KEGG   PATHWAY: ath03013
Entry
ath03013                    Pathway                                
Name
Nucleocytoplasmic transport - Arabidopsis thaliana (thale cress)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
ath03013  Nucleocytoplasmic transport
ath03013

Other DBs
GO: 0050658
Organism
Arabidopsis thaliana (thale cress) [GN:ath]
Gene
AT1G02140  MAGO; mago nashi family protein [KO:K12877]
AT1G02690  IMPA-6; importin alpha isoform 6 [KO:K15042]
AT1G07920  [KO:K03231]
AT1G07930  [KO:K03231]
AT1G07940  [KO:K03231]
AT1G09270  IMPA-4; importin alpha isoform 4 [KO:K15042]
AT1G10390  [KO:K14297]
AT1G11400  PYM; partner of Y14-MAGO [KO:K14294]
AT1G12930  [KO:K15436]
AT1G13120  GLE1; nucleoporin GLE1-like protein [KO:K18723]
AT1G14850  NUP155; nucleoporin 155 [KO:K14312]
AT1G15200  [KO:K13114]
AT1G15850  [KO:K14298]
AT1G16610  SR45; arginine/serine-rich 45 [KO:K14325]
AT1G24310  [KO:K14308]
AT1G24706  THO2; THO2 [KO:K12879]
AT1G26170  [KO:K20224]
AT1G33410  SAR1; SUPPRESSOR OF AUXIN RESISTANCE1 [KO:K14303]
AT1G33980  UPF3; Smg-4/UPF3 family protein [KO:K14328]
AT1G35550  [KO:K03231]
AT1G45233  THO5; THO complex, subunit 5 [KO:K13174]
AT1G51380  [KO:K13025] [EC:5.6.2.7]
AT1G51510  Y14; RNA-binding (RRM/RBD/RNP motifs) family protein [KO:K12876]
AT1G55540  LNO1; Nuclear pore complex protein [KO:K14317]
AT1G59660  [KO:K14297]
AT1G64350  SEH1H; Transducin/WD40 repeat-like superfamily protein [KO:K14299]
AT1G66260  [KO:K12881]
AT1G72560  PSD; ARM repeat superfamily protein [KO:K14288]
AT1G73240  [KO:K14315]
AT1G75340  [KO:K14321]
AT1G79280  NUA; nuclear pore anchor [KO:K09291]
AT1G80670  RAE1; Transducin/WD40 repeat-like superfamily protein [KO:K14298]
AT1G80680  SAR3; SUPPRESSOR OF AUXIN RESISTANCE 3 [KO:K14297]
AT2G03820  NMD3; nonsense-mediated mRNA decay NMD3 family protein [KO:K07562]
AT2G05120  [KO:K14300]
AT2G13540  ABH1; ARM repeat superfamily protein [KO:K12882]
AT2G16950  TRN1; transportin 1 [KO:K18752]
AT2G19430  DWA1; DWD (DDB1-binding WD40 protein) hypersensitive to ABA 1 [KO:K13175]
AT2G29210  [KO:K13171]
AT2G30050  [KO:K14004]
AT2G31660  SAD2; ARM repeat superfamily protein [KO:K20223]
AT2G32790  [KO:K10577]
AT2G39260  [KO:K14327]
AT2G41620  [KO:K14309]
AT2G45000  EMB2766; structural constituent of nuclear pore [KO:K14306]
AT2G45640  SAP18; SIN3 associated polypeptide P18 [KO:K14324]
AT2G46520  [KO:K18423]
AT3G01340  [KO:K14004]
AT3G02420  [KO:K20724]
AT3G02950  THO7; Tho complex subunit 7/Mft1p [KO:K13176]
AT3G03110  XPO1B; exportin 1B [KO:K14290]
AT3G04490  [KO:K25203]
AT3G05040  HST; ARM repeat superfamily protein [KO:K14289]
AT3G05720  IMPA-7; importin alpha isoform 7 [KO:K15042]
AT3G06000  [KO:K14319]
AT3G06720  IMPA-1; importin alpha isoform 1 [KO:K15042]
AT3G08943  [KO:K14293]
AT3G08947  [KO:K14293]
AT3G08960  [KO:K25201]
AT3G14120  [KO:K14301]
AT3G16310  [KO:K14313]
AT3G19760  EIF4A-III; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
AT3G20430  [KO:K14291]
AT3G53110  LOS4; P-loop containing nucleoside triphosphate hydrolases superfamily protein [KO:K18655] [EC:5.6.2.7]
AT3G56900  [KO:K14320]
AT3G57350  [KO:K14309]
AT3G57870  SCE1; sumo conjugation enzyme 1 [KO:K10577]
AT3G59020  [KO:K20223]
AT3G63130  RANGAP1; RAN GTPase activating protein 1 [KO:K14319]
AT4G02150  MOS6; ARM repeat superfamily protein [KO:K15042]
AT4G24880  [KO:K13151]
AT4G27640  [KO:K20221]
AT4G27960  UBC9; ubiquitin conjugating enzyme 9 [KO:K10577]
AT4G30840  [KO:K14305]
AT4G32910  [KO:K14304]
AT4G37130  [KO:K14307]
AT4G38760  [KO:K14311]
AT4G39680  [KO:K12875]
AT5G02530  [KO:K12881]
AT5G03070  IMPA-9; importin alpha isoform 9 [KO:K15042]
AT5G05680  MOS7; nuclear pore complex protein-like protein [KO:K14318]
AT5G06120  [KO:K18460]
AT5G09860  THO1; nuclear matrix protein-like protein [KO:K12878]
AT5G11170  UAP56a; DEAD/DEAH box RNA helicase family protein [KO:K12812] [EC:5.6.2.7]
AT5G11200  UAP56b; DEAD/DEAH box RNA helicase family protein [KO:K12812] [EC:5.6.2.7]
AT5G16790  THO7; Tho complex subunit 7/Mft1p [KO:K13176]
AT5G17020  XPO1A; exportin 1A [KO:K14290]
AT5G19320  RANGAP2; RAN GTPase activating protein 2 [KO:K14319]
AT5G19820  emb2734; ARM repeat superfamily protein [KO:K20222]
AT5G20010  RAN-1; RAS-related nuclear protein-1 [KO:K07936]
AT5G20020  RAN2; RAS-related GTP-binding nuclear protein 2 [KO:K07936]
AT5G37720  ALY4; ALWAYS EARLY 4 [KO:K12881]
AT5G40480  EMB3012; embryo defective 3012 [KO:K14314]
AT5G42920  THO5; THO complex, subunit 5 [KO:K13174]
AT5G44200  CBP20; CAP-binding protein 20 [KO:K12883]
AT5G47010  LBA1; RNA helicase [KO:K14326] [EC:5.6.2.5 5.6.2.3]
AT5G49310  IMPA-5; importin alpha isoform 5 [KO:K15042]
AT5G51200  EMB3142; nuclear pore complex protein (DUF3414) [KO:K14310]
AT5G53480  [KO:K14293]
AT5G55080  RAN4; ras-related nuclear protein 4 [KO:K07936]
AT5G55190  RAN3; RAN GTPase 3 [KO:K07936]
AT5G56130  TEX1; Transducin/WD40 repeat-like superfamily protein [KO:K12880]
AT5G59950  [KO:K12881]
AT5G60390  [KO:K03231]
AT5G62600  MOS14; ARM repeat superfamily protein [KO:K15436]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
ath03015  mRNA surveillance pathway
KO pathway
ko03013   

DBGET integrated database retrieval system