KEGG   PATHWAY: sasa04620
Entry
sasa04620                   Pathway                                
Name
Toll-like receptor signaling pathway - Salmo salar (Atlantic salmon)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
sasa04620  Toll-like receptor signaling pathway
sasa04620

Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106604777  toll-like receptor 6 [KO:K05398]
106608430  toll-like receptor 2 [KO:K10159]
106580799  toll-like receptor 2 type-2 [KO:K10159]
106605325  toll-like receptor 2 type-1 [KO:K10159]
100196705  bpi; Bactericidal permeability-increasing protein [KO:K05399]
106602560  tlr3; toll like receptor 3 [KO:K05401]
106571469  tlr5; toll like receptor 5 [KO:K10168]
106572741  toll-like receptor 5 [KO:K10168]
100136921  tl/lrr; toll-like leucine-rich repeat [KO:K10168]
106586812  TLR7; toll-like receptor 7 [KO:K05404]
100136557  tlr9; toll-like receptor 9 [KO:K05404]
106568387  TLR8b1; toll-like receptor 8 [KO:K10170]
106563113  TLR8b2; toll-like receptor 8 [KO:K10170]
106581917  TLR8a2; toll-like receptor 8 [KO:K10170]
100302030  TLR8-like [KO:K10170]
106580864  cathepsin K-like [KO:K01371] [EC:3.4.22.38]
100195370  catk; Cathepsin K [KO:K01371] [EC:3.4.22.38]
106609976  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
106601744  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
106606203  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
106606735  RAC1; ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
106589605  rac1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
106598808  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
106568747  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
106572046  pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
106581359  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
106613931  pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
106613172  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
106600405  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106567700  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
106599005  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
106560529  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106613635  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106569403  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106568949  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
106573900  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106563018  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
106584012  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106587034  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
106582637  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106585772  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106602915  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106607890  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106610858  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106564869  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106613111  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106581334  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106571474  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100194605  akt2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
106589689  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100169858  TOLIP; toll-interacting protein-like [KO:K05402]
106587464  toll-interacting protein-like [KO:K05402]
100169859  myd88; myeloid differentiation primary response 88 [KO:K04729]
106581078  toll/interleukin-1 receptor domain-containing adapter protein-like [KO:K05403]
106561969  FADD; FAS-associated death domain protein-like [KO:K02373]
106587129  FADD; FAS-associated death domain protein-like [KO:K02373]
106569473  caspase-8-like [KO:K04398] [EC:3.4.22.61]
106586254  caspase-8-like [KO:K04398] [EC:3.4.22.61]
106582462  caspase-8-like [KO:K04398] [EC:3.4.22.61]
100196744  irak4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
106566344  interleukin-1 receptor-associated kinase 1-like [KO:K04730] [EC:2.7.11.1]
106562692  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
106592035  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
106590780  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
106594427  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1-like [KO:K04403]
106607744  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404]
106571309  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2-like [KO:K04404]
106572417  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
100196829  map3k7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
106610755  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
106571331  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
106572992  NF-kappa-B essential modulator-like [KO:K07210]
106590733  ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
106592447  NF-kappa-B essential modulator-like [KO:K07210]
106579286  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106579422  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106589264  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106580426  ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106601178  IKBA; NF-kappa-B inhibitor alpha-like [KO:K04734]
106607598  IKBA; NF-kappa-B inhibitor alpha-like [KO:K04734]
106611175  IKBA; NF-kappa-B inhibitor alpha-like [KO:K04734]
106571222  IKBA; NF-kappa-B inhibitor alpha-like [KO:K04734]
106604768  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
106611703  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
106608684  putative transcription factor p65 homolog [KO:K04735]
106577543  transcription factor p65-like [KO:K04735]
106578553  mitogen-activated protein kinase kinase kinase 8-like [KO:K04415] [EC:2.7.11.25]
100380500  m3k8; Mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
106584829  map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106600441  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
106613775  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106569535  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
100194780  mp2k2; Dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106570952  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106600714  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106592057  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
100380511  mk03; Mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106601934  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
106606355  dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
106606359  dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100136944  mkk6a; mitogen-activated protein kinase kinase 6a [KO:K04433] [EC:2.7.12.2]
100192337  mkk6b; MAPK kinase 6b [KO:K04433] [EC:2.7.12.2]
100192338  mkk6c; MAPK kinase 6c [KO:K04433] [EC:2.7.12.2]
106601504  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
106578855  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
106589490  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
100196891  map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
106587435  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
106564723  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
106609456  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
106609457  MK12; mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106561402  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106566975  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106566983  mitogen-activated protein kinase 14A [KO:K04441] [EC:2.7.11.24]
106573286  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106572737  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106572761  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106566105  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106566106  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106576243  MK12; mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106576244  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
100137046  p38b; mitogen activated protein kinase p38b [KO:K04441] [EC:2.7.11.24]
100196619  mk13; Mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100136932  p38a; mitogen activated protein kinase p38a [KO:K04441] [EC:2.7.11.24]
106604288  mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106560362  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106604910  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
106568502  mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106576863  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
106579004  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106563760  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
106589346  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
106600411  jun; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
106613963  JUN; transcription factor AP-1-like [KO:K04448]
106569413  transcription factor AP-1-like [KO:K04448]
106568560  transcription factor AP-1-like [KO:K04448]
106584280  JUN; transcription factor AP-1-like [KO:K04448]
106572830  transcription factor AP-1-like [KO:K04448]
106591288  proto-oncogene c-Fos-like [KO:K04379]
106608293  proto-oncogene c-Fos-like [KO:K04379]
106608294  proto-oncogene c-Fos-like [KO:K04379]
106611096  proto-oncogene c-Fos-like [KO:K04379]
106571028  proto-oncogene c-Fos-like [KO:K04379]
106571032  proto-oncogene c-Fos-like [KO:K04379]
100136457  tnf-alpha-1; tumor necrosis factor alpha-1 precursor [KO:K03156]
100136458  tnf-alpha-2; tumor necrosis factor alpha-2 precursor [KO:K03156]
100136509  tumor necrosis factor alpha [KO:K03156]
106589058  tumor necrosis factor-like [KO:K03156]
106562915  IL-1b3; interleukin-1 beta-like [KO:K04519]
106570815  interleukin-1 beta-like [KO:K04519]
100136449  interleukin-1 beta [KO:K04519]
106570581  IL6; interleukin-6 [KO:K05405]
106588787  interleukin-6-like [KO:K05405]
106580951  uncharacterized LOC106580951 [KO:K05406]
106604286  interleukin-12 subunit beta-like [KO:K05425]
106603888  IL12B; interleukin-12 subunit beta-like [KO:K05425]
106607975  IL12B; interleukin-12 subunit beta-like [KO:K05425]
106612126  interleukin-12 subunit beta-like [KO:K05425]
106567437  interleukin-12 subunit beta-like [KO:K05425]
106601371  permeability factor 2-like [KO:K10030]
106601388  growth-regulated alpha protein-like [KO:K10030]
106607048  permeability factor 2-like [KO:K10030]
100195681  il8; interleukin 8 [KO:K10030]
100196393  mip2a; Macrophage inflammatory protein 2-alpha [KO:K10030]
106580715  interleukin-8-like [KO:K10030]
106595660  interleukin-8-like [KO:K10030]
100196096  ccl8; C-C motif chemokine 8 [KO:K05408]
106608548  CCL4; C-C motif chemokine 4-like [KO:K12964]
106560915  C-C motif chemokine 8-like [KO:K12964]
106584543  TIR domain-containing adapter molecule 1-like [KO:K05842]
106599735  receptor-interacting serine/threonine-protein kinase 1-like [KO:K02861] [EC:2.7.11.1]
106569156  ripk1; receptor interacting serine/threonine kinase 1 [KO:K02861] [EC:2.7.11.1]
106609132  interferon regulatory factor 5-like [KO:K09446]
100194823  irf5; interferon regulatory factor 5 [KO:K09446]
100192336  irf7; interferon regulatory factor 7 [KO:K09447]
100329194  irf7b; interferon regulatory factor 7B [KO:K09447]
106565715  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like [KO:K07211] [EC:2.7.11.10]
100861582  tbk1; TANK-binding kinase 1 [KO:K05410] [EC:2.7.11.10]
106600975  TNF receptor-associated factor 3-like [KO:K03174]
106611198  traf3; TNF receptor associated factor 3 [KO:K03174]
100337625  irf-3; interferon regulatory factor 3 [KO:K05411]
106567123  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
100196207  tnr5; Tumor necrosis factor receptor superfamily member 5 [KO:K03160]
106575707  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
106576603  tumor necrosis factor receptor superfamily member 5-like [KO:K03160]
106581370  uncharacterized LOC106581370 [KO:K05412]
106597877  interferon tau-like [KO:K05414]
106600780  interferon alpha-3-like [KO:K05414]
106600783  interferon a3-like [KO:K05414]
106600865  interferon a3 [KO:K05414]
106600866  interferon a3-like [KO:K05414]
106600867  interferon a3-like [KO:K05414]
106600962  interferon a3-like [KO:K05414]
106600963  interferon; interferon a3-like [KO:K05414]
106600964  interferon a3-like [KO:K05414]
106600965  IFNc2; interferon alpha-1-like [KO:K05414]
106600969  interferon a3-like [KO:K05414]
106600970  interferon beta-like [KO:K05414]
106607408  interferon tau-9-like [KO:K05414]
106607525  interferon alpha-3-like [KO:K05414]
106607528  interferon alpha-6-like [KO:K05414]
106607529  interferon alpha-2-like [KO:K05414]
106597883  interferon alpha-2-like [KO:K05414]
100136436  ifna2; interferon alpha 2 [KO:K05414]
106593233  interferon a3-like [KO:K05414]
101448043  IFNc [KO:K05414]
106589965  interferon a3-like [KO:K05414]
106596334  interferon a3-like [KO:K05414]
106592586  interferon a3-like [KO:K05414]
100137019  ifna1; interferon alpha 1 [KO:K05414]
106597742  interferon alpha-2-like [KO:K05414]
106597870  interferon alpha-2-like [KO:K05414]
106594533  interferon alpha-2-like [KO:K05414]
106594534  interferon alpha-2-like [KO:K05414]
106590949  interferon a3-like [KO:K05414]
106593349  interferon alpha-3-like [KO:K05414]
106593350  interferon a3-like [KO:K05414]
106595256  interferon alpha-2-like [KO:K05414]
106598185  interferon a3-like [KO:K05414]
106593342  interferon alpha-3-like [KO:K05414]
101448041  IFNd [KO:K05414]
106607463  interferon a3-like [KO:K05414]
101448042  IFNb [KO:K05414]
106600961  ifne; interferon epsilon [KO:K05414]
106593401  interferon alpha/beta receptor 2-like [KO:K05131]
106595354  interferon alpha/beta receptor 2-like [KO:K05131]
106597313  interferon alpha/beta receptor 2-like [KO:K05131]
100196051  i20ra; Interleukin-20 receptor alpha chain [KO:K05131]
106586858  CRFB2; interleukin-10 receptor subunit beta-like [KO:K05131]
106598436  tyrosine-protein kinase JAK1-like [KO:K11217] [EC:2.7.10.2]
106568720  tyrosine-protein kinase JAK1-like [KO:K11217] [EC:2.7.10.2]
100286690  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
106560467  jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
106601287  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
106607218  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
106597276  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
100136558  STAT1; signal transducer and activator of transcription 1 alpha [KO:K11220]
106586142  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
100270812  stat2; signal transducer and activator of transcription 2 [KO:K11221]
106590411  interferon regulatory factor 8-like [KO:K04693]
100380435  irf9; interferon regulatory factor 9 [KO:K04693]
100195999  cxl10; C-X-C motif chemokine 10 [KO:K12671]
106576872  C-X-C motif chemokine 9-like [KO:K05416]
106577833  interleukin-8-like [KO:K05416]
106570878  C-X-C motif chemokine 11-like [KO:K12672]
100196194  scyb7; Platelet basic protein [KO:K12672]
106570889  SCYB7; C-X-C motif chemokine 11-like [KO:K12672]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
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Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
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Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
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Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
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Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
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Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
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J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
sasa04010  MAPK signaling pathway
sasa04060  Cytokine-cytokine receptor interaction
sasa04120  Ubiquitin mediated proteolysis
sasa04210  Apoptosis
KO pathway
ko04620   
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