KEGG   PATHWAY: lve04620
Entry
lve04620                    Pathway                                
Name
Toll-like receptor signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description
Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class
Organismal Systems; Immune system
Pathway map
lve04620  Toll-like receptor signaling pathway
lve04620

Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068485  LBP; lipopolysaccharide-binding protein [KO:K05399]
103068617  [KO:K05414]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103068685  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
103068842  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103069029  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103069117  [KO:K11220]
103069127  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
103069181  [KO:K05414]
103069739  [KO:K05414]
103069819  LY96; lymphocyte antigen 96 [KO:K05400]
103069880  IRF9; interferon regulatory factor 9 [KO:K04693]
103070260  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103070441  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
103070943  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103071515  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
103071861  JUN; transcription factor AP-1 [KO:K04448]
103072186  TLR5; LOW QUALITY PROTEIN: toll-like receptor 5 [KO:K10168]
103072682  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103072956  [KO:K04379]
103073041  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
103073219  [KO:K05414]
103073772  [KO:K05415]
103073775  CXCL10; c-X-C motif chemokine 10 [KO:K12671]
103074050  CXCL9; c-X-C motif chemokine 9 [KO:K05416]
103074326  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103074334  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103074659  TLR4; toll-like receptor 4 [KO:K10160]
103074749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103075087  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
103075340  MAP3K7; mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
103075543  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103077054  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103077222  IRF7; interferon regulatory factor 7 [KO:K09447]
103077530  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103078049  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103078296  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
103078399  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103078710  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103078728  SPP1; osteopontin isoform X1 [KO:K06250]
103078792  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103078933  CXCL11; c-X-C motif chemokine 11 [KO:K12672]
103079299  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
103079935  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103080339  FADD; FAS-associated death domain protein [KO:K02373]
103080704  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
103080924  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103081090  TLR3; LOW QUALITY PROTEIN: toll-like receptor 3 [KO:K05401]
103081332  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103081545  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
103081641  [KO:K04433] [EC:2.7.12.2]
103081732  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
103081814  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103082257  TOLLIP; toll-interacting protein [KO:K05402]
103082585  TLR8; toll-like receptor 8 [KO:K10170]
103082805  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
103082846  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
103083209  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103083231  TNF; tumor necrosis factor [KO:K03156]
103083704  IL12B; interleukin-12 subunit beta [KO:K05425]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103084128  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103084433  FOS; proto-oncogene c-Fos isoform X1 [KO:K04379]
103084510  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103084630  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103084854  TWF2; toll-like receptor 9-like isoform X1 [KO:K10161]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103085940  CD80; T-lymphocyte activation antigen CD80 isoform X1 [KO:K05412]
103086219  IL8; interleukin-8 [KO:K10030]
103087058  IRF5; interferon regulatory factor 5 isoform X1 [KO:K09446]
103087161  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103087676  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103088205  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103088500  CCL5; c-C motif chemokine 5 [KO:K12499]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103088795  [KO:K03175] [EC:2.3.2.27]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103089296  CCL3; LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 3 [KO:K05408]
103089570  [KO:K05408]
103089823  CCL4; c-C motif chemokine 4 [KO:K12964]
103090179  [KO:K10159]
103090542  TLR1; toll-like receptor 1 [KO:K05398]
103090661  [KO:K05414]
103090769  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103090784  IL1B; interleukin-1 beta [KO:K04519]
103090802  TLR6; toll-like receptor 6 [KO:K10169]
103091202  [KO:K05414]
103091203  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103091499  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
103091611  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
Reference
PMID:17275323
  Authors
Kawai T, Akira S.
  Title
TLR signaling.
  Journal
Semin Immunol 19:24-32 (2007)
DOI:10.1016/j.smim.2006.12.004
Reference
PMID:17457343
  Authors
O'Neill LA, Bowie AG.
  Title
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
  Journal
Nat Rev Immunol 7:353-64 (2007)
DOI:10.1038/nri2079
Reference
PMID:16932750
  Authors
Honda K, Taniguchi T.
  Title
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
  Journal
Nat Rev Immunol 6:644-58 (2006)
DOI:10.1038/nri1900
Reference
PMID:17395581
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and Type I interferons.
  Journal
J Biol Chem 282:15319-23 (2007)
DOI:10.1074/jbc.R700009200
Reference
PMID:16497588
  Authors
Akira S, Uematsu S, Takeuchi O.
  Title
Pathogen recognition and innate immunity.
  Journal
Cell 124:783-801 (2006)
DOI:10.1016/j.cell.2006.02.015
Reference
PMID:14698224
  Authors
Yamamoto M, Takeda K, Akira S.
  Title
TIR domain-containing adaptors define the specificity of TLR signaling.
  Journal
Mol Immunol 40:861-8 (2004)
DOI:10.1016/j.molimm.2003.10.006
Reference
PMID:12734364
  Authors
Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
  Title
The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
  Journal
J Immunol 170:5165-75 (2003)
DOI:10.4049/jimmunol.170.10.5165
Reference
PMID:14751764
  Authors
Aderem A, Smith KD.
  Title
A systems approach to dissecting immunity and inflammation.
  Journal
Semin Immunol 16:55-67 (2004)
DOI:10.1016/j.smim.2003.10.002
Reference
PMID:17637696
  Authors
Banerjee A, Gerondakis S.
  Title
Coordinating TLR-activated signaling pathways in cells of the immune system.
  Journal
Immunol Cell Biol 85:420-4 (2007)
DOI:10.1038/sj.icb.7100098
Reference
PMID:17507094
  Authors
Loniewski KJ, Patial S, Parameswaran N.
  Title
Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
  Journal
Mol Immunol 44:3715-23 (2007)
DOI:10.1016/j.molimm.2007.04.002
Reference
PMID:11101877
  Authors
Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
  Title
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
  Journal
Nat Immunol 1:533-40 (2000)
DOI:10.1038/82797
Reference
PMID:16924467
  Authors
Uematsu S, Akira S.
  Title
Toll-like receptors and innate immunity.
  Journal
J Mol Med 84:712-25 (2006)
DOI:10.1007/s00109-006-0084-y
Related
pathway
lve04010  MAPK signaling pathway
lve04060  Cytokine-cytokine receptor interaction
lve04064  NF-kappa B signaling pathway
lve04120  Ubiquitin mediated proteolysis
lve04151  PI3K-Akt signaling pathway
lve04210  Apoptosis
lve04610  Complement and coagulation cascades
lve04630  JAK-STAT signaling pathway
KO pathway
ko04620   

DBGET integrated database retrieval system