]
108535228  [KO:K02270]
108535266  PSMA7; LOW QUALITY PROTEIN: proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
108535273  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
108535274  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
108535460  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
108535520  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
108535521  [KO:K08738]
108535631  [KO:K00416]
108535636  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108535638  [KO:K02271]
108535888  [KO:K05863]
108535903  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108536276  PSMC5; 26S protease regulatory subunit 8 isoform X1 [KO:K03066]
108536287  [KO:K08738]
108536327  [KO:K03945]
108536431  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
108536453  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
108536503  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
108536532  [KO:K02268]
108536542  [KO:K00413]
108536840  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
108536866  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
108537065  [KO:K03963]
108537092  C5; complement C5 [KO:K03994]
108537102  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
108537157  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
108537161  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
108537259  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
108537403  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
108537436  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
108537794  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108537879  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
108537975  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
108537987  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
108538081  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
108538089  [KO:K04565] [EC:1.15.1.1]
108538160  [KO:K02268]
108538318  PSMD1; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
108538409  [KO:K03963]
108538439  C1QB; complement C1q subcomponent subunit B [KO:K03987]
108538440  C1QC; complement C1q subcomponent subunit C [KO:K03988]
108538441  C1QA; complement C1q subcomponent subunit A [KO:K03986]
108538456  [KO:K02272]
108538574  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
108538827  [KO:K08738]
108538844  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
108538989  RYR1; ryanodine receptor 1 [KO:K04961]
108539058  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
108539077  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
108539355  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108539403  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108539422  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
108540003  [KO:K04345] [EC:2.7.11.11]
108540349  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108540717  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
108540721  [KO:K02272]
108540785  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108541117  [KO:K02272]
108541175  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108541227  [KO:K02268]
108541249  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
108541286  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
108541378  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
108541464  CCL5; C-C motif chemokine 5 [KO:K12499]
108541536  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
108541619  TUBB1; tubulin beta-1 chain [KO:K07375]
108541621  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
108541689  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
108541700  EGR1; early growth response protein 1 [KO:K09203]
108541714  TUBA8; tubulin alpha-8 chain [KO:K07374]
108541757  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
108541808  IL1A; interleukin-1 alpha [KO:K04383]
108541809  IL1B; interleukin-1 beta [KO:K04519]
108541984  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
108542095  [KO:K02272]
108542119  [KO:K02272]
108542547  [KO:K02267]
108542554  [KO:K02270]
108542557  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
108542570  STIP1; stress-induced-phosphoprotein 1 isoform X1 [KO:K09553]
108542584  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
108542734  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108542795  [KO:K04348] [EC:3.1.3.16]
108542832  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
108542840  NOTCH1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599]
108542864  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
108542878  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
108542921  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
108542935  [KO:K03938]
108543209  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
108543345  [KO:K02268]
108543433  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
108543462  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
108543568  NDUFA6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
108544543  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
108544591  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108544739  C6; complement component C6 [KO:K03995]
108544742  C7; complement component C7 isoform X1 [KO:K03996]
108545075  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
PMID:27055367
  Authors
Saa P, Harris DA, Cervenakova L
  Title
Mechanisms of prion-induced neurodegeneration.
  Journal
Expert Rev Mol Med 18:e5 (2016)
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Reference
PMID:25584786
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  Title
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Mol Cell Neurosci 66:12-20 (2015)
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Reference
PMID:20889378
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  Title
The intricate mechanisms of neurodegeneration in prion diseases.
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Trends Mol Med 17:14-24 (2011)
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Reference
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Reference
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Reference
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Reference
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  Title
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Reference
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Reference
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Neurobiol Dis 8:743-63 (2001)
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Reference
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  Title
Prions: protein only or something more? Overview of potential prion cofactors.
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Reference
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J Neurosci Res 75:153-61 (2004)
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Reference
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Reference
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  Title
Prion biology relevant to bovine spongiform encephalopathy.
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J Anim Sci 83:1455-76 (2005)
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Reference
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  Title
Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
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Biochem Biophys Res Commun 483:1148-1155 (2017)
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Reference
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  Title
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Int J Mol Sci 20:E5107 (2019)
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Reference
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Int J Mol Sci 20:E6004 (2019)
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Reference
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Mol Neurobiol 56:6035-6045 (2019)
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Reference
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Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
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Reference
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Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
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  Authors
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  Title
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Reference
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  Title
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Reference
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Reference
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Reference
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An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
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Neurobiol Dis 23:669-78 (2006)
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Reference
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Reference
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Disease-associated prion protein oligomers inhibit the 26S proteasome.
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Reference
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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
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Reference
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Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
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Reference
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Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
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Front Cell Neurosci 13:350 (2019)
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Reference
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  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
  Journal
PLoS One 12:e0188340 (2017)
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Reference
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Understanding the neurospecificity of Prion protein signaling.
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Front Biosci (Landmark Ed) 16:169-86 (2011)
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Reference
PMID:23479001
  Authors
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  Title
Prion protein and its role in signal transduction.
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Cell Mol Biol Lett 18:209-30 (2013)
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Reference
PMID:28507517
  Authors
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The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
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Front Aging Neurosci 9:120 (2017)
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Reference
PMID:15528202
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
  Journal
J Biol Chem 280:1529-34 (2005)
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Reference
PMID:15640354
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
  Journal
Proc Natl Acad Sci U S A 102:886-91 (2005)
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Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
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Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
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Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
DOI:10.1172/JCI90605
Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
rbb00190  Oxidative phosphorylation
rbb03050  Proteasome
rbb04020  Calcium signaling pathway
rbb04140  Autophagy - animal
rbb04141  Protein processing in endoplasmic reticulum
rbb04142  Lysosome
rbb04144  Endocytosis
rbb04210  Apoptosis
rbb04330  Notch signaling pathway
rbb04610  Complement and coagulation cascades
rbb04668  TNF signaling pathway
KO pathway
ko05020   

DBGET integrated database retrieval system