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Entry |
Name |
Definition |
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N00225
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EBV EBNA2 to RBP-Jk-mediated transcription
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EBNA2 == SNW1 → RBPJ ⇒ (LMP1,CR2,HES1,FCER2,RUNX3,MYC)
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N00226
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EBV EBNA3A/3B/3C to RBP-Jk-mediated transcription
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(EBNA3A,EBNA3B,EBNA3C) ⊣ RBPJ ⇒ LMP1
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N00227
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TGFA-EGFR-PLCG-PKC signaling pathway
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TGFA → EGFR → PLCG → IP3 → (Ca2+,DAG) → PKC → ELK1
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N00228
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TGFA-overexpression to PLCG-PKC signaling pathway
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TGFA* → EGFR → PLCG → IP3 → (Ca2+,DAG) → PKC → ELK1
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N00229
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TGFA-EGFR-RAS-ERK signaling pathway
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TGFA → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00230
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TGFA-overexpression to RAS-ERK signaling pathway
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TGFA* → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00231
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TGFA-EGFR-PI3K signaling pathway
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TGFA → EGFR → PI3K → PIP3 → AKT → MTOR
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N00232
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TGFA-overexpression to PI3K signaling pathway
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TGFA* → EGFR → PI3K → PIP3 → AKT
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N00233
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IGF-IGF1R-RAS-ERK signaling pathway
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IGF → IGF1R → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00234
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IGF2-IGF1R-PI3K signaling pathway
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IGF2 → IGF1R → PI3K → PIP3 → AKT → MTOR → S6K
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N00235
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IGF2-overexpression to RAS-ERK signaling pathway
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IGF2* → IGF1R → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00236
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IGF2-overexpression to PI3K signaling pathway
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IGF2* → IGF1R → PI3K → PIP3 → AKT → MTOR → S6K
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N00237
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IGF1R-overexpression to RAS-ERK signaling pathway
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IGF2 → IGF1R* → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00238
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IGF1R-overexpression to PI3K signaling pathway
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IGF2 → IGF1R* → PI3K → PIP3 → AKT → MTOR → S6K
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N00239
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Telomerase activity
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TERC ⌿ DNA
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N00240
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TERT-overexpression to telomerase activity
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(TERT*+TERC) → DNA
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N00241
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TGFBR2-reduced expression to TGF-beta signaling pathway
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(TGFBR2*+TGFBR1) ⌿ (SMAD2,SMAD3)
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N00242
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Mutation-inactivated AXIN to Wnt signaling pathway
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(GSK3B+APC) ⌿ AXIN* ⌿ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1)
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N00243
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KEAP1-NRF2 signaling pathway
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(O2-,HO2,H2O2,OH,ACRL,4HNE,NO) ⊣ KEAP1 ⊣ NRF2 ⇒ (HMOX1,NQO1,GST,TXNRD1)
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N00244
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Mutation-inactivated KEAP1 to KEAP1-NRF2 signaling pathway
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KEAP1* ⌿ NRF2 ⇒ (HMOX1,NQO1,GST,TXNRD1)
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N00245
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Mutation-activated NRF2 to KEAP1-NRF2 signaling pathway
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KEAP1 ⌿ NRF2* ⇒ (HMOX1,NQO1,GST,TXNRD1)
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N00246
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HGF-overexpression to RAS-ERK signaling pathway
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HGF* → MET → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00247
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HGF-overexpression to PI3K signaling pathway
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HGF* → MET → GAB1 → PI3K → PIP3 → AKT ⊣ BAD
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N00248
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MET-overexpression to RAS-ERK signaling pathway
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MET* → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00249
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MET-overexpression to PI3K signaling pathway
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MET* → GAB1 → PI3K → PIP3 → AKT ⊣ BAD
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N00250
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CDX2-overexpression to transcriptional activation
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CDX2* ⇒ (MUC2,CDH17,REG4,ABCB1)
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N00251
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CDX2-overexpression to transcriptional repression
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CDX2* ⫤ SHH
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N00252
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Amplified ERBB2 to RAS-ERK signaling pathway
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EGF → (ERBB2*+EGFR) → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00253
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Amplified ERBB2 to PI3K signaling pathway
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EGF → (ERBB2*+EGFR) → PI3K → PIP3 → AKT → MTOR → S6K
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N00254
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CDKN1B-reduced expression to p27-cell cycle G1/S
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CDKN1B* ⌿ (CCNE+CDK2) → RB1 ⌿ E2F
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N00255
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Amplified CCNE to cell cycle G1/S
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(CCNE*+CDK2) → RB1 ⌿ E2F
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N00256
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TGFBR1-reduced expression to TGF-beta signaling pathway
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(TGFBR2+TGFBR1*) ⌿ (SMAD2,SMAD3)
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N00257
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Loss of CDH1 to beta-catenin signaling pathway
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CDH1* ⌿ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1)
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N00258
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Mutation-inactivated CDH1 to beta-catenin signaling pathway
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CDH1* ⌿ CTNNB1 → TCF/LEF ⇒ (MYC,CCND1)
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N00259
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Amplified MET to RAS-ERK signaling pathway
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MET* → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00260
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Amplified MET to PI3K signaling pathway
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MET* → GAB1 → PI3K → PIP3 → AKT → MTOR
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N00261
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KSHV vIRF2 to IFN signaling pathway
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vIRF2 ⊣ (STAT1+STAT2+IRF9)
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N00262
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EBV EBNA3C to intrinsic apoptotic pathway
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EBNA3C ⊣ BCL2L11
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N00263
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EBV EBNA3C to p53-mediated transcription
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EBNA3C → MDM2 ⊣ TP53 ⇒ (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)
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N00264
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EBV EBNA3C to p27-Cell cycle G1/S
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EBNA3C → SKP2 ⊣ CDKN1B ⊣ ((CCNA,CCNE)+CDK2) → RB1 ⌿ E2F
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