KEGG   PATHWAY: ccae04010
Entry
ccae04010                   Pathway                                
Name
MAPK signaling pathway - Cyanistes caeruleus (blue tit)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
ccae04010  MAPK signaling pathway
ccae04010

Other DBs
GO: 0000165
Organism
Cyanistes caeruleus (blue tit) [GN:ccae]
Gene
111936929  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
111928486  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111935128  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111932617  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
111937356  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
111936289  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
111934819  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
111939717  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
111923300  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
111935189  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
111935121  voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
111928463  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
111924154  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
111940551  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
111932372  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
111937431  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
111931272  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
111936301  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
111937571  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
111937432  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
111944070  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
111932863  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111937433  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111936199  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111936095  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
111932951  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111928326  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
111931085  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111938823  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111926640  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
111933843  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
111941576  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
111930328  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
111926964  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
111927874  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
111937976  NF1; neurofibromin [KO:K08052]
111941591  RASA1; ras GTPase-activating protein 1 [KO:K04352]
111933520  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
111939824  RAP1A; ras-related protein Rap-1A [KO:K04353]
111932715  RAP1B; LOW QUALITY PROTEIN: ras-related protein Rap-1b [KO:K07836]
111927782  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
111938749  TGFA; protransforming growth factor alpha [KO:K08774]
111929442  AREG; amphiregulin [KO:K09782]
111935800  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
111931248  FGF8; fibroblast growth factor 8 [KO:K04358]
111934105  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
111929223  FGF16; fibroblast growth factor 16 [KO:K04358]
111928437  FGF20; fibroblast growth factor 20 [KO:K04358]
111929453  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
111946013  fibroblast growth factor 17-like [KO:K04358]
111929899  FGF6; fibroblast growth factor 6 [KO:K04358]
111935684  FGF18; fibroblast growth factor 18 [KO:K04358]
111930412  FGF3; fibroblast growth factor 3 [KO:K04358]
111930413  FGF4; fibroblast growth factor 4 [KO:K04358]
111923652  FGF9; fibroblast growth factor 9 [KO:K04358]
111944138  FGF10; fibroblast growth factor 10 [KO:K04358]
111930414  FGF19; fibroblast growth factor 19 [KO:K22603]
111930076  FGF23; fibroblast growth factor 23 [KO:K22428]
111939656  NGF; beta-nerve growth factor [KO:K02582]
111930478  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
111923386  NTF3; neurotrophin-3 [KO:K04356]
111930707  INS; insulin [KO:K04526]
111936136  IGF1; insulin-like growth factor I [KO:K05459]
111930776  IGF2; insulin-like growth factor II [KO:K13769]
111936274  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
111934907  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
111927858  PDGFC; platelet-derived growth factor C [KO:K05450]
111923382  PDGFD; platelet-derived growth factor D [KO:K05450]
111939755  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
111937682  KITLG; kit ligand [KO:K05461]
111943457  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
111927585  VEGFA; vascular endothelial growth factor A [KO:K05448]
111929568  PGF; placenta growth factor [KO:K16859]
111927934  vascular endothelial growth factor C-like [KO:K05449]
111927936  vascular endothelial growth factor C-like isoform X1 [KO:K05449]
111922840  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
111923284  hepatocyte growth factor-like [KO:K05460]
111923285  HGF; hepatocyte growth factor [KO:K05460]
111924341  ANGPT1; angiopoietin-1 [KO:K05465]
111925891  ANGPT2; LOW QUALITY PROTEIN: angiopoietin-2 [KO:K05466]
111943695  angiopoietin-4-like [KO:K05467]
111940248  EFNA2; ephrin-A2 [KO:K05462]
111940867  EFNA5; ephrin-A5 [KO:K05462]
111939600  ephrin-A3-like [KO:K05462]
111941022  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
111932923  ARTN; artemin [KO:K25415]
111923657  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111944944  receptor tyrosine-protein kinase erbB-2-like [KO:K05083] [EC:2.7.10.1]
111931698  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
111931870  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
111938850  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
111931374  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111927721  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
111943286  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111939539  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
111940854  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
111940344  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
111933868  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111928019  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111935543  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111935546  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
111928444  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
111923247  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
111923182  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
111929245  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
111943904  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111935550  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111928018  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
111931552  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111943846  hepatocyte growth factor receptor-like [KO:K05099] [EC:2.7.10.1]
111941340  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
111931023  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111937316  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111929515  SOS2; son of sevenless homolog 2 [KO:K03099]
111926571  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111930717  HRAS; GTPase HRas [KO:K02833]
111945773  KRAS; GTPase KRas isoform X1 [KO:K07827]
111939625  NRAS; GTPase NRas [KO:K07828]
111930555  RRAS2; ras-related protein R-Ras2 [KO:K07830]
111932216  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
111936843  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
111935240  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111933966  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111940193  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111929418  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
111936534  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111933091  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
111940219  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
111922881  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
111928570  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
111939088  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
111926930  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
111934860  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
111939848  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
111925128  MYC; myc proto-oncogene protein [KO:K04377]
111926361  SRF; serum response factor [KO:K04378]
111945660  FOS; proto-oncogene c-Fos [KO:K04379]
111940054  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
111939094  STMN1; stathmin [KO:K04381]
111932478  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
111930078  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
111930079  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
111930080  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
111930225  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
111930226  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
111930228  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
111930229  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
111930230  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
111938925  interleukin-1 receptor antagonist protein-like [KO:K04519]
111942551  transforming growth factor beta-1-like [KO:K13375]
111926211  TGFB2; transforming growth factor beta-2 [KO:K13376]
111929961  TGFB3; transforming growth factor beta-3 [KO:K13377]
111938725  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111942272  interleukin-1 receptor type 1-like [KO:K04386]
111933457  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
111923709  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
111932269  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
111923501  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
111932669  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111930915  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111936023  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111944780  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111937502  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
111938571  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
111934556  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111945572  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
111936895  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
111925454  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
111932046  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111930105  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
111941727  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111934894  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
111926823  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
111926574  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
111922274  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
111925537  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111933722  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111938249  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
111924510  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
111924099  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
111941445  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
111932210  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
111939927  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
111925531  mitogen-activated protein kinase kinase kinase 3-like isoform X1 [KO:K04421] [EC:2.7.11.25]
111930888  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
111926874  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
111933696  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
111932076  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
111926799  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
111925720  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111926951  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
111936575  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
111937776  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
111937201  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
111922673  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
111936127  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
111937452  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111930189  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
111936225  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
111936642  CRKL; crk-like protein [KO:K04438]
111937736  CRK; adapter molecule crk isoform X1 [KO:K04438]
111941144  ARRB1; beta-arrestin-1 [KO:K04439]
111928823  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111935562  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111931141  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111922987  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
111923053  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
111939795  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
111939796  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111936426  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
111939739  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111935195  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
111929890  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
111941854  M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
111923921  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
111934774  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
111932998  JUN; transcription factor AP-1 [KO:K04448]
111932059  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111944162  MAX; protein max [KO:K04453]
111941564  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
111937703  HSPB1; heat shock protein beta-1 [KO:K04455]
111929760  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111922589  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
111927570  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111929708  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
111929709  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
111932830  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
111930793  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
111939732  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
111935377  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
111935318  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111928389  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111930696  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111930193  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111930954  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111933474  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111926233  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
111939988  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111939329  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111933313  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
111933960  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
111940500  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
111940095  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
111938770  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111942179  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111937883  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
111927739  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111931106  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
111946144  uncharacterized protein LOC111946144 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
ccae04070  Phosphatidylinositol signaling system
ccae04110  Cell cycle
ccae04115  p53 signaling pathway
ccae04210  Apoptosis
ccae04310  Wnt signaling pathway
KO pathway
ko04010   
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