VARIANT: 2064v3
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Entry
2064v3 Variant
Name
ERBB2 amplification
Gene
ERBB2
erb-b2 receptor tyrosine kinase 2 [KO:
K05083
]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
amplification
ClinVar:
148363
58696
57282
dbVar:
nsv817369
nsv531185
nsv529527
Network
nt06210
ERK signaling
nt06214
PI3K signaling
nt06261
Gastric cancer
Element
N00252
Amplified ERBB2 to RAS-ERK signaling pathway
N00253
Amplified ERBB2 to PI3K signaling pathway
N10009
Tyrosine kinase inhibitor to HER2 overexpression/amplification
Drug target
Neratinib (
DG02303
):
D10898
<US>
Pertuzumab:
D05446
<JP/US>
Trastuzumab emtansine:
D09980
<JP/US>
Reference
PMID:
26267324
Authors
Riquelme I, Saavedra K, Espinoza JA, Weber H, Garcia P, Nervi B, Garrido M, Corvalan AH, Roa JC, Bizama C
Title
Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.
Journal
Oncotarget 6:24750-79 (2015)
DOI:
10.18632/oncotarget.4990
Reference
PMID:
16154715
Authors
Stock M, Otto F
Title
Gene deregulation in gastric cancer.
Journal
Gene 360:1-19 (2005)
DOI:
10.1016/j.gene.2005.06.026
Reference
PMID:
15224192
Authors
Zheng L, Wang L, Ajani J, Xie K.
Title
Molecular basis of gastric cancer development and progression.
Journal
Gastric Cancer 7:61-77 (2004)
DOI:
10.1007/s10120-004-0277-4
LinkDB
All DBs
Homo sapiens (human): 1956
Help
Entry
1956 CDS
T01001
Symbol
EGFR, ERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
Name
(RefSeq) epidermal growth factor receptor
KO
K04361
epidermal growth factor receptor [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa01522
Endocrine resistance
hsa04010
MAPK signaling pathway
hsa04012
ErbB signaling pathway
hsa04014
Ras signaling pathway
hsa04015
Rap1 signaling pathway
hsa04020
Calcium signaling pathway
hsa04066
HIF-1 signaling pathway
hsa04068
FoxO signaling pathway
hsa04072
Phospholipase D signaling pathway
hsa04144
Endocytosis
hsa04151
PI3K-Akt signaling pathway
hsa04510
Focal adhesion
hsa04520
Adherens junction
hsa04540
Gap junction
hsa04630
JAK-STAT signaling pathway
hsa04810
Regulation of actin cytoskeleton
hsa04912
GnRH signaling pathway
hsa04915
Estrogen signaling pathway
hsa04921
Oxytocin signaling pathway
hsa04926
Relaxin signaling pathway
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa04934
Cushing syndrome
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05131
Shigellosis
hsa05160
Hepatitis C
hsa05163
Human cytomegalovirus infection
hsa05165
Human papillomavirus infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05210
Colorectal cancer
hsa05212
Pancreatic cancer
hsa05213
Endometrial cancer
hsa05214
Glioma
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05219
Bladder cancer
hsa05223
Non-small cell lung cancer
hsa05224
Breast cancer
hsa05225
Hepatocellular carcinoma
hsa05226
Gastric cancer
hsa05230
Central carbon metabolism in cancer
hsa05231
Choline metabolism in cancer
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06110
MAPK signaling (viruses and bacteria)
nt06114
PI3K signaling (viruses)
nt06120
Calcium signaling (viruses and bacteria)
nt06135
Cytoskeletal regulation (viruses and bacteria)
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06170
Influenza A virus (IAV)
nt06210
ERK signaling
nt06213
Other RAS signaling
nt06214
PI3K signaling
nt06219
JAK-STAT signaling
nt06220
Calcium signaling
nt06260
Colorectal cancer
nt06261
Gastric cancer
nt06262
Pancreatic cancer
nt06263
Hepatocellular carcinoma
nt06265
Bladder cancer
nt06266
Non-small cell lung cancer
nt06268
Melanoma
nt06270
Breast cancer
nt06271
Endometrial cancer
nt06273
Glioma
nt06274
Thyroid cancer
nt06276
Chronic myeloid leukemia
nt06310
CRH-ACTH-cortisol signaling
nt06360
Cushing syndrome
Element
N00001
EGF-EGFR-RAS-ERK signaling pathway
N00006
Amplified EGFR to RAS-ERK signaling pathway
N00014
Mutation-activated EGFR to RAS-ERK signaling pathway
N00021
EGF-ERBB2-RAS-ERK signaling pathway
N00022
ERBB2-overexpression to RAS-ERK signaling pathway
N00023
EGF-EGFR-PLCG-ERK signaling pathway
N00024
Mutation-activated EGFR to PLCG-ERK signaling pathway
N00026
EGF-EGFR-PLCG-CAMK signaling pathway
N00027
Amplified EGFR to PLCG-CAMK signaling pathway
N00030
EGF-EGFR-RAS-PI3K signaling pathway
N00033
EGF-EGFR-PI3K signaling pathway
N00034
ERBB2-overexpression to PI3K signaling pathway
N00035
Amplified EGFR to PI3K signaling pathway
N00036
Mutation-activated EGFR to PI3K signaling pathway
N00041
EGFR-overexpression to RAS-ERK signaling pathway
N00042
EGFR-overexpression to PI3K signaling pathway
N00094
EGF-Jak-STAT signaling pathway
N00095
ERBB2-overexpression to EGF-Jak-STAT signaling pathway
N00096
EGF-EGFR-RAS-RASSF1 signaling pathway
N00103
EGF-EGFR-RAS-RalGDS signaling pathway
N00147
EGF-EGFR-PLCG-calcineurin signaling pathway
N00227
TGFA-EGFR-PLCG-PKC signaling pathway
N00228
TGFA-overexpression to PLCG-PKC signaling pathway
N00229
TGFA-EGFR-RAS-ERK signaling pathway
N00230
TGFA-overexpression to RAS-ERK signaling pathway
N00231
TGFA-EGFR-PI3K signaling pathway
N00232
TGFA-overexpression to PI3K signaling pathway
N00252
Amplified ERBB2 to RAS-ERK signaling pathway
N00253
Amplified ERBB2 to PI3K signaling pathway
N00276
EGF-overexpression to RAS-ERK signaling pathway
N00277
EREG-EGFR-RAS-ERK signaling pathway
N00278
EREG-overexpression to RAS-ERK signaling pathway
N00279
AREG-EGFR-RAS-ERK signaling pathway
N00280
AREG-overexpression to RAS-ERK signaling pathway
N00281
EGF-overexpression to PI3K signaling pathway
N00282
EREG-EGFR-PI3K signaling pathway
N00283
EREG-overexpression to PI3K signaling pathway
N00284
AREG-EGFR-PI3K signaling pathway
N00285
AREG-overexpression to PI3K signaling pathway
N00318
EGFR-ERK-ACTH signaling pathway
N00319
Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway
N00366
HPV E5 to EGFR-PI3K signaling pathway
N00367
HPV E5 to EGFR-RAS-ERK signaling pathway
N00390
EGF-EGFR-PI3K-NFKB signaling pathway
N00391
HCMV gB to EGFR-PI3K-NFKB signaling pathway
N00392
HCMV gB to EGFR-RAS-ERK signaling pathway
N00513
Mutation-activated EGFR to RAS-ERK signaling pathway
N00514
Mutation-activated EGFR to PI3K signaling pathway
N00542
EGF-EGFR-RAS-JNK signaling pathway
N01078
EGF-EGFR-Actin signaling pathway
N01354
BPA to RAS-ERK signaling pathway
N01355
Arsenic to PI3K signaling pathway
N10005
First/second-generation tyrosine kinase inhibitor to EGFR mutation
N10006
Third-generation tyrosine kinase inhibitor to EGFR mutation
Disease
H00014
Non-small cell lung cancer
H00016
Oral cancer
H00017
Esophageal cancer
H00022
Bladder cancer
H00028
Choriocarcinoma
H00030
Cervical cancer
H00031
Breast cancer
H00042
Glioma
H00055
Laryngeal cancer
H01508
Salivary gland cancer
H01559
Oropharyngeal cancer
H02467
Neonatal inflammatory skin and bowel disease
Drug target
Afatinib (
DG00717
):
D09724
D09733
<JP/US>
Amivantamab:
D11894
<US>
D11894
<US>
Aumolertinib (
DG03209
):
D12258
D12259
Canertinib dihydrochloride:
D03350
Cetuximab:
D03455
<JP/US>
Cetuximab sarotalocan:
D11803
Cetuximab sarotalocan sodium:
D11805
<JP>
Dacomitinib (
DG01793
):
D09883
D10514
<JP/US>
Duligotuzumab:
D11750
Erlotinib (
DG00711
):
D04023
<JP/US>
D07907
Gefitinib:
D01977
<JP/US>
Icotinib:
D11251
Imgatuzumab:
D10439
Lapatinib (
DG00715
):
D04024
<JP/US>
D08108
Lazertinib (
DG03205
):
D11980
D12245
Lifirafenib (
DG03009
):
D11410
D11411
Masoprocol:
D04862
Mavelertinib:
D11368
Mobocertinib (
DG03148
):
D11969
<US>
D12001
Modotuximab:
D11125
Naquotinib (
DG03112
):
D10886
D10958
Nazartinib (
DG03015
):
D11430
D11434
Necitumumab:
D10018
<JP/US>
Neratinib (
DG02303
):
D08950
D10898
<US>
Olmutinib (
DG02916
):
D10859
D11115
Osimertinib:
D10766
<JP/US>
Panitumumab:
D05350
<JP/US>
Pelitinib:
D05399
Poziotinib (
DG03196
):
D12229
D12230
Rindopepimut:
D09660
Rociletinib:
D10858
Serclutamab:
D11872
Serclutamab talirine:
D11874
Tesevatinib (
DG03101
):
D11772
D11773
Vandetanib:
D06407
<JP/US>
Varlitinib (
DG01357
):
D09689
D09690
Zalutumumab:
D10031
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
1956 (EGFR)
04012 ErbB signaling pathway
1956 (EGFR)
04014 Ras signaling pathway
1956 (EGFR)
04015 Rap1 signaling pathway
1956 (EGFR)
04630 JAK-STAT signaling pathway
1956 (EGFR)
04066 HIF-1 signaling pathway
1956 (EGFR)
04068 FoxO signaling pathway
1956 (EGFR)
04020 Calcium signaling pathway
1956 (EGFR)
04072 Phospholipase D signaling pathway
1956 (EGFR)
04151 PI3K-Akt signaling pathway
1956 (EGFR)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
1956 (EGFR)
09144 Cellular community - eukaryotes
04510 Focal adhesion
1956 (EGFR)
04520 Adherens junction
1956 (EGFR)
04540 Gap junction
1956 (EGFR)
09142 Cell motility
04810 Regulation of actin cytoskeleton
1956 (EGFR)
09150 Organismal Systems
09152 Endocrine system
04912 GnRH signaling pathway
1956 (EGFR)
04915 Estrogen signaling pathway
1956 (EGFR)
04921 Oxytocin signaling pathway
1956 (EGFR)
04926 Relaxin signaling pathway
1956 (EGFR)
04928 Parathyroid hormone synthesis, secretion and action
1956 (EGFR)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
1956 (EGFR)
05206 MicroRNAs in cancer
1956 (EGFR)
05205 Proteoglycans in cancer
1956 (EGFR)
05207 Chemical carcinogenesis - receptor activation
1956 (EGFR)
05208 Chemical carcinogenesis - reactive oxygen species
1956 (EGFR)
05230 Central carbon metabolism in cancer
1956 (EGFR)
05231 Choline metabolism in cancer
1956 (EGFR)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
1956 (EGFR)
09162 Cancer: specific types
05210 Colorectal cancer
1956 (EGFR)
05212 Pancreatic cancer
1956 (EGFR)
05225 Hepatocellular carcinoma
1956 (EGFR)
05226 Gastric cancer
1956 (EGFR)
05214 Glioma
1956 (EGFR)
05218 Melanoma
1956 (EGFR)
05219 Bladder cancer
1956 (EGFR)
05215 Prostate cancer
1956 (EGFR)
05213 Endometrial cancer
1956 (EGFR)
05224 Breast cancer
1956 (EGFR)
05223 Non-small cell lung cancer
1956 (EGFR)
09172 Infectious disease: viral
05160 Hepatitis C
1956 (EGFR)
05171 Coronavirus disease - COVID-19
1956 (EGFR)
05163 Human cytomegalovirus infection
1956 (EGFR)
05165 Human papillomavirus infection
1956 (EGFR)
09171 Infectious disease: bacterial
05120 Epithelial cell signaling in Helicobacter pylori infection
1956 (EGFR)
05131 Shigellosis
1956 (EGFR)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
1956 (EGFR)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
1956 (EGFR)
01522 Endocrine resistance
1956 (EGFR)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
1956 (EGFR)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
1956 (EGFR)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
1956 (EGFR)
Protein kinases [BR:
hsa01001
]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
1956 (EGFR)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
1956 (EGFR)
Exosomal proteins of pancreatic cancer cells
1956 (EGFR)
Exosomal proteins of bladder cancer cells
1956 (EGFR)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
GF_recep_IV
Pkinase
Furin-like
Kinase-like
APH
GAPT
ABC1
Kdo
Motif
Other DBs
NCBI-GeneID:
1956
NCBI-ProteinID:
NP_005219
OMIM:
131550
HGNC:
3236
Ensembl:
ENSG00000146648
Pharos:
P00533
(Tclin)
UniProt:
P00533
Q504U8
F2YGG7
Structure
PDB
LinkDB
All DBs
Position
7:55019017..55211628
Genome browser
AA seq
1210 aa
AA seq
DB search
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
NT seq
3633 nt
NT seq
+upstream
nt +downstream
nt
atgcgaccctccgggacggccggggcagcgctcctggcgctgctggctgcgctctgcccg
gcgagtcgggctctggaggaaaagaaagtttgccaaggcacgagtaacaagctcacgcag
ttgggcacttttgaagatcattttctcagcctccagaggatgttcaataactgtgaggtg
gtccttgggaatttggaaattacctatgtgcagaggaattatgatctttccttcttaaag
accatccaggaggtggctggttatgtcctcattgccctcaacacagtggagcgaattcct
ttggaaaacctgcagatcatcagaggaaatatgtactacgaaaattcctatgccttagca
gtcttatctaactatgatgcaaataaaaccggactgaaggagctgcccatgagaaattta
caggaaatcctgcatggcgccgtgcggttcagcaacaaccctgccctgtgcaacgtggag
agcatccagtggcgggacatagtcagcagtgactttctcagcaacatgtcgatggacttc
cagaaccacctgggcagctgccaaaagtgtgatccaagctgtcccaatgggagctgctgg
ggtgcaggagaggagaactgccagaaactgaccaaaatcatctgtgcccagcagtgctcc
gggcgctgccgtggcaagtcccccagtgactgctgccacaaccagtgtgctgcaggctgc
acaggcccccgggagagcgactgcctggtctgccgcaaattccgagacgaagccacgtgc
aaggacacctgccccccactcatgctctacaaccccaccacgtaccagatggatgtgaac
cccgagggcaaatacagctttggtgccacctgcgtgaagaagtgtccccgtaattatgtg
gtgacagatcacggctcgtgcgtccgagcctgtggggccgacagctatgagatggaggaa
gacggcgtccgcaagtgtaagaagtgcgaagggccttgccgcaaagtgtgtaacggaata
ggtattggtgaatttaaagactcactctccataaatgctacgaatattaaacacttcaaa
aactgcacctccatcagtggcgatctccacatcctgccggtggcatttaggggtgactcc
ttcacacatactcctcctctggatccacaggaactggatattctgaaaaccgtaaaggaa
atcacagggtttttgctgattcaggcttggcctgaaaacaggacggacctccatgccttt
gagaacctagaaatcatacgcggcaggaccaagcaacatggtcagttttctcttgcagtc
gtcagcctgaacataacatccttgggattacgctccctcaaggagataagtgatggagat
gtgataatttcaggaaacaaaaatttgtgctatgcaaatacaataaactggaaaaaactg
tttgggacctccggtcagaaaaccaaaattataagcaacagaggtgaaaacagctgcaag
gccacaggccaggtctgccatgccttgtgctcccccgagggctgctggggcccggagccc
agggactgcgtctcttgccggaatgtcagccgaggcagggaatgcgtggacaagtgcaac
cttctggagggtgagccaagggagtttgtggagaactctgagtgcatacagtgccaccca
gagtgcctgcctcaggccatgaacatcacctgcacaggacggggaccagacaactgtatc
cagtgtgcccactacattgacggcccccactgcgtcaagacctgcccggcaggagtcatg
ggagaaaacaacaccctggtctggaagtacgcagacgccggccatgtgtgccacctgtgc
catccaaactgcacctacggatgcactgggccaggtcttgaaggctgtccaacgaatggg
cctaagatcccgtccatcgccactgggatggtgggggccctcctcttgctgctggtggtg
gccctggggatcggcctcttcatgcgaaggcgccacatcgttcggaagcgcacgctgcgg
aggctgctgcaggagagggagcttgtggagcctcttacacccagtggagaagctcccaac
caagctctcttgaggatcttgaaggaaactgaattcaaaaagatcaaagtgctgggctcc
ggtgcgttcggcacggtgtataagggactctggatcccagaaggtgagaaagttaaaatt
cccgtcgctatcaaggaattaagagaagcaacatctccgaaagccaacaaggaaatcctc
gatgaagcctacgtgatggccagcgtggacaacccccacgtgtgccgcctgctgggcatc
tgcctcacctccaccgtgcagctcatcacgcagctcatgcccttcggctgcctcctggac
tatgtccgggaacacaaagacaatattggctcccagtacctgctcaactggtgtgtgcag
atcgcaaagggcatgaactacttggaggaccgtcgcttggtgcaccgcgacctggcagcc
aggaacgtactggtgaaaacaccgcagcatgtcaagatcacagattttgggctggccaaa
ctgctgggtgcggaagagaaagaataccatgcagaaggaggcaaagtgcctatcaagtgg
atggcattggaatcaattttacacagaatctatacccaccagagtgatgtctggagctac
ggggtgactgtttgggagttgatgacctttggatccaagccatatgacggaatccctgcc
agcgagatctcctccatcctggagaaaggagaacgcctccctcagccacccatatgtacc
atcgatgtctacatgatcatggtcaagtgctggatgatagacgcagatagtcgcccaaag
ttccgtgagttgatcatcgaattctccaaaatggcccgagacccccagcgctaccttgtc
attcagggggatgaaagaatgcatttgccaagtcctacagactccaacttctaccgtgcc
ctgatggatgaagaagacatggacgacgtggtggatgccgacgagtacctcatcccacag
cagggcttcttcagcagcccctccacgtcacggactcccctcctgagctctctgagtgca
accagcaacaattccaccgtggcttgcattgatagaaatgggctgcaaagctgtcccatc
aaggaagacagcttcttgcagcgatacagctcagaccccacaggcgccttgactgaggac
agcatagacgacaccttcctcccagtgcctgaatacataaaccagtccgttcccaaaagg
cccgctggctctgtgcagaatcctgtctatcacaatcagcctctgaaccccgcgcccagc
agagacccacactaccaggacccccacagcactgcagtgggcaaccccgagtatctcaac
actgtccagcccacctgtgtcaacagcacattcgacagccctgcccactgggcccagaaa
ggcagccaccaaattagcctggacaaccctgactaccagcaggacttctttcccaaggaa
gccaagccaaatggcatctttaagggctccacagctgaaaatgcagaatacctaagggtc
gcgccacaaagcagtgaatttattggagcatga
DBGET
integrated database retrieval system
