KEGG   PATHWAY: mlf04810
Entry
mlf04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Myotis lucifugus (little brown bat)
Class
Cellular Processes; Cell motility
Pathway map
mlf04810  Regulation of actin cytoskeleton
mlf04810

Other DBs
GO: 0030036
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102416877  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102416933  [KO:K13708]
102416999  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102417388  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102417402  GSN; gelsolin isoform X1 [KO:K05768]
102417411  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
102417415  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
102417618  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
102417633  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102417755  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102417802  VAV1; proto-oncogene vav [KO:K05730]
102417873  MYH10; myosin-10 [KO:K10352]
102418229  LPAR1; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 1 [KO:K04289]
102418373  ITGB7; integrin beta-7 [KO:K06590]
102418575  PDGFD; platelet-derived growth factor D [KO:K05450]
102418608  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
102418852  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102419131  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102419225  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
102419324  [KO:K02649]
102419496  [KO:K12329]
102420198  [KO:K16848]
102420269  CRKL; crk-like protein isoform X1 [KO:K04438]
102420275  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
102420344  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
102420488  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
102420569  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
102420799  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
102420818  FGF16; fibroblast growth factor 16 [KO:K04358]
102421040  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
102421777  ITGB3; integrin beta-3 [KO:K06493]
102421786  FGF6; fibroblast growth factor 6 [KO:K04358]
102421923  F2R; proteinase-activated receptor 1 [KO:K03914]
102422006  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4 [KO:K00889] [EC:2.7.1.68]
102422136  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102422236  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102422264  RHOA; transforming protein RhoA [KO:K04513]
102422362  [KO:K16848]
102422404  ITGA8; integrin alpha-8 [KO:K06584]
102422469  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102422517  PFN3; profilin-3 [KO:K05759]
102422575  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102422649  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102422721  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
102423374  RRAS; ras-related protein R-Ras [KO:K07829]
102423392  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
102423450  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102423544  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
102423665  ENAH; protein enabled homolog [KO:K05746]
102423748  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102423782  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
102423786  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
102423952  ITGAE; integrin alpha-E [KO:K06524]
102424044  [KO:K08007]
102424151  ACTR3B; actin-related protein 3B isoform X9 [KO:K18584]
102424220  BDKRB2; B2 bradykinin receptor [KO:K03916]
102424256  EGF; pro-epidermal growth factor [KO:K04357]
102424308  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
102424312  FAM49B; protein FAM49B isoform X2 [KO:K27976]
102424764  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
102424873  PFN4; profilin-4 [KO:K05759]
102424880  SCIN; adseverin isoform X1 [KO:K05768]
102425197  RGCC; regulator of cell cycle RGCC isoform X3 [KO:K26108]
102425233  [KO:K05692]
102425270  BDKRB1; LOW QUALITY PROTEIN: B1 bradykinin receptor [KO:K03915]
102425275  ITGB2; integrin beta-2 [KO:K06464]
102425316  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X6 [KO:K13710]
102425389  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
102426004  FGF19; fibroblast growth factor 19 [KO:K22603]
102426106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102426164  PFN2; profilin-2 [KO:K05759]
102426314  FGF4; fibroblast growth factor 4 [KO:K04358]
102426340  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102426387  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
102426445  MSN; moesin [KO:K05763]
102426451  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102426634  FGF3; fibroblast growth factor 3 [KO:K04358]
102426679  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
102426780  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102427404  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102427607  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102427655  ITGA7; integrin alpha-7 [KO:K06583]
102427666  PXN; paxillin isoform X1 [KO:K05760]
102427675  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102427794  CFL1; cofilin-1 [KO:K05765]
102427890  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102428022  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
102428066  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102428075  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
102428528  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102428536  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102428863  FGF7; fibroblast growth factor 7 [KO:K04358]
102428940  MYH11; LOW QUALITY PROTEIN: myosin-11 [KO:K10352]
102429013  ACTR3; actin-related protein 3 isoform X2 [KO:K18584]
102429230  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102429518  FAM49A; protein FAM49A [KO:K27976]
102429793  MYL10; myosin regulatory light chain 10 [KO:K12756]
102429857  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
102429864  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
102429928  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
102429955  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
102430047  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
102430207  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102430574  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
102430727  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
102430737  INS; insulin [KO:K04526]
102430744  NRAS; GTPase NRas [KO:K07828]
102430746  [KO:K04513]
102430800  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
102430982  RDX; radixin isoform X1 [KO:K05762]
102431239  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
102431344  FGF1; fibroblast growth factor 1 [KO:K18496]
102431423  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102431483  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
102431516  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
102431567  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102431589  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
102431641  KNG1; kininogen-1 [KO:K03898]
102431810  INSRR; LOW QUALITY PROTEIN: insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
102431820  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
102431949  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102431984  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
102431999  KRAS; GTPase KRas isoform X1 [KO:K07827]
102432233  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
102432339  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102432377  [KO:K03898]
102432454  FGF20; fibroblast growth factor 20 [KO:K04358]
102432473  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X2 [KO:K05729]
102432519  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102432520  FGF21; fibroblast growth factor 21 [KO:K22429]
102432599  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102432691  [KO:K03898]
102432738  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
102433011  [KO:K03898]
102433295  WASF2; wiskott-Aldrich syndrome protein family member 2 isoform X2 [KO:K05748]
102433374  [KO:K05692]
102433515  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2 [KO:K00921] [EC:2.7.1.150]
102433527  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
102433534  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102433766  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
102433918  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
102434163  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
102434453  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102434731  C8A; complement component C8 alpha chain [KO:K03997]
102435040  C8B; complement component C8 beta chain [KO:K03998]
102435209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102435224  C9; complement component C9 [KO:K04000]
102435241  BRAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102435256  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102435332  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
102435389  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102435667  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102435769  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102436075  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
102436155  VCL; vinculin [KO:K05700]
102436383  [KO:K06269] [EC:3.1.3.16]
102436424  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102436444  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102436594  IQGAP3; LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP3 [KO:K05767]
102436650  CFL2; cofilin-2 isoform X2 [KO:K05765]
102436681  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
102436734  ITGAL; integrin alpha-L isoform X2 [KO:K05718]
102436989  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X2 [KO:K04639]
102437015  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102437203  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102437257  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
102437258  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
102437417  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102437531  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102437942  ABI2; abl interactor 2 isoform X4 [KO:K05751]
102438044  PAK3; serine/threonine-protein kinase PAK 3 isoform X4 [KO:K05733] [EC:2.7.11.1]
102438169  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
102438222  GIT1; LOW QUALITY PROTEIN: ARF GTPase-activating protein GIT1 [KO:K05737]
102438342  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102438347  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
102438432  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
102438448  ITGA9; integrin alpha-9 [KO:K06585]
102438838  FGF10; fibroblast growth factor 10 [KO:K04358]
102438960  [KO:K05764]
102438979  ARHGEF4; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 4 [KO:K05769]
102438984  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102439024  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102439030  SSH2; protein phosphatase Slingshot homolog 2 isoform X6 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102439031  NCKAP1L; nck-associated protein 1-like [KO:K05750]
102439092  [KO:K10352]
102439118  [KO:K22429]
102439153  ITGAV; integrin alpha-V [KO:K06487]
102439196  ITGAD; LOW QUALITY PROTEIN: integrin alpha-D [KO:K06594]
102439596  ITGA4; integrin alpha-4 [KO:K06483]
102439783  SSH1; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102439844  FGD3; LOW QUALITY PROTEIN: FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
102439923  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102440287  C7; complement component C7 isoform X1 [KO:K03996]
102440413  ACTN4; LOW QUALITY PROTEIN: alpha-actinin-4 [KO:K05699]
102440432  FGF18; fibroblast growth factor 18 [KO:K04358]
102440437  FN1; fibronectin isoform X7 [KO:K05717]
102440463  ARHGEF1; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 1 [KO:K12330]
102440525  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
102440736  CRK; adapter molecule crk isoform X1 [KO:K04438]
102440901  C6; complement component C6 [KO:K03995]
102441064  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102441373  [KO:K03898]
102441522  [KO:K02649]
102441579  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102441680  BRK1; protein BRICK1 [KO:K05752]
102441901  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102441944  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
102442414  PFN1; profilin-1 [KO:K05759]
102442553  [KO:K12757]
102442780  C5; complement C5 [KO:K03994]
102442814  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102442835  FGF9; fibroblast growth factor 9 [KO:K04358]
102442866  [KO:K12757]
102442926  SOS1; son of sevenless homolog 1 [KO:K03099]
102442936  [KO:K03898]
102442955  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102443084  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
102443146  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
102443158  [KO:K13708]
102443221  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102443279  [KO:K04456] [EC:2.7.11.1]
102443283  [KO:K05749]
106694368  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
111825105  [KO:K03898]
111825710  FGF2; fibroblast growth factor 2 [KO:K18497]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mlf04010  MAPK signaling pathway
mlf04510  Focal adhesion
mlf04520  Adherens junction
KO pathway
ko04810   

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