KEGG   PATHWAY: llv04120
Entry
llv04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Lutra lutra (Eurasian river otter)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
llv04120  Ubiquitin mediated proteolysis
llv04120

Other DBs
GO: 0016567
Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125087415  polyubiquitin-B isoform X1 [KO:K04551]
125099136  polyubiquitin [KO:K04551]
125082105  polyubiquitin-C [KO:K08770]
125100166  ubiquitin-like [KO:K02927]
125108923  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
125102899  LOW QUALITY PROTEIN: ubiquitin-60S ribosomal protein L40-like [KO:K02927]
125081993  ubiquitin-60S ribosomal protein L40 [KO:K02927]
125108777  ubiquitin-40S ribosomal protein S27a [KO:K02977]
125084841  ubiquitin-40S ribosomal protein S27a [KO:K02977]
125091384  ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
125089220  SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
125102260  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
125089096  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
125109959  NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
125079965  ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
125093775  LOW QUALITY PROTEIN: ubiquitin-like modifier-activating enzyme 6 [KO:K10699] [EC:6.2.1.45]
125091996  ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
125098124  ubiquitin-conjugating enzyme E2 A-like [KO:K10573] [EC:2.3.2.23]
125100553  ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
125108838  ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
125099648  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
125083899  ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
125084701  ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
125093231  ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
125104781  ubiquitin-conjugating enzyme E2 E3-like [KO:K20217] [EC:2.3.2.23]
125104973  ubiquitin-conjugating enzyme E2 E2 isoform X1 [KO:K20217] [EC:2.3.2.23]
125105039  ubiquitin-conjugating enzyme E2 E1 [KO:K20217] [EC:2.3.2.23]
125095273  NEDD8-conjugating enzyme UBE2F isoform X1 [KO:K10687] [EC:2.3.2.34]
125086725  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
125095663  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
125093348  ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
125081469  ubiquitin-conjugating enzyme E2 H isoform X1 [KO:K10576] [EC:2.3.2.23]
125090221  SUMO-conjugating enzyme UBC9 [KO:K10577]
125102495  ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
125085597  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
125097710  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
125093655  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 K-like [KO:K04649] [EC:2.3.2.23]
125083455  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
125083471  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
125095313  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
125082080  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
125079476  ubiquitin/ISG15-conjugating enzyme E2 L6-like isoform X1 [KO:K04553] [EC:2.3.2.23]
125089034  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
125107956  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
125100059  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
125093085  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
125086335  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
125087637  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
125105556  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
125086828  (E3-independent) E2 ubiquitin-conjugating enzyme isoform X1 [KO:K10581] [EC:2.3.2.24]
125100638  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
125086094  ubiquitin-conjugating enzyme E2 Q1 isoform X1 [KO:K10582] [EC:2.3.2.23]
125104866  ubiquitin-conjugating enzyme E2 Q2 isoform X1 [KO:K10582] [EC:2.3.2.23]
125083495  ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
125087540  ubiquitin-conjugating enzyme E2 R1 isoform X1 [KO:K02207] [EC:2.3.2.23]
125106928  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 R1-like [KO:K02207] [EC:2.3.2.23]
125089263  ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
125098210  ubiquitin-conjugating enzyme E2 U-like isoform X1 [KO:K10584] [EC:2.3.2.23]
125096943  ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
125086943  ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
125109560  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6-like [KO:K10586] [EC:2.3.2.23]
125103740  ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
125082042  ubiquitin-protein ligase E3B isoform X1 [KO:K10588] [EC:2.3.2.26]
125081449  ubiquitin-protein ligase E3C isoform X1 [KO:K10589] [EC:2.3.2.26]
125087154  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
125090427  E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
125108541  E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
125097785  NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform X1 [KO:K05633] [EC:2.3.2.26]
125089158  NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
125095169  E3 ubiquitin-protein ligase TRIP12 isoform X1 [KO:K10590] [EC:2.3.2.26]
125103904  E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
125082500  E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
125091290  E3 ubiquitin-protein ligase HUWE1 isoform X1 [KO:K10592] [EC:2.3.2.26]
125099167  E3 ubiquitin-protein ligase UBR5 isoform X1 [KO:K10593] [EC:2.3.2.26]
125104082  probable E3 ubiquitin-protein ligase HERC1 isoform X1 [KO:K10594] [EC:2.3.2.26]
125103801  E3 ubiquitin-protein ligase HERC2 isoform X1 [KO:K10595] [EC:2.3.2.26]
125093165  probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
125084440  probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
125078231  ubiquitin conjugation factor E4 A isoform X1 [KO:K10596] [EC:2.3.2.27]
125097072  ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
125090524  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
125081871  RING-type E3 ubiquitin-protein ligase PPIL2 isoform X1 [KO:K10598] [EC:5.2.1.8]
125078819  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
125108521  RING finger protein 37 isoform X1 [KO:K10600]
125107551  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
125080015  E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
125096644  E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
125089789  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-C-like [KO:K22518] [EC:2.3.2.27]
125102349  E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
125092042  E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
125089881  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
125103723  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
125078866  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125101058  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
125085797  E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
125093837  RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
125079331  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2-like [KO:K16060]
125079332  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
125091577  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
125109748  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 7-like [KO:K16061]
125104268  E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
125082457  E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
125098624  E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
125086734  E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
125078683  E3 ubiquitin-protein ligase synoviolin isoform X1 [KO:K10601] [EC:2.3.2.27]
125103214  E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
125087833  autoimmune regulator-like [KO:K10603]
125090957  E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
125086735  breast cancer type 1 susceptibility protein homolog isoform X1 [KO:K10605] [EC:2.3.2.27]
125108367  E3 ubiquitin-protein ligase FANCL isoform X1 [KO:K10606] [EC:2.3.2.27]
125091921  E3 ubiquitin-protein ligase Midline-1 isoform X1 [KO:K08285] [EC:2.3.2.27]
125083204  E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
125088033  E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
125106731  RING-box protein 1b isoform X1 [KO:K03868] [EC:2.3.2.32]
125080978  cullin-1 [KO:K03347]
125099904  S-phase kinase-associated protein 1 [KO:K03094]
125083871  S-phase kinase-associated protein 1 [KO:K03094]
125092302  S-phase kinase-associated protein 1-like [KO:K03094]
125093902  S-phase kinase-associated protein 1-like [KO:K03094]
125094285  S-phase kinase-associated protein 1-like [KO:K03094]
125103677  S-phase kinase-associated protein 1 [KO:K03094]
125080113  S-phase kinase-associated protein 1-like [KO:K03094]
125081063  S-phase kinase-associated protein 1-like [KO:K03094]
125105513  S-phase kinase-associated protein 1-like [KO:K03094]
125089125  S-phase kinase-associated protein 1-like [KO:K03094]
125089985  S-phase kinase-associated protein 1-like [KO:K03094]
125098885  S-phase kinase-associated protein 1-like [KO:K03094]
125084574  F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
125100543  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
125099857  S-phase kinase-associated protein 2 [KO:K03875]
125093043  F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
125098028  F-box only protein 2 isoform X1 [KO:K10099]
125100644  F-box only protein 4 isoform X1 [KO:K10291]
125106920  cullin-2 [KO:K03870]
125083518  elongin-C-like [KO:K03872]
125096944  elongin-C [KO:K03872]
125090381  elongin-B [KO:K03873]
125108726  von Hippel-Lindau disease tumor suppressor isoform X1 [KO:K03871]
125095132  cullin-3 isoform X1 [KO:K03869]
125084836  kelch-like ECH-associated protein 1 [KO:K10456]
125083705  kelch-like protein 9 [KO:K10447]
125092057  kelch-like protein 13 isoform X1 [KO:K10447]
125100572  kelch-like protein 13 [KO:K10447]
125084511  rho-related BTB domain-containing protein 1 isoform X1 [KO:K07868]
125092869  rho-related BTB domain-containing protein 2 isoform X1 [KO:K07868]
125091276  cullin-4B isoform X1 [KO:K10609]
125092635  cullin-4B-like [KO:K10609]
125094859  cullin-4A isoform X1 [KO:K10609]
125080046  DNA damage-binding protein 1 [KO:K10610]
125078755  DNA damage-binding protein 2 isoform X1 [KO:K10140]
125099877  DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
125105085  DET1 homolog isoform X1 [KO:K10571]
125098139  RING-box protein 2 isoform X1 [KO:K10611]
125078457  cullin-5 isoform X1 [KO:K10612]
125091067  suppressor of cytokine signaling 1 [KO:K04694]
125086889  suppressor of cytokine signaling 3 [KO:K04696]
125102368  cullin-7 isoform X1 [KO:K10613]
125082283  F-box/WD repeat-containing protein 8 [KO:K10264]
125087911  anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
125092371  cell division cycle protein 20 homolog [KO:K03363]
125097971  cell division cycle protein 20 homolog [KO:K03363]
125086840  fizzy-related protein homolog isoform X1 [KO:K03364]
125108834  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
125087135  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
125093599  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
125082292  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
125094877  cell division cycle protein 16 homolog [KO:K03353]
125096336  cell division cycle protein 16 homolog [KO:K03353]
125082010  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
125099798  cell division cycle protein 23 homolog isoform X1 [KO:K03355]
125093000  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 10-like [KO:K03357]
125083224  anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
125104156  anaphase-promoting complex subunit 13 [KO:K12456]
125078306  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
125085081  anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
llv03050  Proteasome
KO pathway
ko04120   
LinkDB

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