KEGG   REACTION: R02788
Entry
R02788                      Reaction                               
Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming);
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminoheptanedioate ligase (ADP-forming)
Definition
ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-Diaminoheptanedioate <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
Equation
C00002 + C00692 + C00680 <=> C00008 + C00009 + C04877
Reaction class
RC00002  C00002_C00008
RC00064  C00680_C04877
RC00090  C00692_C04877
Enzyme
6.3.2.13
Pathway
rn00300  Lysine biosynthesis
rn00550  Peptidoglycan biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.13
     R02788  ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-Diaminoheptanedioate <=> ADP + Orthophosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
Orthology
K01928  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
K15792  MurE/MurF fusion protein [EC:6.3.2.13 6.3.2.10]
Other DBs
RHEA: 23679
LinkDB

KEGG   RCLASS: RC00090
Entry
RC00090                     RClass                                 
Definition
C5a-C6a:N1b+*-*+O6a:C1b+O5a-C1b+O6a
Reactant pair
C00025_C00051    C00025_C00669    C00025_C01047
C00025_C02166    C00025_C02320    C00025_C03153
C00025_C04138    C00025_C05711    C00025_C06114
C00025_C06462    C00025_C15699    C00025_C15767
C00025_C18008    C00025_C20843    C00025_C20926
C00025_C20995    C00025_C21015    C00025_C21539
C00025_C21620    C00025_C21622    C00025_C21664
C00025_C22033    C00025_C22139    C00025_C22140
C00026_C03623    C00026_C21858    C00037_C03838
C00042_C04421    C00042_C05931    C00049_C04540
C00051_C02090    C00051_C05730    C00051_C16562
C00051_C16563    C00051_C16566    C00051_C16567
C00099_C00386    C00099_C01262    C00099_C05340
C00099_C05341    C00101_C03541    C00101_C09332
C00120_C04681    C00120_C04682    C00120_C04727
C00120_C04801    C00120_C05552    C00158_C20333
C00158_C22072    C00158_C22101    C00158_C22102
C00219_C11695    C00234_C05928    C00334_C00884
C00347_C04305    C00383_C15607    C00489_C15666
C00692_C04877    C00692_C05892    C00692_C19720
C00695_C01921    C00695_C05122    C00831_C00864
C00864_C20814    C00876_C19151    C00876_C19152
C00954_C04211    C00954_C22224    C00956_C05556
C00956_C05557    C01255_C02378    C01585_C02722
C02378_C20988    C02528_C05465    C02528_C05466
C02871_C04375    C03492_C04352    C04483_C05463
C04483_C05464    C05551_C07086    C05554_C20333
C05635_C05832    C05928_C05929    C06507_C06508
C06507_C06509    C06866_C18202    C07073_C16647
C08262_C16696    C08491_C21509    C11735_C16561
C15810_C21437    C16237_C16241    C16593_C16594
C19710_C19713    C19885_C19886    C19885_C19889
C19885_C20948    C19885_C20951    C20957_C21160
C21177_C21178
 » show all
Related class
Reaction
R00059 R00411 R00494 R00894 R00910 R00911 R00912 R00942
R01077 R01164 R01166 R01585 R01587 R01654 R01917 R01918
R01991 R01992 R02040 R02734 R02786 R02788 R02797 R02929
R02930 R02973 R03095 R03286 R03288 R03421 R03620 R03822
R03916 R03935 R03970 R03971 R03975 R03977 R04103 R04144
R04230 R04231 R04242 R04486 R04487 R04562 R04563 R04582
R04604 R04868 R04870 R04906 R05197 R05207 R05226 R05835
R06361 R06529 R07302 R07402 R07414 R07419 R07629 R07643
R08295 R08300 R08323 R08350 R08351 R08352 R08353 R08354
R08355 R08412 R08707 R08906 R09400 R09401 R09536 R09593
R09596 R09775 R09779 R09875 R10090 R10091 R10752 R10772
R10902 R10929 R10933 R10975 R10993 R11021 R11143 R11190
R11207 R11208 R11524 R11622 R11792 R11793 R11794 R11795
R11950 R12024 R12251 R12308 R12353 R12354 R12410 R12412
R12513
 » show all
Enzyme
2.3.1.164       2.3.2.2         2.3.2.-         3.1.1.1         
3.4.13.4        3.4.13.5        3.4.13.18       3.4.13.20       
3.4.14.13       3.4.19.9        3.4.19.13       3.4.19.14       
3.4.19.16       3.5.1.11        3.5.1.12        3.5.1.18        
3.5.1.24        3.5.1.26        3.5.1.36        3.5.1.39        
3.5.1.46        3.5.1.52        3.5.1.55        3.5.1.65        
3.5.1.74        3.5.1.78        3.5.1.90        3.5.1.92        
3.5.1.93        3.5.1.94        3.5.1.95        3.5.1.96        
3.5.1.99        3.5.1.118       3.5.1.119       3.5.1.127       
3.5.1.128       3.5.1.129       3.5.1.130       3.5.1.132       
3.5.1.134       3.5.1.-         3.13.1.6        6.2.1.39        
6.3.1.6         6.3.1.8         6.3.1.9         6.3.1.10        
6.3.1.11        6.3.1.18        6.3.1.19        6.3.1.20        
6.3.2.2         6.3.2.5         6.3.2.7         6.3.2.11        
6.3.2.12        6.3.2.13        6.3.2.17        6.3.2.18        
6.3.2.20        6.3.2.26        6.3.2.30        6.3.2.32        
6.3.2.34        6.3.2.37        6.3.2.38        6.3.2.39        
6.3.2.43        6.3.2.51        6.3.2.52        6.3.2.54        
6.3.2.57        6.3.2.58        6.3.2.60        6.3.2.-         
6.3.4.9         6.3.4.10        6.3.4.11        6.3.4.12        
6.3.4.13        6.3.4.15        6.3.4.24
 » show all
Pathway
rn00120  Primary bile acid biosynthesis
rn00240  Pyrimidine metabolism
rn00311  Penicillin and cephalosporin biosynthesis
rn00330  Arginine and proline metabolism
rn00380  Tryptophan metabolism
rn00410  beta-Alanine metabolism
rn00480  Glutathione metabolism
rn00550  Peptidoglycan biosynthesis
rn00680  Methane metabolism
rn00770  Pantothenate and CoA biosynthesis
rn00780  Biotin metabolism
rn00790  Folate biosynthesis
rn00860  Porphyrin metabolism
rn00930  Caprolactam degradation
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01240  Biosynthesis of cofactors
Orthology
K00681  gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
K01307  gamma-glutamyl hydrolase [EC:3.4.19.9]
K01435  biotinidase [EC:3.5.1.12]
K01439  succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
K01442  choloylglycine hydrolase [EC:3.5.1.24]
K01453  6-aminohexanoate-oligomer exohydrolase [EC:3.5.1.46]
K01460  glutathionylspermidine amidase/synthetase [EC:3.5.1.78 6.3.1.8]
K01833  trypanothione synthetase/amidase [EC:6.3.1.9 3.5.1.-]
K01917  glutathionylspermidine synthase [EC:6.3.1.8]
K01919  glutamate--cysteine ligase [EC:6.3.2.2]
K01922  phosphopantothenate---cysteine ligase (ATP) [EC:6.3.2.51]
K01928  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
K01930  folylpolyglutamate synthase [EC:6.3.2.17]
K01945  phosphoribosylamine---glycine ligase [EC:6.3.4.13]
K02225  cobalamin biosynthesis protein CobC
K02227  adenosylcobinamide-phosphate synthase [EC:6.3.1.10]
K03800  lipoate---protein ligase [EC:6.3.1.20]
K03894  N2-citryl-N6-acetyl-N6-hydroxylysine synthase [EC:6.3.2.38]
K03895  aerobactin synthase [EC:6.3.2.39]
K05362  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7]
K05526  succinylglutamate desuccinylase [EC:3.5.1.96]
K05604  beta-Ala-His dipeptidase [EC:3.4.13.20]
K05827  [lysine-biosynthesis-protein LysW]---L-2-aminoadipate ligase [EC:6.3.2.43]
K05831  [amino group carrier protein]-lysine/ornithine hydrolase [EC:3.5.1.130 3.5.1.132]
K06048  glutamate---cysteine ligase / carboxylate-amine ligase [EC:6.3.2.2 6.3.-.-]
K06914  tyramine---L-glutamate ligase [EC:6.3.4.24]
K07008  gamma-glutamyl hercynylcysteine S-oxide hydrolase [EC:3.5.1.118]
K08069  pantetheine hydrolase [EC:3.5.1.92]
K08260  adenosylcobinamide hydrolase [EC:3.5.1.90]
K08660  cytosolic nonspecific dipeptidase [EC:3.4.13.18]
K09470  gamma-glutamylputrescine synthase [EC:6.3.1.11]
K09473  gamma-glutamyl-gamma-aminobutyrate hydrolase [EC:3.5.1.94]
K10852  isopenicillin-N N-acyltransferase [EC:2.3.1.164]
K11204  glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
K11205  glutamate--cysteine ligase regulatory subunit
K11206  deaminated glutathione amidase [EC:3.5.1.128]
K11754  dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
K11787  phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 2.1.2.2 6.3.3.1]
K11788  phosphoribosylamine--glycine ligase / phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.4.13 6.3.3.1]
K12234  coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34]
K12743  N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase [EC:6.3.2.26]
K12748  glutaryl-7-aminocephalosporanic-acid acylase [EC:3.5.1.93]
K13038  phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5]
K13559  [BtrI acyl-carrier protein]--L-glutamate ligase [EC:6.2.1.39]
K13571  proteasome accessory factor A [EC:6.3.1.19]
K13713  fusion protein PurCD [EC:6.3.2.6 6.3.4.13]
K14506  jasmonic acid-amino synthetase [EC:6.3.2.52]
K14755  carnosine synthase [EC:6.3.2.11]
K14940  gamma-F420-2:alpha-L-glutamate ligase [EC:6.3.2.32]
K15792  MurE/MurF fusion protein [EC:6.3.2.13 6.3.2.10]
K18572  putative pantetheine hydrolase [EC:3.5.1.-]
K18592  gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]
K19412  glutamate---[amino group carrier protein] ligase [EC:6.3.2.60]
K19795  ureidomalonase [EC:3.5.1.95]
K21140  [CysO sulfur-carrier protein]-S-L-cysteine hydrolase [EC:3.13.1.6]
K21604  jasmonoyl-L-amino acid hydrolase [EC:3.5.1.127]
K21977  phosphopantothenate---cysteine ligase (CTP) [EC:6.3.2.5]
K22099  dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
K22314  glucosinolate gamma-glutamyl hydrolase [EC:3.4.19.16]
K23150  N5-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase [EC:3.5.1.129]
K23372  L-2,3-diaminopropanoate---citrate ligase [EC:6.3.2.54]
K23446  D-ornithine---citrate ligase [EC:6.3.2.58]
K23447  staphyloferrin A synthase [EC:6.3.2.57]
K23672  L-propargylglycine--L-glutamate ligase [EC:6.3.2.-]
K24998  dehydro coenzyme F420 reductase / coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:1.3.8.17 6.3.2.31 6.3.2.34]
K25032  alpha-aminoadipate-LysW ligase/glutamate-LysW ligase [EC:6.3.2.43 6.3.2.60]

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