KEGG   PATHWAY: mpah04530
Entry
mpah04530                   Pathway                                
Name
Tight junction - Mus pahari (shrew mouse)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mpah04530  Tight junction
mpah04530

Other DBs
GO: 0005923
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110312867  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
110312912  Micall2; MICAL-like protein 2 isoform X1 [KO:K21068]
110312925  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
110312960  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
110312976  Cldn4; claudin-4 [KO:K06087]
110312980  Cldn3; claudin-3 [KO:K06087]
110313074  Actb; actin, cytoplasmic 1 [KO:K05692]
110313087  Cldn15; claudin-15 [KO:K06087]
110313198  [KO:K06087]
110313250  [KO:K06087]
110313291  [KO:K06087]
110313292  Cldn34; claudin-34 [KO:K06087]
110313316  Amot; angiomotin [KO:K16819]
110313345  Msn; moesin isoform X1 [KO:K05763]
110313355  Tjp1; tight junction protein ZO-1 isoform X1 [KO:K05701]
110313655  Rap2c; ras-related protein Rap-2c [KO:K07839]
110314062  Was; wiskott-Aldrich syndrome protein [KO:K05747]
110314132  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
110314217  Cldn2; claudin-2 [KO:K06087]
110314553  [KO:K06087]
110315523  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
110315960  Ybx3; Y-box-binding protein 3 isoform X1 [KO:K06099]
110316188  Actr3b; actin-related protein 3B [KO:K18584]
110316246  Tjp2; tight junction protein ZO-2 isoform X1 [KO:K06098]
110316306  [KO:K07374]
110316323  Arpc4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
110316395  Tuba8; tubulin alpha-8 chain isoform X1 [KO:K07374]
110316409  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
110316417  [KO:K07374]
110316437  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
110316712  Cldn12; claudin-12 [KO:K06087]
110317793  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110318283  Pcna; proliferating cell nuclear antigen isoform X1 [KO:K04802]
110318312  Myl9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
110318541  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
110318764  Arhgap17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
110318782  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
110318923  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
110319838  Arhgef2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
110319896  Prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
110319932  Rap1a; ras-related protein Rap-1A [KO:K04353]
110320094  Cd1d; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
110320095  [KO:K06448]
110320315  Rab13; ras-related protein Rab-13 isoform X1 [KO:K06109]
110320316  Cldn11; claudin-11 [KO:K06087]
110320429  Cgn; cingulin isoform X1 [KO:K06102]
110320445  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
110320995  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110321226  Actr3; actin-related protein 3 [KO:K18584]
110321284  Tuba4a; tubulin alpha-4A chain isoform X1 [KO:K07374]
110321362  Arpc2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
110321720  Cttn; src substrate cortactin isoform X1 [KO:K06106]
110321734  Arpc5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
110322106  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
110322186  F11r; junctional adhesion molecule A [KO:K06089]
110322378  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
110322668  Mpp4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
110322847  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110322937  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
110322950  Mpdz; multiple PDZ domain protein isoform X1 [KO:K06095]
110323027  Patj; inaD-like protein isoform X1 [KO:K06092]
110323060  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110323252  Jun; transcription factor AP-1 [KO:K04448]
110323287  Epb41l4b; LOW QUALITY PROTEIN: band 4.1-like protein 4B [KO:K21111]
110323517  Cldn19; claudin-19 [KO:K06087]
110324181  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
110324364  Mpp5; MAGUK p55 subfamily member 5 [KO:K06091]
110324839  [KO:K07839]
110324934  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
110325235  [KO:K07374]
110325313  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
110325466  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110325649  Cldn10; claudin-10 isoform X1 [KO:K06087]
110325882  Gata4; transcription factor GATA-4 isoform X1 [KO:K09183]
110325961  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110326187  Tjp3; tight junction protein ZO-3 isoform X1 [KO:K06097]
110326196  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110326255  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
110326359  Myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
110326378  [KO:K04513]
110326551  Myl6b; myosin light chain 6B [KO:K12751]
110326951  Bves; blood vessel epicardial substance [KO:K21108]
110327149  Cldn25; putative claudin-25 [KO:K06087]
110327234  Rdx; radixin isoform X1 [KO:K05762]
110327300  Nedd4; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
110327602  Amotl1; angiomotin-like protein 1 [KO:K06104]
110327722  Jam3; junctional adhesion molecule C [KO:K06785]
110327762  Amotl2; angiomotin-like protein 2 isoform X1 [KO:K06104]
110327907  Rhoa; transforming protein RhoA isoform X1 [KO:K04513]
110328003  Rab8b; ras-related protein Rab-8B [KO:K07902]
110328009  Cgnl1; cingulin-like protein 1 [KO:K21110]
110328136  Cldn18; claudin-18 isoform X1 [KO:K06087]
110328279  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
110328784  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
110328949  Map3k1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
110329108  Ocln; occludin [KO:K06088]
110329118  Marveld2; MARVEL domain-containing protein 2 [KO:K17291]
110329411  Hcls1; hematopoietic lineage cell-specific protein [KO:K06106]
110329471  Myh11; myosin-11 isoform X1 [KO:K10352]
110329625  Cldn1; claudin-1 [KO:K06087]
110329713  Runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
110329715  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
110329722  Cldn5; claudin-5 [KO:K06087]
110329778  Jam2; junctional adhesion molecule B [KO:K06735]
110329902  Igsf5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
110329976  Cldn16; claudin-16 [KO:K06087]
110330072  Cldn8; claudin-8 [KO:K06087]
110330109  Cldn14; claudin-14 [KO:K06087]
110330140  Cldn17; claudin-17 [KO:K06087]
110330159  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
110330198  Nf2; merlin isoform X1 [KO:K16684]
110330369  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
110330376  Whamm; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
110330449  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110330537  Actr2; actin-related protein 2 isoform X1 [KO:K17260]
110331089  Myh10; myosin-10 isoform X1 [KO:K10352]
110331106  Actg1; actin, cytoplasmic 2 [KO:K05692]
110331339  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110331422  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110331461  Llgl2; lethal(2) giant larvae protein homolog 2 [KO:K06094]
110331568  Rapgef6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
110331745  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X1 [KO:K13365]
110331764  Llgl1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
110332203  Cldn7; claudin-7 [KO:K06087]
110332423  Hspa4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
110332652  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110332843  Ppp2r2b; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
110333139  Nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
110333164  Myh14; myosin-14 isoform X1 [KO:K10352]
110333218  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
110333268  Synpo; synaptopodin isoform X1 [KO:K21112]
110333507  Dlg2; disks large homolog 2 isoform X1 [KO:K12075]
110333549  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
110334021  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
110334563  [KO:K07374]
110334582  Myh9; myosin-9 [KO:K10352]
110334588  Scrib; protein scribble homolog isoform X1 [KO:K16175]
110334627  [KO:K07374]
110334696  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
110335458  Myl12b; myosin regulatory light chain 12B isoform X1 [KO:K12757]
110335459  [KO:K12757]
110335633  Tjap1; tight junction-associated protein 1 isoform X1 [KO:K06105]
110336071  Crb3; protein crumbs homolog 3 isoform X1 [KO:K06090]
110336160  Prkce; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
110336304  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
110336400  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110336413  Vasp; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
110336451  Rab8a; ras-related protein Rab-8A [KO:K07901]
110336469  Sympk; symplekin [KO:K06100]
110336920  [KO:K21066]
110337052  Cldn23; claudin-23 [KO:K06087]
110337128  [KO:K06087]
110337220  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110337225  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
110337228  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
110337655  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
110337741  Marveld3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
110337870  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
110337932  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
110338212  Cldn20; claudin-20 [KO:K06087]
110338251  Cldn6; claudin-6 [KO:K06087]
110338269  Cldn9; claudin-9 [KO:K06087]
110338407  Afdn; afadin isoform X1 [KO:K05702]
110338525  Ezr; ezrin isoform X1 [KO:K08007]
110338744  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
110339030  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110339090  Arpc1b; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
110339155  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
mpah04520  Adherens junction
mpah04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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