KEGG   PATHWAY: mlf04010
Entry
mlf04010                    Pathway                                
Name
MAPK signaling pathway - Myotis lucifugus (little brown bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mlf04010  MAPK signaling pathway
mlf04010

Other DBs
GO: 0000165
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102416825  KITLG; kit ligand isoform X6 [KO:K05461]
102417312  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4 [KO:K07209] [EC:2.7.11.10]
102417411  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
102417415  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
102417433  FOS; proto-oncogene c-Fos [KO:K04379]
102417755  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102417782  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102417951  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102417960  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102418196  NTF3; neurotrophin-3 [KO:K04356]
102418251  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
102418362  RAP1A; ras-related protein Rap-1A [KO:K04353]
102418395  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102418405  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102418507  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102418575  PDGFD; platelet-derived growth factor D [KO:K05450]
102418742  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
102418852  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102418865  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102419083  [KO:K19663] [EC:2.7.11.13]
102419131  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102419474  RELB; transcription factor RelB [KO:K09253]
102419659  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102419664  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102419721  [KO:K16342] [EC:3.1.1.4]
102419846  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102420246  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
102420269  CRKL; crk-like protein isoform X1 [KO:K04438]
102420377  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102420552  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
102420687  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102420695  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102420709  ARRB2; beta-arrestin-2 isoform X2 [KO:K04439]
102420713  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102420799  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
102420805  NGFR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102420818  FGF16; fibroblast growth factor 16 [KO:K04358]
102420982  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102421027  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102421097  NF1; neurofibromin [KO:K08052]
102421161  VEGFD; vascular endothelial growth factor D [KO:K05449]
102421207  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102421300  PGF; placenta growth factor isoform X1 [KO:K16859]
102421767  [KO:K17534] [EC:2.7.11.25]
102421786  FGF6; fibroblast growth factor 6 [KO:K04358]
102421812  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
102421835  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102422136  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102422236  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102422327  [KO:K05096] [EC:2.7.10.1]
102422410  JUND; LOW QUALITY PROTEIN: transcription factor jun-D [KO:K04449]
102422469  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102422494  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102422669  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102422798  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
102422986  MAX; protein max isoform X1 [KO:K04453]
102423298  ELK4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
102423374  RRAS; ras-related protein R-Ras [KO:K07829]
102423450  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102423534  MAP3K20; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
102423622  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102423631  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
102423748  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102423786  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
102423871  FLNA; filamin-A [KO:K04437]
102424041  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102424062  MAPK8IP2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
102424085  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102424124  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
102424236  RELA; transcription factor p65 [KO:K04735]
102424256  EGF; pro-epidermal growth factor [KO:K04357]
102424289  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
102424304  MAPT; microtubule-associated protein tau isoform X8 [KO:K04380]
102424419  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
102424719  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102424732  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
102424881  MAP3K21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
102425210  [KO:K03283]
102425374  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102425420  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102425512  [KO:K03283]
102425603  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102425732  CD14; monocyte differentiation antigen CD14 [KO:K04391]
102425815  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
102425826  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
102425874  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102426004  FGF19; fibroblast growth factor 19 [KO:K22603]
102426111  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102426152  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102426209  LAMTOR3; ragulator complex protein LAMTOR3 isoform X4 [KO:K04370]
102426303  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
102426307  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
102426314  FGF4; fibroblast growth factor 4 [KO:K04358]
102426369  DUSP9; LOW QUALITY PROTEIN: dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
102426387  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
102426433  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102426451  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102426511  MYC; myc proto-oncogene protein [KO:K04377]
102426617  AREG; amphiregulin [KO:K09782]
102426634  FGF3; fibroblast growth factor 3 [KO:K04358]
102426780  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102426842  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
102426847  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
102426867  IL1A; interleukin-1 alpha [KO:K04383]
102426882  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102427030  NGF; beta-nerve growth factor [KO:K02582]
102427189  IL1B; interleukin-1 beta [KO:K04519]
102427327  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
102427498  RASGRP2; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2 [KO:K12361]
102427788  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102427815  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
102427825  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102428066  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102428240  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102428242  DUSP4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102428335  DUSP16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102428349  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
102428507  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
102428528  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102428565  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
102428614  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102428621  EFNA1; ephrin-A1 [KO:K05462]
102428736  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102428803  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102428863  FGF7; fibroblast growth factor 7 [KO:K04358]
102428921  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
102429105  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
102429330  SRF; serum response factor [KO:K04378]
102429407  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102429475  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102429560  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102429644  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102429707  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
102429748  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102429915  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102429928  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
102429943  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
102429952  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
102430005  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102430156  STMN1; stathmin [KO:K04381]
102430192  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102430582  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102430595  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102430727  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
102430737  INS; insulin [KO:K04526]
102430744  NRAS; GTPase NRas [KO:K07828]
102430855  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
102431344  FGF1; fibroblast growth factor 1 [KO:K18496]
102431418  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
102431488  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
102431497  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102431540  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
102431603  TAOK3; serine/threonine-protein kinase TAO3 isoform X2 [KO:K04429] [EC:2.7.11.1]
102431961  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102431995  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
102431999  KRAS; GTPase KRas isoform X1 [KO:K07827]
102432233  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
102432273  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102432403  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102432454  FGF20; fibroblast growth factor 20 [KO:K04358]
102432497  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102432520  FGF21; fibroblast growth factor 21 [KO:K22429]
102432599  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102432804  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
102433075  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102433176  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
102433190  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102433470  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X2 [KO:K04864]
102433509  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X13 [KO:K04372] [EC:2.7.11.1]
102433848  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X3 [KO:K04733] [EC:2.7.11.1]
102433980  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
102434121  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
102434274  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102434312  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
102434406  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
102434410  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102434453  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102434624  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
102434634  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
102434907  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102435068  TGFB1; transforming growth factor beta-1 [KO:K13375]
102435158  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
102435209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102435241  BRAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102435532  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
102435571  [KO:K05462]
102435667  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102435748  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102435872  MEF2C; myocyte-specific enhancer factor 2C isoform X2 [KO:K04454]
102435955  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
102436047  [KO:K04460] [EC:3.1.3.16]
102436137  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
102436167  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
102436320  DAXX; death domain-associated protein 6 [KO:K02308]
102436397  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102436424  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102436484  EFNA3; LOW QUALITY PROTEIN: ephrin-A3 [KO:K05462]
102436800  EFNA4; ephrin-A4 [KO:K05462]
102436804  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102437031  [KO:K04386]
102437052  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102437122  DUSP2; LOW QUALITY PROTEIN: dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102437124  NRTN; neurturin isoform X2 [KO:K25414]
102437208  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X2 [KO:K04458] [EC:3.1.3.48]
102437355  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
102437412  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
102437415  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
102437455  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102437531  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102437558  TNF; tumor necrosis factor isoform X1 [KO:K03156]
102437763  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102437773  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102437934  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102437971  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
102438038  VEGFC; vascular endothelial growth factor C [KO:K05449]
102438050  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102438260  PPM1B; protein phosphatase 1B isoform X3 [KO:K04461] [EC:3.1.3.16]
102438329  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X2 [KO:K05084] [EC:2.7.10.1]
102438357  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102438419  CASP3; caspase-3 isoform X3 [KO:K02187] [EC:3.4.22.56]
102438597  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102438706  HSPB1; heat shock protein beta-1 [KO:K04455]
102438731  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
102438838  FGF10; fibroblast growth factor 10 [KO:K04358]
102438914  [KO:K04441] [EC:2.7.11.24]
102438932  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102439024  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102439118  [KO:K22429]
102439228  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102439232  ANGPT4; angiopoietin-4 [KO:K05467]
102439377  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
102439412  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102439429  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102439442  RASGRP4; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 4 [KO:K12363]
102439641  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102439712  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
102439774  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
102439775  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
102439923  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102439932  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102440089  EREG; proepiregulin [KO:K09784]
102440217  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X4 [KO:K04442] [EC:2.7.11.1]
102440265  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3 [KO:K04372] [EC:2.7.11.1]
102440432  FGF18; fibroblast growth factor 18 [KO:K04358]
102440614  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102440705  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102440736  CRK; adapter molecule crk isoform X1 [KO:K04438]
102440792  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102440836  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102440990  CACNA2D1; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
102441003  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102441042  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102441121  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102441142  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
102441232  RAP1B; ras-related protein Rap-1b [KO:K07836]
102441297  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102441450  TGFB3; transforming growth factor beta-3 [KO:K13377]
102441458  PSPN; persephin [KO:K25416]
102441579  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102442075  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
102442119  CACNG3; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102442473  KDR; vascular endothelial growth factor receptor 2 isoform X3 [KO:K05098] [EC:2.7.10.1]
102442629  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
102442787  KIT; mast/stem cell growth factor receptor Kit isoform X2 [KO:K05091] [EC:2.7.10.1]
102442814  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102442835  FGF9; fibroblast growth factor 9 [KO:K04358]
102442880  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102442922  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102442926  SOS1; son of sevenless homolog 1 [KO:K03099]
102443135  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102443221  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102443279  [KO:K04456] [EC:2.7.11.1]
106695515  [KO:K05466]
111825710  FGF2; fibroblast growth factor 2 [KO:K18497]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mlf04070  Phosphatidylinositol signaling system
mlf04110  Cell cycle
mlf04115  p53 signaling pathway
mlf04210  Apoptosis
mlf04310  Wnt signaling pathway
mlf04668  TNF signaling pathway
KO pathway
ko04010   

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