KEGG   PATHWAY: cbor04060
Entry
cbor04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Calonectris borealis (Cory's shearwater)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
cbor04060  Cytokine-cytokine receptor interaction
cbor04060

Organism
Calonectris borealis (Cory's shearwater) [GN:cbor]
Gene
142073543  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
142073594  ACVRL1; activin receptor type-1-like [KO:K13594] [EC:2.7.11.30]
142073595  [KO:K22688]
142073622  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
142073640  [KO:K22689]
142073688  GDF11; growth/differentiation factor 11 [KO:K22679]
142073767  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
142073782  IL23A; interleukin-23 subunit alpha [KO:K05426]
142073860  EPOR; erythropoietin receptor [KO:K05079]
142073863  [KO:K05477]
142073903  [KO:K05066]
142073934  [KO:K05066]
142074018  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
142074304  [KO:K05417]
142074437  EPO; erythropoietin [KO:K05437]
142074656  [KO:K05081]
142074659  [KO:K05415]
142074692  [KO:K05415]
142074712  [KO:K05415]
142074713  [KO:K05415]
142074715  [KO:K05415]
142074742  [KO:K05415]
142074762  [KO:K05415]
142074763  [KO:K05415]
142074764  [KO:K05415]
142074765  [KO:K05415]
142074774  [KO:K05415]
142074775  [KO:K05415]
142074793  [KO:K05415]
142074803  [KO:K05415]
142074804  [KO:K05415]
142074812  [KO:K05415]
142074815  [KO:K05415]
142074893  [KO:K05058]
142074898  [KO:K05415]
142074908  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
142074909  [KO:K05415]
142074931  [KO:K05415]
142074932  [KO:K05415]
142074933  [KO:K05415]
142074935  [KO:K05415]
142074936  [KO:K05415]
142075010  [KO:K05080]
142075021  [KO:K05056]
142075033  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
142075044  [KO:K04386]
142075054  IL18R1; interleukin-18 receptor 1 [KO:K05173]
142075059  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
142075061  [KO:K05060]
142075063  [KO:K16062]
142075121  [KO:K05415]
142075161  [KO:K05415]
142075229  [KO:K05415]
142075273  LIFR; leukemia inhibitory factor receptor [KO:K05058]
142075334  [KO:K05415]
142075339  [KO:K05415]
142075355  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
142075374  [KO:K05415]
142075375  [KO:K05415]
142075400  [KO:K16062]
142075448  [KO:K05057]
142075451  [KO:K05415]
142075473  [KO:K05415]
142075474  [KO:K05415]
142075495  [KO:K05415]
142075496  [KO:K05415]
142075506  [KO:K05414]
142075516  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
142075559  [KO:K05415]
142075560  [KO:K05415]
142075565  [KO:K05415]
142075588  [KO:K05415]
142075605  [KO:K05415]
142075606  [KO:K05415]
142075639  [KO:K05172]
142075676  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
142075701  [KO:K05415]
142075714  GHR; growth hormone receptor [KO:K05080]
142075718  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
142075719  [KO:K05415]
142075720  [KO:K05415]
142075837  [KO:K05512]
142075909  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
142075922  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
142076032  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
142076075  PRLR; prolactin receptor [KO:K05081]
142076093  [KO:K05415]
142076204  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
142076688  [KO:K05417]
142077757  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
142077788  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
142077802  IL17D; interleukin-17D [KO:K05492]
142077957  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
142078258  PRL; prolactin [KO:K05439]
142078286  XCR1; chemokine XC receptor 1 [KO:K04193]
142078691  IL7; interleukin-7 [KO:K05431]
142078939  [KO:K05074]
142079040  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
142079094  BMP6; bone morphogenetic protein 6 [KO:K16620]
142079167  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
142079194  IL15RA; interleukin-15 receptor subunit alpha [KO:K05068]
142079201  INHBA; inhibin beta A chain [KO:K04667]
142079261  CCR4; C-C chemokine receptor type 4 [KO:K04179]
142079262  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
142079263  [KO:K04183]
142079288  CCR9; C-C chemokine receptor type 9 [KO:K04184]
142079290  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
142079291  [KO:K04180]
142079292  [KO:K04180]
142079293  [KO:K04183]
142079302  ACKR4; atypical chemokine receptor 4 [KO:K04186]
142079340  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
142079418  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
142079647  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
142079819  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
142079838  GDF6; growth/differentiation factor 6 [KO:K20012]
142080084  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
142080205  BMP5; bone morphogenetic protein 5 [KO:K04663]
142080486  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
142080487  IFNGR1; interferon gamma receptor 1 [KO:K05132]
142080871  LEP; leptin [KO:K05424]
142080896  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
142081138  BMP2; bone morphogenetic protein 2 [KO:K21283]
142081223  CCR6; LOW QUALITY PROTEIN: C-C chemokine receptor type 6 [KO:K04181]
142081301  [KO:K05494]
142081302  IL17A; interleukin-17A [KO:K05489]
142081309  GDF7; growth/differentiation factor 7 [KO:K20013]
142081780  RELL1; RELT-like protein 1 isoform X1 [KO:K26541]
142082184  IL15; interleukin-15 [KO:K05433]
142082236  IL21; interleukin-21 [KO:K05434]
142082324  [KO:K10030]
142082326  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
142082339  BMP3; bone morphogenetic protein 3 [KO:K05496]
142082369  [KO:K10030]
142082528  [KO:K10032]
142082529  [KO:K10032]
142082536  [KO:K10030]
142082849  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
142083217  BMP4; bone morphogenetic protein 4 [KO:K04662]
142083337  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
142083339  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
142083368  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
142083388  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
142083462  INHBB; inhibin beta B chain [KO:K22687]
142083491  [KO:K05050]
142083495  [KO:K05439]
142083534  INHA; inhibin alpha chain [KO:K05500]
142083681  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
142083801  ACKR3; atypical chemokine receptor 3 [KO:K04304]
142083812  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
142083826  IFNG; interferon gamma [KO:K04687]
142083840  [KO:K04388] [EC:2.7.11.30]
142083910  IL26; interleukin-26 [KO:K05446]
142083940  MSTN; growth/differentiation factor 8 [KO:K05497]
142083948  [KO:K22669]
142084014  IL22; interleukin-22 [KO:K05445]
142084137  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
142084242  [KO:K21283]
142084244  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
142084250  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
142084598  GDF2; growth/differentiation factor 2 [KO:K05503]
142084599  GDF10; growth/differentiation factor 10 [KO:K22674]
142084693  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
142084704  LEPR; leptin receptor [KO:K05062]
142084833  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
142084876  MPL; LOW QUALITY PROTEIN: thrombopoietin receptor [KO:K05082]
142084887  [KO:K04738]
142084891  [KO:K04738]
142085097  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
142085098  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
142085336  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
142085400  THPO; thrombopoietin [KO:K06854]
142085441  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
142085573  CCL20; C-C motif chemokine 20 [KO:K14625]
142085642  IL12A; interleukin-12 subunit alpha [KO:K05406]
142086024  IL17RE; interleukin-17 receptor E [KO:K05168]
142086083  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
142086160  IL17RC; interleukin-17 receptor C [KO:K05166]
142086407  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
142086665  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
142086998  [KO:K05508]
142086999  [KO:K21083]
142087127  IL34; interleukin-34 [KO:K22633]
142087216  [KO:K21083]
142087287  IL17C; interleukin-17C [KO:K05491]
142087534  BMP15; bone morphogenetic protein 15 [KO:K05498]
142087563  EDA; ectodysplasin-A [KO:K05480]
142087621  CD40LG; CD40 ligand [KO:K03161]
142087648  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
142087661  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
142087667  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
142087904  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
142088010  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
142088423  CNTF; ciliary neurotrophic factor [KO:K05420]
142088501  IL17B; interleukin-17B [KO:K05490]
142088528  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
142088583  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
142088648  IL12B; interleukin-12 subunit beta [KO:K05425]
142088796  GDF9; growth/differentiation factor 9 [KO:K22673]
142088895  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
142088898  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
142088977  IL4; interleukin-4 [KO:K05430]
142089004  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
142089077  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
142089317  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
142089319  IL21R; interleukin-21 receptor [KO:K05075]
142089320  [KO:K05073]
142089450  IL20RB; LOW QUALITY PROTEIN: interleukin-20 receptor subunit beta [KO:K05137]
142089488  GDF5; growth/differentiation factor 5 [KO:K04664]
142089610  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
142089734  BMP7; bone morphogenetic protein 7 [KO:K16621]
142089819  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
142089896  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
142090376  LIF; leukemia inhibitory factor [KO:K05419]
142090718  [KO:K12499]
142090719  [KO:K12964]
142090782  [KO:K05514]
142090791  [KO:K12964]
142091339  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
142091543  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
142091838  [KO:K05438]
142091869  [KO:K05507]
142091934  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
142091985  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
142092009  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
142092015  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
142092100  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
142092126  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
142092146  CSF3; granulocyte colony-stimulating factor [KO:K05423]
142092157  CCR10; C-C chemokine receptor type 10 [KO:K04185]
142092297  TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146]
142092311  TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160]
142092340  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
142092393  [KO:K05154]
142092456  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
142092459  [KO:K05141]
142092586  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
142092630  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
142092644  IL18; interleukin-18 [KO:K05482]
142092823  [KO:K16622]
142092960  IFNLR1; interferon lambda receptor 1 [KO:K05140]
142092987  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
142093036  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
142093135  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
142093216  IL10; interleukin-10 [KO:K05443]
142093218  [KO:K22667]
142093315  NGF; beta-nerve growth factor [KO:K02582]
142093484  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
142093504  BMP10; bone morphogenetic protein 10 [KO:K22670]
142093507  NODAL; nodal homolog [KO:K04666]
142093627  [KO:K05483]
142093628  [KO:K05481]
142093659  [KO:K04519]
142093733  EBI3; interleukin-27 subunit beta [KO:K24476]
142093767  GDF15; growth/differentiation factor 15 isoform X1 [KO:K05504]
142093862  [KO:K21283]
142093895  AMH; muellerian-inhibiting factor [KO:K04665]
142093953  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
142093967  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

DBGET integrated database retrieval system