KEGG   PATHWAY: ccae04020
Entry
ccae04020                   Pathway                                
Name
Calcium signaling pathway - Cyanistes caeruleus (blue tit)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
ccae04020  Calcium signaling pathway
ccae04020

Other DBs
GO: 0019722
Organism
Cyanistes caeruleus (blue tit) [GN:ccae]
Gene
111930894  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
111926558  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
111933482  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
111935222  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
111939756  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
111926838  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
111930319  muscarinic acetylcholine receptor M5-like [KO:K04133]
111930320  muscarinic acetylcholine receptor M5-like [KO:K04133]
111936631  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
111937793  ADORA2B; adenosine receptor A2b [KO:K04267]
111930959  ADRB1; beta-1 adrenergic receptor [KO:K04141]
111935768  ADRB2; beta-2 adrenergic receptor [KO:K04142]
111935442  DRD1; D(1A) dopamine receptor [KO:K04144]
111928469  DRD5; D(1B) dopamine receptor [KO:K05840]
111930919  D(1) dopamine receptor-like [KO:K05840]
111938815  LOW QUALITY PROTEIN: D(1) dopamine receptor-like [KO:K05840]
111935472  HRH2; histamine H2 receptor [KO:K04150]
111928319  probable G-protein coupled receptor No9 [KO:K04150]
111935781  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
111932293  5-hydroxytryptamine receptor 5B-like [KO:K04161]
111925485  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
111938505  HTR6; 5-hydroxytryptamine receptor 6 isoform X1 [KO:K04162]
111929127  5-hydroxytryptamine receptor 7-like [KO:K04163]
111930916  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
111938030  GNAS; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
111924987  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
111923918  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
111925673  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
111934618  ADCY7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
111925137  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
111925138  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
111935874  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
111932863  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111927187  PLN; cardiac phospholamban [KO:K05852]
111926475  SLN; sarcolipin [KO:K22642]
111936382  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
111937672  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
111942993  STIM1; stromal interaction molecule 1 [KO:K16059]
111928125  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
111936395  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
111937694  ORAI2; protein orai-2 [KO:K16057]
111928486  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111935128  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111939717  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
111936929  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
111932617  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
111937356  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
111936289  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
111934819  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
111934178  CHRFAM7A; CHRNA7-FAM7A fusion protein [KO:K04809]
111941714  neuronal acetylcholine receptor subunit alpha-7-like isoform X1 [KO:K04809]
111936905  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
111935929  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
111934106  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
111937552  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
111941663  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
111940242  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
111937673  P2RX1; P2X purinoceptor 1 [KO:K05215]
111936388  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
111937802  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
111936778  P2X purinoceptor 6-like [KO:K05221]
111927063  RYR2; ryanodine receptor 2 [KO:K04962]
111930094  RYR3; ryanodine receptor 3 [KO:K04963]
111927210  TRDN; triadin isoform X1 [KO:K23449]
111939028  CASQ2; calsequestrin-2 [KO:K23445]
111924696  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
111928587  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
111926400  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
111936668  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
111938797  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
111935785  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
111929107  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
111933486  AGTR1; type-1 angiotensin II receptor [KO:K04166]
111928842  EDNRA; endothelin-1 receptor [KO:K04197]
111929267  LOW QUALITY PROTEIN: endothelin receptor type B-like [KO:K04198]
111926926  EDNRB; endothelin receptor type B [KO:K04198]
111940635  F2R; proteinase-activated receptor 1 [KO:K03914]
111927059  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
111924947  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
111922847  GRPR; gastrin-releasing peptide receptor isoform X1 [KO:K04169]
111935229  HRH1; histamine H1 receptor isoform X1 [KO:K04149]
111933427  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
111929360  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
111933807  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
111926318  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
111938075  NTSR1; neurotensin receptor type 1 [KO:K04211]
111934914  OXTR; oxytocin receptor [KO:K04229]
111939677  AVPR1B; vasopressin V1b receptor [KO:K04227]
111939026  PTAFR; platelet-activating factor receptor [KO:K04279]
111933173  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
111929837  BDKRB1; B1 bradykinin receptor [KO:K03915]
111929838  BDKRB2; B2 bradykinin receptor [KO:K03916]
111938772  substance-P receptor-like [KO:K04222]
111931494  TACR2; substance-K receptor isoform X1 [KO:K04223]
111927749  TACR3; neuromedin-K receptor [KO:K04224]
111940349  TBXA2R; thromboxane A2 receptor [KO:K04264]
111924356  TRHR; thyrotropin-releasing hormone receptor isoform X1 [KO:K04282]
111938300  thyrotropin-releasing hormone receptor-like [KO:K04282]
111928395  CCKAR; cholecystokinin receptor type A [KO:K04194]
111931764  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
111940710  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111940370  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
111927782  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
111938749  TGFA; protransforming growth factor alpha [KO:K08774]
111936274  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
111934907  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
111927858  PDGFC; platelet-derived growth factor C [KO:K05450]
111923382  PDGFD; platelet-derived growth factor D [KO:K05450]
111935800  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
111931248  FGF8; fibroblast growth factor 8 [KO:K04358]
111934105  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
111929223  FGF16; fibroblast growth factor 16 [KO:K04358]
111928437  FGF20; fibroblast growth factor 20 [KO:K04358]
111929453  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
111946013  fibroblast growth factor 17-like [KO:K04358]
111929899  FGF6; fibroblast growth factor 6 [KO:K04358]
111935684  FGF18; fibroblast growth factor 18 [KO:K04358]
111930412  FGF3; fibroblast growth factor 3 [KO:K04358]
111930413  FGF4; fibroblast growth factor 4 [KO:K04358]
111923652  FGF9; fibroblast growth factor 9 [KO:K04358]
111944138  FGF10; fibroblast growth factor 10 [KO:K04358]
111930414  FGF19; fibroblast growth factor 19 [KO:K22603]
111930076  FGF23; fibroblast growth factor 23 [KO:K22428]
111927585  VEGFA; vascular endothelial growth factor A [KO:K05448]
111927934  vascular endothelial growth factor C-like [KO:K05449]
111927936  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
111922840  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
111939656  NGF; beta-nerve growth factor [KO:K02582]
111923284  hepatocyte growth factor-like [KO:K05460]
111923285  HGF; hepatocyte growth factor [KO:K05460]
111935202  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
111941022  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
111923657  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111944944  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
111931698  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
111931870  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
111928019  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111935543  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111938850  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
111931374  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111927721  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
111943286  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111923182  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
111929245  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
111943904  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111935550  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111928018  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
111939539  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
111940854  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
111933874  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
111931552  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111943846  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
111935327  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
111931023  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111945990  Ig heavy chain Mem5-like [KO:K06856]
111943573  LOW QUALITY PROTEIN: uncharacterized protein LOC111943573 [KO:K06856]
111932186  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
111925533  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
111940037  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
111926455  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
111926460  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111930495  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111938259  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
111925206  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
111934454  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
111931184  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
111928307  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
111934931  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111930014  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
111939798  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
111928170  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
111936569  TPCN1; two pore calcium channel protein 1 [KO:K16896]
111930660  TPCN2; two pore calcium channel protein 2 [KO:K14077]
111932848  MCOLN2; mucolipin-2 [KO:K04993]
111932846  MCOLN3; mucolipin-3 [KO:K04994]
111937276  SPHK1; LOW QUALITY PROTEIN: sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
111931455  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
111935601  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
111931054  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
111938867  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
111928433  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
111944525  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
111944386  ADP/ATP translocase 2 [KO:K05863]
111931034  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
111935166  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
111945501  TNNC2; troponin C, skeletal muscle [KO:K12042]
111927637  calmodulin [KO:K02183]
111929893  CALM1; calmodulin-1 [KO:K02183]
111923171  calmodulin, striated muscle [KO:K02183]
111943688  calmodulin-like protein 4 [KO:K02183]
111937725  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
111922865  PHKA2; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
111929321  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
111934637  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
111940063  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111923845  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
111932252  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
111934649  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
111938138  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
111923213  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
111939803  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
111935038  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
111935541  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
111928996  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111931070  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111945916  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
111944618  uncharacterized protein LOC111944618 [KO:K05869] [EC:2.7.11.17]
111940603  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
111928326  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
111931085  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111938823  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111926640  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
111939740  TFEB; transcription factor EB [KO:K15590]
111923921  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
111938436  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
111934774  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
111936662  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
111937881  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
111932028  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
111923690  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
111927477  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
111930074  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
111926278  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
111937433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111936199  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
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