KEGG   PATHWAY: elk04630
elk04630                    Pathway                                

JAK-STAT signaling pathway - Enhydra lutris kenyoni (northern sea otter)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
elk04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
111154869  interleukin-2 [KO:K05429]
111140799  interleukin-3-like [KO:K04736]
111141099  interleukin-4 [KO:K05430]
111141209  interleukin-5 [KO:K05428]
111147365  interleukin-6 isoform X1 [KO:K05405]
111156814  interleukin-7 isoform X1 [KO:K05431]
111141057  interleukin-9 [KO:K05432]
111151100  interleukin-10 [KO:K05443]
111139584  interleukin-11 [KO:K05417]
111150468  interleukin-12 subunit alpha [KO:K05406]
111141150  interleukin-12 subunit beta [KO:K05425]
111141294  interleukin-13 [KO:K05435]
111149196  interleukin-15 [KO:K05433]
111159932  interleukin-17D [KO:K05492]
111151192  interleukin-19 [KO:K05444]
111150936  interleukin-20 [KO:K22667]
111157589  interleukin-21 [KO:K05434]
111142363  interleukin-22 [KO:K05445]
111160242  interleukin-23 subunit alpha [KO:K05426]
111151003  interleukin-24 [KO:K22668]
111140482  interferon alpha-1/2-like [KO:K05414]
111159856  interferon alpha-1/2-like [KO:K05414]
111159858  interferon alpha-1/2-like [KO:K05414]
111159859  interferon alpha-1/2-like [KO:K05414]
111159861  interferon alpha-1/2-like [KO:K05414]
111159862  interferon alpha-1/2-like [KO:K05414]
111156578  interferon alpha-2-like [KO:K05414]
111156593  interferon alpha-1/2-like [KO:K05414]
111156594  interferon alpha-1/2-like [KO:K05414]
111156604  interferon alpha-like [KO:K05414]
111140592  interferon alpha-1/2-like [KO:K05414]
111156606  interferon alpha-1/2-like [KO:K05414]
111156609  interferon alpha-1/2-like [KO:K05414]
111140329  interferon alpha-1/2-like [KO:K05414]
111140335  interferon alpha-1/2-like [KO:K05414]
111140336  interferon alpha-1/2-like [KO:K05414]
111156577  interferon beta [KO:K05415]
111142126  interferon gamma [KO:K04687]
111159843  LOW QUALITY PROTEIN: interferon epsilon [KO:K05442]
111159868  interferon kappa [KO:K05441]
111161574  interferon lambda-1-like [KO:K05447]
111161564  interferon lambda-3-like [KO:K22669]
111160020  oncostatin-M [KO:K05418]
111160085  leukemia inhibitory factor [KO:K05419]
111148355  LOW QUALITY PROTEIN: thymic stromal lymphopoietin [KO:K05436]
111162344  cardiotrophin-1 isoform X1 [KO:K05422]
111162204  cardiotrophin-2 [KO:K24382]
111141239  granulocyte-macrophage colony-stimulating factor [KO:K05427]
111149426  ciliary neurotrophic factor [KO:K05420]
111151817  granulocyte colony-stimulating factor [KO:K05423]
111145625  erythropoietin [KO:K05437]
111158084  somatotropin isoform X1 [KO:K05438]
111151979  leptin [KO:K05424]
111151805  thrombopoietin isoform X1 [KO:K06854]
111138630  prolactin isoform X1 [KO:K05439]
111156359  pro-epidermal growth factor isoform X1 [KO:K04357]
111145884  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
111157534  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
111158621  interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
111157559  interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
111161041  cytokine receptor common subunit gamma [KO:K05070]
111157156  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
111162191  interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
111144290  interleukin-5 receptor subunit alpha [KO:K05067]
111138952  interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
111141253  interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
111156295  interleukin-9 receptor [KO:K05073]
111153726  interleukin-10 receptor subunit alpha [KO:K05134]
111155723  LOW QUALITY PROTEIN: interleukin-10 receptor subunit beta [KO:K05135]
111145851  interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
111144102  interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
111143098  interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
111157297  interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
111160969  interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
111158614  interleukin-15 receptor subunit alpha [KO:K05074]
111140459  interleukin-20 receptor subunit alpha-like [KO:K05136]
111147475  interleukin-20 receptor subunit alpha [KO:K05136]
111155008  interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
111162173  interleukin-21 receptor isoform X1 [KO:K05075]
111154911  interleukin-22 receptor subunit alpha-1 [KO:K05138]
111147765  interleukin-22 receptor subunit alpha-2 [KO:K05139]
111143244  interleukin-23 receptor [KO:K05065]
111162412  interleukin-27 receptor subunit alpha [KO:K19598]
111156948  interleukin-6 receptor subunit beta [KO:K05060]
111155707  interferon alpha/beta receptor 1 [KO:K05130]
111155645  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
111147686  interferon gamma receptor 1 [KO:K05132]
111155682  interferon gamma receptor 2 isoform X1 [KO:K05133]
111154913  interferon lambda receptor 1 [KO:K05140]
111141176  oncostatin-M-specific receptor subunit beta [KO:K05057]
111140973  leukemia inhibitory factor receptor [KO:K05058]
111157190  cytokine receptor-like factor 2 [KO:K05078]
111146386  ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
111157141  granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
111157114  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
111157480  cytokine receptor common subunit beta isoform X1 [KO:K04738]
111143352  granulocyte colony-stimulating factor receptor [KO:K05061]
111162487  erythropoietin receptor [KO:K05079]
111140951  growth hormone receptor [KO:K05080]
111143310  leptin receptor isoform X1 [KO:K05062]
111143522  thrombopoietin receptor [KO:K05082]
111141177  prolactin receptor isoform X1 [KO:K05081]
111157042  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:]
111148924  platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:]
111140848  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:]
111142881  tyrosine-protein kinase JAK1 [KO:K11217] [EC:]
111153517  tyrosine-protein kinase JAK2 [KO:K04447] [EC:]
111143876  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:]
111162402  non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:]
111144592  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
111160141  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111151241  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111141082  signal transducer and activator of transcription 4 [KO:K11222]
111151211  signal transducer and activator of transcription 5A [KO:K11223]
111151253  signal transducer and activator of transcription 5B [KO:K11224]
111160115  signal transducer and activator of transcription 6 [KO:K11225]
111144142  cytokine-inducible SH2-containing protein [KO:K04701]
111156124  suppressor of cytokine signaling 1 [KO:K04694]
111142151  LOW QUALITY PROTEIN: suppressor of cytokine signaling 2 [KO:K04695]
111160348  suppressor of cytokine signaling 3 [KO:K04696]
111140665  suppressor of cytokine signaling 4 [KO:K04697]
111155864  suppressor of cytokine signaling 5 [KO:K04698]
111154286  suppressor of cytokine signaling 6 [KO:K04699]
111151637  suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
111154217  apoptosis regulator Bcl-2 [KO:K02161]
111161960  induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1 [KO:K02539]
111161961  induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1 [KO:K02539]
111141775  bcl-2-like protein 1 [KO:K04570]
111147734  serine/threonine-protein kinase pim-1 [KO:K04702] [EC:]
111146783  myc proto-oncogene protein [KO:K04377]
111149458  G1/S-specific cyclin-D1 [KO:K04503]
111159766  G1/S-specific cyclin-D2 [KO:K10151]
111147855  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111147618  cyclin-dependent kinase inhibitor 1 [KO:K06625]
111141059  aldehyde oxidase 4-like isoform X1 [KO:K00157] [EC:]
111142784  aldehyde oxidase 2 [KO:K00157] [EC:]
111153602  aldehyde oxidase [KO:K00157] [EC:]
111158105  glial fibrillary acidic protein isoform X1 [KO:K05640]
111144809  signal transducing adapter molecule 2 [KO:K04705]
111155550  signal transducing adapter molecule 1 [KO:K04705]
111142429  tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:]
111159680  tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:]
111140721  interferon regulatory factor 9 isoform X1 [KO:K04693]
111157665  histone acetyltransferase p300 [KO:K04498] [EC:]
111156131  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:]
111153180  E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
111142425  E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
111162013  E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
111161688  E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:]
111139337  four and a half LIM domains protein 1 isoform X1 [KO:K14365]
111154862  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:]
111156454  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:]
111160411  growth factor receptor-bound protein 2 [KO:K04364]
111158354  son of sevenless homolog 1 isoform X1 [KO:K03099]
111160889  son of sevenless homolog 2 isoform X1 [KO:K03099]
111140316  GTPase HRas isoform X1 [KO:K02833]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
111154883  serine/threonine-protein kinase mTOR [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
elk04010  MAPK signaling pathway
elk04060  Cytokine-cytokine receptor interaction
elk04110  Cell cycle
elk04120  Ubiquitin mediated proteolysis
elk04151  PI3K-Akt signaling pathway
elk04210  Apoptosis
KO pathway

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