KEGG   PATHWAY: csyr04620
Entry
csyr04620                   Pathway                                
Name
Toll-like receptor signaling pathway - Carlito syrichta (Philippine tarsier)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
csyr04620  Toll-like receptor signaling pathway
csyr04620

Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103255043  TLR1; toll-like receptor 1 [KO:K05398]
103274468  TLR2; toll-like receptor 2 [KO:K10159]
103255062  TLR6; toll-like receptor 6 [KO:K10169]
103258843  LBP; lipopolysaccharide-binding protein [KO:K05399]
103277118  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103273346  LY96; lymphocyte antigen 96 isoform X2 [KO:K05400]
103258420  TLR3; toll-like receptor 3 [KO:K05401]
103255573  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
103276839  TLR5; toll-like receptor 5 [KO:K10168]
103275031  TLR7; toll-like receptor 7 [KO:K05404]
103268521  TLR8; toll-like receptor 8 [KO:K10170]
103251387  CTSK; cathepsin K isoform X1 [KO:K01371] [EC:3.4.22.38]
103255929  toll-like receptor 9 isoform X1 [KO:K10161]
103264336  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103273938  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103254239  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103271676  TOLLIP; toll-interacting protein [KO:K05402]
103270832  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103270561  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
103262441  FADD; FAS-associated death domain protein [KO:K02373]
103273365  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103276369  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
103274081  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103263671  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103254079  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103259721  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
103255498  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103263189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103256847  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103273993  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103274648  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103252103  RELA; transcription factor p65 [KO:K04735]
103276430  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103277453  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103251709  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103265435  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103274188  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103264569  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103254297  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
103274589  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103251143  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103249454  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103249455  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103263392  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103263391  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103252280  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103272968  MAPK8; mitogen-activated protein kinase 8 isoform X5 [KO:K04440] [EC:2.7.11.24]
103255312  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103274529  JUN; transcription factor AP-1 [KO:K04448]
103266527  FOS; proto-oncogene c-Fos [KO:K04379]
103270149  TNF; tumor necrosis factor [KO:K03156]
103259440  IL1B; interleukin-1 beta [KO:K04519]
103268608  IL6; interleukin-6 [KO:K05405]
103258245  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
103265030  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
103266387  interleukin-8-like [KO:K10030]
103259317  CXCL8; interleukin-8 [KO:K10030]
103265808  CCL5; C-C motif chemokine 5 [KO:K12499]
103271195  C-C motif chemokine 3-like [KO:K05408]
103254389  C-C motif chemokine 4 isoform X1 [KO:K12964]
103275027  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
103272007  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103265949  IRF5; interferon regulatory factor 5 isoform X1 [KO:K09446]
103259835  SPP1; osteopontin isoform X1 [KO:K06250]
103257998  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
103271912  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
103250762  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103249777  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
103260263  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
103254574  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
103255013  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
103260907  interferon alpha-5-like [KO:K05414]
103260908  interferon alpha-5-like [KO:K05414]
103260910  interferon alpha-5-like [KO:K05414]
103274154  interferon alpha-5-like [KO:K05414]
103274155  interferon alpha-5-like [KO:K05414]
103274156  interferon alpha-10-like [KO:K05414]
103274157  interferon alpha-17-like [KO:K05414]
103274161  interferon alpha-5-like [KO:K05414]
103274163  interferon alpha-17-like [KO:K05414]
103274165  interferon alpha-5-like [KO:K05414]
103274168  interferon alpha-5-like [KO:K05414]
103260915  IFNB1; interferon beta [KO:K05415]
103269359  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103269362  interferon alpha/beta receptor 2 [KO:K05131]
103262860  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103250948  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103256404  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103258295  LOW QUALITY PROTEIN: signal transducer and activator of transcription 2-like [KO:K11221]
103272248  IRF9; interferon regulatory factor 9 [KO:K04693]
103271589  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
103271588  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
103271590  C-X-C motif chemokine 11 [KO:K12672]
103254943  C-X-C motif chemokine 11-like [KO:K12672]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
csyr04010  MAPK signaling pathway
csyr04060  Cytokine-cytokine receptor interaction
csyr04064  NF-kappa B signaling pathway
csyr04120  Ubiquitin mediated proteolysis
csyr04151  PI3K-Akt signaling pathway
csyr04210  Apoptosis
csyr04610  Complement and coagulation cascades
csyr04630  JAK-STAT signaling pathway
KO pathway
ko04620   
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