KEGG   PATHWAY: sasa04120
Entry
sasa04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Salmo salar (Atlantic salmon)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
sasa04120  Ubiquitin mediated proteolysis
sasa04120

Other DBs
GO: 0016567
Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106603500  ubc; ubiquitin C [KO:K08770]
106599031  UBIQ; ubiquitin-60S ribosomal protein L40-like [KO:K02927]
106613625  UBIQ; ubiquitin-60S ribosomal protein L40-like [KO:K02927]
100136537  UBIQ; ubiquitin-60S ribosomal protein L40 [KO:K02927]
106584630  ubiquitin-60S ribosomal protein L40 [KO:K02927]
100194659  UBIQ; ubiquitin A-52 residue ribosomal protein fusion product 1like 2 [KO:K02927]
106577118  UBIQ; ubiquitin-40S ribosomal protein S27a [KO:K02977]
100194654  UBIQ; ribosomal protein S27-3 [KO:K02977]
106566326  uba1; ubiquitin like modifier activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
106566065  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
106612594  SUMO-activating enzyme subunit 1-like [KO:K10684] [EC:6.2.1.45]
100286575  sae1; SUMO1 activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
106560931  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
100196620  sae2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
106572411  NEDD8-activating enzyme E1 catalytic subunit-like [KO:K10686] [EC:6.2.1.64]
106567275  uba3; ubiquitin like modifier activating enzyme 3 [KO:K10686] [EC:6.2.1.64]
100196693  uba3; ubiquitin-like modifier activating enzyme 3 [KO:K10686] [EC:6.2.1.64]
106602516  ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
106611512  ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
106582136  UBE2A; ubiquitin-conjugating enzyme E2 A-like [KO:K10573] [EC:2.3.2.23]
100195873  ube2a; ubiquitin-conjugating enzyme E2A (RAD6 homolog) [KO:K10573] [EC:2.3.2.23]
106586675  UBE2A; ubiquitin-conjugating enzyme E2 A-like [KO:K10573] [EC:2.3.2.23]
106567528  ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
100286422  ube2b; ubiquitin-conjugating enzyme E2B (RAD6 homolog) [KO:K10574] [EC:2.3.2.23]
106565291  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
100195599  ube2c; ubiquitin-conjugating enzyme E2C [KO:K06688] [EC:2.3.2.23]
106563190  UB2D2; ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
106560770  UB2D4; ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
106607701  UB2D4; ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
106604403  UB2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
106603036  UB2D2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
106611705  UB2D2; ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
106612114  ube2d2; ubiquitin conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
106563627  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
106580382  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
106577066  ub2d4; ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
106595133  UB2D4; ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
100194508  ube2d2; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) [KO:K06689] [EC:2.3.2.23]
106585615  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
106582094  UB2E1; ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
106582102  ubiquitin-conjugating enzyme E2 E2-like [KO:K20217] [EC:2.3.2.23]
106605266  ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
106605267  UB2E1; ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
106570282  ubiquitin-conjugating enzyme E2 E2-like [KO:K20217] [EC:2.3.2.23]
106570284  ube2e1; ubiquitin conjugating enzyme E2 E1 [KO:K20217] [EC:2.3.2.23]
100196756  ub2e2; Ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
100195242  ub2e3; Ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
100194512  ube2e3; ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) [KO:K20217] [EC:2.3.2.23]
106588666  ubiquitin-conjugating enzyme E2 E1-like [KO:K20217] [EC:2.3.2.23]
106582389  NEDD8-conjugating enzyme UBE2F-like [KO:K10687] [EC:2.3.2.34]
100380844  ube2f; ubiquitin-conjugating enzyme E2F (putative) [KO:K10687] [EC:2.3.2.34]
106603929  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
106567414  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
106579958  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
100194539  ube2g1; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) [KO:K10575] [EC:2.3.2.23]
100195437  ub2g1; Ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
106585472  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
106582559  ube2g2; ubiquitin conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
106573382  ubiquitin-conjugating enzyme E2 H-like [KO:K10576] [EC:2.3.2.23]
106561328  ubiquitin-conjugating enzyme E2 H-like [KO:K10576] [EC:2.3.2.23]
106576478  ubiquitin-conjugating enzyme E2 H-like [KO:K10576] [EC:2.3.2.23]
100306815  ube2h; ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) [KO:K10576] [EC:2.3.2.23]
106600883  UBC9; SUMO-conjugating enzyme UBC9-like [KO:K10577]
106601101  UBC9B; SUMO-conjugating enzyme UBC9-B [KO:K10577]
106607450  UBC9B; SUMO-conjugating enzyme UBC9-like [KO:K10577]
106607355  UBC9B; SUMO-conjugating enzyme UBC9-B [KO:K10577]
106579230  ube2i; ubiquitin conjugating enzyme E2 I [KO:K10577]
106578266  UBC9B; SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
100194967  ube2j1; ubiquitin conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
106571293  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
106565615  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
100286428  ube2j2; ubiquitin conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
106602110  UBE2K; ubiquitin-conjugating enzyme E2 K-like [KO:K04649] [EC:2.3.2.23]
106604781  ube2k; ubiquitin conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
106611694  ube2k; ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
106596414  ubiquitin-conjugating enzyme E2 K-like [KO:K04649] [EC:2.3.2.23]
106595367  ubiquitin-conjugating enzyme E2 K [KO:K04649] [EC:2.3.2.23]
106562742  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
106570866  UB2L3; ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
100196255  ub2l3; Ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
106585881  ube2l3; ubiquitin conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
106600804  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
100380794  ubc12; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
106609528  UBE2N; ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
106573305  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
106576396  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
100196168  ube2n; ubiquitin-conjugating enzyme E2N [KO:K10580] [EC:2.3.2.23]
106588250  E2/E3 hybrid ubiquitin-protein ligase UBE2O-like [KO:K10581] [EC:2.3.2.24]
106564911  E2/E3 hybrid ubiquitin-protein ligase UBE2O-like [KO:K10581] [EC:2.3.2.24]
106570337  ube2ql1; ubiquitin conjugating enzyme E2 Q family like 1 [KO:K10582] [EC:2.3.2.23]
106562136  ubiquitin-conjugating enzyme E2 Q2-like [KO:K10582] [EC:2.3.2.23]
106584716  ubiquitin-conjugating enzyme E2 Q2-like [KO:K10582] [EC:2.3.2.23]
106588697  ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
106587229  ubiquitin-conjugating enzyme E2 Q2-like [KO:K10582] [EC:2.3.2.23]
106565188  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
106613805  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
106569523  UB2R1; ubiquitin-conjugating enzyme E2 R1-like [KO:K02207] [EC:2.3.2.23]
106585695  ubiquitin-conjugating enzyme E2 R2-like [KO:K02207] [EC:2.3.2.23]
100194908  ub2r2; Ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
100194582  ube2r2; ubiquitin-conjugating enzyme E2R 2 [KO:K02207] [EC:2.3.2.23]
100195086  ub2r1; Ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
106584404  ubiquitin-conjugating enzyme E2 R1-like [KO:K02207] [EC:2.3.2.23]
106575167  ube2s; ubiquitin conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
106605770  ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
106598611  ubiquitin-conjugating enzyme E2 U-like [KO:K10584] [EC:2.3.2.23]
106579737  ube2w; ubiquitin conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
106591739  probable ubiquitin-conjugating enzyme E2 W-B [KO:K10688] [EC:2.3.2.23 2.3.2.25]
106607493  ubiquitin-conjugating enzyme E2 Z-like [KO:K10585] [EC:2.3.2.23]
100380568  ube2z; Ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
106576946  baculoviral IAP repeat-containing protein 6-like [KO:K10586] [EC:2.3.2.23]
106606575  baculoviral IAP repeat-containing protein 6-like [KO:K10586] [EC:2.3.2.23]
106592393  ubiquitin-protein ligase E3A-like [KO:K10587] [EC:2.3.2.26]
106575664  ubiquitin-protein ligase E3A-like [KO:K10587] [EC:2.3.2.26]
106575697  ubiquitin-protein ligase E3A-like [KO:K10587] [EC:2.3.2.26]
106574742  ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
106574119  ubiquitin-protein ligase E3A-like [KO:K10587] [EC:2.3.2.26]
106560665  ubiquitin-protein ligase E3A-like [KO:K10587] [EC:2.3.2.26]
106580104  ubiquitin-protein ligase E3B-like [KO:K10588] [EC:2.3.2.26]
106585662  ubiquitin-protein ligase E3B-like [KO:K10588] [EC:2.3.2.26]
106578613  ubiquitin-protein ligase E3C-like [KO:K10589] [EC:2.3.2.26]
106588327  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
106601396  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
106607065  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
106564903  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
106565280  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
106566898  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
106572363  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
106583663  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
106578528  wwp1; WW domain containing E3 ubiquitin protein ligase 1 [KO:K05633] [EC:2.3.2.26]
106573662  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
106560906  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
106612584  E3 ubiquitin-protein ligase TRIP12-like [KO:K10590] [EC:2.3.2.26]
106580884  E3 ubiquitin-protein ligase TRIP12 [KO:K10590] [EC:2.3.2.26]
106562216  E3 ubiquitin-protein ligase NEDD4-like [KO:K10591] [EC:2.3.2.26]
106587433  E3 ubiquitin-protein ligase NEDD4-like [KO:K10591] [EC:2.3.2.26]
106568483  nedd4l; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase [KO:K13305] [EC:2.3.2.26]
100380641  huwe1; E3 ubiquitin-protein ligase HUWE1 [KO:K10592] [EC:2.3.2.26]
106567026  E3 ubiquitin-protein ligase HUWE1-like [KO:K10592] [EC:2.3.2.26]
106579145  E3 ubiquitin-protein ligase UBR5-like [KO:K10593] [EC:2.3.2.26]
106605530  E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
106576577  herc1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [KO:K10594] [EC:2.3.2.26]
106568497  probable E3 ubiquitin-protein ligase HERC1 [KO:K10594] [EC:2.3.2.26]
106613411  herc2; HECT and RLD domain containing E3 ubiquitin protein ligase 2 [KO:K10595] [EC:2.3.2.26]
106602650  E3 ISG15--protein ligase HERC5-like [KO:K10614] [EC:2.3.2.26]
106610289  probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
106597100  E3 ISG15--protein ligase HERC5-like [KO:K10614] [EC:2.3.2.26]
106602322  probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
106576831  herc4; HECT and RLD domain containing E3 ubiquitin protein ligase 4 [KO:K10615] [EC:2.3.2.26]
106612478  ube4a; ubiquitination factor E4A [KO:K10596] [EC:2.3.2.27]
106572050  ube4b; ubiquitination factor E4B [KO:K10597] [EC:2.3.2.27]
100380420  ube4b; ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) [KO:K10597] [EC:2.3.2.27]
106606340  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
106579200  stub1; STIP1 homology and U-box containing protein 1 [KO:K09561] [EC:2.3.2.27]
106593034  STIP1 homology and U box-containing protein 1-like [KO:K09561] [EC:2.3.2.27]
100380839  ppil2; peptidylprolyl isomerase like 2 [KO:K10598] [EC:5.2.1.8]
106602585  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
106611702  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
106609896  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
100380596  prp19; PRP19/PSO4 homolog (S. cerevisiae) [KO:K10599] [EC:2.3.2.27]
106580617  RING finger protein 37-like [KO:K10600]
106585184  RING finger protein 37-like [KO:K10600]
106609861  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597239  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597562  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597420  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106593772  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597741  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597260  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597762  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106597621  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106594600  mdm2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
106597585  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
106603416  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
106567671  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
106612473  cbl; Cbl proto-oncogene [KO:K04707] [EC:2.3.2.27]
106602828  cblb; Cbl proto-oncogene B [KO:K22517] [EC:2.3.2.27]
106605677  E3 ubiquitin-protein ligase CBL-like [KO:K22518] [EC:2.3.2.27]
106577440  E3 ubiquitin-protein ligase CBL-like [KO:K22518] [EC:2.3.2.27]
106576740  park2; parkin RBR E3 ubiquitin protein ligase [KO:K04556] [EC:2.3.2.31]
106573709  E3 ubiquitin-protein ligase Siah1-like [KO:K04506] [EC:2.3.2.27]
106560862  siah1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:2.3.2.27]
106562692  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
106592035  TNF receptor-associated factor 6-like [KO:K03175] [EC:2.3.2.27]
106571505  map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
106562896  mitogen-activated protein kinase kinase kinase 1-like [KO:K04416] [EC:2.7.11.25]
106599409  rfwd2; ring finger and WD repeat domain 2 [KO:K10143] [EC:2.3.2.27]
106569074  E3 ubiquitin-protein ligase RFWD2-like [KO:K10143] [EC:2.3.2.27]
106580050  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
106585722  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
106585368  RING finger and CHY zinc finger domain-containing protein 1-like [KO:K10144] [EC:2.3.2.27]
106604062  inhibitor of apoptosis protein-like [KO:K16060]
106563947  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
106604301  E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
106612162  BIRC4; E3 ubiquitin-protein ligase XIAP-like [KO:K04725] [EC:2.3.2.27]
106600607  baculoviral IAP repeat-containing protein 7-like [KO:K16061]
106566594  baculoviral IAP repeat-containing protein 7-like [KO:K16061]
106562666  E3 SUMO-protein ligase PIAS1-like [KO:K04706] [EC:2.3.2.-]
106561853  pias1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:2.3.2.-]
106595921  E3 SUMO-protein ligase PIAS1-like [KO:K04706] [EC:2.3.2.-]
106584817  E3 SUMO-protein ligase PIAS1-like [KO:K04706] [EC:2.3.2.-]
106585990  E3 SUMO-protein ligase PIAS2-like [KO:K16063] [EC:2.3.2.-]
106570963  E3 SUMO-protein ligase PIAS2-like [KO:K16063] [EC:2.3.2.-]
106613774  E3 SUMO-protein ligase PIAS4-like [KO:K16065] [EC:2.3.2.27]
106569534  E3 SUMO-protein ligase PIAS4-like [KO:K16065] [EC:2.3.2.27]
106584429  E3 SUMO-protein ligase PIAS4-like [KO:K16065] [EC:2.3.2.27]
106604148  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
106612292  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
106574154  E3 ubiquitin-protein ligase NHLRC1-like [KO:K10602] [EC:2.3.2.27]
106595790  E3 ubiquitin-protein ligase NHLRC1-like [KO:K10602] [EC:2.3.2.27]
106594862  E3 ubiquitin-protein ligase NHLRC1-like [KO:K10602] [EC:2.3.2.27]
106596027  E3 ubiquitin-protein ligase NHLRC1-like [KO:K10602] [EC:2.3.2.27]
106597497  E3 ubiquitin-protein ligase NHLRC1-like [KO:K10602] [EC:2.3.2.27]
106568810  aire; autoimmune regulator [KO:K10603]
106601086  E3 ubiquitin-protein ligase MGRN1-like [KO:K10604] [EC:2.3.2.27]
106607363  probable E3 ubiquitin-protein ligase MGRN1 [KO:K10604] [EC:2.3.2.27]
106579155  brca1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
106576979  fancl; Fanconi anemia complementation group L [KO:K10606] [EC:2.3.2.27]
106574413  E3 ubiquitin-protein ligase Midline-1-like [KO:K08285] [EC:2.3.2.27]
106575281  E3 ubiquitin-protein ligase Midline-1-like [KO:K08285] [EC:2.3.2.27]
106586808  E3 ubiquitin-protein ligase Midline-1-like [KO:K08285] [EC:2.3.2.27]
106581913  E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:2.3.2.27]
106565915  E3 ubiquitin-protein ligase TRIM32-like [KO:K10607] [EC:2.3.2.27]
106563269  E3 ubiquitin-protein ligase TRIM32-like [KO:K10607] [EC:2.3.2.27]
106603466  trim37; tripartite motif containing 37 [KO:K10608] [EC:2.3.2.27]
106567666  E3 ubiquitin-protein ligase TRIM37-like [KO:K10608] [EC:2.3.2.27]
106601243  rbx1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
100136424  rbx1; ring-box 1 [KO:K03868] [EC:2.3.2.32]
106569218  cullin-1-like [KO:K03347]
106578388  cullin-1-like [KO:K03347]
106599302  cullin-1 [KO:K03347]
106567526  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100195936  skp1; S-phase kinase-associated protein 1 [KO:K03094]
106603254  FBW1B; F-box/WD repeat-containing protein 11-like [KO:K03362]
106604789  F-box/WD repeat-containing protein 11-like [KO:K03362]
106611815  FBW1B; F-box/WD repeat-containing protein 11 [KO:K03362]
106568099  FBW1B; F-box/WD repeat-containing protein 11-like [KO:K03362]
106563829  S-phase kinase-associated protein 2-like [KO:K03875]
106568170  S-phase kinase-associated protein 2-like [KO:K03875]
106602374  F-box/WD repeat-containing protein 7 [KO:K10260]
106602376  F-box/WD repeat-containing protein 7-like [KO:K10260]
106583126  F-box only protein 2-like [KO:K10099]
100194812  fbxo4; F-box protein 4 [KO:K10291]
106578538  cul2; cullin 2 [KO:K03870]
106579736  eloc; elongin C [KO:K03872]
106590672  ELOC; transcription elongation factor B polypeptide 1 [KO:K03872]
106601585  transcription elongation factor B polypeptide 2 [KO:K03873]
106579072  elob; elongin B [KO:K03873]
100196457  elob; Transcription elongation factor B polypeptide 2 [KO:K03873]
100380306  vhl; von Hippel-Lindau tumor suppressor [KO:K03871]
106600593  cullin-3-like [KO:K03869]
106580681  cullin-3 [KO:K03869]
106569638  cullin-3-like [KO:K03869]
106612448  cullin-3-like [KO:K03869]
106590064  kelch-like ECH-associated protein 1 [KO:K10456]
106574506  kelch-like ECH-associated protein 1 [KO:K10456]
106564503  kelch-like ECH-associated protein 1 [KO:K10456]
106603113  kelch-like protein 13 [KO:K10447]
106563441  kelch-like protein 13 [KO:K10447]
106586598  kelch-like protein 9 [KO:K10447]
100195079  klh13; Kelch-like protein 13 [KO:K10447]
106604002  rho-related BTB domain-containing protein 1-like [KO:K07868]
106579856  rho-related BTB domain-containing protein 2-like [KO:K07868]
106585803  rho-related BTB domain-containing protein 2-like [KO:K07868]
106585588  rho-related BTB domain-containing protein 2-like [KO:K07868]
106580155  rho-related BTB domain-containing protein 2-like [KO:K07868]
106604435  cullin-4B-like [KO:K10609]
106574804  cullin-4A-like [KO:K10609]
106575909  cullin-4A-like [KO:K10609]
100194954  cul4b; cullin 4B [KO:K10609]
106561926  DDB1; DNA damage-binding protein 1-like [KO:K10610]
100306841  ddb1; DNA damage-binding protein 1 [KO:K10610]
106584815  ddb2; damage specific DNA binding protein 2 [KO:K10140]
106580591  ercc8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit [KO:K10570]
106560940  DET1 homolog [KO:K10571]
100380576  det1; de-etiolated homolog 1 (Arabidopsis) [KO:K10571]
106580882  RBX2; RING-box protein 2 [KO:K10611]
100195710  rbx2; RING-box protein 2 [KO:K10611]
106599537  RING-box protein 2-like [KO:K10611]
106603716  cullin-5-like [KO:K10612]
106567583  cullin-5-like [KO:K10612]
106581017  cullin-5-like [KO:K10612]
106612887  cul5; cullin 5 [KO:K10612]
106563996  suppressor of cytokine signaling 1-like [KO:K04694]
106591927  SOCS1; suppressor of cytokine signaling 1-like [KO:K04694]
106599570  suppressor of cytokine signaling 1-like [KO:K04694]
106599427  suppressor of cytokine signaling 1-like [KO:K04694]
106596088  suppressor of cytokine signaling 1-like [KO:K04694]
106612385  suppressor of cytokine signaling 3-like [KO:K04696]
106601915  suppressor of cytokine signaling 3-like [KO:K04696]
106606429  suppressor of cytokine signaling 3-like [KO:K04696]
106589833  suppressor of cytokine signaling 3-like [KO:K04696]
106585232  fbxw8; F-box and WD repeat domain containing 8 [KO:K10264]
106588092  anaphase-promoting complex subunit 11 [KO:K03358]
106564932  anaphase-promoting complex subunit 11-like [KO:K03358]
106566731  anaphase-promoting complex subunit 2-like [KO:K03349]
106563313  anaphase-promoting complex subunit 2-like [KO:K03349]
100194750  cdc20; cell division cycle 20 [KO:K03363]
106569201  cell division cycle protein 20 homolog [KO:K03363]
106585932  cdc20b; cell division cycle 20B [KO:K03363]
106599985  fizzy-related protein homolog [KO:K03364]
106569402  FZR; fizzy-related protein homolog [KO:K03364]
106569538  fizzy-related protein homolog [KO:K03364]
106613917  FZR; fizzy-related protein homolog [KO:K03364]
106608142  anaphase-promoting complex subunit 1-like [KO:K03348]
106600875  CDC27; cell division cycle protein 27 homolog [KO:K03350]
100194929  cdc27; cell division cycle 27 [KO:K03350]
106560255  anapc4; anaphase promoting complex subunit 4 [KO:K03351]
100306794  anapc5; anaphase promoting complex subunit 5 [KO:K03352]
106581643  cell division cycle protein 16 homolog [KO:K03353]
106586025  cell division cycle protein 16 homolog [KO:K03353]
100286578  anapc7; anaphase promoting complex subunit 7 [KO:K03354]
106585471  anaphase-promoting complex subunit 7-like [KO:K03354]
106603039  cell division cycle protein 23 homolog [KO:K03355]
100380698  cdc23; cell division cycle protein 23 homolog [KO:K03355]
106578198  anapc10; anaphase promoting complex subunit 10 [KO:K03357]
106567795  anaphase-promoting complex subunit CDC26-like [KO:K03359]
100195816  cdc26; cell division cycle 26 [KO:K03359]
106603647  anaphase-promoting complex subunit 13-like [KO:K12456]
100286719  anc13; Anaphase-promoting complex subunit 13 [KO:K12456]
106613224  anapc15; anaphase promoting complex subunit 15 [KO:K25228]
106594499  anaphase-promoting complex subunit 16 [KO:K25229]
106594500  anaphase-promoting complex subunit 16 [KO:K25229]
106560840  anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
sasa03050  Proteasome
KO pathway
ko04120   
LinkDB

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