Entry
Name
Cytokine-cytokine receptor interaction - Lipotes vexillifer (Yangtze River dolphin)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
lve04060 Cytokine-cytokine receptor interaction
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:
lve ]
Gene
103069127 IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131 ]
103069573 TNFRSF6B; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
103070132 IL36RN; LOW QUALITY PROTEIN: interleukin-36 receptor antagonist protein [KO:K05483 ]
103070400 IL1F10; LOW QUALITY PROTEIN: interleukin-1 family member 10 [KO:K05488 ]
103071515 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
103072191 EDA2R; tumor necrosis factor receptor superfamily member 27-like isoform X1 [KO:K05163 ]
103072461 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
103072521 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
103072790 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
103073066 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
103073382 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
103074386 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
103074658 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
103074739 IL10RB; LOW QUALITY PROTEIN: interleukin-10 receptor subunit beta [KO:K05135 ]
103075275 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
103075698 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
103076047 IL17RB; LOW QUALITY PROTEIN: interleukin 17 receptor B [KO:K05165 ]
103076206 TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
103076530 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
103076750 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
103077876 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
103078166 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
103078336 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
103078363 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A isoform X1 [KO:K05149 ]
103078622 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
103078682 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
103078939 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
103079098 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
103079299 IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406 ]
103079416 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
103080104 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
103080586 IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174 ]
103081286 IL31RA; LOW QUALITY PROTEIN: interleukin 31 receptor A [KO:K22630 ]
103081741 IFNGR2; LOW QUALITY PROTEIN: interferon gamma receptor 2 [KO:K05133 ]
103081795 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
103082113 IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132 ]
103082651 IL13RA2; LOW QUALITY PROTEIN: interleukin-13 receptor subunit alpha-2 [KO:K05077 ]
103082720 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
103082831 CCL27; LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 27 [KO:K16598 ]
103082964 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
103083521 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721 ]
103083689 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
103084330 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
103084646 TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
103084995 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
103085088 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
103085100 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
103085343 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
103085500 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
103085615 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
103085970 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
103086194 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
103087361 TNFRSF25; tumor necrosis factor receptor superfamily member 25-like [KO:K05160 ]
103088179 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
103089107 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
103089274 TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
103089296 CCL3; LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 3 [KO:K05408 ]
103089757 CCR2; LOW QUALITY PROTEIN: c-C chemokine receptor type 2 [KO:K04177 ]
103090534 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway