Entry Name JAK-STAT signaling pathway - Lipotes vexillifer (Yangtze River dolphin)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Lipotes vexillifer (Yangtze River dolphin) [GN:
lve ]
Gene 103068832 STAT4; signal transducer and activator of transcription 4 [KO:K11222 ]
103069127 IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131 ]
103070370 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
103071052 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
103073382 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
103073908 STAT6; signal transducer and activator of transcription 6 [KO:K11225 ]
103074739 IL10RB; LOW QUALITY PROTEIN: interleukin-10 receptor subunit beta [KO:K05135 ]
103075275 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
103075698 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
103076530 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
103078725 PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
103079299 IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406 ]
103079416 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
103079766 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
103080733 CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625 ]
103081286 IL31RA; LOW QUALITY PROTEIN: interleukin 31 receptor A [KO:K22630 ]
103081732 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
103081741 IFNGR2; LOW QUALITY PROTEIN: interferon gamma receptor 2 [KO:K05133 ]
103082113 IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132 ]
103082258 STAT5B; LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B [KO:K11224 ]
103082535 STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
103082651 IL13RA2; LOW QUALITY PROTEIN: interleukin-13 receptor subunit alpha-2 [KO:K05077 ]
103083689 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
103083960 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
103085145 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
103085303 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103085500 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
103086495 STAT3; signal transducer and activator of transcription 3 [KO:K04692 ]
103088756 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
103089107 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
103089188 FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365 ]
103089257 PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
103090688 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
103090946 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1 [KO:K02539 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related lve04060 Cytokine-cytokine receptor interaction
KO pathway
